Synthesis and Characteristics of the Organic Layered Structure Material of $(C_4H_9NH_3)_2Fe_xPb_1-xCl_4$

정수진,인리주,오응주,조웅인,김규홍,요철현,Jeong, Su Jin,In, Ri Ju,O, Eung Ju,Jo, Ung In,Kim, Gyu Hong,Yo, Cheol Hyeon Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.7

K2NiF4-type organic-based perovskites of the (C4H9NH3)2FexPb1-xCl4 (x=0.00, 0.25, 0.50, and 0.75) system have been synthesized using a low-temperatu re solution method under a flowing argon gas. When stoichiometric butylamine, iron chloride, and lead chloride are mixed, a yellow solution are obtained from slow cooling of 90 to -10 $^{\circ}C.$ The final product is a plate-like yellow crystal. The X-ray crystallographic analysis has been carried out using XRD in the range of $5^{\circ}{\leq}$ 2${\theta}$ ${\leq}80^{\circ}.$ The local symmetry around the absorbing Pb atom of the samples has been determined by the EXAFS spectroscopic study. The crystals assign to orthorhombic system by the XRD analysis. The FT-IR spectra are analyzed in the range of 600 to 3300 cm-1 . DSC and TGA are measured to detect thermal stability between 30 and 300 $^{\circ}C.$ Two endothermic peaks are detected in all samples. The electrical conductivity has been measured using the four-probes technique for the (C4H9NH3)2FexPb1-xCl4 system in 300-460 K. Photoluminescence phenomenon was also investigated at room-temperature.

냉간시동시 자동차용 저온활성촉매의 성능 향상을 위한 수치적 설계

정수진,김우승,Jeong, Soo-Jin,Kim, Woo-Seung 대한기계학회 2000 大韓機械學會論文集B Vol.24 No.9

Light-off catalyst has been used for minimization of cold-start emissions. Improved cold-start performance of light-off catalyst needs the optimal design in terms of flow distribution, geometric surface area, precious metal loading, cell density and space velocity. In this study, these influential factors are numerically investigated using integrated numerical technique by considering not only 3-D fluid flow but also heat and mass transfer with chemical reactions. The present results indicate that uneven catalyst loading of depositing high active catalyst at upstream of monolith is beneficial during warm-up period but its effect is severely deteriorated when the space velocity is above 100,000 $hr^{-1}$ To maximize light-off performance, this study suggests that 1) a light-off catalyst be designed double substrate type; 2) the substrate with high GSA and high PM loading at face be placed at the front monolith; and 3) the cell density of the rear monolith be lower to reduce the pressure drop.

자동차용 촉매변환기의 최적설계를 위한 열 및 유동특성에 대한 수치적 연구

정수진,김우승,Jeong, Soo-Jin,Kim, Woo-Seung 대한기계학회 1999 大韓機械學會論文集B Vol.23 No.7

In the present work, the effect of a flow maldistribution on the thermal and conversion response of 8 monolith catalytic converter is Investigated. To achieve this goal, a combined chemical reaction and multi-dimensional fluid dynamic mathematical model has been developed. The present results show that flow uniformity within the monolith brick has 8 great impact on light-off performance of the catalytic converter. In the case of lower flow uniformity, large portions of the monolith remain cold due to locally concentrated high velocities and CO, HC are unconverted during warm-up period, which loads to retardation of light-off. It has been also found that the heat-up pattern of the monolith ill similar to the flow distribution profile, In the early stage of the reaction. It may be concluded that flow maldistribution can cause a significant retardation of the light-off and hence can eventually worsen tho conversion efficiency of automotive catalytic converter.

Streptomyces somaliensis가 생산하는 세포외 Phospholipase D의 유전자 서열 분석과 Transphosphatidylation 활성 특성

정수진,이선희,엄태붕,Jeong Sujin,Lee Sun-Hee,Uhm Tai-Boong 한국미생물학회 2004 미생물학회지 Vol.40 No.3

