특허 분석을 통한 건설 기술 연구 기획

김창윤(Kim Chang-Yoon),김형관(Kim Hyoung-Kwan),김창완(Kim Chang-Wan),한승헌(Han Seung-Heon),김문겸(Kim Moon-Kyum) 대한건축학회 2008 大韓建築學會論文集 : 構造系 Vol.24 No.12

Diverse research efforts that have been conducted are reflected in the patent information. Patent analysis facilitates the understanding of the major technological area and how the technologies change. It provides the essential data for strategy development of research and development. In this paper, based on literature analysis and expert review, 40 keywords had been selected for searching advanced construction patents. 737 patents of US, EU, and Japan during January 1991 and May 2006 are analyzed. Technology trends of each phase of construction lifecycle are derived through the patent data and patent map analysis. Construction research and development strategies are deduced based on the patent analysis. This research effort suggests a systematic methodology for how patent information is incorporated into new construction research and development plans.

개선된 텍스쳐 정보를 이용한 갑작스러운 조명 변화에 강인한 이동 물체 탐지

오요한(Yoe Han O),장형진(Hyung Jin Chang),김수완(Soo Wan Kim),최진영(Jin Young Choi) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.10

Moving object detection is a fundamental technique in visual surveillance. Robust technique to enhance performance of moving object detection is required for several bad conditions in real external circumtance. In case of sudden illumination change in outdoor condition. many objects are determined as moving object though they are not really moving, but just their illumination changes. This makes the detection result untrustworthy. In this paper, robust moving object detecton to sudden illumination change using gaussian mixture background model and new texture information using background from the weighted sum of recent images is proposed.

Thermoplasma acidophilum의 20S Proteasome에 의한 ATPase-활성적 단백질분해에 관한 연구

우기민,장예진,조만희,김창세,김완종,조성호,이상한 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.1

The eukaryotic 26S proteasome is an ATP/ubiquitin-dependent proteolytic complex consisting of the 20S core particle and 19S ATPase complex. However, because of its complexity and unstable properties, this study was carried out to present more simple and stable model for the ATP-activated proteolytic complex in prokaryotes which can take the place of the eukaryotic 26S proteasome. For this purpose, recombinant Thermoplasma 20S proteasome (T20S) and Methanococcus MS4, a sequence homolog of one ATPase subunit in the 19S ATPase complex, were successfully isolated from Escherichia coli (E. coli). The α and β subunits of T20S expressed in E. coli could assemble for themselves, and showed the peptide-hydrolyzing activity. Whereas both T20S and R20S (the 20S complex from rabbit skeletal muscle) had the highest peptidase activity against Suc-LLVY-AMC, a good substrate for chymotrypsin-like peptidase activity, the specific activity of T20S was slightly lower than that of R20S. In addition, several reagents such as KCI, SDS, and ovalbumin were shown to have different effects on the peptidase activities between T20S and R20S. When the ATPase activity of the purified MS4 were assayed , the Km for ATP was about 0.5 mM, and casein could stimulate the activity more than 2 fold without the change in Km. This result implicates that protein-activated ATPase may induce the conformational change of casein, and therefore suggests that MS4 ATPase may activate the proteolytic activity of the 20S proteasome via accelerating the recognition and translocation of the protein substrates.

Gene Expression Analysis of the Bromobenzene Treated Liver with Non-hepatotoxic Doses in Mice

Lim, Jung-Sun,Jeong, Sun-Young,Hwang, Ji-Yoon,Park, Han-Jin,Cho, Jae-Woo,Song, Chang-Woo,Kim, Yang-Seok,Lee, Wan-Seon,Moon, Jin-Hee,Han, Sang-Seop,Yoon, Seok-Joo The Korean Society of Toxicogenomics and Toxicopro 2005 Molecular & cellular toxicology Vol.1 No.4

Bromobenzene (BB) is well known hepatotoxicant. Also, BB is an industrial solvent that arouses toxicity predominantly in the liver where it causes centrilobular necrosis. BB is subjected to Cytochrome P450 mediated epoxidation followed by either conjugation with glutathione, enzymatic hydrolysis or further oxidation. In this study, we focused on BB-induced gene expression at non-hepatotoxic dose. Mice were exposed to two levels of BB, sampled at 24 h, and hepatic gene expression levels were determined to evaluate dose dependent changes. When examining the toxic dose of BB treated group in other previous studies, genes related to heat shock protein, oxidative stress, and drug metabolism are expressed. Compared to these results, our study, in which non-toxic dose of BB was administrated, showed similar patterns as the toxic conditions above. The purpose of the study was to select genes that showed changes in relation to the differing dose through confirmation of the difference within transcriptomic boundaries, but those that are not detected by the existing classic toxicology tools in non-hepatotoxic dose.

공분산 구조방정식을 이용한 한국판 고령자 활동능력 지표의 개발에 있어서의 교차타당성의 검토

한창완 우송대학교 2004 우송대학교 논문집 Vol.9 No.-

The purpose of this study was to examine the cross validity of Korean Index of Competence. Subjects were 302 elderly utilizing care services and 278 older adults attending community activities held at the 15 senior welfare centers in Seoul. The cross validation in terms of confirmatory factor analysis was performed. In this analysis, the second-order factor model developed by Park and his colleagues (1998) was used. The model consisted of one second-order factor Competence and three first-order factors Instrumental Self-maintenance, Intellectual Activity, and Social Role. The result of analysis demonstrated the factor model adequately fit to the data, and confirmed cross-validity of the index. Furthermore, the utility of the index was examined in terms of relation to self-perceived health. The results indicated that the competence assessed by the scale sufficiently predicted the degree of self-perceived health. This result implies the Korean Index of Competence is useful in evaluating health status in community older adults and outcomes of community-based health services.

