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신상용,유정희,김정연,김연주,우희연,권민정,염준섭 대한감염학회 2012 Infection and Chemotherapy Vol.44 No.5
In Korea, Plasmodium vivax (P. vivax) is the most common agent of malaria infection. However, as travel to regions where malaria is endemic increases, so do the numbers of Plasmodium falciparum and mixed infections. P. falciparum predominates, while P. vivax is rare in west-central Africa. We report on a case of mixed malaria infection with severe hemolytic anemia caused by P. falciparum and P. vivax in a 38-yearold man after traveling to Angola. A diagnosis of P. falciparum malaria was made by microscopic examination. However, both P. vivax and P. falciparum were detected by the polymerase chain reaction (PCR). As a radical cure P. vivax , the patient was treated with mefloquine, artemether, and primaquine. Both P. falciparum and P. vivax had disappeared from peripheral blood by admission day 4, however, low grade fever and headache persisted, and his hemoglobin and hematocrit levels were depleted. A peripheral blood smear was negative for both P. vivax and P. falciparum;however, a direct anti-globulin test and anti-nuclear antibody test were positive,suggesting immune hemolytic anemia. After conservative treatment, which included a transfusion with packed red blood cells (RBC), his symptoms and signs showed improvement and laboratory findings were normalized.
신상용,조진희,김희진,장준호,이승태,김선희 대한진단검사의학회 2015 Annals of Laboratory Medicine Vol.35 No.5
This erratum is being published to correct the printing error on page 34 of the article entitled ‘Flow cytometric white blood cell differential using CytoDiff is excellent for counting blasts’ by Jimin Kahng et al. in Ann Lab Med 2015;35:28-34 as follows.
Hb Heathrow [β103(G5)Phe→Leu], a First Report in an Asian Patient with Erythrocytosis
신상용,김훈구,김현영,김희진 연세대학교의과대학 2017 Yonsei medical journal Vol.58 No.3
Congenital erythrocytosis (CE) is a rare and heterogeneous disease. The high oxygen affinity hemoglobin (Hb) variants are the most common cause of CE. Herein, we report a Korean patient with isolated erythrocytosis. A 25-year-old man was referred to our hospital for evaluation of high Hb level (Hb 20.4 g/dL, hematocrit 58%, reticulocyte count 2.90%, white blood cell count 6.83×109/L, and platelet count 195×109/L). Bone marrow biopsy revealed normocellular marrow without myeloproliferative features. JAK2 (V617F, exon 12), CALR (exon 9), and MPL W515K/L mutations were not detected. P50 (partial pressure at which Hb is half saturated with oxygen), which is an indicator of left-shift of oxygen dissociation curve (high oxygen affinity state), was 14.3 mm Hg (reference value 22.6–29.4 mm Hg). He was suspected to have CE. Mutation analysis of the HBB gene revealed the known Hb variant, Hb Heathrow [β103(G5)Phe→Leu]. This is the first report of Hb Heathrow in Asian.
신상용,이승태,김현영,박창훈,김희진,김종원,김석진,김원석,김선희 대한혈액학회 2016 Blood Research Vol.51 No.3
BackgroundRecent studies have identified a high prevalence of the MYD88 L265P mutation in lympho-plasmacytic lymphoma (LPL)/Waldenstrom macroglobulinemia (WM) cases, whereas low frequencies have been observed in other B cell non-Hodgkin lymphomas (NHLs). MethodsWe evaluated the sensitivity of the mutant enrichment 3’-modified oligonucleotide (MEMO)-PCR technique, a new detection method. We examined the MYD88 L265P mu-tation in a series of Korean patients with LPL/WM and other B cell NHLs in bone marrow aspirates, using the MEMO-PCR technique. ResultsThe sensitivity of MEMO-PCR was estimated to be approximately 10‒16.7%. MYD88L265P was detected in 21 of 28 LPL cases (75%) and only three of 69 B cell NHL cases (4.3%). ConclusionAlthough MEMO-PCR had relatively low sensitivity, we confirmed the high prevalence of the MYD88 L265P mutation in Korean LPL patients. Our study suggests the diagnostic value of MYD88 L265P for differentiating B-cell NHLs.