테라비트급 나노 스케일 SONOS 플래시 메모리 제작 및 소자 특성 평가

김주연,김문경,김병철,김정우,서광열,Kim, Joo-Yeon,Kim, Moon-Kyung,Kim, Byung-Cheul,Kim, Jung-Woo,Seo, Kwang-Yell 한국전기전자재료학회 2007 전기전자재료학회논문지 Vol.20 No.12

To implement tera bit level non-volatile memories of low power and fast operation, proving statistical reproductivity and satisfying reliabilities at the nano-scale are a key challenge. We fabricate the charge trapping nano scaled SONOS unit memories and 64 bit flash arrays and evaluate reliability and performance of them. In case of the dielectric stack thickness of 4.5 /9.3 /6.5 nm with the channel width and length of 34 nm and 31nm respectively, the device has about 3.5 V threshold voltage shift with write voltage of $10\;{\mu}s$, 15 V and erase voltage of 10 ms, -15 V. And retention and endurance characteristics are above 10 years and $10^5$ cycle, respectively. The device with LDD(Lightly Doped Drain) process shows reduction of short channel effect and GIDL(Gate Induced Drain Leakage) current. Moreover we investigate three different types of flash memory arrays.

^99mTc-DMSA 검사에서 상대 신섭취율 산출 시 양면상 촬영의 유용성에 대한 고찰

김주연,이한울,권오준,김정열,박민수,조석원,강천구,김재삼,Kim, Joo-Yeon,Lee, Han-Wool,Kwon, O-Jun,Kim, Jung-Yul,Park, Min-Soo,Cho, Seok-Won,Kang, Chun-Goo,Kim, Jae-Sam 대한핵의학기술학회 2015 핵의학 기술 Vol.19 No.1

