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신이식 환자에서 발생한 뇌 Aspergillosis 에서 Liposomal Amphotericin B 와 내시경적 수술을 이용한 성공적인 치료
우영식(Young Sik Woo),김미정(Mi Jung Kim),장재혁(Jae Heuk Jang),황수은(Soo Eun Hwang),정지성(Ji Sung Chung),신미정(Mi Jung Sin),양철우(Chul Woo Yang),김용수(Yong Soo Kim),방병기(Byung Kee Bang),박주현(Joo Hyun Park) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.4
Aspergillosis involving central nervous system is a rare but life-threatening complication in renal transplant recipients. Its mortality rate approaches almost 100% in spite of various therapeutic regimens. We here report a case of successful treatment of brain aspergillosis with liposomal amphotericin B and endoscopic surgery. A 58-year- old renal transplant recipient admitted due to headache which was developed 5 months ago. He received renal transplant 10 years ago. After admission, brain MRI revealed brain abscess on frontal lobe and this was treated with antibiotics and amphotericin B. On 20 th hospital day, endoscopic surgery via intranasal approach was performed and pathologic finding was consistent with aspergillosis. During treatment, his graft function was progressively deteriorated(serum creatinine level 2.27 mg/dL4.1 mg/dL) and amphoterinc B was replaced with ambisome. Thereafter, renal function was improved(serum creatinine 2.0 mg/dL on 46 th hospital day). Second operation was performed on 50 th hospital day to remove remnant pathologic lesion, and ambisome was continously adminstered. The brain MRI which was performed on 70 th hospital day showed much improvement. He was discharged with oral antifungal drug(itraconazole). Our case demonstrates the successful treatment of brain aspergillosis with medial treatment and minimal invasive surgery.
대학교수의 교수역량에 대한 중요도 인식 A대학 교수자를 중심으로
우영식(Woo, Youngsik),임영재(Im, Youngjae) 한국핵심역량교육학회 2021 핵심역량교육연구 Vol.6 No.2
교수역량은 교수로서 갖추어야 할 일반적 교수역량과 함께 각 대학의 교육비전과 인재상, 특성 및 상황에 따라 특별히 강조되어야 할 역량도 포함되기 때문에 대학별로 강조되는 교수역량에 차이가 발생한다. 따라서 더욱 정확한 교수역량 진단으로 해당 대학의 조직역량 특성을 반영할 필요가 있다. 본 연구는 보건계열 중심의 A대학의 중요도와 실행도를 분석하고, 이를 IPA에 적용하여 교수역량의 우선순위 및 대학교수들이 인식하는 교수역량을 살펴보는데 있다. A대학의 120명 교수를 대상으로 2019년 7월 1일부터 7월 12일까지 설문지를 배부하였다. 자료 분석에 사용한 유효한 설문지는 총 85부로 SPSS 25.0을 활용하여 대응표본 t-검정를 실시하였으며 IPA분석을 하였다. 연구결과 A대학 교수역량 전체에 대한 중요도와 실행도에서 가장 큰 차이를 나타낸 핵심역량 전체 영역은 교과지식이였으며, 핵심역량 영역별에서는 연구, 독서활동과 강의 후 성찰, 강의계획안 작성, 외부(학교, 교수)상호협력, 협동학습 기회 제공으로 나타났다. 인구학적 실행에 따른 중요도-실행도 차이가 가장 크게 나타난 영역은 성별에 따른 차이분석에서 남자는 자원관리, 여자는 교과지식이였고, 직급에 따른 차이분석에서 정교수는 환경조성, 부교수이하는 진단성찰이였다. IPA분석 결과 최우선으로 개선해야 할 항목은 다양한 과제 제공으로 나타났다. 본 연구결과는 A대학과 비슷한 교육목표와 조직을 가지고 있는 대학에 근무하는 교수자의 교수역량 강화를 위한 프로그램 개발에 기초자료를 제공한다는 점에서 의의를 가진다. Because teaching competences include general teaching skills to be equipped as professors and those to be emphasized according to each university s educational vision, talent, and characteristics, there is a difference in teaching ability that is emphasized by each university. Therefore, a more accurate diagnosis of teaching competency needs to reflect the characteristics of the organizational competency of the university. This study is based on analyzing the importance and practice of universities A centered on the health system and applying it to IPA to identify the priorities of teaching competencies. The questionnaire was distributed to 120 professors at the University of A from July 2, 2019 to July 13, 2019. A total of 85 valid questionnaires were used for data analysis, and a corresponding sample t-test was conducted using SPS 25.0 and an IPA analysis was performed. The study found that the entire area of core competences, which showed the greatest difference in importance and practice, was textbook knowledge, and that each area of core competency was research, reading activities and post-teaching reflections, providing opportunities for cooperative learning, outside (school, teaching) mutual cooperation, and providing opportunities for cooperative learning. The areas where the difference in importance-execution according to demographic practice was the resource management of men and the knowledge of women s textbooks in the analysis of differences by gender, and the sophistication professor in the analysis of differences by rank was the environmental composition and the diagnostic reflection of co-chairs. The IPA analysis showed that the top priority items for improvement were to provide various tasks. This research result is meaningful in that it provides basic data on the development of programs to strengthen the teaching ability of professors working at universities with similar educational goals and organizations.
