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      • KCI등재

        전갈(全蝎) 약침액(藥鍼液)의 항돌연변이(抗突然變異) 및 항암(抗癌) 효과(效果)

        김소형,김갑성,Kim, So-Houng,Kim, Kap-Sung 대한침구의학회 2000 대한침구의학회지 Vol.17 No.3

        Objective : The aim of this study is to determine the antimutagenic effect and genetic safety of Buthus martensi Karsch aqua-acupuncture solution(BMKAS) against various chemical carcinogens. Method : Ames(Salmonella typhimurium) test and Rec assay(Bacillus subtilis) were used as indicators for DNA damage and antimutagenesis. Furthermore, the levels of umu operon expression by measuring the ${\beta}$-galactosidase activity wete monitored with the SOS umu test using S. typhimurium 1535 containing plasmid pSK1002. And the host-mediated assay was used to investigate the mutagenicity and antimutagenicity of BMKAS inducing various chemical carcinogens after the activation with in vivo metabolic systems. Results : From the results, BMKAS did not atfect DNA of S. typhimurium and B. subtilis strains and showed no mutagenicity at the all concentrations of tested solution. Furthermore BMKAS dose-dependently protected the mutagenecity by AF-2, 2-AA and B[a]P. These phenomena was also similar to that after metabolic activation of BMKAS in in vivo system. Conclusion : These results suggested that BMKAS did not show the mutagenicity and protected the mutagenesis against various chemical carcinogens by four different methods used in this study.

      • SCOPUSKCI등재

        A Spontaneous Growth of a Diaphorase Enzyme Layer over a Gold Electrode for the Catalytic Reduction of $NAD^+$

        김소형,윤세옥,강찬,Kim, So Hyeong,Yun, Se Ok,Gang, Chan Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.11

        A diaphorase enzyme electrode for the catalytic reduction of NAD+ , the oxidized form of nicotinamide adenine dinucleotide, has been prepared. The enzyme layer grew spontaneously over an aminoethanethiol self assembled monolayer on a go ld plate electrode. The growth was accomplished by simply dipping the electrode covered by the aminoethanethiol monolayer into a solution containing both glutaraldehyde and diaphorase. We suggested that the glutaraldehyde as a cross-linking reagent was attached to the amino groups of the aminoethanethiol monolayer and the diaphorase enzyme molecules were bound to free aldehyde groups of the glutaraldehyde. Further attachments of the enzyme molecules over the bound enzyme molecules continued with the bridging of the glutaraldehyde. In frequency measurements with a quartz crystal microbalance, the frequency decrease was much more than it was for that of the enzyme monolayer formation, and an enzyme layer thicker than a monolayer was formed. The modified electrode was employed to reduce NAD+ , using diffusional methyl viologen as an electron transfer mediator. The NAD+ was electrocatalytically reduced, and the catalytic current was almost equivalent to that with the multilayered electrode of ten enzyme layers.

      • KCI등재

        일개 한방병원에 파킨슨병으로 내원한 환자의 사상의학적 특성에 관한 고찰

        김소형,이슬,이용재,배나영,이정윤,Kim, So-Hyoung,Lee, Seul,Lee, Yong-Jae,Bae, Na-Young,Lee, Jeong-yun 사상체질의학회 2018 사상체질의학회지 Vol.30 No.3

        Objectives The aim of this study was to make an analysis of clinical characteristics and status of Sasang constitutional medicine of patients with Parkinson's Disease who visited a Korean medicine hospital. Methods We studied 129 patients with Parkinson's Disease who visited a Korean medicine hospital from September 1, 2012 to June 30, 2018. We retrospectively collected medical history and characteristics of subjects using data of EMR (electronic medical record). Results The proportion of female was higher than male. The average age was 60s. The patients visited a hospital more than one year after the occurrence of symptoms. And they were mostly under western medicine treatment. Among the 129 patients, 56 persons(43.4%) were Taeeumin, 45 persons(34.9%) Soyangin and 28 persons Soeumin(21.7%). In the distribution of prescription according Sasang Constitutional Medicine symptomatology, there was no significant difference in the proportion of exterior cold disease(48.9%) and interior heat disease(51.1%) in Soyangin. Meanwhile the proportion of heat disease's prescription was higher than cold disease in Taeeumin(73.2%) and Soeumin(84.1%). The majority of disease were Dry-febrile symptom(73.2%) of heat disease in Taeeumin, Yang depletion-syndrome(64.3%) of heat disease in Soeumin, and Gyolhyung-symptom(33.3%) of exterior cold disease and Wasting thirst-syndrome(22.2%) of interior heat disease in Soyangin, Conclusions By Developing of guideline for treatment of Parkinson's Disease through analyzing on clinical characteristics and distribution of Sasang Constitutional Medicine symptomatology could contribute to the improvement of the cure rate and accuracy of constitution pattern.

