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      • SCOPUSKCI등재

        각종 악성종양에서 (惡性腫瘍) Levamisole 이 혈청 (血淸) Ferritin 및 임파구 (淋巴球) 로제트 형성율에 (形成率) 미치는 영향

        유종선 ( Jong Sun Rew ),윤종만 ( Chong Mann Yoon ),박세원 ( Sei Won Park ) 대한소화기학회 1983 대한소화기학회지 Vol.15 No.2

        N/A The effect of short-term levamisole therapy on serum ferritin and E-rosette forming lymphocytes was studied in 29 patients with various malignant tumors. And 8 normal person. In patients with malignant tumors, active form of T-lymphocytes were more decreased than total form of T-lymphocytes and serum ferritin was significantly increased. Levamisole had a moderate enhancing effect on E-rosette formation in patients with malignant tumors. These effect was more prominent in total form of T-lymphocytes than active form of T-lymphocytes, which suggested that active form of T-lymphocytes were more seriously affected than total form of T-lymphocytes and former may be more important in cellmediated immunity of the malignant patients. Serum ferritin was decreased in average 22% after levamisole therapy, but none of cases reduced to normal range in patients with significantly elevated serum ferritin level. There was close correlation(r=0.51) between decrease in serum ferritin and enhancing effect on E-rosette formation in malignant tumors after short-term levamisole therapy. These results indicate that levamisole as a role of immunotherapy may be beneficial in patients with malignant tumors.

      • SCOPUSKCI등재
      • SCOPUSKCI등재
      • SCOPUSKCI등재

        Allantoin 에 의한 소화성궤양의 (消化性潰瘍) 국소요법

        최진,유종선,김양순,조국현,윤종만 ( Jin Choi,Jong Sun Rew,Yang Soon Kim,Kook Hyun Cho,Chong Mann Yoon ) 대한소화기학회 1981 대한소화기학회지 Vol.13 No.1

        In a recent three years period, therapeutic effect of topical therapy with Allantoin was studied on 16 cases of benign peptic ulcer who have no improvement after 3 months of med- ical therapy, recurrent ulcer or poor condition for operation. Comparative study was perfor- med in control group, 10 cases with conventional medical therapy. The results were as follows; In topical therapy group, marked subjective improvement was observed after lweek. Also definite healing by endoscopic examination was noted in 8 cases(50%) at 4 weeks, in 1I cases (69%) at 6 weeks, in 13 cases(81po) at 8 weeks and in 16 cases(100%) at 12 weeks. While in medical therapy group, healing was observed only in 21% at 4 weeks, in 44po at 8 weeks and 54% at 12 weeks. 2. During and after performing topical therapy, any complication or side effects were not observed. Also recurrence was not found for 4month to 2 years.

      • SCOPUSKCI등재

        각종 간질환에 (肝疾患) 있어서 r - GTP 와 SGOT , SGPT 의 활성에 관한 연구

        김세종(Sei Jong Kim),유종선(Jong Sun Rew),양동희(Dong Hi Yang),장건성(Kun Sung Jang),박종춘(Jong Chun Park),이태희(Tae Hi Lee) 대한소화기학회 1982 대한소화기학회지 Vol.14 No.1