$^{99m}Tc-DMSA$ 신장 신티그라피는 피질에 주로 섭취되어 신실질을 영상화하고 좌우 신장 및 배후방사능에 관심영역을 설정함으로써 상대 신섭취율을 평가할 수 있는 검사로, 진단 및 치료 후 경과관찰에 이용되고 있다. 본 논문에서는 후면상과 양면상 촬영 시 그리고 신장의 깊이를 적용한 경우의 상대 신섭취율 변화를 비교하여 상관관계를 알아보고자 한다. 실험은 신장 팬텀 및 조직등가물질을 이용하여 신장의 깊이에 차이를 주며 깊이 당 각 5번씩 총 25번을 진행하였다. 임상연구는 2014년 2월부터 10월까지 본원에 내원하여 $^{99m}Tc-DMSA$ 검사를 시행한 36명의 성인 환자를 대상으로 하였다. 장비는 감마카메라 INFINIA를 사용하였으며 GE사의 Xeleris Ver. 2.1220을 이용하여 신장 및 배후 방사능 모두 자동으로 관심영역을 설정하였다. 또한 환자별 신장 깊이의 차이를 고려하여 측면상을 촬영한 후 실제 신장 깊이를 측정하였다. 후면상에서의 산술평균값과 양면상에서의 기하학적 평균값 그리고 후면상에 신장 깊이를 적용해준 상대 신섭취율을 비교해보고 유의한 차이가 있는지 살펴보았다. 팬텀 실험 결과 좌, 우 신장 깊이의 차이가 1 cm 미만인 경우에는 양면상을 촬영했을 때와 후면상에 실제 깊이를 적용해준 경우 유의한 차이를 보이지 않았으나(P>0.05), 1 cm를 초과한 경우에는 유의한 차이를 보였다(P<0.05). 임상 연구에서는 후면상만을 촬영해준 경우와 후면상에 신장 깊이를 적용해준 경우의 상관관계(r=0.988)에 비해 양면상을 촬영해준 경우와 후면상에 신장의 깊이를 적용하여 보정해준 경우가 더 높은 상관관계(r=0.999)를 나타냈다. 본 연구에서는 양면상과 후면상을 촬영했을 때의 상대 신섭취율 차이를 확인할 수 있었다. 후면상만 촬영한 경우에도 깊이를 보정해줬을 때와 비교하여 상관관계가 있음을 알 수 있었으나 오차를 줄이기 위해서는 양면상을 촬영해주는 방법을 권고한다. Purpose $^{99m}Tc-DMSA$ renal scintigraphy serves as location, size and shape of kidney, so it has been used for diagnosis and passage observation after the operation or treatment. There are 3 methods of calculating the relative renal uptake ratio such as geometric mean of the counts from the anterior and posterior views, arithmetical mean from the only posterior view and posterior view which applied the renal depths. In this study, we seek to correlation between the change of total relative uptake ratio according to different inspection methods of obtaining the renal count rate. Materials and Methods The phantom experiments proceeded 5 times depending on each renal depth with the kidney phantom and tissue equivalent materials. In the clinical research, we investigated 36 adult patients who had visited our hospital from february to october, 2014 and received $^{99m}Tc-DMSA$ renal scan. The equipment was used as a gamma camera named INFINIA (General Electric Healthcare, milwaukee, USA) and we drew the region of interests through semiautomatic method by using Xeleris Ver. 2.1220 of GE. In addition, we obtained the lateral view of kidney to measure the renal depth of each patient. Then the results were compared with 3 methods of calculating relative renal uptake ratio. Results The phantom studies show when the difference between the left ant right kidney depth were less than 1 cm, there were no statistically significant difference among values calculated through anterior and posterior views and only posterior view (P>0.05), while the excess of 1cm, the results showed a statistically significant change in the value (P<0.05). In case of clinical research, the correlation between total relative uptake ratio by obtaining both sides of image and posterior view applied the kidney depth (r=0.999) was higher than by obtaining only posterior view and applying the kidney depth to one side image (r=0.988). Conclusion This study has found that, the difference of calculating total relative uptake ratio compared with obtaining anterior and posterior views and only posterior view. In order to reduce the error, we recommend the method of obtaining anterior and posterior views and is considered to be useful, particularly the patients have similar uptake ratio of left and right kidney and difficulties of measurements of kidney depth.

백내장 수술 후 생긴 낭포황반부종에서의 유리체강내 트리암시놀론 주입술 일차치료 효과

김주연,김정목,유영주,김철구,조성원,이태곤.Joo Yeon Kim. MD. Joung Mok Kim. MD. Young Ju Lew. MD. PhD. Chul Gu Kim. MD. Sung Won Cho. MD. PhD. Tae Gon Lee. MD 대한안과학회 2012 대한안과학회지 Vol.53 No.3

Purpose: To report the clinical manifestations of intravitreal triamcinolone injection as a primary treatment method for patients with cystoid macular edema after cataract surgery. Methods: The present retrospective study was comprised of patients diagnosed with cystoid macular edema after cataract surgery performed between March 2006 and March 2008. To treat the edema, intravitreal triamcinolone injection was administered. Best corrected visual acuity (BCVA) and central macular thickness were measured, and complications as well as efficacy of the treatment were evaluated. Results: Twelve eyes were selected for the present study with a mean patient age of 67.3 years. The average period between cataract surgery and diagnosis of cystoid macular edema was 7.6 weeks. All 12 eyes received an intravitreal triamcinolone injection, and the patients were followed up for an average of 6.7 months. BCVA (log MAR) was changed from 0.29 ± 0.12 to 0.11 ± 0.09, showing statistically significant improvement (p = 0.000). The OCT showed that the average CMT was statistically decreased from 390.58 ± 94.98 μm to 165.17 ± 39.95 μm (p = 0.001). No complications were reported after the procedure, and vision and edema improved after one month in all 12 eyes. Conclusions: After performing intravitreal triamcinolone injection as a primary treatment method for cystoid macular edema which developed after cataract surgery, rapid recovery and improvement of vision and macular thickness were confirmed in all 12 eyes. J Korean Ophthalmol Soc 2012;53(3):428-433

