예측알고리즘 적용을 위한 데이터세트 구성이 근적외선 분광광도계를 이용한 옥수수 품질평가에 미치는 영향

최성원,이창석,박창희,김동희,박성권,김법균,문상호,Choi, Sung-Won,Lee, Chang-Sug,Park, Chang-Hee,Kim, Dong-Hee,Park, Sung-Kwon,Kim, Beob-Gyun,Moon, Sang-Ho 한국축산환경학회 2014 한국축산시설환경학회지 Vol.20 No.3

The objectives were to assess the use of near-infrared reflectance spectroscopy (NIRS) as a tool for estimating nutrient compositions of corn kernel, and to apply an NIRS-based indium gallium arsenide array detector to the system for collecting spectra and analyzing calibration equations using equipments designed for field application. Partial Least Squares Regression (PLSR) was employed to develop calibration equations based on representative data sets. The kennard-stone algorithm was applied to induce a calibration set and a validation set. As a result, the method for structuring a calibration set significantly affected prediction accuracy. The prediction of chemical composition of corn kernel resulted in the following (kennard-stone algorithm: relative) moisture ($R^2=0.82$, RMSEP=0.183), crude protein ($R^2=0.80$, RMSEP=0.142), crude fat ($R^2=0.84$, RMSEP=0.098), crude fiber ($R^2=0.74$, RMSEP=0.098), and crude ash ($R^2=0.81$, RMSEP=0.048). Result of this experiment showed the potential of NIRS to predict the chemical composition of corn kernel.

당뇨망막병증 환자에서의 망막지혈증

최성원,김유철.Sung Won Choi. MD. Yu Cheol Kim. MD 대한안과학회 2014 대한안과학회지 Vol.55 No.4

Purpose: To report a case of lipemia retinalis in a patient with diabetes. Case summary: A 27-year-old female with type 2 diabetes visited our clinic with visual disturbance in her left eye while being followed up from a pars plana vitrectomy in her right eye for proliferative diabetic retinopathy. On fundus examination of both eyes, the retinal vessels were creamy white and the retinal veins were undistinguishable from the retinal arteries. The serum triglyceride level was 2,676 mg/dL. The patient was asymptomatic except for visual impairment due to vitreous hemorrhage in her left eye. The patient was diagnosed with lipemia retinalis and chylomicronemia syndrome. After controlling the triglyceride level, funduscopic findings in the both eyes were improved. However, the visual acuity in her right eye remained unchanged. Conclusions: Lipemia retinalis can be a sign of a systemic condition although it may not affect visual acuity. Fundus examination may be a useful tool in the early diagnosis of hyperlipidemia. J Korean Ophthalmol Soc 2014;55(4):623-627

40세 이하에서 발생한 열공망막박리의 고찰

최성원,김광수,김유철,Sung Won Choi,MD,Kwang Soo Kim,MD,Yu Cheol Kim,MD 대한안과학회 2014 대한안과학회지 Vol.55 No.12

Purpose: To investigate the risk factors and the factors affecting surgical and visual outcomes of rhegmatogenous retinal detachment in patients under 40 years of age. Methods: This retrospective study included 88 patients (96 eyes) diagnosed with rhegmatogenous retinal detachment that were followed up for more than 3 months postoperatively. Patients were categorized into 3 groups according to age. The etiologic risk factors and the primary anatomical and functional success rates were analyzed. Preoperative factors that could affect postoperative visual acuity and primary anatomical outcome, such as subretinal strands and proliferative vitreoretinopathy (grade C or worse), were analyzed. Results: Myopia more severe than -4.0 diopters was the most common predisposing factor in all 3 groups. Anatomical success rates and functional success rates were not significantly different among the groups. Prevalence of macular detachment and proliferative vitreoretinopathy were highest in group 1. The presence of subretinal strands was highest in group 2 and proliferative vitreoretinopathy was highest in group 1. Patients with preoperative subretinal strands showed a lower primary anatomical success rate in group 1 and poor postoperative visual acuity in groups 1 and 2. Patients with proliferative vitreoretinopathy had poor postoperative visual acuity however there was no significant difference in primary anatomical success rate among the groups.Conclusions: Proliferative vitreoretinopathy did not affect the anatomical success rate but did affect visual outcome in rhegmatogenous retinal detachment in patients under age 40. Subretinal strands contributed to a lower anatomical success rate and poorer visual outcome in such patients that were under age 18. J Korean Ophthalmol Soc 2014;55(12):1808-1813