세포외 phospholipase D (PLD)를 과량 생산하는 균주 JE-11을 토양으로부터 분리하였다. 16S rDNA에 의한 분석과 형태적, 생리적 특성을 조사한 결과 이 균은 Streptomyces somaliensis로 동정되었다. 선발한 S. somaliensis로 부터 PLD를 암호화하는 유전자(sspld) 분리하고 염기서열을 조사하였다. Open reading frame을 분석한 결과 33개의 아미노산으로 이루어진 분비 signal peptide와 505개의 아미노산으로 구성된 PLD단백질을 암호화하는 것으로 예상되었다. 또한, sspld의 염기 서열로부터 유추된 단백질 서열은 기존에 보고된 다른 Streptomyces PLD들과 70-88%의 서열 유사성을 보였다. 이 PLD는 96-98%(㏖/㏖)의 수율로서, Phosphatidylcholine을 glycerol과 serine을 기질로 하여 각각 phosphatidylglycerol 과phosphatidylserine으로 전환을 하였으나, 알코올 공여체인 inositol과 ethanolamine과는 반응하지 않았다. A bacterial strain JE-ll found to produce active extracellular phospholipase D (PLD) was selected from the soil isolates. It was identified as Streptomyces somaliensis on the basis of 16S rDNA sequence analysis, morphological and physiological characteristics. The gene (sspld) encoding S. somaliensis PLD was isolated and characterized. The open reading frame was suggested to encode 538 amino acids with a signal peptide of 33 amino acids. The deduced amino acid sequence of the sspld shared a sequence similarity of 70-88% with PLDs of other Streptomyces sp. so far reported. The PLD converted phosphatidylcholine to phosphatidylglycerol or phosphatidylserine with the yield of 96 to 99% (㏖/㏖), but did not act on inositol or ethanolamine as a transphosphatidylation donor.

건강보험 빅 데이터를 활용한 종합병원에서의 포괄수가제 적용 전·후 재원일수와 진료비의 변화

정수진,최성우,Jeong, Su-Jin,Choi, Seong-Woo 한국전자통신학회 2017 한국전자통신학회 논문지 Vol.12 No.2

본 연구는 일 종합병원 산부인과 환자를 대상으로 2013년 7월 1일 포괄수가제가 확대시행 전 후의 재원일수와 진료비를 비교 분석하여 포괄수가제 시행의 효과를 파악하고자 수행되었다. G광역시 소재 일 종합병원에서 2013년 1년간 산부인과 포괄수가제 질병군의 수술(자궁 및 자궁부속기 수술, 제왕절개술)을 받고 퇴원한 환자로, 행위별 수가제 적용 대상자는 2013년 1월~6월까지 입원한 환자 204명이었고, 포괄수가제 적용 대상자는 2013년 7월~12월까지 입원한 환자 194명으로 총 398명의 재원일수 및 진료비를 공분산분석(ANCOVA)하였다. 본 연구결과 재원일수는 행위별수가제에서 6.65(0.13)일, 포괄수가제에서 6.40(0.12)일로 감소하였고(p=0.013), 급여총진료비는 행위별수가제에서 1,726,333(46,331)원, 포괄수가제에서 2,271,115(37,069)으로 증가하였고(p<0.001), 보험자부담금은 행위별수가제에서 1,387,142(41,938)원, 포괄수가제에서 1,800,914(28,300)원으로 증가였다(p<0.001). 급여본인부담금은 행위별수가제에서 339,190(8,404)원, 포괄수가제에서 70,201(9,255)원으로 감소하였고(p<0.001), 비급여비용은 행위별수가제에서 642,243(22,039)원, 포괄수가제에서 197,507(9,091)원으로 감소하였고(p<0.001), 환자 총본인부담금도 행위별수가제에서 981,433(25,947)원, 포괄수가제에서 667,708(13,286)원으로 감소하였다(p<0.001). 본 연구결과 산부인과 환자에 대한 포괄수가제 적용은 재원일수, 비급여비용, 총본인부담금을 감소시켰고, 급여본인부담금, 보험자부담금, 급여총진료비를 증가시키는 효과를 보였다. This study aimed to identify appropriateness and efficiency in the DRG payment system by analysing the hospital length of stay and changes in fees before and after the application of DRG payment system. The subjects of the study were a total of 398 patients consisting of 204 for the fee for service system and 194 for the DRG payment system. They received surgery in the Obstetrics and Gynecology (OBGY) department of a general hospital in G metropolitan city between January and December 2013. The mean hospital length of stay was significantly decreased after application of the DRG payment system(p=0.013). Total fees, insurance charges, and deductions increased significantly(p<0.001), and non-payment charges and total deductions decreased significantly(p<0.001). Application of the DRG payment system reduced length of stay, non-payment charges and total patient's cost sharing and increased out-of-pocket, insurance charges, and total fees.

공동주택 거주자의 에너지사용의식에 따른 에너지사용행동 특성분석

정수진,한정원,Jung, Su-Jin,Han, Jeong-Won 한국주거학회 2013 한국주거학회 논문집 Vol.24 No.3

As household energy consumption has increased, serious environmental problems, such as resource depletion and global warming, are becoming global issues. It is essential to conduct the energy use of residents living in apartments in order to come up with alternative solutions for energy savings. Therefore, this study examined the energy use awareness of apartment residents and their energy use behavior by various types of awareness. To understand their energy use behavior according to the awareness of the subjects, the energy awareness dimension was created with five factors and they were subject to a cluster analysis; then, the subjects were categorized into three groups. Finally, the difference of energy use behavior was examined by groups of energy awareness. G1 represents the group that is indifferent to energy savings and believes that convenience is an important factor. Also, with respect to energy use behavior, this group tends to pursue convenience. G2 is the group that is conscious of energy use costs thereby enduring some inconvenience, and shows savings behavior in daily life and household affairs. Although, G3 is very aware of the significance for the necessity of energy saving, their energy saving behavior is relatively negative. Regarding these different characteristics of each resident group in their energy saving awareness and behaviors, diverse methods and promotion in energy education are required. Furthermore, an effective energy policy should be established based on the understanding of energy consumption.

