제대정맥혈 세포로부터 호산구의 유도

장헌수,김은영,주재학,어수택,김용훈,정일엽,박춘식 대한내과학회 1999 대한내과학회 추계학술대회 Vol.57 No.-

Diagnostic Value of Clinical Parameters in the Prediction of Aspirin-Exacerbated Respiratory Disease in Asthma

장헌수,박종숙,장안수,박성우,우수택,김영훈,박춘식 대한천식알레르기학회 2011 Allergy, Asthma & Immunology Research Vol.3 No.4

Purpose: Aspirin-exacerbated respiratory disease (AERD) has attracted a great deal of attention because of its association with increased asthma severity. However, oral aspirin challenge (OAC) to diagnose AERD is a time-consuming procedure, and some patients experience serious complications. Thus, we evaluated diagnostic values of non-invasive clinical parameters to predict AERD in asthmatic patients. Methods: A total of 836 Korean subjects were recruited from an asthma cohort. They underwent OAC, and clinical parameters including the history of aspirin hypersensitivity,nasal polyposis, and chronic sinusitis of aspirin-tolerant asthma (ATA) and AERD asthmatic patients were compared. Results: Significant differences (P<0.01) were found in eight parameters: age at diagnosis, body mass index, FEV1%, PC20, history of urticaria, nasal polyps, chronic sinusitis,and history of aspirin hypersensitivity. After logistic regression analysis based on the eight clinical parameters, nasal polyps, history of aspirin intolerance, sinusitis, and log [PC20 methacholine] remained significantly associated with AERD (P<0.05). The sensitivity and specificity of the history of aspirin hypersensitivity to predict AERD were 64.7% and 92.0%, respectively, and the positive and negative predictive values were 56.9% and 94.1%, respectively. Overall, the accuracy of the test was 88.2%. The accuracy of the tests for nasal polyps and chronic sinusitis were 67.3% and 60.4%, respectively. Conclusions: Among clinical parameters associated with AERD, the history of aspirin hypersensitivity has the best positive and negative predictive values for the oral aspirin challenge test. Because the false-positive and -negative rates were still high, additional non-invasive methods are needed to reduce the rate of false outcomes.

과두흡수환자의 자기공명영상 사진 평가 및 악안면 골격형태에 대한 연구

장헌수,허윤경,김균요,고유정,채종문,최재갑,Jang, Heon-Su,Hur, Yun-Kyung,Kim, Kyun-Yo,Ko, Yu-Jeong,Chae, Jong-Moon,Choi, Jae-Kap 대한안면통증구강내과학회 2009 Journal of Oral Medicine and Pain Vol.34 No.4

The aim of this study was to investigate clinical assessment, panorama & MRI findings and cephalometric characteristics in 42 patients with condylar resorption, who visited in the Department of Oral Medicine Kyungpook National University Hospital at 2006. The results were as follows; 1. Clinical assessment 1) Female was 34 and male was 8, females were predominant. Distribution of age showed as follows; 10s was 14, 20s was 13, 30s was 7, 40s was 3, 50s was 4 and 60s was 1 patient. 10s and 20s were predominant. 2) Most of the patients had parafunctional habit. 2. Findings of panorama & MRI 1) Most of the patients had degree of Grade II condylar resorption by panorama taking. 2) Most of the patients had disc dislocation and belonged to the degree of stage IV by MRI taking. 3. Cephalometric Characteristics 1) SN, SAr and saddle angle in female patients were significantly smaller and SN in male patients showed only significantly smaller than normal group. 2) SNA showed no difference from the normal group in both patients. SNB was smaller and ANB was lager in female patients than normal group. 3) SN-GoMe and FMA increased in patients. 4) Total posterior facial height & ramus height were significantly smaller. 5) Mandibular body length did not show any significant difference.

