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      • SCOPUSKCI등재
      • SCIESCOPUSKCI등재

        신생흰쥐 척수후근신경절 세포에서 전압의존성 $K^+$ 전류의 동정

        지목,정승준,김상정,,Kim, Ji-Mok,Jung, Sung-Jun,Kim, Sang-Jeong,Kim, Jun 대한약리학회 1997 The Korean Journal of Physiology & Pharmacology Vol.1 No.6

        Dorsal root ganglion (DRG) is composed of neuronal cell bodies of primary afferents with diverse functions. Various types of ion channels present on DRG neurons may reflect those functions. In the present study, voltage-gated potassium currents in DRG neurons of neonatal rats were characterized by whole-cell voltage clamp method. Two types of delayed rectifier and three types of transient potassium currents were identified according to their electrophysiological properties. The delayed rectifier currents were named $I_{Ke}$ (early inactivating) and $I_{K1}$ (late inactivating). Steady state inactivation of $I_{Ke}$ began from -100 mV lasting until -20 mV. $I_{K1}$ could be distinguished from $I_{Ke}$ by its inactivation voltage range, from -70 mV to +10 mV. Three transient currents were named $I_{Af}$ (fast inactivation), $I_{Ai}$ (intermediate inactivation kinetics), and $I_{As}$ (slow inactivation). $I_{Af}$ showed fast inactivation with time constant of $10.6{\pm}2.0$ msec, $I_{Ai}$ of $36.9{\pm}13.9$ msec, and $I_{As}$ of $60.6{\pm}2.9$ msec at +30 mV, respectively. They also had distinct steady state inactivation range of each. Each cell expressed diverse combination of potassium currents. The cells most frequently observed were those which expressed both $I_{K1}$ and $I_{Af}$, and they had large diameters. The cells expressing $I_{Ke}$ and expressing $I_{Ke}$, $I_{Ai}$, and $I_{As}$ usually had small diameters. Judging from cell diameter, capsaicin sensitivity or action potential duration, candidates for nociceptor were the cells expressing $I_{Ke}$, expressing $I_{Ke}$ and $I_{Ai}$, and expressing $I_{Ke}$ and $I_{As}$. The types and distribution of potassium currents in neonatal rat DRG were similar to those of adult rat DRG (Gold et al, 1996b).

      • SCOPUSKCI등재

        식도 정맥류 출혈에 대한 내시경적 경화요법의 장기 관찰 결과

        정정명(Jung Myung Chung),최하진(Ha Jin Choi),윤중근(Jung Kun Yoon),병제(Byoung Jae Kim),박경태(Kyung Tae Park),김상정(Sang Jeong Kim) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1

        N/A Esophageal Varices Bleeding is one of the major causes of death among the patients with liver cirrhosis or portal hypertenison, and it represents,50% mortality each episode of bleeding. As the method for the treatment of Esophageal Varices Bleeding, supportive cares such as Balloon tamponade, infusion of vasopressin are usually practiced but the results of therapy have been found unsatisfactory. Although surgical therapy can also be expected to improve the one-year survival rate, its long-term survival rate is very low because of high incidence of morbidity. For the purpose of improving these therapeutic defects, Endoscopic Injection Sclerotherapy has been tried as a new method and its good effects have been reported recently. Endoscopic Injection Sclerotherapy is so effective on the emergency treatment of Esophageal Varices Bleeding. However, it gives rise to many debates on the improvement of long-term survival rate. To investigate long-term prognosis of Endoscopic Injection Sclerotherapy, we evaluated the survival rates and the therapeutic effects on 150 patients with Esophageal Varices Bleeding, who were treated by Endoscopic Injection Sclerotherapv and could be followed up by the Department of Internal Medicine, In-Je Medical College. The results are as follow;. 1) Rebleeding occurred in,53 cases(35.3%) among patients followed up over one month after the first Endoscopic Injection Sclerotherapy. The incidence of rebleeding was highest within 6 months, noted in 23 cases (15.3%) which were 43.3% of all rebleedings. 2) Major complications of Injection Sclerotherapy were 6 cases of aspiration pneumonia. 4 cases of esophageal ulcer, 3 cases of esophageal stenosis, and of mediastinitis.Among all 16 cases fatal complications were estimated in cases. 3)During the follow up-period, 66 cases (44.0%) were expired. 26 cases (17.3%), which were 39.4% of all mortality, of expired cases were within one month after Sclerotherapy. The causes of their deaths were of hepatic failure in 35 cases(23.3%), of hepatoma in 16 cases (10.7%). of uncontrolled bleeding in 13 cases (8.7%), and of complications in 2 cases (1.3%). 4) The one-year survival rate of the patient afteer Sclerotherapy was 70.0%, and the four-years survival rate 40.0% (8 cases of 20 cases were survived). The survival rate of those patients was concerned with Child's Classicfication and remarkeable reduction in survival rate was noted in Child's class C. As the preceeding results, it isconsidered to be obvious that Endoscopic Injection Sclerotherapy is a recommendable method for the treatment and Esophageal Varices Bleeding. However, still high frequency of rebleeding and Hospital mortality are considered as projects to be improved hereafter.

