한국 건강심리학 연구주제의 흐름: 2002-2021

한규만,최지명,이민규 한국건강심리학회 2022 한국심리학회지 건강 Vol.27 No.6

본 연구는 의미 네트워크 분석을 통하여 한국 건강심리학의 연구주제의 흐름을 확인하여, 건강심리학의 변화를 예측하고 발전 방향을 모색하는 것을 목적으로 실시되었다. 이를 위하여, 2002년부터 2021년까지 20년간 『한국심리학회지: 건강』에 게재된 논문 994편의 논문 제목에서 추출된 1207개의 주제어를 대상으로 빈도수가 높은 주제어를 추출하고, 주제어 간의 관계를 확인하기 위하여 의미 네트워크 분석을 실시하였다. 분석결과는 다음과 같다. 첫째, 『한국심리학회지: 건강』의 주요 연구는 프로그램의 효과, 변인 간의 관계 및 확인을 하는 것에 초점을 두고 있었으며, 주요 주제어는 정서 및 스트레스와 관련된 연구들이 많았음을 확인하였다. 둘째, 『한국심리학회지: 건강』의 연구들은 주요 주제어인 정서를 중심으로 광범위한 연구를 실시하고 있음을 확인하였다. 이후 본 연구의 결과를 기반으로 향후 발전 방향에 대한 논의 및 제한점을 제시하였다.

감정표현불능증 특성을 보이는 건강한 여성의 화소 기반 형태분석 방법을 통한 회백질 용적 감소의 정량적 분석

한규만,최인광,한명일,이민수,함병주 대한우울조울병학회 2012 우울조울병 Vol.10 No.3

Objectives : Alexithymia is a condition characterized by impaired ability to identify and describe subjective feelings. In this study, we aimed to investigate whether an alexithymic trait is associated with structural abnormalities in cerebral cortex in healthy adults with voxel-based morphometry (VBM). Method : 71 healthy women were enrolled in this study and the Korean version of 20-item Toronto Alexithymia Scale (TAS-20) was carried out to determine their alexithymic traits. Gray matter (GM) volume was assessed with a VBM protocol from magnetic resonance images acquired on a 1.5 T scanner. We compared GM volumes between subjects with alexithymic traits and non-alexithymic subjects. Results : In the reigion-of-interest (ROI) analysis of both frontal lobes and hippocampal regions, the subjects with alexithymic traits showed a trend of smaller GM volume in the superior frontal gyrus (Talairach coordinate=-12, 23, 53 ; cluster size=47 ; Z-score=3.26), parahippocampalgyrus (24, -34, -9 ; 38 ; 2.95) and middle frontal gyrus (42, 50, 17 ; 22 ; 2.87). Conclusion : Our results suggest that the subjects with alexithymic traits would have a trend of smaller GM volumes in the superior frontal gyrus, parahippocampalgyrus and middle frontal gyrus.

밸러드 부흥운동과 낭만적 문학 밸러드의 탄생: 퍼시와 워즈워스를 중심으로

한규만 현대영미어문학회 2018 현대영미어문학 Vol.36 No.1

This paper explores the evolution of British ballads and the impact of the ballad tradition on Romanticism during the eighteenth and nineteenth centuries. Through the period, the traditional and broadside ballads of folk people were collected and published by antiquarians such as Thomas Percy and Sir Walter Scott. W. Wordsworth and many Romantic period poets imitated Percy’s Reliques and were influenced by the themes and techniques of the ballads of the lower class. In Lyrical Ballads, Wordsworth is seen to adopt the ballad tradition as the basis of his poetics of Romanticism. He is considered to creatively imitate the characters, subjects and poetic techniques of popular ballads for his literary ballads. The ballad tradition includes the anonymity and orality of folk people as well as the language of common people and the incidents of their lives. .

