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정권,김도군,고석오 대한토목학회 2017 KSCE Journal of Civil Engineering Vol.21 No.1
Natural Organic Matter (NOM) and Effluent Organic Matter (EfOM) have been regarded as the major membrane foulants in advanced water treatment or wastewater reuse processes. In this study, the adsorption of Suwannee River NOM (SRNOM) and EfOM from a wastewater treatment plant by Carbon-Based Nanomaterials (CBNs) including Single-Wall Carbon Nanotube (SWCNT), Multi-wall Carbon Nanotube (MWCNT) and Expanded Graphite (EG) was investigated to mitigate their membrane fouling potentials. Adsorption of SRNOM and EfOM showed Langmuir type adsorption with constant adsorption enthalpy, regardless of the adsorbents. MWCNT showed the highest adsorption capacity for SRNOM and EfOM, while SWCNT showed the greatest reduction in Soluble Microbial Products (SMP) in EfOM. The UV/Vis spectrophotometry, fluorescence spectrophotometry, and size exclusion chromatography showed that high molecular weight fraction of SRNOM and EfOM was preferentially adsorbed onto ordered CBNs such as SWCNT, MWCNT, and EG. It was also evidenced that SMP adsorptions by SWCNT was significantly higher than those by MWCNT. The results imply that a pretreatment with SWCNT or EG can reduce membrane fouling via adsorption of SMP and high molecular weight organic fractions in EfOM.
반복적인 의식변화와 운동실조를 주소로 진단된 지발형 Ornithine Transcarbamylase Deficiency 1례
정권,김은영,김경심,김용욱,유한욱,Jung, Kwon,Kim, Eun Young,Kim, Kyoung Sim,Kim, Yong Wook,Yoo, Han Wook 대한유전성대사질환학회 2003 대한유전성대사질환학회지 Vol.3 No.1
저자들은 반복적이며 간헐적인 기면, 정신착란과 운동실조를 주소로 내원한 6세 여아에서, 고암모니아혈증과 혈장 glutamine, 요 orotic acid의 증가를 보여 지발형 OTC 결핍증으로 진단하고, 분자유전학적 검사상 exon 6에서 221번째 아미노산 lysine에 해당하는 염기 AAG가 AAT(asparagine)로 치환된 돌연변이를 이형접합자(heterozygote)로 보인하였던 1례를 경험하였기에 보고하는 바이다. Ornithine transcarbamylase(OTC) deficiency is the most common of all the urea cycle disorders. In this X-linked disorder, the hemizygote males are more severely affected than heterozygote females. The Heterozygote female may have mild episodic hyperammonemia symptoms in late infancy or childhood(late onset) or no clinical manifestations. Here we report a 6 year-old girl with late onset OTC deficiency who showed recurrent episodic lethargy, mental confusion and ataxia. On mutation analysis using DNA sequencing after PCR amplification of the 10 exons of OTC gene, G to T transversion in codon 221, causing substitution of asparagine for lysine was detected in exon 6.
Lin28a attenuates TGF-β-induced renal fibrosis
정권수,Yeo Jin Hwang,Jun-Hyuk Choi,이경민 생화학분자생물학회 2020 BMB Reports Vol.53 No.11
Lin28a has diverse functions including regulation of cancer, reprogramming and regeneration, but whether it promotes injury or is a protective reaction to renal injury is unknown. We studied how Lin28a acts in unilateral ureteral obstruction (UUO)-induced renal fibrosis following unilateral ureteral obstruction, in a mouse model. We further defined the role of Lin28a in transforming growth factor (TGF)-signaling pathways in renal fibrosis through in vitro study using human tubular epithelium-like HK-2 cells. In the mouse unilateral ureteral obstruction model, obstruction markedly decreased the expression of Lin28a, increased the expression of renal fibrotic markers such as type I collagen, α-SMA, vimentin and fibronectin. In TGF-β-stimulated HK-2 cells, the expression of Lin28a was reduced and the expression of renal fibrotic markers such as type I collagen, α-SMA, vimentin and fibronectin was increased. Adenovirus-mediated overexpression of Lin28a inhibited the expression of TGF-β-stimulated type I collagen, α-SMA, vimentin and fibronectin. Lin28a inhibited TGF-β-stimulated SMAD3 activity, via inhibition of SMAD3 phosphorylation, but not the MAPK pathway ERK, JNK or p38. Lin28a attenuates renal fibrosis in obstructive nephropathy, making its mechanism a possible therapeutic target for chronic kidney disease.
검측자료 분석을 통한 궤도 구성품의 확률론적 수명 평가
정권삼 ( Jung Kwon-sam ),정민철 ( Jung Min-chul ),김정훈 ( Kim Jung-hun ),공정식 ( Kong Jung-sik ) 한국구조물진단유지관리공학회 2008 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.12 No.2
Generally, the analysis of data of the railroad components is most effective method for the efficient maintenance of railway. Especially, the tracks damaged directly by train, have as important position with the inspection data. This study suggest the Life-Cycle performance of railroad by analysis of Inspection data such as geometry measurements, ultrasonic inspections, wear, failures, corrugation, fastener check, sleeper check, ballast check. In this study, detected wear data and main factors of railroad abrasion analysis are accomplished to predict the remainder of service life of railway tracks for efficient maintenance. Also, wear-time probabilistic distribution curve which can be adapted to safety assessment is computed.
정권수,조정구 順天大學校 師範大學 附屬 科學敎育硏究所 1994 科學과 敎育 Vol.2 No.-
본 논문에서는 PM 공간 상에서 양립사상의 성질을 이용하여 세 개의 사상들의 공통 부동점 정리를 증명하였다. 이 결과는 Singh와 Pant[5]의 결과를 일반화한 것이다.