K562 세포주에서 Genistein에 의해 억제되는 Radiation-induced Apoptosis의 조절 유전자

정수진,진영희,유여진,도창호,정민호,허기영,배혜란,양광모,문창우,오신근,허원주,이형식,Jeong, Soo-Jin,Jin, Young-Hee,Yoo, Yeo-Jin,Do, Chang-Ho,Jeong, Min-Ho,Huh, Gi-Yeong,Bae, Hye-Ran,Yang, Kwang-Mo,Moon, Chang-Woo,Oh, Sin-Geun,Hur, Won-Jo 대한방사선종양학회 2001 Radiation Oncology Journal Vol.19 No.3

목적 : K562 세포를 대상으로 PTK inhibitor (herbimycinA와 genistein)에 의한 방사선 유도 apoptosis의 변화에 따른 관련 유전자를 탐색하고자 하였다. 대상 및 방법 : K562 세포는 $2\times10^5\;cells/mL$의 비율로 준비하여 대수증식기로 성장한 세포를 각각의 실험조건에 따라 처리하여 사용하였다. 방사선 조사는 6-MV X-Ray 10 Gy (Clinac 1800C, Varian, USA)를 $200\~300\;cGy/min$의 선량율로 상온에서 일정하게 조사하였다. Herbimycin A (HMA, Calbiochem, UK)와 genistein (Calbiochem, UK)은 dimethylsulfoxide (DMSO, Sigma, UK)에 녹여서 각각 1 mM과 10 mM의 농축용액으로 조제한 각각 250 nM과 $25\;{\mu}M$의 최종농도로 처리하였다. 내성 변화의 조절에 관여하는 유전자를 찾고자 PCR-select cDNA subtractive hybridization을 실시하여 128개의 차별 발현되는 clones을 재선별하였다. DNA sequencing을 통하여 염기서열을 분석하였으며, GenBank database를 이용하여 이미 밝혀진 유전자들과의 상동성을 비교하였다. 상동성을 갖는 clone을 확인하여 이를 probe로 사용하여 방사선 단독조사한 실험군과 방사선과 HMA 또는 genistein을 동시 처리한 실험군들간의 mRNA 발현의 차이를 Northern hybridization을 통하여 확인하였다. 결과 : homo sapiens Smad6 유전자와 $95\%$의 상동성을 갖는 clone을 확인하였다. 이를 probe로 사용하여 방사선 단독 조사한 실험군과 방사선과 HMA 또는 genistein을 동시 처리한 실험군들간의 mRNA 발현의 차이를 비교 분석한 결과, 방사선과 genistein을 동시 처리한 실험군의 mRNA 발현이 방사선 단독 조사한 실험군과 방사선과 HMA를 처리한 실험군들에 비하여 현저히 높았다. 결론 : Smad6와 방사선에 의해 유도되는 apoptosis의 억제에 관한 연관성을 보고한 문헌은 없으나, Smad6가 일부세포에서 apoptosis를 억제한다는 보고들과, 본 연구에서 관찰한 genistein에 의한 방사선에 의해 유도되는 apoptosis의 억제에서 그 발현이 두드러지게 증가한 점 등을 미루어 보아 방사선에 의하여 유도된 apoptosis의 억제 및 방사선 내성의 조절에도 관여할 것으로 생각된다. Prupose : The genes involved on the suppression or radiation-induced apoptosis by genistein in K562 leukemia cell line was investigated. Materials and methods : K562 cells in exponential growth phase were irradiated with a linear accelerator at room temperature. For X-ray irradiation and drug treatment, cultures were prepared at $2\times10^5\;cells/mL$. The cells were irradiated with 10 Gy (Clinac 1800C, Varian, USA), Stock solutions of herbimycin A (HMA, Calbiochem, UK) and genistein (Calbiochem, UK) were prepared in dimethylsulfoxide (DMSO, Sigma, UK). After incubation at $37^{\circ}C$ for 24 h, PCR-select cDNA subtractive hybridization, dot hybridization, DNA sequencing and Northern hybridization were examined. Results : Smad6 gene was identified from the differentially expressed genes in K562 cells incubated with genistein which had been selected by PCR-select cDNA subtractive hybridization. The mRNA expression of Smad6 in K562 cells incubated with genistein was also higher than control group by Northern hybridization analysis. Conclusion : We have shown that Smad6 involved on the suppression of radiation-induced apoptosis by genistein in K562 leukemia cell line. It is plausible that the relationship between Smad6 and the suppression of radiation-induced apoptosis is essential for treatment development based on molecular targeting designed to modify radiation-induced apoptosis.

