http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
위암종에서 p53 유전자 산물에 대한 면역조직화학적 연구
류도현(Do Hyun Rheu),주영은(Young Eun Joo),김태두(Tai Du Kim),지미선(Mi Sun Ji),양대현(Dai Hyun Yang),유종선(Chong Sun Rew),박창수(Chang Soo Park),윤종만(Chong Mann Yoon) 대한내과학회 1995 대한내과학회지 Vol.48 No.4
N/A bronchogenic carcinoma and breast cancer. Although gastric cancer is the most frequent tumor in Korea, few article was reported about the mutation of p53 gene in gastric cancer. In this study, immunohistochemical staining for the mutant p53 gene product was performed to see the relation of the mutation of p53 gene to the pathologic type and staging in the gastric cancer, and to evaluate the usefulness of the mutant p53 gene as a index of gastric cancer. Methods: The mutation of p53 gene was studied with immunohistochemical staining of paraffin section which was obtained in the surgically resected 87 gastric cancer patients. Results: 1) Positive reaction for p53 gene product was observed mainly in the nuclei of tumor cells and negative reaction was observed in the normal mucosal epithelium around cancer foci. 2) The positivity of p53 gene product was 61.2% of the gastric carcinoma overall. By the histological differentiation, the positivity was 57.7% in the well differentiated adenocarcinoma, 60% in the moderately differentiated adenocarcinoma and 72.5% in the poorly differentiated adenocarcinoma, Poorly differentiated adenocarcinoma revealed the highest positivity(p<0.05). 3) Positive cell ratio of p53 gene product in cancer nest had a increased tendency in the poorly differentiated rather than in the well differentiated adenocarcinoma. Conclusion: From the above result, the mutation of p53 gene was highly expressed in gastric cancer and positive reaction of p53 gene product was highly increased in poorly differentiated cancer cell.
위암종에서 Epidermal Growth Factor Receptor 의 발현에 관한 연구 - 면역조직화학적 염색 및 in situ Hybridization -
조정곤(Jung Kon Cho),류도현(Do Hyun Rheu),최성규(Sung Kyu Choi),유종선(Jong Sun Rew),윤종만(Chong Mann Yoon),박창수(Chang Soo Park) 대한내과학회 1996 대한내과학회지 Vol.51 No.1
N/A Objectives: Gastric carcinoma is the leading cause of death among cancer patients in Korea. The etiologic factors of gastric carcinoma were suggested to chronic gastritis, genetic defect, food and environmental factor. Recently, the studies for oncogene and tumor marker have been actively performed to investigate the causes of gastric carcinoma. Epidermal growth factor receptor(EGFR) has homology in amino acids with c-erb B2 oncogene product. EGFR was identified in the placenta, chorionic villi and gastrointestinal mucosa. But it was more expressed in tumor cells, and it may be usedas a tumor marker. Methods: To investigate the correlation between EGFR and malignant potentiality in gastric carcinoma, we performed in situ hybridization of EGFR mRNA and immunohistochemistry of c-erb B2 and EGFR in 127 cases of formalin fixed paraffin embedded tissue sections of gastric carcinoma. Results: The positive reaction for c-erb B2, EGFR protein and EGFR mRNA was identified in the cytoplasm of tumor cells. The positive ratio was 44.196 in c-erb B2, 63.8% in EGFR, and EGFR mRNA was expressed in 72.4% of cases. The expression of c-erb B2 was not related with differentiation of cells, tumor size, invasiveness and metastasis. However the expression of EGFR and EGFR mRNA was related to the invasion of primary tumor and lymph node metastasis (p<.0.05). And expression of EGFR mRNA was increased in the advances of clinical stage. Conclusion: These above results suggest that the expression of EGFR mRNA is related with malignant potentiality of gastric carcinoma. EGFR mRNA might be used as tumor marker and prognostic factor of gastric carcinoma.
전남 화순지역에서 40 세이상 주민 2,021 명에 대한 성인병 검진결과
박종욱(Jong Wook Park),김병채(Byeong Chae Kim),류도현(Do Hyun Rheu),남미영(Mee Young Kim),최기철(Ki Chul Choi),김수완(Soo Wan Kim),김남호(Nam Ho Kim),강영준(Young Joon Kang),김원영(Won Young Kim) 대한내과학회 1998 대한내과학회지 Vol.55 No.2
N/A Objective: Middle-aged and geriatric diseases are becoming prevalent in developing countries and some industrialized nations. The present study was undertaken to determine the prevalence of middle-aged and geriatric diseases in Hwasun County, a rural area of Korea, and to examine the correlation between them and various clinical parameters. Methods: Population-based cross-sectional study by random cluster sampling of registered residents over 39years of age was performed. Out of the 3,138 subjects scheduled for the survey, 2,021 residents (male 812, female 1,209) underwent the actual examinations(response rate:64.4%). We examined their weight, height, blood pressure, diet pattern, past and family history, alcohol-drinking and smoking history, and various laboratory parameters. Result: The mean body mass index (BMD was 22.8 ±3.8. In BMI criteria, the crude prevalence of obesity was found to be 24.6% (grade I obesity' 22.9%, grade II obesity; 1.7%). We found the increasing hypertension, diabetes mellitus, hypercholesterolemia as BNI increased. Overall crude prevalence was 21.4% for hypertension defined as BP (blood pressure) ≥140/90mmHg or subject on medication, and 16.1% for BP ≥160/100mmHg or subject on medication. The crude prevalence of diabetes mellitus, hypercholesterolemia, alcoholic liver disease, ischemic heart disease diagnosed by electrocardiography were 6.2%, 6.0%, 4.4%, and 2.3%, respectively. These prevalence were found to be relatively lower than those of reported elsewhere in the world. Conclusion ' These data indicate that middle-aged and geriatric diseases in the rural area of korea are becoming prevalent, although they are less prevalent than in the urban area or advanced countries. We hope that the present study contributes to understand the prevalence of middle-aged and geriatric diseases in the rural area of K and to prevent and control them adequately.