How Inflammation Affects the Brain in Depression: A Review of Functional and Structural MRI Studies

한규만,함병주 대한신경과학회 2021 Journal of Clinical Neurology Vol.17 No.4

This narrative review discusses how peripheral and central inflammation processes affect brain function and structure in depression, and reports on recent peripheral inflammatory marker-based functional and structural magnetic resonance imaging (MRI) studies from the perspective of neural-circuit dysfunction in depression. Chronic stress stimulates the activity of microglial cells, which increases the production of pro-inflammatory cytokines in the brain. In addition, microglial activation promotes a shift from the synthesis of serotonin to the synthesis of neurotoxic metabolites of the kynurenine pathway, which induces glutamatemediated excitotoxicity in neurons. Furthermore, the region specificity of microglial activation is hypothesized to contribute to the vulnerability of specific brain regions in the depressionrelated neural circuits to inflammation-mediated brain injury. MRI studies are increasingly investigating how the blood levels of inflammatory markers such as C-reactive protein, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α are associated with functional and structural neuroimaging markers in depression. Functional MRI studies have found that peripheral inflammatory markers are associated with aberrant activation patterns and altered functional connectivity in neural circuits involved in emotion regulation, reward processing, and cognitive control in depression. Structural MRI studies have suggested that peripheral inflammatory markers are related to reduced cortical gray matter and subcortical volumes, cortical thinning, and decreased integrity of white matter tracts within depression-related neural circuits. These neuroimaging findings may improve our understanding of the relationships between neuroinflammatory processes at the molecular level and macroscale in vivo neuralcircuit dysfunction in depression

결혼, 그럼에도 불구하고

한규만 기독교대한성결교회 활천사 2015 활천 Vol.738 No.5

CYP2D6 P34S Polymorphism and Outcomes of Escitalopram Treatment in Koreans with Major Depression

한규만,장헌수,최인광,함병주,이민수 대한신경정신의학회 2013 PSYCHIATRY INVESTIGATION Vol.10 No.3

Objective Cytochrome P450 (CYP) enzymatic activity, which is influenced by CYP genetic polymorphism, is known to affect the inter-individual variation in the efficacy and tolerability of antidepressants in major depressive disorder (MDD). Escitalopram is metabolized by CYP2D6, and recent studies have reported a correlation between clinical outcomes and CYP2D6 genetic polymorphism. The purpose of this study was to determine the relationship between the CYP2D6 P34S polymorphism (C188T, rs1065852) and the efficacy of escitalopram treatment in Korean patients with MDD. Methods A total of 94 patients diagnosed with MDD were recruited for the study and their symptoms were evaluated using the 21-item Hamilton Depression Rating scale (HAMD-21). The association between the CYP2D6 P34S polymorphism and the clinical outcomes (remission and response) was investigated after 1, 2, 4, 8, and 12 weeks of escitalopram treatment using multiple logistic regression analysis and χ2 test. Results The proportion of P allele carriers (PP, PS) in remission status was greater than that of S allele homozygotes (SS) after 8 and 12 weeks of escitalopram treatment. Similarly, P allele carriers exhibited a greater treatment response after 8 and 12 weeks of escitalopram treatment than S allele homozygotes. Conclusion Our results suggest that the P allele of the CYP2D6 P34S polymorphism is a favorable factor in escitalopram treatment for MDD, and that the CYP2D6 P34S polymorphism may be a good genetic marker for predicting escitalopram treatment outcomes.

