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급성복증 환자의 일반외과 응급 진료: 개원초 377예에 관한 임상분석
이환봉 ( Whan Bong Lee ),김진천 ( Jin Cheon Kim ),김석구 ( Suk Koo Kim ) 대한외상학회 1991 大韓外傷學會誌 Vol.4 No.2
377 patients complaining abdominal pain who were treated by surgical department in emergency room from 1989 June to 1990 June were analyzeed and disease prevalence were obtained as follows; acute appendicitis 163 cases (43.1 %), non-specific abdominal pain (NSAPs) 61 cases (16.1 %), cholelithiasis 33 cases (8.7%), perforated peptic ulcer 23 cases (6.1 %), intestinal abhesion 21 cases (5.6%), gynecologic problems 18 cases (4.8%), intraabdominal malignancy 17 cases (4.5%), abdominal trauma 14 cases (3.7%) and others 28 cases (7.4%). The most frequent problem in the age group 0-15 were non-specific abdominal pain, and cholelithiasis in the age group over 60. But not a single case of non-specific abdominal pain was found in the age group over 60. The overall morbidity was 16.2%, whereas mortality 2.7%. Increasing tendency of morbidity found in the age group over all 60 were due to respiratory complications, and cholelithiasis. Trauma was the most frequent cause of death. Among surgical interventions of 291 cases (79.3%), 31 cases (10.6%) showed negative laparotomies which were explored under the impression of acute appendicitis. Because only a few study about the acute abdomen in general review has been tried, we have tried initial analysis of acute abdominal pain patients in Emergency room treated by surgical department.
허유창(Yu Chang Hur),이환봉(Whan Bong Lee),박길수(Gil Soo Park) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.6
N/A One hundred cases of intussusception who were treated by surgical intervention at the department of general surgery. Eul Ji General Hospital, Seoul from 1987 to 1993 were reviewed. The majority of patients(84.0%) were under 1 year of age, and more than half were between 3 and 5 months. Male to female sex ratio was 3: 1. The most frequent symptom was abdominal pain(89.0%). Duration of symptom between 13 and 24 hours was most frequent(31.0%). Pathologic leading point was identified only in 16 patients(16.0 %) and mesenteric lymphadenitis was the most common one. Ileocecal type was most fre- quent. In the method of operations, manual reduction was performed in 83.0% of cases, and bowel resection and anastomosis was performed in 14 cases. The causes of bowel resection were presence of leading points(10 cases), bowel gangrene(3 cases) bowel per- foration during the attempt of barium enema reduction(1 case). Absence of intuss usception suggested spontaneous reduction at laparotomy was noted in three cases(3.0%). Post operative complications were present in 8 cases(8.0%) and there was no postopera- tive mortality. Delayed surgical intervention could necessitate bowel resection and pro- longed hospitalization. Accordingly a prompt decision for celiotomy or not should be made, after air enema or barium enema trial as indicated.(Korean J Gastroenterol 1994; 26: 919 924)
Adiramycin이 C6 glioma 세포에 미치는 영향에 대한 원지의 효과
이은미,최유선,손영우,유교상,하대호,이환봉,장철호,이정헌,이강창,이승현,박승택,이건목,류도곤 대한동의생리학회,대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.6
To elucidate the cytotoxic effect of adriamycin on C6 glioma cells, we examined the neurotoxicity induced by adriamycin by MTX assay when C6 glioma cells were cultured in the media containing various concentrations of adriamycin for 72 hours. In addition, neuroprotective effects of herb extract such Polygalae Radix(PR), on adriamycin-induced neurotoxicity in cultured C6 glioma cells were evaluated after C6 glioma cells were preincubated with various concentrations of herb extract, PR for 2 hours before 6uM adriamycin for 72 hours. Adriamycin decreased remarkably cell viability in dose-and time-dependent manner in these cultures, and also herb extract, PR increased cell viability of C6 glioma cells damaged by adriamycin. From these results, it is suggested that adriamycin was highly toxic in cultured C6 glioma cells, and PR was effective in blocking the neurotoxicity induced by adriamycin in these cultures.
과산화수소로 손상된 배양 심근세포에 대한 골쇄보의 영향
이병찬,이종화,이환봉,이강창 대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.3
To examine the cytotoxicity of reactive oxygen species in cultured rat myocardial cells, cytotoxic effect was determined by MTT assay after cultured cells were incubated for 4 hours in the media containing 1∼30μM of H_2O_2. And also, the protective effect of Drynariae Rhizoma(DR) was determined in these cultrures. Cell viability was significantly decreased in a dose-dependent manner after exposure of 15μM H_2O_2 to cultured rat myocardials for 4 hours. In the protective effect of DR, DR prevented the H_2O_2-induced cytotoxicity in these cultures. From these results, it suggests that H_2O_2 has toxic effect in cultured mouse myocardial cells and DR has protective effect on the cytotoxicity induced by H_2O_2.
Lovastatin의 암세포에 대한 항증식 효과에 관한 연구
이환봉,장정순 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.1
Background: Lovastatin which is a potent inhibitor of HMG-CoA reductase has antiproliferative effect on cancer cells. We investigated the cell cycle regulatory mechanism of anti-proliferative effect of lovastatin and its therapeutic value on cancer treatment. Methods: MDA-MB-231, an ER negative breast cancer cell line and PC-3-M, an androgen independent prostate cancer cell line were grown up to use. We checked expression pattern of cell cycle regulatory proteins such as cyclins, cdk inhibitors including p21, cdks, RB and RB family protein p107 with lovastatin by Western blot analysis and immunoprecipitation. Results: The proliferative tendency of breast cancer and prostate cancer cells was decreased with 10 μM lovastatin. Cyclin D1 was decreased, however p21, a cdk inhibitor was increased with lovastatin. There is no change in the protein level of cyclin E, cdk4 and cdk2. After 36 h incubation with lovastatin, RB and p107 were dephosphorylated and showed increased binding with transcription factor E2F1 and E2F4 respectively. Conclusion: These results show that lovastatin has antiproliferative effects on breast and prostate cancer cells. The cell cycle regulatory effects of lovastatin come to G1 phase and those are mediated by cyclin D1 depression, p21 induction and decreased activity of cdk4. In accordance with them RB dephosphorylation and its sucessive binding with E2F1 seem to have important role in growth inhibitory effect of lovastatin. These data suggest that growth inhibitory activity of lovastatin by way of cell cycle regulation supports the therapeutic value for cancer treatment.