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Self-Assembly of gold nano particles on templated patterns formed by wrinkling
김재겸,유필진 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
Surface-ordered nanoparticles were studied via template-guided selfassembly of spherical monodisperse gold nanoparticles in wrinkled templates. Surface instability and pattern formation based on difference in thermal expansion between bilayers was employed as a guidline for patterned particle assembly. Tuning the wrinkle`s wavelength enables us to precisely confirm the assembly morphology and fabricate line and complex nano-particles patterns. Furthermore, surface charge on wrinkles can be changed using different silica precursors. It helps to arrange gold nanoparticles in wrinkles or cover nano-colloids on wrinkled surface controlling electrostatic interaction between particles and surface. It is expected that highly regular 1- and 2-dimensional patterned nano gold colloids will be promising candidates for various applications such as sensors, surface enhanced raman spectroscopy, photovoltaics or plasmon enhanced solar cells.
김재겸,신의철,김초롱,박귀근,최수정,박증석,신동훈 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.11
In this study, the protective effects of Brussels sprouts extract and its major constituents against oxidative stress-induced damages were investigated in rat pheochromocytoma cells and Institute of Cancer Research mice. The major constituents of Brussels sprouts (3,40,5,7-tetrahydroxyflavone (kaempferol), indole-3-carbinol, and phenethyl isothiocyanate) were selectively tested. Of these, the flavonoid compound, kaempferol exhibited the highest potency in radical scavenging activity (1,1-diphenyl-2-picryl hydrazyl assay and oxygen radical absorbance capacity assay) and was most protective against oxidative stress in neuronal cell assays (measurement of intracellular oxidative stress levels and cell viability). In mice, after 4 weeks of kaempferol administration, significant protection against amyloid beta (Ab) peptide-induced neurotoxicity was also observed, as assessed through the passive avoidance test. Taken together, the results suggest that Brussels sprouts could be protective against Ab-induced neurotoxicity, possibly due to the antioxidative capacity of its major constituent, kaempferol.
김재겸,임호정,신동훈,김초롱,김미정,천지연,신의철 한국원예학회 2015 Horticulture, Environment, and Biotechnology Vol.56 No.4
Complete fatty acid profile and major phytosterols of nearly all commercially available vegetable oils, obtained from local grocery stores in South Korea, were analyzed (n = 15). Subsequently, the contribution of specific oil componentsto antioxidative effects, measured using conventional 2,2-diphenyl-1-icrylhydrazyl (DPPH) and 2’,7’-dichlorofluorescindiacetate (DCF-DA) assays, was assessed via principal component analysis (PCA). The rat pheochromocytoma cell line was used for the DCF-DA analysis. One of the phytosterols (i.e., β-sitosterol) was positively correlated with DPPH and negatively correlated with the intracellular oxidative levels of neuronal cells, measured by DCF-DA. In addition, through the comparison between loading plot and score plot, groups of oils with similar properties were identified and their associations and unforeseen factors were elucidated by virtue of PCA. Taken together, the results herein suggest that the combination of chromatographic analysis and multivariate analysis could be a useful method to elucidate the role of responsible nutrients as well as associated similarities (or dissimilarities) of sample characteristics in biological outcomes.
김재겸,신의철,김초롱,박귀근,최수정,조홍연,신동훈 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.4
Fatty acid profiles of commercially available tree nuts were analyzed and association between fatty acid composition and protective effects against oxidative stress was investigated. Among commercially available tree nuts,walnuts showed the most potent protective effects for both cell viability and 2',7'-dichlorofluorescein (DCF) formation. Neuronal cell viability and inhibition of intracellular oxidative stress were inversely related to saturated fatty acid contents in tree nuts. Eigen analysis revealed that principal component (PC) 1 was mainly contributed by 2',7'-dichlorofluorescin diacetate (DCF-DA), DPPH, and C18:2 and C18:3. PC2was contributed by MTT assay, and saturated fatty acids. Walnuts exhibited the highest potency against oxidative stress closely related with C18:3, based on principal component analysis (PCA) and Pearson’s correlation analyses. A combination of fatty acid profiling using chromatographic analysis and PCA is a promising method to evaluate oxidative stress.