      • KCI등재

        태양인 해역증으로 진단한 근위축성 측삭경화증 환자 치험 1례

        김소형,이미숙,박유경,배나영,Kim, So-Hyoung,Lee, Mi-Suk,Park, Yu-Gyeong,Bae, Na-Young 사상체질의학회 2016 사상체질의학회지 Vol.28 No.3

        Objectives This case study was about a Taeyangin patient with Amyotrophic Lateral Sclerosis identified as Hae-Yeok pattern. In this study, we report the significant improvement of extremity weakness of this patient after Sasang Constitutional medicine treatment.Methods The patient was identified as Taeyangin Hae-Yeok pattern and treated with Ogapijangchuk-tang and acupuncture. Korean-Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (K-ALSFRS-R) was used to assess the overall function of the patient. And the Global Assessment Scale (GAS) was used to assess the change of upper and lower extremities weakness after the treatment.Result and Conclusion The K-ALSFRS-R total score decreased from 30 points to 26 points and extremity weakness showed significant improvement in GAS after 12 days treatment. Furthermore, walking distance was much longer after treatment. In conclusion, this study shows that Sasang constitutional medicine can be effective treatment for Taeyangin patient with Amyotrophic Lateral Sclerosis.

      • KCI등재

        무선 인터넷 서비스를 위한 WiBro시스템의 효율적인 부하 제어 절차 제안 및 성능분석

        김소형,김정호,Kim, So-Hyoung,Kim, Jeong-Ho 한국통신학회 2007 韓國通信學會論文誌 Vol.32 No.5A

        In this paper, we propose the load control procedure for WiBro system in order to keep the data traffic throughput maximum. The transmitter at a mobile terminal can estimate maximum available power for each user and then the maximum number of subchannels can be calculated considering the total available power. The data traffic throughput and the total throughput (the sum of signaling traffic and data traffic throughput) are considered. As the number of bandwidth requests per frame increases, the data traffic throughput can significantly decrease. Therefore, the load control procedure is indispensible to maintain the data throughput at the maximum level. So, we propose the load control procedure to prevent data traffic throughput from decreasing and evaluate the proposed procedure through the computer simulation under the multi-user environment. The maximum throughput can be maintained by applying the proposed procedure. 본 논문에서는 WiBro 시스템의 특징을 바탕으로 데이터 트래픽의 수율을 최대로 유지 할 수 있도록 기존 방법을 개선한 부하 제어 방법을 제안하고 컴퓨터 시뮬레이션을 통하여 성능을 평가한다. 송신단에서 단위 사용자당 최대 할당 가능한 전력이 주어졌을 때, 송출 가능한 전력범위 내에서 최대의 수율을 갖도록 각 부반송파에 데이터 비트를 할당하는 알고리즘을 바탕으로 WiBro 시스템의 전체 수율(throughput)과 데이터 트래픽 관점에서 시스템의 수율을 고려하였다. 제안하는 방안의 평가를 위해 사용된 시스템의 파라메터로 WiBro시스템의 규격값들을 사용한다. 현재 시스템의 부하제어 절차로는 접속과다로 인한 대역폭 요구(bandwidth request)의 증가로 인하여 과부하 상태에 이를 때 시그널링 트래픽으로 인하여 데이터의 수율이 급격히 감소하며 접속지연이 매우 증가하게 된다. 이러한 현상을 막을 수 있는 부하 제어 방법을 제안하고 다중 사용자 환경에서 시뮬레이션을 통하여 평가한다.