비후성 반흔 각질세포와 정상 각질세포의 유전자 비교분석

최성원,정호윤,임영국,김훈남,오지원,김문규,전세화,홍용택,Choi, Sung-Won,Chung, Ho-Yun,Lim, Young-Kook,Kim, Hoon-Nam,Oh, Ji-Won,Kim, Moon-Kyu,Jeon, Sae-Hwa,Hong, Yong-Taek 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.4

Purpose: There is no clear evidence of the original cause of hypertrophic scar, and the effective method of treatment is not yet established. Recently the steps of searching in gene and molecular level are proceeding. we are trying to recognize the difference between keratinocytes of hypertrophic scar and normal skin. Then we do support the comprehension of the scar formation mechanism and scar management. Methods: Total RNAs were extracted from cultured keratinocytes from 4 hypertrophic scars and normal skins. The cDNA chips were prepared. A total of 3063 cDNAs from human cDNA library were arrayed. And the scanning data were analyzed. Results: On microarray, heat shock protein, pyruvate kinase, tumor rejection antigen were more than 2 fold intensity genes. Among them, heat shock 70 kd protein showed the strongest intensity difference. Conclusion: In this study, it can be concluded that heat shock proteins play an important role in the process of wound healing and scar formation. This study provides basic biologic information for scar research. The new way of the prevention and treatment of scar formation would be introduced with further investigations.

단안 상사근 마비와 동반된 수평 사시의 특징 및 치료 예후

최성원,정세환,라상훈,Sung Won Choi,Se Hwan Jung,Sang Hoon Rah 대한안과학회 2007 대한안과학회지 Vol.48 No.3

Purpose: To review the clinical characteristics and treatment outcomes in horizontal strabismus combined with unilateral superior oblique palsy (SOP). Methods: A retrospective review of medical records was conducted in 21 patients with unilateral SOP treated between January 2001 and December 2005. Patients had more than 6 months of follow-up at the Department of Ophthalmology, Wonju College of Medicine. Results: Among 21 patients (11 male, 10 female) with unilateral SOP, 57.1% of patients had horizontal strabismus. The mean vertical deviation was 12.56±3.81 (8~24) PD. All patients with horizontal strabismus had exotropia and the mean deviation was 10.57±4.58 (6~20) PD. A standard 10mm inferior oblique (IO) recession was performed uniformly at the paretic eye in all patients. In 7 of the patients (58.3%, exotropia greater than or equal to 10PD), horizontal rectus muscle recession was performed simultaneously. In these 7 cases, vertical and horizontal deviation less than or equal to 4PD was achieved (one patient with 10PD remaining hypertropia excluded). In 5 cases with exodeviation less than 10PD, isolated IO recession without horizontal rectus recession on the ipsilateral side achieved orthophoria in the primary position. In 9 cases of isolated SOP, all patients showed orthophoria in the primary position. Conclusions: This study demonstrates horizontal strabismus is combined with unilateral SOP in a high percentage of patients. Additionally, in all cases, all the incidents of horizontal deviation was involved exotropia. A standard 10 mm recession of the IO in combination with horizontal rectus recession is an effective surgical technique. It has an especially high success rate in patients with unilateral SOP (≤14PD vertical deviation) with exodeviation greater than 10PD. In patients with exodeviation less than 10PD, an isolated IO recession is sufficiently effective.