사료내 미량광물질 강화 복합미생물 첨가가 산란노계의 계란생산 및 난질개선에 마치는 영향

정수진,주은정,이우식,윤병선,이주삼,남기택,황성구,Jeong, Soo-Jin,Joo, Eun-Jung,Lee, Woo-Sic,Yon, Byeng-Sun,Lee, Ju-Sam,Nam, Ki-Taek,Hwang, Seong-Gu 한국유기농업학회 2004 韓國有機農業學會誌 Vol.12 No.2

In recent years, the consumption of livestock products were markedly decreased by awareness of world-widely occurred diseases including mad cow disease, Foot and mouth disease, Hog cholera, and Poultry Influenza virus. the consumers ara also wanting to have highly safe food such as organic animal products because of concerning about residual of antibiotics in animal products. However, disease control and impairment of productivity are the major problem in organic animal production. On these points of view, the present study was undertaken to investigate the effects of 1% or 2% of dietary probiotics fortified with various minerals on improvement of egg production and egg quality in old lay6r feeding low quality feed mainly composed of food waste, sesame meal, and rice bran. After 4 weeks of experimental feeding, the diameter of spreading of egg white was clearly decreased from 11.2cm of control eggs to 10.5m and 10.1m in 1% and 2% treatment group eggs, respectively. The color of egg yolk was 9.3 in control eggs but remarkably increased in treatment groups showing 10.1~10.2. Egg production was 75.8% in control layers but significantly increased to 79.8% of 1% treatment group and 82.9% of 2% treatment group layers. Egg weights (C : 66.3g, 1% : 73.2g, and 2% : 76.7g) and egg shell thickness (C : 0.33mm, 1% : 0.35mm and 2% : 0.36mm) were also increased by the addition of 1% or 2% of probiotics when compared to those of control group eggs. All together, it has been suggested that dietary addition of probiotics fortified with various minerals can improve the egg quality and egg production in layer's productivities by the recycling of organic waste resources such as food waste and agricultural by-products.

소아 만성 복통의 진단적 평가 -기능성 복통과의 감별점을 중심으로-

정수진,Jeong, Su Jin 대한소아소화기영양학회 2008 Pediatric gastroenterology, hepatology & nutrition Vol.11 No.suppl2

Chronic abdominal pain, defined as long-lasting intermittent or constant abdominal pain, is a common pediatric problem encountered by primary care physicians and medical subspecialists. Chronic abdominal pain in children is usually functional, i.e., without objective evidence of an underlying organic disorder. Functional abdominal pain is categorized as functional dyspepsia, irritable bowel syndrome, functional abdominal pain, abdominal migraine, and aerophagia according to the Rome II criteria for pediatric functional gastrointestinal disorders. There is insufficient evidence to state that the nature of abdominal pain or the presence of associated symptoms can discriminate between functional and organic disorders. The presence of alarming symptoms or signs, such as weight loss, gastrointestinal bleeding, persistent fever, and chronic severe diarrhea, is associated with a higher prevalence of organic disease. Most children with chronic abdominal pain are unlikely to require diagnostic testing; such children often need pharmacologic and behavioral therapy.

소아의 흔한 질병 상황에서 식이, 영양의 중요성

정수진,Jeong, Su-Jin 대한소아소화기영양학회 2011 Pediatric gastroenterology, hepatology & nutrition Vol.14 No.1

The influence of nutrition during early life on physical growth as well as mental development has been thoroughly discussed in the literature. The physical dimensions of the body are greatly influenced by nutrition, particularly during the period of rapid growth in early childhood. Nutritional status affects every pediatric patient's response toillness. Good nutrition is important for achieving normal growth and development. It is indicated that permanent impairment of the central nervous system may result from dietary restriction of imbalance during certain periods of life. If children under 3 years of age show a good nutritional status, it may be assumed that they are well nourished. Several common diseases of children such as iron deficiency, chronic constipation and atopic dermatitis are known food related diseases. Patients with chronic illness and those at risk of malnutrition should have detailed nutritional assessments done. Components of a complete nutritional assessment include a medical history, nutritional history including dietary intake, physical examination, anthropometrics (weight, length or stature, head circumference, midarm circumference, and triceps skinfold thickness), pubertal staging, skeletal maturity staging, and biochemical tests of nutritional status. The use of age, gender, and disease-specific growth charts is essential in assessing nutritional status and monitoring nutrition interventions. Nutrition assessment and dietary counseling is helpful for the cure of disease, and moreover, the prevention of illness.