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장혜연,On-Yu Hong,Hyun Jo Youn,김민걸,Cheorl-Ho Kim,정성후,Jong-Suk Kim 생화학분자생물학회 2020 BMB Reports Vol.53 No.4
Activation of peroxisome proliferator-activated receptor (PPAR) serves as a key factor in the proliferation and invasion of breast cancer cells and is a potential therapeutic target for breast cancer. However, the mechanisms underlying this effect remain largely unknown. Heme oxygenase-1 (HO-1) is induced and overexpressed in various cancers and is associated with features of tumor aggressiveness. Recent studies have shown that HO-1 is a major downstream target of PPAR. In this study, we investigated the effects of induction of HO-1 by PPAR on TPAinduced MMP-9 expression and cell invasion using MCF-7 breast cancer cells. TPA treatment increased NF-B /AP-1 DNA binding as well as MMP-9 expression. These effects were significantly blocked by 15d-PGJ2, a natural PPAR ligand. 15d-PGJ2 induced HO-1 expression in a dose-dependent manner. Interestingly, HO-1 siRNA significantly attenuated the inhibition of TPA-induced MMP-9 protein expression and cell invasion by 15d-PGJ2. These results suggest that 15d-PGJ2 inhibits TPA-induced MMP- 9 expression and invasion of MCF-7 cells by means of a heme oxygenase-1-dependent mechanism. Therefore, PPAR/HO-1 signaling- pathway inhibition may be beneficial for prevention and treatment of breast cancer.
장혜연,지영훈,한정수,Abdul Manan Khan,안재용,한창수 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.
In this study, we developed a wearable robot operating on the external skeleton to support the movements of a weak person’s upper limbs, mainly 3-degree of freedom (DOF) of the shoulder, 1-degree of freedom of the elbow. Moreover, we applied a redundant degree of freedom to design an upper extremities wearable robot that accurately follows the movement of the upper limbs. Namely, we applied 4 driving parts to the robot to enable 3-degree of freedom for shoulders by optimizing the conformance between the links and body movement range. The optimal design which minimizes error where the robot and the body is adjusted, improves wear sensation and signal input. We attached a multi-axes load-cell to generate motion intent signals detecting the movements of the body. According to the EMG signal measurements when moving the upper limbs with the robot on, the RMS value decreased compared to that without the robot. This is due to the decrease in muscle activity, which results from using smaller muscular strength. That is to say, when comparing the same movements, the person wearing the robot used less muscular strength with the help of the robot. Also through SEF50 analysis of the EMG signals, we were able to verify that the muscle fatigue lessened.
지적장애 아동 및 청소년을 위한 실행기능향상 애플리케이션 ‘YESS’의 효과성 검증: 학교훈련 기반 예비연구
장혜연,정경미 한국재활심리학회 2022 재활심리연구 Vol.29 No.1
지적장애(Intellectual Disability)로 진단된 아동·청소년은 작업기억, 계획력, 억제력 및 인지적 유연성을 포함한 실행기능에 상당한 결함을 보이며, 이는 일상생활, 학업, 대인관계 등 다양한 적응영역에서의 어려움을 초래한다. 본 연구에서는 지적장애 아동·청소년의 실행기능 향상을 위한 앱 기반 훈련 프로그램 ’YESS’를 개발하고, 학교 세팅에서 진행되는 훈련이 실행기능 향상에 효과가 있는지 살펴보았다. 이를 위해, 연구 참가기준을 충족한 42명의 아동·청소년을 훈련집단과 대기집단에 무선할당 하고, 약 55일 동안 학교에서 앱 기반 훈련을 실시하였다. 훈련 전후로 아동의 4가지 실행기능 영역을 측정하는 인지검사와 부모와 교사를 대상으로 부모 양육스트레스, 건강관련 삶의 질, 집행기능 곤란, 교사 직무 스트레스를 평가하는 자기보고식 설문지를 실시하였다. 연구결과, 훈련 후 훈련집단이 대기집단에 비해 계획력 과제 수행이 유의미하게 증가하였고 교사가 보고한 직무소진에서 유의미한 감소를 나타냈다. 한편, 다른 3 영역의 아동 인지과제와 부모 및 교사 설문에서는 유의미한 변화가 관찰되지 않았다. 본 연구 결과를 바탕으로 앱 기반 실행기능 훈련 효과성에 대한 연구적 함의와 함께 본 연구의 한계 및 후속 연구를 위한 제언을 논의하였다.
