결합제의 종류와 양에 따라 분무건조된 페라이트 분말의 성형특성

홍대영,변순천,제해준,홍국선 한국세라믹학회 1995 한국세라믹학회지 Vol.32 No.9

Mn-Zn ferrite granules were formed by a spray-drying method of the slurry containing different kinds and concentrations of binders at various temperatures. The slurry was made by conventional ceramic processing method, that is, by mixing Fe2O3, MnO, ZnO powders (52 : 24 : 24 mol%), calcining and milling. Typical shape of the spray dried granules was spherical. The compaction behavior of these granules was dependent on the spray-drying temperature and the kind and concentration of binders. At lower pressure the granules were displaced and at higher pressure the granules were deformed and fractured to fill pores among the granules. The optimum concentration of the binder was 0.5wt%. The granules containing 0.5wt% PVA 205 were deformed and fractured well and the green density was higher than others. At higher concentrations of the binder the granules were deformed rather than fractured, therefore the green density was lowered because of the remaining unfilled pores. The decomposition temperature and the heat released were increased with increasing the concentration of the binders. The compaction response of the granules containing PVA 205 was more efficient than those containing PVA 217 and PVA 117. Green density was not dependent on the degree of hydrolysis of the binders. The compaction response of the granules spray-dried at 15$0^{\circ}C$ was most efficient.

Dicamba 급성 중독으로 인한 사망 1례

홍대영,엄욱현,이경미,김지혜,한승백,서주현,김준식,노형근,Hong Dae-Young,Um Wook-Hyun,Lee Kyoung-Mi,Kim Ji-Hye,Han Seung-Baik,Suh Joo-Hyun,Kim Jun-Sig,Roh Hyung-Keun 대한임상독성학회 2006 대한임상독성학회지 Vol.4 No.1

Dicamba is a benzoic acid and classified as a chemically related chlorophenoxy herbicide which is widely used for the control of broad-leaved weeds. While the chlorophenoxy herbicide poisoning is known to be uncommon, its ingestion can result in serious or sometimes fatal outcome. A 65-year-old man ingested about 300 ml of dicamba in a suicidal attempt and three hours later he was admitted hospital, complaining abdominal pain, nausea and vomiting. On admission his vital signs were normal and laboratory findings were not remarkable except metabolic acidosis in arterial blood gas analysis. Shortly after the admission endotracheal tube was inserted due to altered mental state and activated charcoal was given after performing gastric lavage. However, his vital signs became unstable 6hrs after the ingestion and mechanical ventilation was started with administration of inotropic agents. In spite of urine alkalization for rapid elimination of the absorbed dicamba, the metabolic acidosis was aggravated with concomitant rhabdomyolysis and acute renal failure, and he died 24 hrs after the ingestion.

유기인계-피레스로이드계 혼합제제 농약에 의한 중독

홍대영,백광제,이경룡,권운용,박준석,어은경,오범진,이미진,이성우,서주현,노형근,김준식,Hong, Dae-Young,Baek, Kwang-Je,Lee, Kyeong-Ryong,Kwon, Woon-Yong,Park, Joon-Seok,Eo, Eun-Kyung,Oh, Bum-Jin,Lee, Mi-Jin,Lee, Sung-Woo,Suh, Joo-Hyun,Roh, 대한임상독성학회 2007 대한임상독성학회지 Vol.5 No.1

Purpose: Owing to organophosphate-pyrethroid mixtures are widely used, suicidal or unintentional poisoning is common. But there have been relatively few reports of poisoning. The purpose of this study is to evaluate the difference of the severity and toxicity between organophosphate-pyrethroid mixtures poisoning and single organophosphate poisoning. Methods: From August 2005 to July 2006, 65 patients presented with organophosphate-pyrethroid mixtures poisoning to emergency medical center. Date were gathered by report form it was drawn up. Results: 65 patients were enrolled in 28 hospitals and their mean age was $56.5{\pm}16.2$ years old. The most common cause of poisoning was suicide, in 52 cases(80%). Chlorpyrifos-cypermethrin, malathion-esfenvalerate were the most frequent chemicals involved, and the mean ingestion amount was 135.4ml. The most common symptom of the patients was nausea/vomiting, in 16 patients. The average GCS score was 13. The mean ICU stay was $4.4{\pm}5.2$ days, and mortality was 3.1%. Conclusion: The severity and toxicity of organophosphate-pyrethroid mixture poisoning were lower than that of single organophosphate poisoning.