      • KCI등재

        혼합분포된 청소년 신체건강행위에 대한 가족 내·외재적 요소의 가지경로 분석 -GMM과 Decision Tree모형중심-

        김소형 ( Kim So-hyeong ),김현옥 ( Kim Hyun-ok ),김경호 ( Kim Kyoung-ho ) 한국가족사회복지학회 2022 한국가족복지학 Vol.69 No.2

        본 연구는 잠재혼합된 청소년의 신체건강행위에 관여하는 가족 내재적·외재적 요소에 대한 가지경로 분석을 통하여, 가족경계를 넘어 발달영역을 확장해 가는 청소년의 신체건강을 제고하기 위하여 이루어졌다. 혼합분포된 청소년의 신체건강행위에 대한 보다 과학적인 분석을 실시하기 위하여 이에 적합한 가우시안믹스처모델(GMM)을 활용하였다. 그리고 가지경로를 분석하기 위해 Decision Tree모형을 활용하였다. jamovi 및 R(ver.4.1.0)/R-studio 분석도구로 활용하여 한국아동·청소년패널조사2018 패널자료의 2차년도(2019년) 데이터 자료(중학교 1학년 2,590명과 보호자 2,590)를 분석하였고 연구결과는 다음과 같다. 첫째, GMM을 통하여 청소년들의 신체건강행위에 대해서 잠재혼합된 두 개의 상이한 집단으로 분류되었으며, 건강행위 군집과 불건강행위 군집으로 명명하였다. 둘째, 두 군집에 대한 t검정 결과, 건강행위 군집이 가족 외재적 요소인 청소년활동 및 교외동아리활동 그리고 가족 내재적 요소인 어머니 근로여부를 제외하고 모두 유의하게 높았다. 셋째, 청소년의 신체적 건강에 대해서 건강행위 군집과 불건강행위 군집을 분류하는 가지경로 분석을 하기 위하여 디시즌트리를 실시한 결과, 가족 외재적 요소인 친구관계와 교사관계가 긍정적이며, 가족 내재적 요소인 어머니의 학력이 고학력일 경우 건강행위 군집으로 분류예측 되었다. This study was conducted to improve the physical health of adolescents who are expanding their developmental domain beyond family boundaries through branch path analysis on the factors involved in the physical health behavior of latent mixed adolescents. In order to conduct a more precise analysis of the mixed-distributed physical health status of mixed-distributed adolescents, an appropriate Gaussian Mixture Model(GMM) was used. And a decision tree model was used to analyze branch paths. Using jamovi and R(ver.4.1.0)/R-studio as an analysis tool, the second year (2019) data of the Korean Children and Youth Panel Survey 2018 panel data (2,590 first-year middle school students and 2,590 guardians) were analyzed. The research results are as follows. First, through GMM, the physical health of adolescents was classified into two different groups that were latent mixed, and they were named the healthy behavior cluster and unhealthy behavior cluster. Second, as a result of t-test for both clusters, the healthy behavior cluster was significantly higher except for youth activities and suburban club activities, which are factors outside the family, and whether or not the mother worked, which is an intrinsic factor in the family. Third, as a result of the decision tree to analyze the branch path that classifies healthy behavior and unhealthy behavior clusters of adolescents, the friend relationship and teacher relationship, which are external factors of the family, are positive, and the mother’s educational background, which is an intrinsic factor of the family, is positive. This high educational level was predicted to be classified as a healthy behavior cluster.