효소 , 대사물질 Streptomyces endus YP - 1 이 생산하는 항암활성 물질의 분리 및 정제

최성원,김병찬,최선진,김동섭,여익현,문순옥,오두환 ( Sung Won Choi,Byoung Chan Kim,Sun Jin Choi,Dong Seob Kim,Ick Hyun Yeo,Soon Ok Moon,Doo Hwan Oh ) 한국미생물생명공학회 1997 한국미생물·생명공학회지 Vol.25 No.5

한방 닭죽 개발 및 최적 배합비율 확립

김경연 ( Kyung Yeon Kim ),백무열 ( Moo Yeol Baik ),박천석 ( Cheon Seok Park ),최성원 ( Sung Won Choi ),김창남 ( Chang Nam Kim ),김병용 ( Byung Yong Kim ) 한국식품영양학회 2013 韓國食品營養學會誌 Vol.26 No.1

죽의 기능성 향상을 위하여 2:1:1:1의 배합으로 혼합한 한약재료(가시오가피, 숙지황, 산약, 백복령)와 닭가슴살 등의 재료를 사용해 한방 영양죽을 제조하였다. 한방 닭죽의 DPPH radical 소거능, SOD 유사활성, 맛의 선호도, cost는 수학적인 canonical model과 trace plot을 이용하여 분석한 결과, SOD 유사활성 이외에는 각 성분들이 독립적으로 작용하여 상호작용이 없는 선형 모델을 보여주었다. DPPH radical 소거능, SOD 유사활성, 맛의 선호도를 최대로, cost를 최소로 목적 범위를 설정하고, 각각의 canonical 계수를 이용하여 수적 최적화를 통하여 최적 배합비를 구한 결과, 한약 혼합물 101g, 닭가슴살 38.66g, 찹쌀 비율 41.34g의 최적 배합비를 구하였으며, 이 배합비에 따른 맛의 선호도는 6.39, DPPH radical 소거능은 17.25㎎VCE/ℓ, SOD 유사활성은 2.25%, cost는 1,382.39 won으로 나타났으며, 여러 결과들 사이에 최적화된 한 값에 수렴하는 desirability는 0.714로 나타났다. 이는 한약혼합물이 많을수록 기능성 면에서는 높게 나타나지만 맛의 선호도면에서는 낮게 나타냈고, 닭가슴살의 경우에도 그 함량이 많을수록 맛의 선호도는 올라갔지만 그에 반해 cost가 높게 올라간 것을 반영한 결과로 사료된다. The objectives of this study were to develop porridge with medicinal herbs and chicken breast meat and to find out the optimum mixing ratio. Several herb extracts such as Acanthopanacis senticosus, Rehmannia glutinosa, Disocorea japonica, and Poria cocos Wolf were used in the ratio of 2, 1, 1, and 1, respectively. The optimum processing condition for herbal chicken porridge was determined by a design expert program. Seventeen experimental points were selected, and herb extracts (82∼101g), chicken breast meat (30∼50g), and glutinous rice (40∼60g) were chosen as the independent variables. The measured responses were preference of taste, DPPH radical scavenging, SOD-like activity, and cost. The optimum formulation of herbal chicken porridge using the numerical analysis was set at herbal extracts (101g), chicken breast meat (38.66g), and glutinous rice (41.34g) with a 0.714 desirability value. DPPH radical scavenging effect, preference of taste and the cost showed a linear model, whereas SOD-like activity showed a quadratic model indicating a higher interaction among the mixture. As a result of proximate composition of optimized herbal chicken porridge, the contents of moisture, carbohydrate, crude protein, crude lipid, and ash contents were 76.4, 9.0, 1.4, 0.5, and 1.6%, the calories of the porridge was 46.1kcal/100g.