UV 검출기 제작을 위한 $8{\times}8$ ReadOut IC에 관한 연구

김주연,김태근,Kim, Joo-Yeon,Kim, Tae-Geun 대한전자공학회 2005 電子工學會論文誌 IE (Industry electronics) Vol.42 No.3

산업용, 의학용 및 군사용, 환경감시용 등 다양한 분야에서 UV 카메라가 이용되고 있다. 높은 분해능과 고효율을 가진 GaN 계열의 III-V족 질화물 반도체를 이용하여 제작한 UV 센서인 포토다이오드로 부터 최적의 자외선 응답을 읽어낼 수 있는 ROIC(ReadOut IC)를 개발 했다. FPA(Focal Plane Array)용 UV $8{\times}8$ ReadOut IC(ROIC)를 설계를 위하여 포토다이오드 타입 센서 소자를 커패시터로 모델링하였다. ROIC는 검출되는 신호를 받아 이를 증폭하고 잡음제거 필터링을 거쳐 픽셀 단위로 순차적으로 출력하는 기능을 수행하도록 하였다. ROIC는 $0.5{\mu}m$ 2Poly, 3Metal N-well CMOS process를 이용하여 제작되었으며, 이방성 전도성 페이스트 (Anisotropic Conductive Paste:ACP)를 사용하는 gold stud bumping 공정으로 ROIC와 포토다이오드 어레이를 하이브리드 패키지 (package)한 후 PC에서 자외선 영상으로 확인함으로써 ROIC의 동작을 검증하였다. A UV camera is being used in various application regions such as industry, medical science, military, and environment monitoring. A ROIC(ReadOut IC) is developed and can read the responses from UV photodiode sensors which are made with III-V nitride semiconductors of GaN series haying high resolution and high efficiency. To design FPA(Focal Plane Array) UV $8{\times}8$ ROIC, the photodiode type sensor devices are modeled as the capacitor type ones. The ROIC reads out signals from the detector at)d outputs sequentially pixel signals after amplifying and noise filtering of them. The ROIC is fabricated using the $0.5{\mu}m$ 2Poly 3Metal N-well CMOS process. And then, it and photodiode array are hybrid bonded by gold stud bumping process using ACP(Anisotropic Conductive Paste). After the packaging, UV images appearing on PC verified the operations of the ROIC.

Ectopic cervical thymic squamous cell carcinoma misdiagnosed as thyroid cancer: a case report

김주연,정은정,Kim Jae-Myung,Lee Han Shin,박태진,정상호,Jeong Chi-Young,주영태 대한종양외과학회 2022 Korean Journal of Clinical Oncology Vol.18 No.2

Ectopic thymic neoplasm, particularly ectopic thymic carcinoma, is a rare disease that presents as a neck mass. Here, we present a case of ectopic thymic squamous carcinoma in a 65-year-old man who presented with persistent hoarseness. After fine needle aspiration cytology, the patient underwent total thyroidectomy with lymph node dissection. The final histopathological examination revealed the ectopic thymic squamous carcinoma. The patient was discharged without any postoperative complications. The patient received adjuvant radiation therapy and did not progress during the 1-year follow-up period.

한파에 따른 표층수온의 지연시간 고찰 - 서해, 남해 -

김주연,박명희,이준수,안지숙,한인성,권미옥,송지영,Kim, Ju-Yeon,Park, Myung-Hee,Lee, Joon-Soo,Ahn, Ji-Suk,Han, In-Seong,Kwon, Mi-Ok,Song, Ji-Yeong 해양환경안전학회 2021 海洋環境安全學會誌 Vol.27 No.6