Expression of VEGF, HGF, IL-6, IL-8, MMP-9, Telomerase in Peripheral Blood of Patients with Head and Neck Squamous Cell Carcinoma

홍대영,이병주,이진춘,왕수건,최진식,노정훈 대한이비인후과학회 2009 Clinical and Experimental Otorhinolaryngology Vol.2 No.4

Objectives. This study investigated the telomerase expression in peripheral blood mononuclear cells (PBMCs) and the relationship between the serum level of several soluble factors such as vascular endothelial growth factor (VEGF), hepatocyte growth factor, interleukin (IL)-6, IL-8, and matrix metallopeptidase-9 and the clinicopathological features of patients with head and neck squamous cell carcinoma (HNSCC). Methods. Peripheral blood samples were collected from 50 HNSCC patients and 15 normal controls. The telomerase activity in the PBMCs was measured by Telomere Repeat Amplification Protocols. The serum levels of the soluble factors were analyzed by enzyme-linked immunosorbent assay. Results. The expression of telomerase in the PBMCs of HNSCC patients was significantly correlated with the N and American Joint Committee on Cancer (AJCC) stages. The serum VEGF level was significantly higher in the patients with an advanced T stage, N stage and AJCC stage. Serum VEGF was significantly related with the expression of telomerase in the PBMCs. The telomerase expression and the VEGF expression were shown to be independent factors associated with poor survival. Conclusion. The telomerase expression in the PBMCs and the serum VEGF level of HNSCC patients were significantly correlated with the N stage, the AJCC stage and the prognosis. Objectives. This study investigated the telomerase expression in peripheral blood mononuclear cells (PBMCs) and the relationship between the serum level of several soluble factors such as vascular endothelial growth factor (VEGF), hepatocyte growth factor, interleukin (IL)-6, IL-8, and matrix metallopeptidase-9 and the clinicopathological features of patients with head and neck squamous cell carcinoma (HNSCC). Methods. Peripheral blood samples were collected from 50 HNSCC patients and 15 normal controls. The telomerase activity in the PBMCs was measured by Telomere Repeat Amplification Protocols. The serum levels of the soluble factors were analyzed by enzyme-linked immunosorbent assay. Results. The expression of telomerase in the PBMCs of HNSCC patients was significantly correlated with the N and American Joint Committee on Cancer (AJCC) stages. The serum VEGF level was significantly higher in the patients with an advanced T stage, N stage and AJCC stage. Serum VEGF was significantly related with the expression of telomerase in the PBMCs. The telomerase expression and the VEGF expression were shown to be independent factors associated with poor survival. Conclusion. The telomerase expression in the PBMCs and the serum VEGF level of HNSCC patients were significantly correlated with the N stage, the AJCC stage and the prognosis.

반복적 허혈증상을 유발하는 척추동맥의 개창성기형- 증 례 보 고 -

홍대영,김문철,이상평,최기환,여형태 대한신경외과학회 2002 Journal of Korean neurosurgical society Vol.31 No.1

In angiographic examinations, abnormalities of vertebral arteries are incidental findings because they are, in most of cases, clinically asymptomatic. We report a case of young woman with a fenestrated anomaly of the left vertebral artery with ischemic strokes. The patient was suffered from repeated attacks of transient ishemic attack(TIA) and cerebral infarction. Vertebral angiography demonstrated a fenestrated anomaly of the left vertebral artery and a large intraluminal thrombus was detected at just proximal of the fenestration. Proximal balloon occlusion of the involved vertebral artery was done and the patient became free from ischemic attack. Follow-up angiography showed well visualization of the posterior circulation through right vertebral artery and the ballooned vertebral artery was well occluded. The left posterior inferior cerebellar artery(PICA) was filled well via collateral circulation from the opposite side. Key words:Ischemic stroke;Fenestrate vertebral artery;Balloon embolization.

응급의료센터에 내원한 소아 폐렴의 진료 지침을 위한 기초 자료 연구

홍대영,이경미,김지혜,김준식,한승백,임대현,손병관,이훈재,이경희 대한소아청소년과학회 2006 Clinical and Experimental Pediatrics (CEP) Vol.49 No.7