우리나라 일부 농촌지역 주민에서의 HbsAg 및 anti - HBs 양성률에 관한 연구 - 최근 3 년간의 변화양상과 산모에서의 양성률을 포함하여 -
박종욱(Jong Wook Park),김병채(Byeong Chae Kim),박종헌(Jong Heon Park),김원영(Won Young Kim),고영일(Young Il Koh),류도현(Do Hyun Rheu) 대한내과학회 1998 대한내과학회지 Vol.55 No.2
N/A Objective: The positive rates of hepatitis B virus (HBV) markers differ according to age, sex, race, locality, sexual behavior, socioeconomic conditions, immunologic and genetic factors. It is a well-known fact that Korea is one of the endemic areas of HBV infection in the world. Past many reports have presented that the gositive rates of HBsAg and anti-HBs in Korea were about 6~14Yo and 30-62%, respectively. However there were a few epidemiological surveys of rural communities on the positive rates of HBV markers. The present study undertook to determine the positive rates of HBsAg and anti-HBs in Hwasun county, a rural area of Korea. Methods We performed Population-based crosssectional study by random cluster sampling of registered residents in Hwasun county. Out of the 2,920 subjects (4.1%) scheduled for the survey, 1,913 residents under- went the actual examination. We tested EG3sAg and anti- HBs by reversed passive hemagglutination (HPHA) and passive hemagglutination (PHA), respectively. Results: The positive rates of HBsAg and anti-HBs in all subjects were 5.6% and 20.8%, respectively, and those were 5.4% and 20.4% in 168 pregnant women, respectively. The positive rate of HRsAg was significantly higher in male (8.2%) than in female (4.0%) (p< 0.01). The positive rate of anti-HBs was 21.4Yo in female, but it was not significanly higher than in male (19.6%). There were no significant differences according to age groups in the positive rates of HBsAg and anti-HRs. Conclusion There are no significant changes in the positive rates of HBsAg and anti-FB3s between the present study for Hwasun county and past many reports in Korea. Although the rate of hepatitis B vaccination increased significantly, it was not effective because that the vaccinated total numbers in the rural area of Korea were probably small. So it is very important to undertake a nationwide program of hepatitis E3 immunization and to educate the residents in rural areas of Korea.
양대현,한상우,주영은,김신묵,김세종,윤종만,김태두,류도현,지미선,유종선 대한소화기내시경학회 1994 Clinical Endoscopy Vol.14 No.1
Leiomyosarcoma of the duodenum is an uncommon tumor and have not specific symptoms and signs, almost all cases of tumor were diagnosed in operating room. This tumor is generally firm, relatively well encapsulated, lobulated and often soft if they undergo hemorrhagic necrosis. Most authors emphasized the relative number of mitosis as the most reliable findings of leiomyosarcoma. Recently, we experienced a case of leiomyosarcoma of duodenum which was confirmed by operative and pathological diagnosis.
양성 위궤양으로 진단된후 내시경검사로 경과 관찰중 확인된 위암에 대한 검토
최성규,김기태,김세종,유종선,윤종만,구철,류도현,문범 대한소화기내시경학회 1996 Clinical Endoscopy Vol.16 No.2
To examine the relationship between gastric ulcer and gastric cancer, we investigated petients with gastric ulcer diagnosed from 1986 to l993. We reviewed the endoscopic reports and films of patients with gastric ulcer retrospective1y. We excluded the patients who was diagnosed as gastric cancer in two years follow-up. The results were as follaws; 1) During follow-up of the original cohort, there were 5 patients(0.5~%) in whom gastric cancer developed at the same site initially diagnosed as gastric ulcer. The gross type of the lesion was early gastric cancer in two and advanced gastric cancer in three patients. 2) The time interval between the initia1 diagnosis of gastric ulcer and cancer development was from 31 months to 70 months (average 51 months). 3) At the initial examination of 5 gastric cancer patients, the diagnosis was active gastric ulcer in four, multiple gastric ulcer in one, and linear gastrie ulcer in one patient. Characteristic endoscopic findjngs were gastric ulcer with clubbing mucosal folds in three and gastric ulcer with bleeding in one patient. 4) During the follow-up period, endoscopicailly and histologically healing of gastric uleer was observed in one patient and histologic finding showed chronic superficial gastritits with intestinal metaplasia. These results suggest that gastric ulcers rarely progress to gastric cancer. However if the endoscopic findings are suspicious for malignancy, then follow-up endoscopy until complete healing should be done.