ABAQUS를 이용한 휨벽체의 비선형 유한요소 해석기법

한민기,박완신,한병찬,황선경,최창식,윤현도 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

The finite element method(FEM) models were developed for the reinforced concrete flexural walls and analysed under constant axial and monotonic lateral load using ABAQUS. The major objective of the present study is to determine if the ABAQUS finite element program can be used to accurately model the post-cracked mode of failure in plastic regions of walls, and, if so, to develop practical failure criteria in the plastic range of the material response. The research comprises constitutive models to represent behavior of the materials that compose a wall on the basis of experimental data, development of techniques that are appropriate for analysis of reinforced concrete structures, verification, and calibration of the global model for reinforced concrete walls of increasing complexity. The proposed FEA technique is verified by Lefas's benchmark data. Results from the analyses of these FEM models offers significant insight into the flexural behavior of benchmark data.

대량의 각혈로 사망한 장티푸스 1예

한상우,유진홍,권순석,김성훈,박지찬,홍은정,최경성,박용완,장준희,안지원,박유경,강지영,박상미,신완식 대한감염학회 2004 감염과 화학요법 Vol.36 No.5

We experienced a 25 year-old male patient with typhoid fever complicated with massive hemoptysis. Pulmonary complication in typhoid fever is very rare and to our knowledge, there has been no report of hemoptysis as a main cause of death with this disease. We herein report a rare case of typhoid fever.

7,12-Dimethylbenz(a)anthracene(DMBA)에 의해 유발된 생쥐 피부종양의 특성

장예진,한상철,김완종 순천향대학교 기초과학연구소 1996 순천향자연과학연구 논문집 Vol.2 No.2

Skin tumor of hairless mouse (Mus musculus) induced by 7,12-dimethylbenz(a)anthracene (DMBA) was observed by light and electron microscopes. On histologic examination, it was revealed that the tumor type was the squamous cell carcinoma. The skin tumor tissue had the thick epidermis and was more keratinized than the case of normal skin. Electron microscopy of the tumor cells, in comparison with normal cells, showed a number of cytoplasmic processes and a cytoplasmic bridge between adjacent cells. Also, the ratio of heterochromatin to euchromatin was high in the tumor cell. There were plentiful free ribosomes and numerous mitochondria in the cytoplasm, suggesting the use of for rapid proliferation. At the dermal-epidermal junction, the basal lamina of tumor cells showed the intermittent discontinuities, through which their cytoplasmic processes penetrate, indicating invasion or metastasis of the tumor cells.

융모성림프구를 보이는 비장변연부 림프종 1예

진한영,손창학,주영돈,박정하,이재익,조영완,이원식 인제대학교 2006 仁濟醫學 Vol.27 No.-

Splenic marginal zone lymphoma is very rare B-cell lymphoma, characterized by an indolent clinical course. Clinical features are moderate-to severe splenomegaly, absolute lymphocytosis, and bone marrow intrasinusoidal infiltration of lymphocyte. We report the case of a 37-year-old male with SMZL. He complained of LUQ pain, who had a massive splenomegaly and moderate lymphocytosis in peripheral blood. Immunophenotyping findings and morphologic findings were consistent with SMZL. He underwent splenectomy and received chemotherapy with cyclophosphamide for eight months. Now, one year later after surgery he has a nearly normal blood count with no treatment.

골형태분석법과 micro-CT를 이용한 골소주 특성에 대한 연구

송영한,이완,이창진,지정현,이병도 대한구강악안면방사선학회 2007 Imaging Science in Dentistry Vol.36 No.1

Purpose : The research was done to investigate the effectiveness of 2D bony morphometry and microstructure of micro-computed tomography (micro-CT) on the osteoporotic bony change. We performed the bone morphometric analysis of proximal femur in ovariectomized rabbits with BMD and micro-CT examination. Materials and Methods : Twenty-one female (Newzealand, about 16 weeks old, 2.9-3.4 kg) rabbits were used. Three rabbits were sacrificed on the day when experiment began (Baseline). The remaining 18 rabbits were divided into two groups. One group was ovariectomized bilaterally (OVX) and the other animals were subjected to sham operation (Sham). Bone specimens were obtained from the right and left femur of sacrificed rabbits. At intervals of 1, 2, 3, 5, 6 months respectively, BMD tests were performed on the proximal femur by using PIXImus 2 (GE Lunar Co. USA), 2-dimensional bone morphometric analysis by custome computer program and 2D/3D bone structure analysis by micro-CT (Skyscan1072, Antwerpen, Belgium). Statistical analysis was carried out for the correlation between bone morphometry , micro-CT and BMD Result : BV/TV, Tb.Th, Tb.N of micro-CT parameters showed higher values in sham group than OVX group. N.Nd/Ar.RI, N.NdNd, N.NdTm, N. TmTm, PmB/Ar.RI, 3-D BoxSlope of 2D morphometric parameters showed higher values in Sham group than OVX group. The micro-CT parameters of Tb.Sp, Tb.N were statistically significant correlated with BMD respectively. Several 2D morphometric parameters were statistically significant correlated with BMD respectively. Conclusion : Several parameters of 2D bony morphometry and micro-CT showed effective aspects on the osteoporotic bony change. (Korean J Oral Maxillofac Radiol 2007; 37 : 27-33)