가열처리가 칡 이소플라본의 열 안정성에 미치는 영향

최성원(Sung-Won Choi),김경선(Kyung-Seon Kim),허남윤(Nam-Yun Hur),김동섭,안순철(Soon-Cheol Ahn),박천석(Cheon-Seok Park),김병용(Byung-Yong Kim),백무열(Moo-Yeol Baik),김대옥(Dae-Ok Kim) 한국생명과학회 2008 생명과학회지 Vol.18 No.10

열처리 조건 및 농도의 차이에 따른 칡 이소플라본인 daidzin과 genistin의 열 안정성에 대하여 조사하였다. Daidzin과 genistin 두 종류의 이소플라본은 처리방법에 상관없이 140℃이상의 열처리 조건에서 초기 30분 동안 급격히 열 안정성이 떨어지고 그 이후 변화가 적게 나타나 처리온도가 높을수록 열 안정성의 변화가 큰 것으로 나타났으며, genistin은 daidzin에 비해 농도차이 에 따른 변화의 차이가 크지 않은 것을 알 수 있었다. 또한 열처리 조건에 따른 반응속도는 모두 두 단계로 나타났는데, daidzin과 genistin 모두 2단계보다 1단계에서 빠른 반응속도를 보여 주었고, daidzin은 고농도 일 수록 더 빠른 반응속도를 나타내는 것을 알 수 있었으나, genistin은 농도에 따른 유의차가 적은 것을 알 수 있었다. Daidzin은 1단계의 고농도에서 온도 의존성이 높게 나타났으며 2단계는 농도에 따른 온도 의존성에 유의차가 없었다. Genistin의 경우 1단계에서는 농도에 의한 온도 의존성이 작게 나타났지만 2단계의 저농도에서 온도 의존성이 높은 것을 알 수 있었다. 농도에 따른 변화를 보면 genistin은 고농도와 저농도 모두 1단계에서 온도 의존성이 큰 것으로 나타났으며 반면 daidzin은 고농도, 저농도 모두 2단계에서 온도 의존성이 높은 것을 알 수 있었다. 또한 daidzin과 genistin 모두 140℃ 이상의 열처리에 의해 이소플라본 glucosidic group이 열에 의해 가수분해되어 daidzein, genistein, glycitein, malonyl-glycitin, acetyl-genistin 등의 중간 유도체 및 aglycone이 생성되며 140℃, 15 min의 처리 조건에서 대부분 가장 많은 양이 생성되는 것을 알 수 있었고, 농도 변화에 따른 함량의 증가는 유의차가 적은 것을 알 수 있었으나 그 중 malonyl daidzin의 경우 열처리 조건에 의해 따른 생성량의 차이가 큰 것을 알 수 있었다. 열처리 후 농축조건이 농축 후 열처리보다 더 많은 daidzin, genistin 유도체들을 생성시킨 것으로 보아 칡 이소플라본의 각 열처리 조건에 따른 열 안정성은 농축 후 열처리보다 열처리 후 농축이 훨씬 더 열에 안정하다는 것을 알 수 있었다. 따라서 칡 이소플라본의 열안정성은 콩 이소플라본과 유사하게 140℃ 이상 열처리에 의해 가수분해반응을 보였고, 이소플라본의 중간 유도체들과 aglycone이 140℃ 이상의 열처리 시 생성되었다. 따라서 칡 이소플라본의 열 안정성은 가열온도와 농도에 의해 큰 영향을 받으며, 콩 이소플라본의 열 안정성과 매우 유사한 특성을 나타내었다. Effect of heat processing on thermal stability of kudzu root isoflavone was investigated for future use such as various processed foods and functional foods. Kudzu root extracts were heated at 80, 100, 121, 140, 165, and 180℃ for up to 90 minutes before and after concentration, respectively. Changes in the amount of isoflavones were monitored using HPLC and thermal stability was investigated using Arrhenius equation. The amount of both daidzin and genistin decreased slightly during heating at 80, 100 and 121℃ but decreased significantly above 140℃. This indicated that daidzin and genistin are stable at temperatures near the boiling point of water. The degradation of both daidzin and genistin occurred in two steps and each step showed typical first order kinetic. The degradation rates were faster in the first step than the second step in both daidzin and genistin. Additionally, the degradation was accelerated when they heated after concentration compared to the sample heated before concentration. These results suggested that degradation of kudzu root isoflavone was highly dependent on both their concentration and heating temperature. This study provides the basic information on thermal stability of kudzu root isoflavones, which can be used for future processing of functional foods.