      • KCI등재

        정파적 수용자의 적대적 매체 지각과 뉴스 미디어 리터러시

        경모(Kyungmo Kim),이승수(Seung Su Lee),김상정(Sang Jung Kim) 한국언론학회 2016 커뮤니케이션 이론 Vol.12 No.3

        이 연구는 자기범주화와 인지정교화의 접점에 주목해 적대적 매체 지각현상을 분석했다. 한국사교과서 국정화 논란을 다룬 뉴스기사(찬성 vs 중립 vs 반대)를 무선배치 피험자 집단에 제시하고 정파적 수용자의 정치이념성향, 자기범주화, 뉴스 미디어 리터러시가 상호작용하면서 뉴스 지각편향이 일어나는 심리과정을 탐색했다. 온라인 실험 결과, 중도(중립)기사를 접한 정파적 수용자가 기사 출처(보도매체)를 내집단 범주화할 때는 동화편향이, 외집단 범주화할 때는 적대적 매체 지각이 일어났다. 보수(찬성)와 진보(반대)로 편향된 기사에 각각 노출됐을 때도 자기범주화를 통한 상대적인 적대적 매체 지각이 관찰됐다. 다음으로, 뉴스 미디어 리터러시가 뉴스 지각편향에 어떻게 작용하는지 분석했다. 중도기사를 접한 경우 뉴스 미디어 리터러시 수준이 높은 정파적 수용자의 뉴스 지각편향이 증폭되는 것으로 나타났다. 보수편향기사에 노출됐을 때 리터러시 수준이 높은 진보 수용자의 상대적인 적대적 매체 지각은 변화하지 않았지만, 리터러시 수준이 높은 보수 수용자의 동화편향은 증폭됐다. 그러나 진보편향기사에 노출된 정파적 수용자에겐 리터러시의 차이에 따른 지각편향의 유의미한 변화가 관찰되지 않았다. 분석결과를 토대로 정파적 수용자의 뉴스 지각편향이 저널리즘에 시사하는 함의를 논의했다. This research analyzed hostile media perception focusing on the crossing point between self-categorization and cognitive elaboration. We randomly assigned people into three groups and suggested news articles about the state approved Korean history textbook issue(agree/neutral/disagree). Then we examined psychological mechanism that evokes news perception bias through interaction between partisan audiences’ political ideologies, self-categorization and news media literacy. The result of online experiments showed that partisans who were exposed to neutral news article had assimilation bias when they categorized the news as their in-group. When partisans were exposed to articles that were conservative biased(agree) and liberal biased(disagree), relative hostile media perception by self-categorization was observed. We then analyzed how media literacy affects news perception bias. When partisans encountered neutral news article, news perception bias was amplified with partisans who had high news media literacy. Relative hostile media perception did not change when liberal partisans who had high media literacy were exposed to conservative biased article. Relative hostile media perception was amplified when conservative partisans who had high news media literacy were exposed to conservative biased article. However, when partisans were exposed to liberal biased news article, no significant difference of news media perception by different levels of news media literacy was observed. Lastly, we discussed about implications of partisans’ news perception bias on journalism based on our experiment results.