Purpose : Pneumonia is one of the most common infections in children who visit emergency departments(ED), but standard clinical guidelines for children with pneumonia in Korea have not been studied. This study was performed to collect and evaluate a data-base of children with pneumonia for establishing clinical guidelines in ED. Methods : This study reviewed 304 children who were diagnosed and treated for pneumonia in the ED at one tertiary hospital between January 2003 and December 2003 retrospectively by reviewing the charts and analyzing the clinical characteristics, laboratory findings, and radiologic findings between an admission group and a discharge group. Results : The 2 year-5 year age group was the top of age distribution and the peak incidence of monthly distribution was December. Two hundred forty seven(81.3 percent) children were hospitalized(admission group), and the mean length of hospitalization was 7.24±3.24 days. The most common indications of admission were fever, tachypnea and an age of less than three months. There was statistical differences in the outpatient department follow-up between the two groups(85.8 percent in admission group vs 35.1 percent in discharge group). Conclusion : More prospective studies are needed to establish clinical standard guidelines for children with pneumonia. This will be helpful in ED management and will aid the prevention of pneumonia. 목 적 : 폐렴은 응급센터에 내원하는 소아 호흡기 질환 중 흔히 볼 수 있는 질환이지만 응급센터에서 진료 및 입원과 퇴원을 결정하는데 기준이 되는 표준 진료 지침이 구축되어 있지 않다. 이것을 위한 응급센터에 내원한 소아 폐렴에 대한 기초 자료가 충분하지 못한 상황이므로 저자들은 일개 삼차 의료기관 응급센터에 내원한 소아 폐렴 환자의 분석을 통해 기초 역학 조사와 함께 입원 및 퇴원에 대해 임상적 차이점과 진료 지침을 알아보고자 하였다. 방 법 : 2003년 1월부터 2003년 12월까지 일개 삼차병원 응급센터를 내원 후 폐렴으로 진단받았던 1개월 이상 15세 미만의 소아 304명을 대상으로 후향적으로 분석하였다. 두 군의 기초 역학 자료로 연령과 성별을 비교하였고, 입원군과 퇴원군에서 임상 증상, 신체 검사 소견, 내원 전 다른 병원 진료 여부, 응급센터 내원 전 증상 지속 기간, 혈액 검사 및 흉부 방사선 촬영 결과, 외래 추적 관찰 여부 등을 비교하였다. 결 과 : 응급센터에 내원한 소아 폐렴 환자의 1년간의 연구에서 남아 168명(55.3%), 여아 136명(44.7%)으로 남녀비는 1.24 : 1이었다. 입원군은 247명(81.3%)이었고 퇴원군은 57명(18.7%)이었다. 연령은 입원군과 퇴원군에서 각각 2-5세 연령대가 많았고(입원군 37.2%, 퇴원군 52.6%) 두 군 모두 겨울철에 많이 내원하였다. 입원 적응의 기준으로는 3개월 미만, 열, 급성 병색을 보이는 경우, 빈호흡 및 수포음 청진 소견과 백혈구 수 증가 등이 두 군에서 통계적으로 유의한 차이를 보였다. 방사선 소견은 입원 결정에 도움을 주지 못했으나 입원 기간에는 영향을 주었고, 입원군에서 퇴원군보다 외래 추적 관찰이 잘 되었다.

悲魂

홍대영 대구대학교 국어교육과 1993 나랏말쌈 Vol.8 No.-

두개내압 상승 평가에서 초음파를 이용한 시각신경집 지름 측정의 유용성

홍대영,조순구,고영길,김강호,이경미,김지혜,김준식,한승백,이훈재 대한응급의학회 2006 大韓應急醫學會誌 Vol.17 No.3

1920년대 민요시의 재인식 - 민요시의 율격을 중심으로

홍대영 대구대학교 국어교육과 1997 나랏말쌈 Vol.12 No.-

비외상성 척추 경막외 혈종

홍대영,김문철,이상평,최기환,여형태 대한신경외과학회 2002 Journal of Korean neurosurgical society Vol.31 No.1

Spontaneous spinal epidural hematoma is a rare entity. Various definitions for spontaneous epidural hematoma have been reported in the literature. The expression of nontraumatic spinal epidural hematoma seems to be less ambiguous and includes idiopathic hematomas and hematomas secondary to coagulopathy, vascular malformations, and tumors. We report three cases of nontraumatic spinal epidural hematomas observed from 1991 to 2000. The causes of the spinal epidural hematomas were not clear in two cases among them, but in the another one case, the cause was determined to be an acquired coagulopathy. We reviewed 24 cases reported in the Korean Journal of Neurosurgery and our three cases with particular emphasis on the various causes such as coagulopathy, vascular malformations and tumors. Among the 27 cases, numerous causes were detected such as three cases of vascular malformation, one case of anticoagulant treatment, five cases of combined lumbar disc herniation, two cases associated with pregnancy and postpartum, one case associated with hypertension, and one case associated with ossification of ligamentum flavum. No causes were detected in the ten cases. The authors reviewed the literature. Key words:Nontraumatic spinal epidural hematoma;Etiology. 연령과 남녀비 4세에서 82세까지 다양하게 분포하였고 평균나이는 37.6세였다. 남자가 20명 여자가 7명(2.9:1)으로 보고되었다. 병력과 혈종원인 및 직업 총 27례 중 혈관기형 3례(수술시야에서 확인한 다음 조직검사에서 확진한 경우), 항응고제 사용의 합병증 1례, 추간판 탈출증을 동반한 경우가 5례, 임신과 출산이 관련된 경우가 2례, 고혈압이 있은 경우가 1례, 황인대 골화증과 동반된 경우가 1례였다. 이 중 직업상 군인, 유도선수, 농구선수거나, 병력 상 무거운 물건을 든 후, 태권도 후와 같이 반복적인 minor trauma가 있을 것으로 추정되는 경우가 8례였다. 어떠한 형태의 원인도 찾을 수 없었던 경우는 총 10례였다. 수술 전 신경학적 결손정도 및 술 후 예후 27례에서 모두 수술을 시행하였고 이 중 수술 전 불완전마비인 16례 중 술 후 완전회복 8례, 부분회복 7례, 변화없음 1례였고 수술 전 완전마비인 6례 중 술 후 완전회복 2례, 부분회복 3례, 변화없음 1례로 보고 되었다. 또한 수술 전 신경근 증상만 보인 5례는 전례에서 완전회복을 보였다.