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악성종양환자에서 중등도 이상의 오심, 구토를 유발하는 항암화학요법 시급성 및 지연성 오심, 구토의 예방에 대한 Dolasetron의 효과
김대성,성혜영,최경미,백지연,노상영,문한림,김춘추,홍영선,Kim, D.S.,Sung, H.Y.,Choi, K.M.,Paik, J.Y.,Roh, S.Y.,Moon, H.,Kim, C.C.,Hong, Y.S. 한국호스피스완화의료학회 2004 한국호스피스.완화의료학회지 Vol.7 No.2
목적: 전향적 임상시험을 통해 중등도 이상의 오심, 구토를 유발하는 항암화학요법제 투여로 인한 급성 및 지연성 오심, 구토의 예방에 있어서 dolasetron mesylate의 유효성 및 안정성을 평가하고자 하였다. 방법: 단일 기관에서 공개형, 단일군 임상시험으로 시행되었다. Dolasetron (1.8 mg/kg)과 dexmamethosone 10 mg을 항함화학요법 시작전에 투여하고 나서 이후 24시간 후부터 4일 연속 경구형 dolasetron(200 mg, 1일 1회)을 투여하였다. 구토의 빈도 오심의 중증도, $5-HT_3$ 이외의 구제 항구토제의 사용여부를 화학요법 시작 제1일부터 5일까지 매일 평가하였다. 결과: 30명의 환자가 연구에 참여하였고, 이 중 28명이 유효성 평가가 가능하였다. 28명 중 4명이 5일동안 구제항구토제를 전혀 사용하지 않는 오심, 구토의 완전 조절을 보였다. 완전 조절을 보이는 환자비율은 제 1일에서 5일로 가면서 17.9/46.4/42.9/53.6/60.7%로 시간이 경과하면서 향상되었다. Cisplatin 포함 화학요법과 비포함 화학요법 모두에서 오심보다는 구토가 보다 잘 조절되었다. Dolasetron에 의한 이상반응은 경증에서 중등도의 두통, 설사, 발열 등이었고, 대개 저절로 회복되었다. 결론: Dolasetron은 중등도 이상의 오심, 구토를 유발하는 항암화학요법에서 급성 및 지연성 오심, 구토의 예방에 있어 기존의 반응률 50%에 상당하는 반응률을 보였으며, 안전성면에서도 수용할 만한 경미한 이상반응만을 보여 오심, 구토의 예방에 유용한 약제로 판단된다. Purpose: To evaluate the efficacy of dolasetron mesylate in controlling nausea and vomiting in the first 24 hours and to extend these comparisons over the next 4 days in patients receiving moderately emetogenic chemotherapy. Methods: This was a single center, open-labeled study with single arm. Dolasetron (1.8 mg/kg) was given intravenously (I.V.) prechemotherapy with 10 mg of dexamethasone IV, followed 24 hours later by oral dolasetron (200 mg once daily) for the subsequent 4 days. The frequency of vomiting, severity of nausea and the presence of rescue antiemetics were assessed daily. Results: Of 30 patients enrolled, 28 were eligible and evaluable for the efficacy. Four out of 28 patients had complete control of nausea and vomiting without any rescue antiemetics through 5 days. The complete control got better as time went by with the rates of 17.9/46.4/42.9/53.6/60.7% on days 1 to 5. Vomiting was better controlled than nausea in both cisplatin-containing and non-containing chemotherapy. The adverse events were mild to moderate degrees of headache, diarrhea and fever, but were recovered spontaneously. Conclusion: Dolasetron was effective and safe for the control of nausea and vomiting in the patients with moderately emetogenic chemotherapeutic agents.
자파르 하미드(Hameed, Z.),홍영선(Hong, Y.S.),안성훈(Ahn, S.H.),조영만(Cho, Y.M.),송철기(Song, C.K.),박종포(Park, Jong-Po) 한국신재생에너지학회 2007 한국신재생에너지학회 학술대회논문집 Vol.2007 No.06
Renewable energy sources such as wind energy is copiously available without any limitation. Wind turbines are used to tap the potential of wind energy which is available in millions of megawatt. Reliability of wind turbine is critical to extract this maximum amount of energy from the wind. We reviewed different techniques, methodologies, and algorithms developed to monitor the performance of wind turbine as well as for an early fault detection to keep away the wind turbines from catastrophic conditions due to sudden breakdowns. To keep the wind turbine in operation, implementation of Condition Monitoring System (CMS) is paramount, and for this purpose ample knowledge of these types of system is mandatory. So, an attempt has been made in this direction to review maximum approaches related to CMS in this piece of writing.
서울지역 4년제 간호대학생들의 임상실습 유,무에 따른 진로태도성숙
권혜진,김보람,김소연,김수임,성정아,신영미,윤서진,이경진,홍영선,이자형,정덕유,신혜원 이화여자대학교 간호과학대학 2009 이화간호학회지 Vol.- No.43
This study was conducted to investigate the differences in the degrees of career attitude maturity according to the clinical practice experience of the college of nursing students. The convenience sample was 275 students attending the college of nursing in Seoul. Data was obtained through a questionnaire from December 1st to 12th, 2008. The instrument used to measure the career attitude maturity in this study was "A barometer of maturity in career attitudes" developed by Ki-hak, Lee(1997). The collected data were analyzed by descriptive statistics, Chronbach's alpha, t-test and ANOVA with the SPSS 16.0 program. Below is the result of this study. 1. The average score for career attitude maturity of nursing students who experienced clinical practices was 135.56(±12.17): higher than the average score of inexperienced students, 134.37(±12.44). However it could not show meaningful differences in the statistics(F=-.805, p=.422). 2. Determinacy, one of five subordinate concepts of career attitude maturity, was statistically significative. On average, the group comprised of students with clinical practices scored 27.60(±3.81): higher than that of unpracticed students, 26.63(±4.26)(F=-1.976, p=.049). 3. The more academic years they have, except for junior year students, the points of career attitude maturity relative to general characteristics were increasingly higher. The points were 132.60(±11.99) for freshmen, 135.93(±12.72) for sophomores, 133.50(±12.57) for juniors and 138.11(±11.24) for seniors(F=2.714, p=.045). 4. According to the age of the group, the grade of career attitude maturity became higher. The scores were 133.21(±12.34) for 18-19yrs., 134.05(±12.16) for 20-22yrs., 138.43(±10.96) for 23-26yrs. and 148.71(±12.76) for 27-32yrs. (F=5.118, p=.002). 5. The average total score for career attitude maturity of nursing students was 135.00(±12.30). Of the five subdivisions―readiness, conviction, determinacy, independence and finality― readiness demonstrated the highest result with 32.33(±4.46) followed by conviction, determinacy, independence and finality respectively. Based on the results, there are some proposals for further researches. As this research was only for college of nursing in Seoul, it is necessary to compare career attitude maturity with 3-year colleges and other departments. In addition, alongside clinical practices there is a growing need to develop programs that will not only provide guidelines but also prepare students for the maturity of their career attitude.