        N/A Of the many hepatic enzymes, only a few are generally used for diagnosis of liver disease. Alkaline phosphatase and aminotransferases are example of two differnet groups of enzymes providing information about pathologic conditions. Aminotransferase reflects hepatic cellular injury with sorbital dehydrogenase and 5-lactic dehydrogenase. Alkaline phosphatase refrects cholestasis and its activity can easily be corrected with that of other enzymes like leucine- aminopepeptidase and 5-nucleotidase. Enzymes indicating alterations of the liver, but not belonging to one of those groups mentioned, include gamma-glutamyl transpeptidase(r-GTP), which was introduced as a test of liver function by Polish authors to indicate chronic hepatitis. A special feature of this enzyme is its increasement with prolonged intake of some drugs or alcohol. This enzyme has been used for differentiating viral hepatitis from obstructive jaundice mainly correlating SGOT or SGPT with r-GTP. Later, r-GTP was not only recommended as an indicator of minor alterations of the liver but also it was introduced as a most sensitive test for alcoholic hepatic cellular injury. The SGOT/SGPT ratio is used as an indicator of minor viral hepatitis and alcoholic induced liver injury. It should be due to the different location in the hepatocyte of the enzyme, as SGPT is present free at cytosol, whereas SGOT is demonstrable at mitochondria and cytosol in hepatocyte. r-GTP in the liver is found in hepatocyte and small bile ductules. The enzyme can be detect by enzyme histochemical methods in hepatocyte and by cytochemical techniques bound to membranes and microsomes. So the observations of SGOT/SGPT, SGOT/r-GTP and r-GTP/SGPT in various hepatic diseases concurrently might be helpful for making the differential diagnosis of the hepatic diseases. So we have observed the ratios of the enzyme activities, SGOT/SGPT, SGOT/r-GTP and r-GTP/SGPT in 20 cases of control group and 130 cases of various hepatic diseases group (Male 107, Female 42), which is including 25 cases of acute viral hepatitis(A.V.H.: Male )9, Female 8 ), 17 cases of chronic active hepatitis(C.A.H.: Male 9, Female 8.), )14cases of chronic persistent hepatitis(C.P.H.: Male 10, Female 4), 14 cases of liver cirrhosis(Male 34, Female 6), 20 cases of primary hepatocellular carcinoma(Male 16, Female 4. ), 8 cases of liver abscess(Male 4, Female 4,) and 12 cases of gall stone(Male 5, Female,7) The results were as follows: 1) In normal control group, the SGOT/SGPT is l.76+- 0.44, SGOT/r-GTP 1.20+-0.67 and r-GTP/SGPT 1, 931+-l. 14 The activity of alkaline phosphatase is 2.6+-0.6 Bessey-Lowry unit 2) In A.V.H. group, the SGOT/SGPT is 0. 78+-0.46, SGOT/r-GTP 3. 46+-2.36 and r-GTP/ SGPT 0.47+-0.91. The ratio af the SGOT/SGPT and r-GPT/SGPT are decreased significantly than the nor mal(p(0.005, p(0.005), but the SGOT/r-GTP is increased significantly, 2.5 times than the normal(p(0.005) It were helpful for differentiating A.V.H. for the other hepatic diseases 3) In C.A.H. group, the SGOT/SGPT is 0. 7+-0.35, SGOT/r-GPT is 1. 63+-1.23 and r-GTP/ SGPT is l.76+-1.38. The each ratio of SGOT/r-GTP and SGPT/SGPT is slightly increased and decreased than the normal(p=0.10, p<0.05) The SGOT/SGPT ratio was markedly decreased. It was helpful for the differentiation of the C.A.H. from the other hepatic diseases. In cirrhosis of liver group, the SGOT/SGPT is 2.05+0.88, SGOT/r-GTP is 1.27+-1.59 and r-GTP/SGPT is 2.97+-2.48. All of the ratios were increased slightly with mild elevation of the alkaline phosphatase activity. It svas also helpful for differential diagnosis of the liver diseases. 5) In primary hepatocellular carcinoma, The SGOT/SGPT is 1.82+-0.97, SGOT/r-GTP is 0.49+-0.29 and r-GTP/SGPT is 5.02+-3.80,The alkaline phosphatase activity was elevated over 2.5 times than the normal as 7.2+-5.2 Bessey-Lowry unit. With the marked elevation of r-GTP/SGPT ratio and alkaline phosphatase activity, the markedly decreased ratio of SGOT/r-GTP were

      • SCOPUSKCI등재

        한국인 위암조직의 에스트로겐 수용체에 관한 연구

        윤종만(Chong Mann Yoon),유종선(Jong Sun Rew),박일종(Il Jong park),서순팔(Soon Pal Suh),유주용(Joo Yong Yoo) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.3