포크 밸러드에 나타난 사랑과 성

한규만 현대영미어문학회 1999 현대영미어문학 Vol.16 No.2

It is often said that folk ballads belong to the literature of the Middle Ages. Although the ballads show frequently the medieval characteristics of setting, characters and literary atmosphere, they actually assert the modern traits of message and theme. This study aims to explore the folk's views of love, sex and marriage in love ballads and the social significance through the close examinations of the story, message and theme. The preparatory step is to analyse the medieval tradition of love, sex and marriage. And love of ballads is classified into four types of betrayed love, romantic love, transcending love and passionate love according to the intensity of human bond between two lovers. Research findings are: 1) Every love ballad has a tragic ending. It has a social meaning: the folk, as the weaker part of society, recognize well that their assertions of new types of love shall be completely defeated by the maintaining group of the status que. 2) The more intense the bond of love is, the more tragic ending the ballad has: betrayed love ballads end in woe and death, romantic love songs end in death and suicide, transcendental love poems end in slaying and burning, and adulterous love narratives end in massacre and butchery. 3) Love ballads show a main conflict between the Christian church tradition of arranged marriage and the pagan tradition of love marriage. The folk asserts in love ballads that spiritual love be united to physical sex. 4) Transcendental love, in contemporary social context, means that the folk prefer pure love to material wealth, free choice of the spouse to families' honor and cosmopolitan marriage to nationalistic marriage. 5) Love ballad, as a genre of folk literature, is ideologically contrasted with art literature. While the latter is based on the medieval chivalrous tradition of patriarchal collectivism, male-dominant society, and the segregation of love and marriage, the former insists on the modern tradition of individualism, society of freedom and equality, the union of love, sex ,and marriage.

근거중심 한국형 우울증 약물학적 치료지침, 개정판(III) : 항우울제의 증량, 교체, 병합 및 강화요법

한규만,박선철,원은수,성승환,이희영,구재우,이경민,이화영,백종우,전홍진,이문수,심세훈,고영훈,이강준,한창수,함병주,최준호,황태연,오강섭,한상우,박용천,이민수 대한신경정신의학회 2013 신경정신의학 Vol.52 No.5

Objectives The aim of this study was to demonstrate the recommendations for antidepressant treatment strategy of dose increment, switching, combination, and augmentation therapy derived from Evidence-Based Korean Pharmacological Treatment Guideline for Depression, Revised Edition. Methods The guideline was developed through adaptation of 12 domestic and foreign clinical guidelines for depression, with key questions concerning pharmacotherapy of depression, and drawing of recommendations. Results The guideline strongly recommended dose increment, switching, and combination and augmentation therapy of antidepressant when patients with depression showed inadequate treatment outcomes from initial antidepressant treatment. The dose increment was strongly recommended when the patients had insufficient response from treatment with tricyclic antidepressants (TCAs), monoamine oxidase inhibitors, selective serotonin reuptake inhibitors (SSRIs), and serotonin and norepinephrine reuptake inhibitors (SNRIs). Switching from SSRI to non-SSRI was also strongly recommended. The combination of initial medication and other classes of antidepressants could benefit from treatment with TCAs, SSRIs, SNRIs, and noradrenergic and specific serotonergic antidepressants. Combination with norepinephrine and dopamine reuptake inhibitors or serotonin-2 antagonist/reuptake inhibitors was weakly recommended. The guideline strongly recommended use of the augmentation strategy of adding lithium or benzodiazepine to initial antidepressants. Augmentation of lamotrigine, T3, methylphenidate, and modafinil was weakly recommended. Conclusion If the initial outcomes of antidepressant therapy are unsatisfactory to the patients the next-step strategies of dose increment, switching, combination and augmentation of antidepressants should be considered after rechecking the patients’ drug compliance, dose, and diagnosis.