본 연구에서는 강한 한파가 발생했던 2018년과 온난 한파가 발생했던 2019년의 기온에 따른 수온의 반응 및 지연시간과 북풍계열 바람 빈도와의 상관관계를 분석하였다. 사용된 시간 자료는 국립수산과학원에서 제공하는 7개 지점 해역별 수온자료와 수온관측소 인근 7개 지점 AWS 기온자료를 이용하였다. 관측되지 못한 자료는 내삽법으로 근사값을 계산하였고, FIR Filter를 이용하여 자료의 주기성을 파악하였다. 그 결과, 강한 한파가 발생했던 2018년은 북풍계열 바람을 통해 차가운 공기가 남하하면서 기온을 하강시켜 전 해역에 저수온을 유발한 반면 온난 한파가 발생했던 2019년은 평년 수준의 기온으로 하강하였지만 수온은 크게 변화하지 않았다. 강한 한파가 발생했던 2018년 기온 하강에 따른 수온의 지연시간은 평균 14시간으로 0.7 이상의 높은 상관성을 나타냈고 온난 한파가 발생했던 2019년은 평균 지연시간이 20시간으로 0.44-0.67 사이의 상관성을 보였다. 본 연구를 통해 해역별로 기온 하강에 따른 표층수온의 반응을 해석하였고 지연시간을 파악함으로써 양식생물의 피해를 최소화하고 한파 피해의 신속한 대응에 기여할 수 것으로 기대한다. In this study, we examined the sea surface temperature (SST), air temperature (AT), and their time lag in response to an extreme cold wave in 2018 and a weak cold wave in 2019, cross-correlating these to the northern wind direction frequency. The data used in this study include SST observations of seven ocean buoys Real-time Information System for Aquaculture Environment provided by the National Institute of Fisheries Science and automatic weather station AT near them recorded every hour; null data was interpolated. A finite impulse response filter was used to identify the appropriate data period. In the extreme cold wave in 2018, the seven locations indicated low SST caused by moving cold air through the northern wind direction. A warm cold wave in 2019, the locations showed that the AT data was similar to the normal AT data, but the SST data did not change notably. During the extreme cold wave of 2018, data showed a high correlation coefficient of about 0.7 and a time lag of about 14 hours between AT and SST; during the weak cold wave of 2019, the correlation coefficient was 0.44-0.67 and time lag about 20 hours between AT and SST. This research will contribute to rapid response to such climate phenomena while minimizing aquaculture damage.

기체주입노즐의 내부유동양식의 구분

김주연,이상용,Kim, Joo-Youn,Lee, Sang-Yong 대한기계학회 2000 大韓機械學會論文集B Vol.24 No.2

An experimental study was conducted to examine the internal flow patterns inside the mixing chamber of effervescent atomizers. The mixing chamber has the rectangular cross section ($8mm{\times}2mm$) and made of transparent acrylic plate for flow visualization. The parameters tested were the air/liquid ratio (ALR), injection. pressure, and the nozzle orifice diameter. Three different flow regimes were observed; bubbly, annular, and intermittent flows. In the bubbly flow regime, the discharged mixture was disintegrated into drops through the bubble expansion and the ligament breakup. On the other hand, in the annular flow regime, the liquid annulus was disintegrated into small drops by the aerodynamic interaction between the phases due to the high relative velocities between the gas and the liquid. In the intermittent flow regime, the bubble-expansion/ligament-disintegration mode and the annulus-disintegration mode appeared alternatively. The correlations representing the transition criteria between the two-phase flow patterns within the mixing chamber were proposed based on the drift-flux models.