위식도역류질환의 한약 치료에 대한 최신 임상 연구 동향 - 半夏를 중심으로 -
장혜연,김영광,정서윤,김도형,김경옥,이영수 대한한방내과학회 2020 大韓韓方內科學會誌 Vol.41 No.6
Objective: The purpose of this study was to review Chinese clinical studies of the treatment of gastroesophageal reflux disease (GERD) with herbal medicine including Pinellia ternata. Methods: We searched the China National Knowledge Infrastructure (CNKI) database for clinical studies on herbal treatments including Pinellia ternata for GERD, from January 1st, 2015 to September 30th, 2019. We evaluated the risk of bias using Cochrane's risk of bias to confirm the quality of the 37 selected documents. Results: The 37 papers included high-dose and middle-dose Pinellia ternata groups. The outcome measures included treatment effectiveness rate, symptom comparisons, and endoscopy effectiveness rates or scores. In both groups, most studies showed significant improvement in the treatment group compared with the control group. The meta-analysis revealed a higher treatment effectiveness rate and a lower recurrence rate in the treatment group than in the control group. Conclusions: Comparing the treatment effect between the two groups was difficult due to the low quality of most studies. However, the results suggest that herbal remedies including Pinellia ternata showed statistically significant improvement in GERD compared to control groups.
장혜연,최희정,이계봉,Sul-Bit Cho,임인재,김희진 대한골대사학회 2016 대한골대사학회지 Vol.23 No.2
Background: Bone mineral density (BMD) is influenced by many factors. Despite the reported association between body components and BMD, most of these studies investigated the relationship between absolute muscle mass or fat mass and BMD in postmenopausal women or elderly subjects. The aim of this study is to investigate the association between muscle mass deficits (MMD) estimated from bioelectrical impedance analysis (BIA) and lumbar spinal BMD in Korean adults 20 to 49 years of age. Methods: This cross-sectional study included 1,765 men and women who visited a health promotion center for a routine checkup. The lumbar spinal BMD was measured by dual energy X-ray absorptiometry. Body composition analysis was performed using BIA. Results: The mean age of the subjects was 40.2±6.3 years. Ten thousand subjects (56.7%) were males and 126 subjects (7.1%) belonged to the low BMD (Z-score ≤-2.0). MMD had the strongest influence on BMD after adjusting for all covariates. The adjusted odds ratio of Group 3 (MDD >2.6 kg) for low BMD was 2.74 (95% CI, 1.46-5.15) after adjusting for age, gender, body mass index, height, and smoking. Conclusions: MMD estimated by BIA showed a significant association with BMD and could be regarded as an independent risk factor for low BMD in adults 20 to 49 years of age. These findings support that interventions such as physical activity or lifestyle changes may simultaneously modify both muscle and bone health in this age group.
1P-496 VOC 저감용 비백금계 저온 산화 촉매개발
장혜연,허일정,안치웅,유영우,이성훈,이동석,이진희,박지훈,서정권,이관영 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
VOCs는 대기중에서 광화학반응을 통해 초미세먼지를 생성할 뿐만 아니라 배출환경 역시 다양하기 때문에 이를 저감하기 위한 배출원별 기술개발이 필요하다. 대표적인 기술로는 촉매 산화반응을 통한 VOCs 제거가 있고, Pt 및 Pd 기반의 백금족 원소(PGMs)를 활용한 촉매가 우수한 저온활성 및 내구성을 보이기 때문에 주요 촉매 성분으로 사용되고 있다. 하지만 고가의 백금계 촉매의 경우 저감시스템의 제작단가를 높이기 때문에, 귀금속 촉매를 대체할 수 있는 촉매물질에 대한 연구개발이 필요하다. 이에 열적 안정성이 우수할 뿐만 아니라 산화반응을 위한 활성산소의 제공이 용이하다고 알려져 있는 Ce-Zr 기반의 촉매에 대한 연구를 수행하였다. Ce-Zr을 지지체로 활용하고 VOC 저온 산화를 위한 활성점으로 비백금계 전이금속을 사용하였을 경우, 백금계 촉매와 동일하거나 다소 높은 저온 산화성능이 나타남을 확인할 수 있었다.