위선암 환자의 말초혈액에서 역전사 중합효소 연쇄반응을 이용한 Cytokeratin 20 양성 미세 전이 암세포의 진단
이승훈(Seung Hoon Lee),진종률(Jong Youl Jin),송치원(Chi Won Song),이희진(Hee Jin Lee),박재후(Jae Hoo Park),박영세(Young Se Park),백창렬(Chang Nyol Paik),우영식(Yeong Sik Woo),김희정,김춘추(Chun Choo Kim),이준욱(Joon Wook Lee) 대한내과학회 2001 대한내과학회지 Vol.60 No.6
N/A Background : The development of metastasis in cancer is one of the main problems after primary tumor resection. The identification of metastases is only possible in the follow-up investigation when there is already a solid tumor mass. Subclinical tumor cell dissemination can be detected by immunocytological staining of cells or by other molecular biological methods, like PCR. We investigated 22 peripheral blood isolates from gastric cancer patients with a cytokeratin (CK) 20 specific nested reverse transcriptase PCR (RT-PCR) for the detection of disseminated tumor cells at the time of diagnosis. Methods : Fresh heparinized peripheral bloods (about 10 mL) were obtained from 22 gastric cancer patients and 10 healthy doctors as controls. Nucleated cells were isolated by a density gradient method. RNA was isolated and then subjected to RT-PCR with CK 20 specific primers. Results : In gastric cancer, 3 of 22 (13.6%) peripheral blood isolates yielded a CK 20 mRNA positive result in a stage undependent manner. Conclusion : We detected disseminated tumor cells in the peripheral blood isolated using CK 20 specific nested RT-PCR method. Studies on a larger scale are needed for further investigation on the relationship between positive rates of CK 20 mRNA and survival rates of stomach cancer, according to cancer stages.(Korean J Med 60:514-520, 2001)
홍창균,안유배,김설혜,우영식,이성구,고승현,송기호,윤건호,강무일,차봉연,이광우,손호영,강성구 대한내분비학회 2001 Endocrinology and metabolism Vol.16 No.4
Pheochromocytoma is usually associated with a combination of various clinical manifestations caused by the overproduction of catecholamines. It is frequently accompanied by impaired glucose tolerance operating through 2 - and - adrenergic mechanisms. A 41-year-old-woman was admitted to the hospital because of poorly-controlled diabetes mellitus and hypertension. She had suffered intermittent paroxysmal attacks of headache and chest discomfort and had been treated intermittently over a 2 year period for diabetes mellitus and hypertension. At admission, the levels of serum epinephrine, norepinephrine urinary excretion of total metanephrine, and VMA were all abnormally elevated. Adrenal CT showed a well-defined, homogenous mass in the right adrenal region and the tumor was diagnosed as pheochromocytoma. After tumor resection, the increased blood level of catecholamines, the urinary excretion of total metanephrine, and VMA were normalized, as was the hyperglycemia state. Diabetes mellitus of the patient was considered permanently resolved after tumor removal by the result of glucose tolerance in 75 g oral glucose tolerance test