      • KCI등재

        소득구간별 아동·청소년의 사회관계에 의한 건강행위 분류예측의 데이터마이닝 비교분석

        김소형 ( Kim So-hyeong ),김현옥 ( Kim Hyun-ok ),김경호 ( Kim Kyoung-ho ) 한국가족사회복지학회 2022 한국가족복지학 Vol.69 No.1

        본 연구는 소득구간별 아동ㆍ청소년의 사회관계에 의한 건강행위 분류예측에 관한 변수 중요도를 분석하기 위해 데이터마이닝 기법을 활용하였다. jamovi 및 R(ver.4.1.0)/R-studio 분석도구로 활용하여 한국아동ㆍ청소년패널조사2018 패널자료의 2차 년도(2019년) 데이터 자료(아동ㆍ청소년 총5,197명과 그들의 보호자 5,197명)를 분석하였고 연구결과는 다음과 같다. 첫째, 혼합분포군집분석을 통해 아동ㆍ청소년의 건강행위 특성에 의해 불건강군집(1군집)과 건강군집(2군집)으로 분류되었으며, 건강군집이 불건강 군집에 비해 주관적 건강인식과 신체활동 정도, 이침 식사 정도가 높게 나타났다. 둘째, t 검정 결과 교사관계, 부모양육태도, 부모와 함께하는 시간, 어머니 학력, 부모의 아침식사여부, 가구소득에서 유의미한 차이가 나타났다. 셋째, 소득구간별 아동ㆍ청소년의 건강행위 특성에 영향을 미치는 사회관계요소가 소득상위구간에 유리하게 작용됨을 확인할 수 있었다. 그리고 사회관계로써 친구관계, 교사관계, 부모관계 그리고 부모요인(학력, 신체활동, 아침식사여부) 중에서 부모의 아침식사여부가 모든 소득구간에서 가장 중요한 변수로 나타났다. In this study, data mining technique was used to analyze the importance of variables in predicting the classification of health behaviors by social relations of children and youth by income category. Using jamovi and R(ver.4.1.0)/R-studio as an analysis tool, the second year (2019) data of the Korean Children and Youth Panel Survey 2018 panel data (a total of 5,197 children and youth and their guardians 5,197) was analyzed, and the results of the study are as follows. First, through mixed distribution cluster analysis, children and youth were classified into unhealthy clusters (cluster 1) and healthy clusters (cluster 2) according to the health behavior characteristics of children and youth. Eating was found to be high. Second, as a result of the t test, significant differences were found in teacher relationship, parenting attitude, time spent with parents, mother’s educational background, whether parents had breakfast, and household income. Third, it was confirmed that the social relation factors that affect the health behavior characteristics of children and youth by income bracket acted favorably in the upper income bracket. And among the social relationships, friend relationship, teacher relationship, parent relationship, and parental factors (educational background, physical activity, breakfast status), whether parents had breakfast was the most important variable in all income categories.

      • SCOPUSKCI등재
      • KCI등재

        KHP 기준에 의한 보험용 단미엑스산제의 지표성분함량 확인연구

        박상준 ( Sang Jun Park ),김소형 ( So Hyung Kim ),김경석 ( Kyeong Seok Kim ),김효선 ( Hyo Seon Kim ),이아영 ( A Yeong Lee ),김호경 ( Ho Kyoung Kim ),김윤경 ( Yun Kyung Kim ) 대한본초학회 2014 大韓本草學會誌 Vol.29 No.3

        Objectives : Since single extract powders was released at 1987, the insurance fee has not been changed, but the price of raw material has been increasing. According to this, Pharmaceutical company couldn`t invest on quality of the product, so, the quality of single extracts went down and lost the consumer`s trust. We checked the contents of marker ingredients in single extract thereby to recover the reliability of insurance-covered herbal preparations. Methods : we bought total twelve products of eight different single extracts of two main pharmaceutical companies among total 65 kinds of single extract powder stipulated in KHP (The Korean Herbal Pharmacopoeia) monograph Ⅲ at Jan. 2013. Assays of selected single extract powders are performed by KHP regulation. And we surveyed price fluctuation of relevant herb raw materials from 2005 to 2012. Results : Among twelve products, eight single extract powders were suitable by the KHP regulation. But four products didn`t reach the content amount of KHP. Marker contents in the single extracts product of Pueraria Root, Licorice, Peony root and Scutellaria Root of A company were 70%, 1%, 23.7% and 75.1%, respectively. Conclusions : We can acertain whether there`s a quality problem in the insurance-covered single extract powders. But, A company is no longer producing these improper single extract powders. As a medicine, single extract powders needs to be strictly quality controlled by the company, and regularly monitored by the KFDA.

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