Temporary Cement가 상아질 접착제의 접착성능에 미치는 영향

장헌수 慶北大學校 齒科大學 1995 慶北齒大論文集 Vol.12 No.1

Temporary cement가 상아질 접착제의 접착성능에 미치는 영향을 평가하기 위해 소의하악 전치 100개를 사용하여 순면의 상아질을 노출시키고 유지놀을 함유하지 않은 Nogenol 및 TempBond NE와 유지놀을 함유한 TempBond 및 산화아연 유지놀세멘트를 각각 도포하여 7일 경과 후 제거하였다. All-Bond 2 및 Super-Bond C&B 상아질 접착제를 제조회사의 지시대로 사용하여 접착시킨뒤 37℃ 항온조에서 24시간 보관 후 인장접착강도를 측정하고, 응집파단율을 산정하였다. 그리고 temporary cement를 적용하지 않은 상아질면과 temporary cement를 도포하였다가 제거한 상아질면에 10% 인산 수용액 및 10% 구연산 수용액으로 각각 산처리한 상아질 표면성상과 접착실험후의 파단면을 주사전자현미경으로 관찰하여 다음의 결과를 얻었다. 1. All-Bond 2로 접착시킨 경우에는 사용한 temporary cement의 종류에 관계없이 실험군의 인장접착강도가 temporary cement를 사용하지 않은 대조군에 비해 유의하게 낮게 나타났으나(P<0.05), Super-Bond C&B로 접착시킨 경우에는 유ㅢ한 차이가 없었다(P>0.05). 2. 유지놀을 함유하는 temporary cement와 유지놀을 함유하지 않는 temporary cement를 각각 적용한 실험군들의 인장접착강도 간에는 유의한 차이가 없었다(P>0.05). 3. 응집파단율 산정결과 All-Bond 2로 접착시킨 경우에는 대조군에서 응집-부착성의 혼합파단양상이, 실험군에서는 부착성 파단양상이 주로 나타났으나, Super-Bond C&B로 접착 시킨 경우에는 대조군과 실험군 모두에서 응집성파단양상이 우세하게 나타났다. 4. 주사전자현미경적 관찰상에서 temporary cement의 종류에 관계없이 temporary cement를 도포한후 제거하고 10% 인산 수용액 또는 10-3 용액으로 전처리한 모든시편에서 미세한 temporary cement 잔존물을 관찰할 수 있었다. This study was conducted to the effect of temporary cement on the adhesiveness of dentin bonding agent to dentin surface. One hundred freshly extracted bovine mandibular incisors were grinded to expose flat labial dentin surface. The dentin surfaces were temporarized with either eugenol-containing temporary cement(TemBond and Zinc Oxide Eugenol cement) or non-eugenol temporary cement(Nogenol and TempBond NE) for 7days, and then the temporarization was removed with surgical currette and the exposed dentin surfaces were water-rinsed. Bonding specimens were made by use of All-Bond 2 and Super-Bond C&B dentin bonding agent, and stored in 37℃ distilleed water for 24hours. The tensile bond strenth and the cohesive failure rate were measured, and then the pretreated dentin surfaces to which the temporary cement had been applied and removed, and finally the fractured dentin surfaces after bonding test were examined under scanning electron microscopoe. The results were as follows: In case of bonding with All-Bond 2, tensile bond stregth of each experimental group was lower than that of the control group(P<0.05), but there was no significant difference between the bond strengths of the control group and each experimental group in case of bonding with Super-Bond C&B(P>0.05). No significant difference between tensile bond strength of experimental group, whether temporary cement contains eugenol or not, was seen(P>0.05). In case of bonding with All-Bond 2, the control group showed cohesive-adhesive mixed failure mode and the experimental groups mainly showed adhesive failure mode, but in case of bonding with Super-Bond C&B, allmost of the control and the experimental groups mainly showed cohesive failure mode. On SEM examination, all of the dentin specimens pretreated with either 10% phosphoric acid or 10% citric acid after application of the temporary cements demonstrated remnants of temporary cement attached to dentin surface.