R.W. Emerson의 散文에 나타난 Self-Reliance의 硏究

韓圭萬 울산대학교 1982 연구논문집 Vol.13 No.1

R. W. Emerson은 19세기 美國作家들 가운데 가장 유명하고 영향력이 至大한 作家중의 한사람이다. 그는 New England Transcendentalism의 代辯人이었으며 그의 사랑의 핵심은 Self-Reliance이다. 그는 當代의 물질주의와 점증하는 産業主義를 못마땅하게 생각하였다. 그는 人間은 神의 形象대로 창조되었음을 주장하였고 自身의 영혼속에 있는 神의 音聲을 들어야 한다고 주장하였다. 따라서 진실한 인간이란 특히 學者는 Self-Reliance를 가져야 한다는 것이다. Self-Reliance의 사상은 Emerson의 全思想의 기초개념이다. 各 個人은 直觀을 통하여 神과 交通할 수 있으므로 결국 人間은 자신의 心性을 통하여 神性과 完全性을 획득할 수 있다는 것이다. 그러나 個人은 社會와 단절되어 살아갈수는 없다. 個人의 社會의식이 높아감에 따라, 人間은 社會에서의 자신의 위치를 찾게 되다. Emerson은 자신의 職分을 詩人으로 확신하였다. 詩人에게는 말한다는 사실이 하나의 行動이었다. 많은 비평가들은 Emerson의 활동시기를 前後期로 나누어 前期에는 社會와 國家, 그리고 敎會를 부인하였고 後期에 와서는 거기에 順應하게 되었다고 주장한다. 그러나 그것은 피상적인 관찰이다. 그가 거부한 것은 社會 그 自體나 社會의 效用이 아니라, 社會의 규율적이고 형식적인 制度와 惡習이었다. 따라서 그가 後期에 와서 社會와 和解를 했다거나 運命에 順應했다는 表現은 걸맞지 않다. 그는 眞理에 充實한 사람이었고 後期에는 새로운 人間像 즉 Man Thinking을 實踐해 본 것이다. 바로 그러한 人間만이 새로운 社會를 건설할 수 있다는 것이다. 그는 항상 個個人은 활동의 主體이오. 社會는 그 活動무대임을 잘 알고 있었다. 個人과 社會의 두 요소는 동시에 兩立해야 하는 상호보완적인 요소인 것이다. Ralph Waldo Emerson has been widely regarded as the most famous and most influential of the nineteenth century American writers. He was the spokesman of New England Transcendentalism. And the core of his thoughts is Self-Reliance. He condemned the materialism and the growing industrialism of his age. But he found it possible to compromise between ideal and reality. He suggested that a man was created in image of God and should hear the voice of God in the should. Consequently a true man, especially a Scholar, should have Self-Reliance, which is the main idea of Emerson's whole thoughts. Each individual can communicate with God through his own intuition, so it is possible to achieve divinity or perfection through his own mind. But every individual cannot live alone without being concerned with society. As the social consciousness increases, each individual seeks to find his role in society. Emerson considered his vocation as Sayer, the poet, Saying words was a kind of action to him. Most critics view that, in his earlier period of Emerson's writings, he rejected the society, the nation and the church. However, it is a superficial observation. It is the formal institutions in society or evil traditions of society that he rejected. Not the uses or good effects of society. And in his later period of writing he has been said to have reconciled himself with society or to yield to the fate. But in my opinion he never submitted to the fate, only faithful to the truth. He spent his later lifetime on showing how to be a new man. Man Thinking, who is able to establish a new society. He was never opposed to the society itself and never reconciled with it. He was always recognizing that they needed each other. Every individual is an actor and society is the stage on which the actor plays. The two factors are compatible at the same time.

