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개구리 心臟에서 Ouabain 效果에 미치는 Serotonin의 影響
이태준,송태효,이태준 의과학연구소 1989 全北醫大論文集 Vol.13 No.2
The influence of 5-hdroxytryptamine and / or cyproheptadine on the action of ouabain was investigated in the isolated frog heart or in the whole fros. 1. LD_50 of ouabain was 2.88㎍/10g in control group. 2. Low doses(100 or 300 ㎍/10g) of 5-hydroxytryptamine increased LD_50 of ouabain, but high dose of the drug decreased LD_50 of ouabain. However, the effect of 5-hydroxytryptamine was blocked by cyproheptadine. 3. Ouabain induced dose-dependent biphasic response ; at low doses(10^-7-10^-6M) ouabain decreased contractile force of myocardium, while high doses of the drug(above 3X10^-6M) increased oncractile force as well as decrease of heart rate. 4. 5-hydroxytryptamine inhibited the negative inotrophic and bradycardiac effects of ouabain, but cyproheptadine did not affect the effects of 5-hydroxytryptamine. From the above results, it is suggested that there are two dose-related ouabain-sensitive sites in frog heart, and bradycardiac effect of ouabain is different from that of extracardiac regions.