해체,제거 작업 시 석면함유 건축자재에서 발생되는 섬유 및 입자상 물질의 특성

최성원 ( Sung Won Choi ),장광명 ( Kwang Myoung Jang ),박경훈 ( Kyung Hoon Park ),김대종 ( Dae Jong Kim ),김현욱 ( Hyun Wook Kim ) 한국산업보건학회 2015 한국산업보건학회지 Vol.25 No.2

Objectives: This study focused on three aspects: characterizing concentrations of airborne particles by size distributions and asbestos fibers generated by various building materials; analyzing the characteristics of fibers produced by each simulation and asbestos fibers released from ACBMs; and investigating correlations of airborne asbestos fibers and particles generated and association of particle and asbestos concentrations. Methods: We selected three ACBMs including an insulation board, cement asbestos slate and wallboard. We constructed 4 scenarios; a) crushing with a hammer; b) cutting with a industrial knife; c) brushing with a metal brush; and d) tightening & loosening with a hand drill. We implemented one simulation for 30 seconds followed by 30 seconds resting period. We repeated a total of 5 cycles for 5 minutes. Results: The highest concentration of particulate & fibrous matters was from crushing with a hammer in each scenario followed by brushing with a metal brush, cutting with a industrial knife, and tightening & loosening with a hand drill. For ACBMs studied, asbestos concentrations were highest from an insulation board followed by cement asbestos slate, and wallboard. No difference in terms of concentration was found between an insulation board and asbestos slate. Fibers with 5~20 μm in length were included in 76~90% of total fibrous matters. The distribution of the straight form fibers was greater than that of the curl form. About 90% of PMTotal released from ACBMs was consisted of PM10 while only 10% of PMTotal was PM2.5. Particulate matters like PM2.5 was significantly correlated with fibrous matters(R2=0.81). Conclusions: We found ACBMs can significantly release asbestos fibers as well as PM2.5. Concentrations of asbestos generated by ACBMs were well correlated with PM2.5.

버페팅 해석에 의한 가설 중 사장교의 동적 내풍안정화 설계 절차

최성원(Choi Sung Won),김호경(Kim Ho-Kyung) 대한토목학회 2007 대한토목학회논문집 A Vol.27 No.4A

켄틸레버 시공되는 사장교의 내풍안전성을 확보하기 위한 설계기법과 절차를 제안하였다. 난류에 의한 가설계의 버페팅 진동은 플러터계수를 사용한 주파수영역 공탄성 해석으로 평가하였다. 주경간 500m의 합성형 사장교를 예제로 제안된 동적 내풍설계 절차의 적용성을 평가하고자 하였다. 검토 결과 가설 중 풍하중에 대한 조합응력이 허용응력을 초과하는 것으로 나타남에 따라 내풍안정화케이블을 적용하여 최대응력을 저감시킬 필요성을 확인하였다. 이를 위하여 가설 순서를 토대로 내풍안정화케이블의 최적 위치를 결정하기 위한 접근법과 결정 과정을 구체적으로 제안하였다. 케이블강교량설계지침에서도 공탄성 해석법을 활용한 동적내풍설계의 필요성이 지적된 바 있으며 이 논문에서는 설계 절차와 실교량 예제를 통하여 하나의 접근 방안을 제안하고자 하였다. An aerodynamic design procedure is proposed for a cable-stayed bridge constructed by a balanced cantilever method. The buffeting responses due to wind turbulences are evaluated by a frequency domain response analysis utilizing flutter derivatives. The applicability of the proposed procedure is demonstrated in a numerical example for a composite cable-stayed bridge having a main span length of 500m. The maximum stress is found to exceed the allowable stress during construction and, therefore, the stabilizing cables are prepared to decrease the expected level of stress in pylon and girder. The optimal positions of stabilizing cables are determined considering overall behavior of the bridge structure through the whole construction process. The design guidelines of cable-supported bridges also recommended aerodynamic design process utilizing aeroelastic analysis technique. This paper proposed a design procedure and numerical example that may conform to the design guideline.