韓國의 敍事民謠와 英美의 포크밸러드에 나타난 主題의 比較分析

韓圭萬 울산대학교 1988 연구논문집 Vol.19 No.2

이 論文의 目的은 한국이 서사민요와 영미의 포크 밸러드의 공통점 특히 공통적인 주제를 파악해 내는 것이다 .제 Ⅰ장은 本 硏究의 意義와 目的 그리고 양자의 硏究 現況을 밝혔다. 제Ⅱ장은 양 장르의 주제분류와 등장인물의 對比를 하였으며, 제Ⅲ은 양자의 敍事장르로서의 공통적 특성을 추출하였다. 제Ⅳ장은 社會的,文學的 觀點에서 조동일이 수집한 서사민요를 19개 하위유형을 나누어 그 의미를 �거하였으며, 제Ⅴ장에서는 英美文化圈에서 가장 인기있다고 하는 7개의 밸러드를 같은 관점에서 논하였다. 本 硏究의 結論은 다음과 같다. 1.한국의 학자들은 서사민요를 "農村女性"의 "길쌈 노동요"라고 단정짓고 있으나 그 槪念이 매우 狹義的이다. 서사민요의 범주에는 진정한 서사 變愛謠뿐만 아니라 超自然的, 宗敎的인 敍事巫歌 및 歷史的인 背景을 갖는 참謠와 諷笑謠의 一部가 포함될 수 았다. 男性謠 중에서 樵夫謠, 어부요, 牧?謠와 그외에도 設話謠, 歌辭的 民謠 중에서 서사민요를 발견할 수 있다. 2.外觀上의 팬터지적인 요소에도 불구하고 양 장르는 寫實主義的인 詩로 規定할 수 있다. 3.주제해석의 열쇠는 겉으로 드러나는 이야기의 결말에 있지 않고 唱者 및 聽者로서의 民의 態度이다. 은 이것을 民의 "情緖的 核心"이라고 하였다. 4.社會的인 觀點에서 보면 兩 장르의 共通主題는 封建的.家父長的 道德律에 대한 民의 抗拒이다. 5.文學的인 觀點에서 보면, 兩者의 共通主題는 悲劇的 現實을 극복하고 人間性의 解放을 성취하려는 民의 意志이다. 6.그 주제는 具體的으로 다음과 같이 分類될 수 있다 : 觀念的인 生活方式이 아닌 實用的이고 經驗的인 生活方式의 表明, 黃金萬能主義가 아닌 人道的인 價値評價, 規制와 抑壓이 아닌 自由와 平等 精神의 高揚, 잔인무도한 복수와 보복이 아닌 寬容과 容恕, 性的인 방종이 아닌 자유롭고 건강한 性 等. 7.一船的인 情緖는 비관적인 자포자기가 아니라 낙관적인 발랄함이며, 절망적인 點從이 아니라 희망에 찬 實踐主義라고 본다. The purpose of this paper is find out the common themes of Korean and Anglo-american narrative folk songs. Chapter I deals with significance and the aims of the study, and its developments in Korea, the U.K. and the U.S.A. Chapter Ⅱ survey the classifications and the characters of the two genres. ChapterⅢ examines the common characteristics of the two as narrative songs. ChapterⅣ investigates, from the social and literary points of view, the meanings of nineteen subtypes of sosaminyo(Korean narrative folk songs), collected by Cho, Dong-I1, ChapterⅤ examines the meanings of the most popular seven ballads. The conclusions are as follows: 1.Korean scholars define sosaminyo s "a weaving song" of "women in the rural villages." The definition is very struct. Categories of sosaminyo may be extended, beyond true love songs, to part of the supernatural and religious shaman's narratives and part of the historical predictions and satires of the folk. And sosaminyo could include some of masculine work sons-those of woodcutters, seamen and herdboys-as well as some of legendary narratives and odes. 2.Depite the seemingly fantastical elements, both genres may be defined as realistic poetry. 3.The key to the interpretation of themes is not the literal meanings of the story but the singer's and listener's attitudes toward the story. T.Coffin, called it "emotional core." 4.From the social point of view, the common theme of the two genres is the protest against the feudal and patriarchal moralities. 5.From the literary point of view, it is the will to overcoming of tragic realities and to the liberation of humanity. 6.Teh themes are classified as follows: not idealistic ways of life but practical and experiential ones, not mammonish ecaluaion but humanitarian one, not brutal revenge but forgiveness, and sexual licentiousness but sexual freedom. 7.The dominant emotions and feelings in both narrative folk songs are not pessimistic resignation but optimistic liveliness, and not desperate passiveism but hopeful activism.