        N/A The biological characteristics and the genesis of gastric carcinoma, the most common malignancy in Korean adult male, have not been established so far. Estrogen receptors (ER) have been idnetified in many hormone-dependent cancer such as breast cancer, prostate cancer and ovarian cancer and utilized clinically to provide hormonal therapeutic manipulation. In order to find any hormonal relation in gastric cancer, the presence of ER was examined in 38 patients with primary gastric carcinoma, six with benign stomach lesions and 17 normal gastric tissues, using monoclonal antibody by enzyme immunoassay in cystosol. The results obtained were as follows; 1) ER concetration (Mean+SD) in cytosol from noraml gastric tissue, benign gastric lesion and gastric cancer tissue were 5.6+4.6, 14.617.7 and 20.1+41.7 fmol/mg protein, respectively. Positivities of ER in normal gastric tissue, benign gastric lesion and gastric cancer tissue were 0, 16.7 and 21.1%, respectively. Concentration and positivity of ER were higher in gastric cancer tissue, especially in female gastric cancer tissue, than noraml gastric tissue and benign gastric lesion. 2) Highest value of ER concentration and ER posiitvity according to the macroscopic classification of the gastric carcinoma was observed in Borrmann type II. There was an increasing tendency in ER positivity as the size of the cancer increase. 3) ER concentration and positivity according to the histologic pattern were higher in poorly and well differentiated tubular adenocarcinoma than mucinous adenocarcinomas, signet ring cell carcinoma and moderately differentiated tubular adenocarcinomas. 4) Concentration and postitivity of ER from cancerous tissue of the postmenopausal patients were more higher than that of the premenopausal patients. These results suggested that there was close reation between the presence of ER and the evolution of gastric carcinoma, but not with the degree of histologic malignancy.

      • SCOPUSKCI등재

        만성 췌장염에서 Camostat Mesilate ( FOIPAN(R) ) 의 임상 효과

        김영진 ( Young Jin Kim ),유종선 ( Jong Sun Rew ),윤종만 ( Chong Mann Yoon ),양대현 ( Dai Hyun Yang ) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.1

        N/A A potent oral protease inhibitor, Camostat Mesilate (FOIPAN), was developed for the therapeutic agent in chronic pancreatitis. The clinical effects were evaluated in 25 patiented with chronic pancreatitis. 200 mg of FOIPAN' was given t.i.d. orally for 4 weeks. FOIPAN was very effective in the alleviation of the suhjective symptoms such as abdomilial pain, nausea and vomiting, indigestion and abdominal full#oess#. The global utility rate of the FOIPAN in the chronic pancreatitis was 76.0%. It was most effective in the patients with elevated serum amylase level. There were no significant side effects during the clinical trial. It could be said that FOIPAN was a safe and effective drug in the treatment of chronic pancreatitis.

      • SCOPUSKCI등재

        원발성 담관암 49예에 대한 임상적 고찰

        윤종만(Chong Mann Yoon),유종선(Jong Sun Rew),최성규(Sung Kyu Choi),양대현(Dae Hyun Yang),이숭(Soong Lee),구철(Chull Koo) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.4

        N/A Bile duct carcinoma is relatively rare malignancy with an extremely grave prognosis. The case records of 49 patients with primary carcinoma of the bile ducts seen at the Chonnam University Hospital from 1981 to 1988 were reviewed and analyzed. The results were as fo]lows 1) The peak age distribution was in seventh decade and the average age being 61.4 years. The sex ratio of male to female was 1.9:l. 2) In 43 of the 49 patients, anatomic location was extrahepatic bile duct. The most frequently involved site among the extrahepatic bile ducts was common bile duct (38.8%). 3) The most common symptom and sign were RUQ abdominal pain (75.5%), jaundice (89.7%), respectively. 4) Serum alkaline phosphatase and r-GTP were more increased in extrahepatic bile duct carcinoma than intrahepatic bile duct carcinoma. 5) Associated disease were clonorchiasis (12.2%), choledocholithiasis (10.2%), and gall stone (4.0%). 6) The most useful diagnostic modality was percutaneous transhepatic cholangiography and focal stenotic lesions (66.6%) were rnost common. 7) Operability and resectability were 26.5%, 16.3%, respectively. 8) Tubular adenocarcinoma was the most frequent histo]ogic type.

