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안진형,이민걸,김수찬,이태호 한국분자세포생물학회 2004 Molecules and cells Vol.18 No.2
Paraneoplastic pemphigus (PNP) is an acquired autoimmune disorder characterized by severe mucosal erosion, and polymorphous cutaneous lesions associated with neoplasia. PNP patients have circulating autoantibodies that bind to stratified and nonstratified epithelia. Previously, we showed that envoplakin was a component of the antigen complex recognized by PNP sera. In the present study we generated a monoclonal antibody, EVP-YS, against human envoplakin. The antibody bound to keratinocyte cell surfaces and reacted with the 210-kDa PNP antigen, confirming its specificity for envoplakin. The variable regions of the heavy (H) and light (L) chain genes were cloned from the hybridoma and shown to belong to mouse H chain subgroup III and κ light chain subgroup V, respectively. The L chain of EVP-YS was 98% identical to the κ chains of some autoantibodies and anti-nucleic acid antibodies, and had an identical amino acid sequence in all three complementary determining regions, suggesting that the H chains determine the specificity of the EVP-YS-envoplakin interaction. The EVP-YS antibody can be used to evaluate the sensitivity and specificity of clinical, histological, and immunological criteria for diagnosing PNP.
white emitting OLED의 전기적 광학적 특성평가
안진형,한성욱,김상호 한국표면공학회 2007 한국표면공학회 학술발표회 초록집 Vol.2007 No.-
저전압 고휘도 광원으 BLU에 효과적으로 응용되고 있는 백색 OLED를 다색 발광층 적층법을 이용하여 제작하고 만들어진 cell의 전기적 광학적 특성을 평가하였다.
안진형,정찬희,Ahn, Jin-Hyeong,Jung, Chan-Hee 한국시뮬레이션학회 2012 한국시뮬레이션학회 논문지 Vol.21 No.1
In this study, underwater behaviors of negative buoyant body and positive buoyant body, which are ejected from a platform, are compared through eject test and simulation. CFD(Computational Fluid Dynamics) method is used to calculate the hydrodynamic derivatives of negative buoyant body with varied hull. Hydrodynamic derivatives that cannot be calculated with CFD are used with the same values of base shape. The pitch angles of test data are much bigger than those of simulated data, and the reason is supposed to be the trailing air effect. A more accurate simulation is possible via modified force modeling which reflects this phenomenon. The underwater behaviors of positive buoyant body and negative buoyant body are somewhat different with each other at the same eject condition, but it may not be a problem in the view of operation. 본 연구에서는 수중에서 사출되는 양성부력체와 음성부력체의 수중거동을 사출시험 및 시뮬레이션을 통하여 비교하였다. 다양한 형상을 갖는 음성부력체의 동유체력 계수는 전산유체역학(CFD: Computatioanl Fluid Dynamics) 기법을 이용하여 계산하였으며, CFD에 의해 계산될 수 없는 계수는 기본형과 같은 값을 적용하였다. 종동요각의 시험 값은 시뮬레이션 값보다 훨씬 크게 나타났는데, 이는 추종공기 효과로 추정하였으며, 이 현상을 반영하여 외력 모델링을 수정함으로써 더욱 정확한 시뮬레이션이 가능하였다. 양성부력체와 음성부력체의 수중거동은 같은 사출 조건에서 다소 차이를 보이지만, 운용의 관점에서는 별다른 문제가 없는 것으로 판단하였다.
성충동 약물 치료가 성범죄자의 성적 환상에 미치는 효과에 대한예비 연구
안진형,심금숙,이재우,이장규,이태준,노일석 대한법의학회 2013 대한법의학회지 Vol.37 No.3
This study investigated the effect of leuprolide acetate treatment on sex offenders’sexual fantasies and behaviors, as well as on their criminogenic psychological character and the risk of second conviction. The study participants consisted of 22 sex offenders who were confined to the National Institute of Forensic Psychiatry. Among them, 9 patients were given off-label leuprolide acetate for three months to inhibit sexual impulses, whereas the others were not given any medication. All sex offenders underwent two psychological evaluations; the first evaluation was conducted before starting medication, and the second was conducted after medication. Wilson’s Sex Fantasy Questionnaire (WSFQ), the Rape Myth Acceptance Scale (RMAS), and the Endorsement of Violence Scale (EVS) were used for evaluation. Leuprolide acetatetreated sex offenders showed a statistically significant decline in the total WSFQ score (p < 0.05). However, the RMAS and EVS scores did not differ after leuprolide acetate treatment, indicating that cognitive distortions like rape myth acceptance and endorsement of violence were unchanged after leuprolide medication. Leuprolide acetate may reduce deviant sexual impulses and fantasies, as suggested by previous research form Korea and other countries. However, it probably cannot alter cognitive distortion. On the basis of these findings, we recommend a combination of leuprolide medication and other therapies, like cognitive behavioral therapy, for the treatment of paraphilic sex offenders.