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윤대현 ( Dae Hyun Yoon ),박진호 ( Jin Ho Park ),조수철 ( Soo Churl Cho ),박민정 ( Min Jeoung Park ),김선신 ( Sun Sin Kim ),최승호 ( Seung Ho Choi ),최수연 ( Su Yeon Choi ),정인경 ( In Kyong Jeong ),이철민 ( Cheol Min Lee ),신찬수 대한비만학회 2005 The Korean journal of obesity Vol.14 No.4
연구배경: 우울증은 여성에서 유병률이 높고 다양한 질환과의 연관성을 보이는데 특히 심혈관계 질환과의 상호 연관성이 보고 되고 있다. 대사증후군 또한 만성 질환 발생에 매우 주요한 위험인자로 그 중요성이 강조되고 있는데 아직 우울증과 대사증후군의 연관성 연구는 제한된 연령의 여성군에서만 소수 진행되었다. 본 연구는 광범위한 연령의 여성을 대상으로 우울증상과 대상증후군의 연관성을 분석해 보고자 한다. 방법: 연구대상자는 15~85세 사이의 여성 4,613명이었다. 대사증후군 존재 유무 평가는 복부미만을 제외하고는 NECP-ATP III 기준을 활용하였고 복부비만의 평가는 최근 제안된 대한비만학회의 새로운 지침을 이용하였다. 우울증상은 Beck 우울 척도로 측정하였다. 결과: 연구대상자 중 594명 (12.9%)이 대사증후군을 가지고 있었다. 우울증을 가진 여성군에서 대사증후군의 존재 빈도가 유의하게 높았고 (P<0.001), 대사증후군 지표수가 증가할수록 우울증상군이 증가하는 경향을 보였다 (P<0.01). 우울증상과 대사증후군 5가지 지표들 (허리둘레, 고혈압, 중성지방, 혈당, 고밀도-콜레스테롤)의 연관성 분석에서는 혈당 상승 (P<0.05)과 복부 미만 (P<0.01)이 통계적으로 유의성을 보였다. 결론: 본 연구의 결과는 여성에서 대사증후군과 우울증 간 연관성이 존재함을 보였고 대사 증후군과 우울증의 상호 역할에 대한 보다 적극적인 이해가 필요함을 시사한다. Background: Depression is prevalent among women and has been associated with a variety of diseases, more specifically with cardiovascular disease. The metabolic syndrome is gaining reputation as an important risk factor for major chronic diseases. However, the study on relationship between depression and metabolic syndrome are scarce and have been limited to restricted age groups involving female participants. The current study examined the association between depressive symptoms and metabolic syndrome in Korean women through broad age ranges. Method: The participants included 4,615 Korean women aged 15~85 years. Each individual was assessed for the presence of metabolic syndrome according to the NECP-ATP III criteria except for waist circumference, for which new criteria recently suggested by Korean Society for Study of the Obesity was used. Depressive symptoms were assessed by Beck Depression Inventory (BDI). Results: Of the total participants, 594 women (12.9%) had metabolic syndrome. There was a graded relationship between depression and number of the metabolic syndrome components (P<0.01). The prevalence of Metabolic syndrome was significantly higher in depressed women (P<0.001). Among the components of metabolic syndrome, High glucose level (P<0.05) and central obesity (P<0.01) were associated with depressive symptoms. Conclusion: This study shows that metabolic syndrome is associated with depressed women through wide range of ages and suggests that further studies on interaction between depression and metabolic syndrome are needed.
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연천지역 주민에서 내당능장애와 공복혈당장애의 임상적 특성 비교
정인경,김상완,박영주,조보연,이홍규,신찬수,김성연,박도준,박경수,김노경,문민경,김선욱 대한당뇨병학회 2000 Diabetes and Metabolism Journal Vol.24 No.1
Background: To compare the clinical characteristics of 1997 American Diabetes Association (ADA) impaired fasting glucose (IFG) based on fasting plasma glucose (FPG) with World Health Organization (WHO) impaired glucose tolerance (IGT) based on oral glucose tolerance test (OGTT) in a Korean population. Methods: The analyses were based on the data of 2,251 subjects aged 30-80 years obtained from the surveys of Yonchon County in Korea in 1993, and the data of 1084 subjects participated in the follow-up survey in 1995. Prevalence of glucose tolerance categories was obtained by using WHO and ADA criteria, and the level of agreement was estimated by x index. Cardiovascular risk profile and the incidence of diabetes based on the ADA criteria after 2 years were compared by focusing on the discordant diagnostic categories namely IGT/NFG in which the subjects were diagnosed as IGT by WHO criteria but normal fasting glucose(NFG) by ADA criteria and NGT/IFG diagnosed as normal glucose tolerance(NGT) by WHO but IFG by ADA. Results The ADA criteria failed to diagnose 69% of IGT patients, that is 62% of them were considered normal and 7% as diabetes. The overall agreement was poor (χ statistics = 0.32, p$lt;0.05). Subjects classified into IGT/NFG or NGT/IFG showed the worse cardiovascular risk profile and higher incidence of diabetes than NGT/NFG. Especially, subjects with NGT/IFG exhibited higher incidence of diabetes than those with IGT/NFG. Conclusion: Although IFG predicts subsequent development of diabetes much better than IGT, the vast majority of the subjects with IGT will be missed according to ADA criteria based on FPG only. Consequently FPG alone could be an inadequate substitute for the OGTT.
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제2형 당뇨병 환자에서 요알부민 배설량과 지단백 분획의 구성 이상과의 관계
김선욱,김진성,전재석,김현규,박경수,김성연,정인경,김재현,이홍규 한국지질학회 1999 韓國脂質學會誌 Vol.9 No.4
Bac㎏round: To assess the relationship between the compositional change of lipoprotein and urinary albumin excretion in selected type 2 diabetic patients with stable metabolic control Methods: Fifty-eight type 2 diabetic patients with stable metabolic status, body mass index$lt;30 ㎏/㎡ and urinary albumin excretion $lt; 1500 ㎎/day were studied. Patients were classified according to their level of UAE as normoalbuminuric (n=30), microalbuminutic (n=18) and macroalburninuric (n=10). We investigated clinical and laboratory features of the groups; total plasma cholesterol and triglyceride concentration, and cholesterol and triglyceride of lipoprotein subfraction which is obtained by sequential ultracentrifugation. Results: Macroalbuminuric patients showed significant increase of total cholesterol compared with normoalbuminuric patients (6.38±1.60 vs 5.28±0.98 mmol/L, p$lt;0.05). But there were no statistical differences in the concentration of triglyceride, and cholesterol and triglyceride of lipoprotein subfraction among the three groups. Conclusion: Our results cannot show the positive association of compositional change of lipoproten subfraction with increased urinary albumin excretion in type 2 diabetic patients. Further studies with the larger sample size to verify the relationships between diabetic nephropathy and cardiovascular disease should be needed in the future.
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