시상골 골절단술시 근심골편의 변위를 방지하기위한 lingual fracture technique

장헌수,안재진,우성도,김종필 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.1

The sagittal split osteotomy of the mandibular ramus is a common procedure which has been used in the correction of mandibular deformities for a few decades. Although the technical improvements have increased the reliability and stability of SSRO procedure, the postoperative relapse is imperative and clinically more significant than any other complication. One of the major causes of the relapse is due to the displacement of the proximal segment during SSRO procedure, which is well documented in the literature. Therefore it is important to preserve the original position of the proximal segment during SSRO proced and maxillofacial fixation period. In the case of mandibular asymmetry, if one side of mandible is advanced and the other side of mandible is setback during SSRO procedure, the proximal segment in the advancement site will rotate laterally and the proximal segment in the setback site will rotate medially. For the prevention of the lateral rotation or flaring of the proximal segment in the advancment site. we deliberately fracture the posterior protion of the distal segment in green-stick fashion during SSRO procedure, and there is no need to fix the fractured lingual segment. We fix the two octeotomized bony segments in the buccal cortex area rigidly with adjustable monocortical plates and screws. During SSRO procedure the lingual fracture technique was applied to nine patients with severe mandibular asymmetry who underwent orthognathic surgery in our hospital since march, 1992. These clinical experiencies enable us to find the lingual fracture technique has the following advantages. 1. The proximal segment is displaced minimally. 2. The osteotomized bony segments are contacted intimately. 3. The postoperative relapse and the healing period are decreased.

Temporary Cement가 상아질 접착제의 접착성능에 미치는 영향

조규증,장헌수 大韓齒科保存學會 1995 Restorative Dentistry & Endodontics Vol.20 No.2

하악골에 발생한 원발성 상피암 2례

장헌수(Heon Soo Chang),김종필(Jong Pil Kim),안재진(Jye Jynn Ann) 대한구강악안면외과학회 1994 대한구강악안면외과학회지 Vol.20 No.3

The primary intraosseous carcinoma(PIOC) of the jaw is extremely rate condition and I defined as a squamous cell carcinoma arising within the jaw having no initial connection with the oral mucosa and developing from the residues of odontogenic epithelium, according to WHO. We present 2 cases of PIOC in the mandible. The first patient 62-year0old male, visited our hospital with a complaint of a nonhealing extraction wound. A biopsy was performed and the microscopic diagnosis of PIOC was made. the patient underwent combined surgical and radiation therapy with no recurrence for 5 years. The second patients, 21-year-old female, complained a intraosseous lesion in the anterior mandible and a lump of submental area. The intraosseous lesion was resected widely and the result of tissue examination was the calcifying odontogenic cyst. Sine the submental lump remained postoperatively, excisional biopsy of the mass was performed and it has turned out to be metastatic lymph node. So that the first surgical specimen was reviewed and fnal dignosis of PIOC was made. The patient underwent radiotherapy and has remained free of local recurrence for 12 months postopertively. We could obtained the interesting clinical experience, that is, the difficulty of diagnosis and atypical clinical manifestation different with most oral carcinoma.

F-152 Metagenomics of sputum bacteria is related with the severity of asthma

손지혜,장헌수,박종숙,어수택,김용훈,박춘식 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.0

Background: The clinical impact of the microbiome has not been revealed in terms of asthma severity. In this study, we characterized microbiome in sputum of asthmatics and to assess the effect of different microbiome compositions on the changes of longitudinal lung function. Methods: The sputum was obtained from the biobank of Soonchunhyang University Bucheon Hospital. We analyzed lung microbiome by using 16s rRNA gene sequencing analysis of the induced sputum cell pellet of 38 asthmatics who were followed up for 1 years; 18 subjects with normal post-bronchodilator FEV1 for 1 year (A), 8 patients with decreased FEV1 under 60% which showed a substantial increase lung function for 1 year (B), and 12 patients with decreased FEV1 under 60% which did not increase during the follow up period (C). Results: On the phylum level, Fusobacteria, SR1, Chloroflexi, Bacteroidetes being among the most differentially abundant between A, B and C. Compared with A, B groups, C groups had lower relative abundance of the phylum Chloroflexi. On the genus level, 34 bacteria including Sphingomonas and Moraxella being among the most differentially abundant between A, B and C. Compared with A, B groups, C groups had lower relative abundance of the genus Dialister, GQ422718_g, Granulicatella, AJ400239_g, APVJ_g. Conclusions: Significant alternation of bacterial communities in sputum was observed according to refractory state of asthmatics. The metagenomic profiles may provide novel aspects for investigating pathophysiology and for developing biomarker for refractory asthma. [funded by 2015-ER7402-00)]