      • KCI등재

        조직검사가 직장 유암종의 내시경 절제에 미치는 영향

        조성범 ( Sung Bum Cho ),박선영 ( Sun Young Park ),윤경원 ( Kyeng Won Yoon ),이석 ( Seok Lee ),이완식 ( Wan Sik Lee ),주영은 ( Young Eun Joo ),김현수 ( Hyen Soo Kim ),최성규 ( Sung Kyu Choi ),유종선 ( Jong Sun Rew ) 대한소화기학회 2009 대한소화기학회지 Vol.53 No.1

        목적: 직장 유암종은 대장내시경 확대로 발견이 증가하고 있으며 일차로 내시경 절제를 고려해야 한다. 하지만 진단 내시경 시 조직검사로 인한 병변 변형에 의해 내시경 절제에 어려움을 겪는 경우가 있다. 따라서 조직검사 후 변형이 직장 유암종의 내시경 절제에 미치는 영향을 분석하여 치료에 도움이 되고자 하였다. 대상 및 방법: 2000년부터 2007년까지 직장 유암종으로 내시경 절제술을 시행한 42예를 조사하여 진단 시 조직검사 유무에 따라 조직검사군 22예와 조직검사 미시행군 20예로 분류하였다. 조직검사군과 미시행군 간 유암종 크기, 위치 등 임상 차이는 없었다. 각 군 간 점막하 주입 시 융기 제한, 내시경 제거 방법 차이 및 분할 절제 유무 등을 조사하였다. 결과: 내시경 절제술 시 점막하 주입에 따른 점막 융기 제한을 보인 경우가 조직검사군에서 17예(77%)로 미시행군 9예(45%)에 비해 많았다(p=0.03). 점막 융기 제한에 영향을 미치는 내시경 소견은 조직검사로 인한 종괴의 함몰된 반흔이 관찰된 경우, 조직검사를 한 5 mm 이하의 유암종, 조직검사 후 활동 궤양이 있는 경우였다. 내시경 절제 시 올가미를 이용한 절제술, cap을 이용한 흡인절제술, 고무밴드 결찰 후 절제술에서는 두 군 간 차이가 없으나 내시경점막하박리술을 이용한 경우는 조직검사군 5예로 미시행군 1예에 비해 많았다. 분할절제된 경우는 조직검사군 5예(23%)로 미시행군 2예(10%)에 비해 많았으나 유의한 차이는 없었다. 결론: 직장 유암종에서 조직검사로 인한 변형은 내시경 절제 시 점막 융기를 저해하는 요인이 될 수 있다. 따라서 내시경 절제 이전 조직검사는 최소한으로 해야 한다. Background/Aims: While endoscopic resection could be considered as the best choice for the treatment of small rectal carcinoid, the colonoscopic biopsies performed at the time of detection may lead to scar and ulcer formation and cause unpredicted difficulty in the endoscopic resection. This study was evaluated to analyze the relationship between the post-biopsy scar and the limitation of submucosal elevation for the endoscopic resection of rectal carcinoids. Methods: Twenty two cases of rectal carcinoid which received prior biopsies before the endoscopic resection were retrospectively compared with 20 non-biopsied cases. All two groups were treated by endoscopic resection from January 2000 to December 2007. There was no difference in the clinical characteristics and endoscopic findings such as size and location between the two groups. Results: The limited submucosal elevation was experienced in 17 cases (77%) in the biopsy group, significantly more frequent than 9 cases (45%) in the non-biopsy group (p=0.03). The colonoscopic findings which contribute to difficult submucosal elevation were the depressive scar formation after biopsy, the size less than 5 mm in the biopsy group, active ulcer formation after biopsy. Regarding the resection method, endoscopic submucosal dissection was frequently adopted (23% vs. 5%) in the biopsy group. The frequency of endoscopic piecemeal resection in biopsy group was higher than non-biopsy group (23% vs 10%), and all cases were subsequently resected by other endoscopic methods. Conculsions: The post-biopsy scar can interfere with successful submucosal elevation for endoscopic resection of rectal carcinoids. The number of forcep biopsy should be minimized in the diagnostic colonoscopy when endoscopic resection is planned rectal carcinoids. (Korean J Gastroenterol 2009;53:36-42)

      • KCI등재후보

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