      • Bronchial cast 1 례

        정한(Chung Han Kim),김상정(Sang Jung Kim),용관(Yong Kwan Kim),이영진(Young Jin Lee),규언(Kyu Earn Kim),이기영(Ki Young Lee) 대한소아알레르기호흡기학회 1996 소아알레르기 및 호흡기학회지 Vol.6 No.2

        The bronchial cast formation is a rare phenomenon which occurs exceptionally in association with pneumonia, asthma, mucoviscidosis, bronchial mucoid impaction, alveolar proteinosis, and bronchiectasis. Such diseases can produce severe obstructive conditions with excessive mucous and mucopurulent secretions in the bronchi and alveoli leading to formation of variable size of cast, In this report, we describe a child with bronchial cast and subsequent atelectasis who was treated with flexible bronchofiberscope to remove it.

      • SCOPUSSCIEKCI등재

        고양이 복외측 연수 호흡신경세포의 활동에 미치는 말초 유해자극의 영향

        창진,김상정,구용숙,,최길수 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.3

        Noxious peripheral nerve stimulation causes changes of arterial blood pressure by way of somatosympathetic reflex, and may play an important role in determining the periodicity of respiratory neurons at the same time. However, little has been known about how noxious stimulation does mediate respiratory control. In the present study, the respiratory neurons of the ventrolateral medulla were identified and characterized, and the responses of these neurons to noxious stimulation were observed, to investigate the role of noxious stimulation in determining respiratory rhythm. Cats were anesthetized with α-chloralose and mechanically ventilated after muscle relaxation. Occipital craniectomy was performed and the floor of the fourth ventricle was exposed. Single cell activities of the ventrolateral medulla were recorded using carbon-filament microelectrodes. Neurons related with respiratory rhythm were identified and the responses to vagal and sciatic nerve stimulation were observed. The following results were obtained. 1) A total of 46 neurons related with mechanical ventilatory cycle was identified, including 13 expiratory augmenting neurons, 11 inspiratory decrementing neurons, and 9 unclassified neurons. 2) The activity of inspiratory augmenting neurons was increased by A-δ intensity stimulation of the vagal and sciatic nerves, and inhibited by C-intensity stimulation of the sciatic nerve. 3) The inspiratory decrementing neurons did not show a significant response to vagal nerve stimulation, but the cell activity was inhibited by A-δ and C-intensity stimulation of the sciatic nerve. 4) The expiratory neuron did not show a significant response to peripheral nerve stimulation. 5) 27 neurons had slower rhythmic activity than mechanical ventilation. Sciatic nerve stimulation increased frequency of rhythmic discharges in these cells. 6) Most of the neurons with slower rhythmic activity during spontaneous respiration followed faster rhythm of mechanical ventilation after muscle relaxation. From these results, it is concluded that the activities of the respiratory neurons, especially inspiratory ones, in ventrolateral medulla are under influence of noxious peripheral stimulation, and they are dependent on the state of the experimental animal.

      • KCI등재후보

        원폭 피폭자와 그 자녀들에 대한 임상적 및 염색체 이상에 관한 연구

        동수,백용균,박상길,정정명,최하진,김상정,최원락 대한내과학회 1986 대한내과학회지 Vol.31 No.4

        Presented in this paper is the data from clinical labaratory examination of 50 Korean atomic-bomb survivors (in Hiroshima and Nagasaki, Japan in 1945). Of them, 15 survivors were karyotyped from their lymphocyte culture for both $quot;stable$quot; and $quot;unstable$quot; types of chromosomal aberrations. Eight of their offspring could be tested for the chromosomal changes and SCE as well. The results were as follows: 1) All survivors were found to have suffered from various diseases, particularly from respiratory disease. Two had malignancies, viz., one case having squamous cell carcinoma of uterine cervix and another adenocarcinoma of stomach. 2) Serum total protein and serum albumin levels were found to be decreased in 18% and 27% of the survivors, respectively. Alkaline phosphatase, SGOT, IgG and IgM were increased in 22%, 6.3%, 36.7% and 13.6% of the survivors, respectively. IgA was within normal limit in all cases. 3) Stable type of chromosomal aberrations was discovered in none of the survivors and the offspring examined. However, approximately 50% of the survivors showed significantly higher incidence of chromatid breakage than normal controls. 4) None of the offspring showed the chromatid breakage, but 75% of them showed significantly higher rate of SCE when compared to controls.

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