CYP2D6 P34S Polymorphism and Outcomes of Escitalopram Treatment in Koreans with Major Depression

한규만,장헌수,최인광,함병주,이민수 대한신경정신의학회 2013 PSYCHIATRY INVESTIGATION Vol.10 No.3

Objective Cytochrome P450 (CYP) enzymatic activity, which is influenced by CYP genetic polymorphism, is known to affect the inter-individual variation in the efficacy and tolerability of antidepressants in major depressive disorder (MDD). Escitalopram is metabolized by CYP2D6, and recent studies have reported a correlation between clinical outcomes and CYP2D6 genetic polymorphism. The purpose of this study was to determine the relationship between the CYP2D6 P34S polymorphism (C188T, rs1065852) and the efficacy of escitalopram treatment in Korean patients with MDD. Methods A total of 94 patients diagnosed with MDD were recruited for the study and their symptoms were evaluated using the 21-item Hamilton Depression Rating scale (HAMD-21). The association between the CYP2D6 P34S polymorphism and the clinical outcomes (remission and response) was investigated after 1, 2, 4, 8, and 12 weeks of escitalopram treatment using multiple logistic regression analysis and χ2 test. Results The proportion of P allele carriers (PP, PS) in remission status was greater than that of S allele homozygotes (SS) after 8 and 12 weeks of escitalopram treatment. Similarly, P allele carriers exhibited a greater treatment response after 8 and 12 weeks of escitalopram treatment than S allele homozygotes. Conclusion Our results suggest that the P allele of the CYP2D6 P34S polymorphism is a favorable factor in escitalopram treatment for MDD, and that the CYP2D6 P34S polymorphism may be a good genetic marker for predicting escitalopram treatment outcomes.

Lung Function Trajectory Types in Never-Smoking Adults With Asthma: Clinical Features and Inflammatory Patterns

김주희,장헌수,신승우,백동규,손지혜,박춘식,박종숙 대한천식알레르기학회 2018 Allergy, Asthma & Immunology Research Vol.10 No.6

Purpose: Asthma is a heterogeneous disease that responds to medications to varying degrees. Cluster analyses have identified several phenotypes and variables related to fixed airway obstruction; however, few longitudinal studies of lung function have been performed on adult asthmatics. We investigated clinical, demographic, and inflammatory factors related to persistent airflow limitation based on lung function trajectories over 1 year. Methods: Serial post-bronchodilator forced expiratory volume (FEV) 1% values were obtained from 1,679 asthmatics who were followed up every 3 months for 1 year. First, a hierarchical cluster analysis was performed using Ward's method to generate a dendrogram for the optimum number of clusters using the complete post-FEV1 sets from 448 subjects. Then, a trajectory cluster analysis of serial post-FEV1 sets was performed using the k-means clustering for the longitudinal data trajectory method. Next, trajectory clustering for the serial post-FEV1 sets of a total of 1,679 asthmatics was performed after imputation of missing post-FEV1 values using regression methods. Results: Trajectories 1 and 2 were associated with normal lung function during the study period, and trajectory 3 was associated with a reversal to normal of the moderately decreased baseline FEV1 within 3 months. Trajectories 4 and 5 were associated with severe asthma with a marked reduction in baseline FEV1. However, the FEV1 associated with trajectory 4 was increased at 3 months, whereas the FEV1 associated with trajectory 5 was persistently disturbed over 1 year. Compared with trajectory 4, trajectory 5 was associated with older asthmatics with less atopy, a lower immunoglobulin E (IgE) level, sputum neutrophilia and higher dosages of oral steroids. In contrast, trajectory 4 was associated with higher sputum and blood eosinophil counts and more frequent exacerbations. Conclusions: Trajectory clustering analysis of FEV1 identified 5 distinct types, representing well-preserved to severely decreased FEV1. Persistent airflow obstruction may be related to non-atopy, a low IgE level, and older age accompanied by neutrophilic inflammation and low baseline FEV1 levels.