흰쥐에서 녹차의 섭취가 ¹⁴C-Benzo[a]pyrene의 조직 분배 및 잔류에 미치는 영향

김주연,노상규,Kim, Ju-Yeon,Noh, Sang-K. 한국식품영양과학회 2011 한국식품영양과학회지 Vol.40 No.6

잔류성이 강하고 높은 지용성질을 가지는 식품오염물질인 benzo[a]pyrene(BaP)은 녹차 섭취에 의해서 소장에서 흡수가 억제되고 총담관으로의 배출이 증가되는 것으로 최근에 보고하였다. 이번 연구는 흰쥐를 이용해서 $^{14}C$-BaP를 복강주사한 후, 사람과 비교해서 1잔에 해당하는 녹차추출물을 4주간 매일 지속적으로 공급하였을 때, $^{14}C$-BaP의 조직분배 및 잔류에 미치는 영향을 조사하였다. 27.4 kBq $^{14}C$-BaP를 복강주사한 후 표준식이와 증류수만 공급된 동물군을 대조군, 표준식이와 녹차추출물(4.7 mg catechins/day)을 공급받은 동물군을 녹차군으로 하여 4주간 사육하였다. 그리고 4주째에 심장, 간장, 뇌, 비장, 신장, 후복막지방, 고환, 부고환지방 조직을 적출하여 무게를 측정하고 각 조직에 잔류하는 $^{14}C$-BaP의 방사선 활성도를 측정하였다. 대조군과 녹차군 모두 연구 시작부터 종료 시까지 지속적으로 체중이 증가하였으나 동물군 간에 유의적인 차이는 없었다. 장기의 무게 또한 각 조직 모두 동물군 간에 유의적인 차이가 없었다. 조직 g당 $^{14}C$-BaP의 잔류량은 심장에서 가장 높았고 다음으로 뇌, 부고환지방, 비장, 신장, 간장, 후복막지방, 고환 순으로 높았으며, 조직 전체의 $^{14}C$-BaP의 잔류량은 부고환지방에서 가장 높았고 다음으로 간장, 후복막지방, 심장, 뇌, 신장, 고환, 비장 순으로 나타났다. 녹차 섭취에 의해서 조직 g당 $^{14}C$-BaP의 방사선 활성도와 조직 전체 당 $^{14}C$-BaP 방사선 활성도 모두 심장, 간장, 뇌, 비장, 부고환지방에서 급격하게 감소된 것으로 나타났다. 이상의 실험결과들을 종합해 볼 때, 4주 동안 하루 1잔에 해당하는 녹차추출물 섭취가 BaP의 조직 분배를 유의적으로 감소시켜 조직 잔류에 영향을 미치는 것을 이 실험을 통해서 확인할 수 있었다. Recently, we showed that green tea extract (GTE) markedly lowers the intestinal absorption of $^{14}C$-benzo[a]pyrene ($^{14}C$-BaP) and enhances its secretion into the biliary route, suggesting a protective role for GTE against body burden. These findings indicate that green tea could be used as an effective dietary means against the toxicity of BaP. The present study, therefore, was designed to investigate if green tea intake could affect the tissue distribution and deposition of $^{14}C$-BaP in rats. Male Sprague-Dawley rats had free access to a nutritionally adequate AIN-93G diet and deionized water. At ~340 g of weight, the rats were injected intraperitoneally with 27.4 kBq of [4-$^{14}C$]-BaP and 5.0 mg of BaP dissolved in $300\;{\mu}L$ of olive oil and then assigned randomly to the following two groups: one group (GTE) of rats was fed the AIN-93G diet with GTE via drinking water at approx. 4.7 mg of catechins/d, whereas the other was fed the same diet but without GTE (control). At 4 wk of dietary treatment with GTE, animals were euthanized and heart, liver, brain, spleen, kidney, retroperitoneal fat, testis, and epididymal fat were collected, weighed, and analyzed for tissue $^{14}C$-BaP. Both the control and GTE groups continuously gained weight throughout the study, but there was no significant difference between the groups. No significant differences were observed in the weights of heart, liver, brain, spleen, kidney, retroperitoneal fat, testis, and epididymal fat. However, the radioactivities of $^{14}C$-BaP, expressed in dpm/g, were significantly lower in the heart, liver, brain, spleen, and epididymal fat of rats receiving GTE as compared to their respective controls. These data indicate that green tea intake markedly lowers tissue accumulation of $^{14}C$-BaP. Taken together, these findings suggest that the decreased tissue levels of BaP by GTE intake may be associated with lowered intestinal absorption of BaP and its enhanced secretion into the bile.

