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김연주,김연주,김용배,이익재,권진이,김규보,차지혜,김명수,조인영,김정훈,박재현,김진희,김주리,신경환,김수산 대한암학회 2022 Cancer Research and Treatment Vol.54 No.2
Purpose This study aimed to investigate the impact of postoperative radiotherapy (PORT) in de novo metastatic breast cancer (dnMBC) patients undergoing planned primary tumor resection (PTR) and to identify the subgroup of patients who would most benefit from PORT. Materials and Methods This study enrolled 426 patients with dnMBC administered PTR alone or with PORT. The primary and secondary outcomes were overall and progression-free survival (OS and PFS), respectively. Results The median follow-up time was 53.7 months (range, 3.1 to 194.4). The 5-year OS and PFS rates were 73.2% and 32.0%, respectively. For OS, clinical T3/4 category, triple-negative breast cancer (TNBC), postoperative chemotherapy alone were significantly poor prognostic factors, and administration of PORT failed to show its significance. Regarding PFS, PORT was a favorable prognostic factor (hazard ratio, 0.64; 95% confidence interval, 0.50 to 0.82; p < 0.001), in addition to T1/2 category, ≤ 5 metastases, and non-TNBC. According to the multivariate analyses of OS in the PORT group, we divided the patients into three groups (group 1, T1/2 and non-TNBC [n=193]; group 2, T3/4 and non-TNBC [n=171]; and group 3, TNBC [n=49]), and evaluated the effect of PORT. Although PORT had no significance for OS in all subgroups, it was a significant factor for good prognosis regarding PFS in groups 1 and 2, not in group 3. Conclusion PORT was associated with a significantly better PFS in patients with dnMBC who underwent PTR. Patients with clinical T1/2 category and non-TNBC benefited most from PORT, while those with TNBC showed little benefit. Purpose This study aimed to investigate the impact of postoperative radiotherapy (PORT) in de novo metastatic breast cancer (dnMBC) patients undergoing planned primary tumor resection (PTR) and to identify the subgroup of patients who would most benefit from PORT.Materials and Methods This study enrolled 426 patients with dnMBC administered PTR alone or with PORT. The primary and secondary outcomes were overall and progression-free survival (OS and PFS), respectively.Results The median follow-up time was 53.7 months (range, 3.1 to 194.4). The 5-year OS and PFS rates were 73.2% and 32.0%, respectively. For OS, clinical T3/4 category, triple-negative breast cancer (TNBC), postoperative chemotherapy alone were significantly poor prognostic factors, and administration of PORT failed to show its significance. Regarding PFS, PORT was a favorable prognostic factor (hazard ratio, 0.64; 95% confidence interval, 0.50 to 0.82; p < 0.001), in addition to T1/2 category, ≤ 5 metastases, and non-TNBC. According to the multivariate analyses of OS in the PORT group, we divided the patients into three groups (group 1, T1/2 and non-TNBC [n=193]; group 2, T3/4 and non-TNBC [n=171]; and group 3, TNBC [n=49]), and evaluated the effect of PORT. Although PORT had no significance for OS in all subgroups, it was a significant factor for good prognosis regarding PFS in groups 1 and 2, not in group 3.Conclusion PORT was associated with a significantly better PFS in patients with dnMBC who underwent PTR. Patients with clinical T1/2 category and non-TNBC benefited most from PORT, while those with TNBC showed little benefit.
金鍊珠,鄭昌壽,朴永禧 中央醫學社 1965 中央醫學 Vol.8 No.1
Recently, on account of the rapidly expanding request of blood in Korea, it is 'very important to study how to collect blood only from healthy human beings. We studied about health condition of professional donors visited Korean Red Cress Blood Service from Janury 1, 1964 till August 31, 1964. 1. The percentage of male professional donors, rejected their donation by various regulation concerning to health examination was 33,7%. On the other hand, it was 68,3% in female donors. 2. It is necessary to change regulation about lower weight for female donors, because about one third of female donors rejected by lower weight. 3. 4.0% of male donors and 12,0% of female donors were rejected by low hemoglobin levels. It was recognized that the campaign of voluntary donation is necessary. for preventing anemia of professional donors.
김연주,김은진,이상원,Kwon Donghyok 질병관리본부 2021 Osong Public Health and Research Persptectives Vol.12 No.3
The variant B.1.1.7 of SARS-CoV-2, the RNA virus causing the pandemic more than a year worldwide, was reported from UK in late Dec, 2020. It was reported that mortality increases by 65% and transmissibility increases by 70%, which may result in an increase of reproduction number to 1.13-1.55 from 0.75-0.85. To analyze the global increasing trend of the variant B.1.1.7, we extracted results of B.1.1.7 from GISAID on May 11 and May 12, 2021, and conducted a dose-response regression. It took 47 days to reach 20% and 121 days to reach 50% among the sequence submitted from UK. In Korea, cases of B.1.1.7 have increased since the first report of three cases on Dec 28 2020. Positive rate of B.1.1.7 in Korea was 21.6% in the week from May 9 to May 15, 2021. Detection rate of the variants is expected to increase further and new variants of SARS-CoV-2 are emerging, so a close monitoring and control would be maintained for months.
노래동화를 활용한 통합적 유아음악교육 프로그램 개발 및 효과성에 관한 연구
김연주,조복희 한국보육지원학회 2012 한국보육지원학회지 Vol.8 No.2
본 연구의 목적은 유아들의 음악표현능력, 언어표현능력 및 창의성을 증진시킬 수 있는노래동화를 활용한 통합적 유아음악교육 프로그램을 개발하고, 그 프로그램에 따라 교육을 실시하여 유아의 음악표현능력, 언어표현능력 및 창의성 증진의 효과를 검증하는데 있다. 노래동화를 활용한 통합적 유아음악교육 프로그램을 구성하기 위해 연구대상 어린이집에서 사용될 노래를 검토하여 곡을 선정하고, 선정된 곡을 토대로 노래동화를 개작하고, 노래부르기, 악기다루기, 음악만들기 등의 음악 영역간의 통합과 신체표현, 언어표현,그림(선)표현 등의 타 영역간의 통합적 활동내용을 포함하여 통합적 유아음악교육 프로그램을 개발하였다. 본 연구의 대상은 두 곳 어린이집의 만 4세 유아 68명을 각각 실험집단과 통제집단으로 배정하여 실험집단에게 프로그램을 8주간 총 16회에 걸쳐서 적용하였다. 자료분석은 음악표현능력, 언어표현능력, 창의성의 집단간 차이검증을 위해 t 검증을실시하였다. 그 결과 : 첫째, 노래동화를 활용한 통합적 유아음악교육 프로그램에 참여는유아의 음악표현능력 및 언어표현능력 증진에 효과가 나타났다. 둘째, 노래동화를 활용한통합적 유아음악교육 프로그램에 참여는 유아의 유창성 증진에 효과가 나타났다.