대학생 개인정보보호 인식조사를 통한 교육 개선방안 연구

김주연,Kim, Ju-yeon 한국정보통신학회 2019 한국정보통신학회논문지 Vol.23 No.3

개인정보의 수집과 사용이 지속적으로 증가하고 있는 추세에서, 개인정보를 보호하기 위한 법적 근거가 마련되고 각종 정책과 제도가 시행되고 있지만, 개인정보보호에 관한 교육과 그 효과에 대한 분석이 부족한 상황이다. 이에 본 연구에서는 대학생들의 개인정보보호에 인식정도와 실제 인지수준에 대해 분석하고, 개인정보보호 교육의 만족도를 조사하였다. 분석결과에서 학생들의 개인정보보호에 대한 관심이나 개인정보 노출 염려는 매우 높은 편이었으나, 실제 개인정보보호를 위한 노력이나 개인정보보호를 위한 권리 및 제도에 대한 인지수준은 매우 낮은 것으로 분석되었다. 또한 정보보호 교육을 받은 경험 및 만족도도 매우 낮은 것으로 조사되었다. 학생들은 개인정보보호 교육의 필요성은 크게 공감하였고, 일회성 교육보다는 정기적이고 지속적인 교육을 선호하는 것으로 분석되었다. In the trend of continuously increasing collection and use of personal information, there are legal grounds for protecting personal information and various policies and systems are implemented, but there is insufficient analysis about education and its effect of personal information protection. In this study, we surveyed and analyzed the degree of awareness and actual perception level in the protection of personal information of college students, and investigated the satisfaction of personal information protection education. The results of the analysis showed that students' interest in privacy protection and concern about personal information exposure was very high, but the efforts to protect personal information and the perception level of rights and systems for protecting personal information was very low. In addition, the experience and satisfaction of education for personal information protection were found to be very low. Students felt that the necessity of education for personal information protection was strongly agreed and preferred regular and continuous education rather than one-time education.

포도막염에 의한 이차개방각녹내장에서 마이토마이신 섬유주절제술과 아메드밸브삽입술의 임상성적

김주연,심형섭,김황기,손용호.Joo Yeon Kim. MD. Hyoung Sub Shim. MD. Hwang Ki Kim. MD. Yong Ho Sohn. MD. PhD 대한안과학회 2010 대한안과학회지 Vol.51 No.4

Purpose: To assess and compare the clinical outcomes of primary trabeculectomy with mitomycin C and Ahmed valve implantation for secondary open-angle glaucoma following uveitis. Methods: This study was conducted retrospectively on 30 eyes of 25 patients with open-angle glaucoma secondary to uveitis that had undergone trabeculectomy with mitomycin C and 33 eyes of 24 patients that had undergone Ahmed valve implantation. The clinical outcome indicators used in this study were intraocular pressure (IOP), number of anti-glaucoma agents, surgical success rate and occurrence of complications. Results: Mean IOP and surgical success rate in patients who had undergone trabeculectomy with mitomycin C after a 12 month postoperative period were 14.0±8.2 mmHg and 76.7%, respectively, while those of patients with Ahmed valve implantation were 13.2±7.7 mmHg and 81.8%. The data did not show clinical significance. There was greater risk of surgical failure in patients at a younger age and/or with diabetes mellitus in cases of having gone through trabeculectomy with mitomycin C. Conclusions: Both trabeculectomy with mitomycon C and Ahmed valve implantation can be considered as primary surgical treatments for patients with open-angle glaucoma secondary to uveitis. However, trabeculectomy with mitomycin C should only be applied to a limited extent in patients that are young and/or have diabetes mellitus. J Korean Ophthalmol Soc 2010;51(4):575-580