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정상 면역 기능을 가진 환자에서 성대에 국한되어 발생한 후두 칸디다증 1예
김보문(Bo Mun Kim),김정규(Jeong Kyu Kim),손호진(Ho Jin Son),길부관(Bu Kwan, Kil) 대한두경부종양학회 2018 대한두경부 종양학회지 Vol.34 No.2
Primary laryngeal candidiasis is rare in immunocompetent patients and is prone to confusion with early glottic carcinoma or leukemia. We experienced a case of 74-year-old man who has 3- month history of hoarseness. The pathologic diagnosis was laryngeal candidiasis. He was treated with antifungal agents for 4 weeks after vocal cord stripping under general anesthesia. After treatment, the patient had no candidiasis or discomfort with his voice. We report this case with a review of literature.
주의력 결핍과잉운동장애 아동의 주의력평가를 위한 T.O.V.A의 유용성 : 예비 연구
최보문,김우선,박난숙 대한신경정신의학회 1994 신경정신의학 Vol.33 No.6
Objects : The authors attempt to compare the mental health states of the elderly between Yanbian and Taegu for investigating the effect of changes in traditional culture on the mental health of the elderly. Methods : Subjects included 647 elderly at Yanbian and 419 elderly at Taegu who were evaluated by CADS (combined anxiety and depression scale). Results : There was significant difference in the CADS scores between the two groups : the elderly at Yanbian scored 37.9士 13.22, the elderly at Taegu scored 44.44士 11.70. The scores of pure depression items were higher than that of the other items in the elderly at Taegu. The scores of decreased libido item were highest in the both group elderly. The subjects over 50 points of CADS scores which mean clinically significant level of anxiety and depression, were 16.2% at Yanbian and 29.1% at Taegu which was significant Results of anxiety and overlapping items were 23.36土 9.00 in the elderly at Yanbian and 25.63 土 7.74 in the elderly at Taegu, whereas depression and overlapping items were 2330± 7.91 in the elderly at Yanbian and 28.52±7.65 in the elderly at Taegu, which was significantly higher in Taegu. Conclusion : These results suggests that changes in traditional culture affects mental health of the elderly significantly, especially alienation and helplessness by changes in culture may increase anxiety and depressive symptoms in the elderly
진균구를 동반한 비정형적 만성 침습형 진균성 부비동염 1예
정영도,김보문,강병준,신승헌 대한이비인후과학회 부산,울산,경남 지부회 2018 임상이비인후과 Vol.29 No.2
Chronic invasive fungal sinusitis (CIFS) is a relatively rare disease which occurs in immunocompetent or immunocompromised patients. We report a case of CIFS in ethmoid sinus with concurrent fungal ball in maxillary sinus. After surgical debridement and antifungal therapy, CIFS recurred with submucosal invasion in nasopharynx and osteomyelitis of clivus. Although CIFS encompasses a slowly progressing invasive fungal disease but potentially aggressive. It should be noted that CIFS could progress and extend through submucosal route without evidence of mucosal lesion.
마누카꿀이 TGF-β1에 의한 비용 섬유모세포의 세포외기질 생성에 미치는 영향
길부관,김보문,강병준,예미경,신승헌 대한이비인후과학회 2019 대한이비인후과학회지 두경부외과학 Vol.62 No.6
Background and Objectives Manuka honey has anti-microbial, anti-inflammatory, andanti-proliferative action with a high concentration of methylglyoxal compound. It is also effectivein killing Staphylococcus aureus biofilm and effective for the acute exacerbation of chronicrhinosinusitis. The aim of this study was to determine the anti-fibrotic effect of manuka honeyin nasal polyp fibroblasts. Materials and Method Primary nasal fibroblasts were isolated from nasal polyps and treatedwith transforming growth factor-beta 1 (TGF-β1). To determine the anti-fibrotic effect of manukahoney, fibroblasts were pre-treated with various concentration of the honey. Reversetranscription-polymerase chain reaction and western blot analysis were then performed to determineα-smooth muscle actin (α-SMA), collagen type I, and matrix metalloproteinase-9(MMP-9) messenger ribonucleic acid (mRNA) expression and protein production in nasal polyp fibroblasts. Phosphorylated Smad (pSmad) 2/3 and phosphorylated adenosine monophosphate-activatedprotein kinase (pAMPK) were then determined by western blotting. Results TGF-β1 stimulation increased α-SMA, collagen type I, and MMP-9 mRNA expressionand protein production in nasal polyp fibroblasts. Manuka honey effectively suppressedα-SMA, collagen type I, and MMP-9 mRNA expression and protein production. Its inhibitoryrole on TGF-β1 induced myofibroblast differentiation and its extracellular matrix productionwas associated with Smad2/3 and AMPK pathway. Conclusion Manuka honey can inhibit TGF-β1 induced myofibroblast differentiation, collagentype I, and MMP-9 production in nasal fibroblasts. These results suggest that manuka honeymight be a useful candidate for the inhibition of nasal polyp formation if further studies invivo were accompanied.
예미경,김보문,신승헌 대한비과학회 2019 Journal of rhinology Vol.26 No.1
Cholesteatoma is common disease entity within the middle ear cavity but is rarely found in the paranasal sinuses, especially themaxillary sinus. We experienced a case of cholesteatoma of the maxillary sinus without history of previous trauma or operation. The patient was not improved by functional endoscopic sinus surgery. The mucosa of the maxillary sinus was removed throughthe Caldwell-Luc approach, and heavy saline irrigation was performed. After reoperation, the postoperative period was uneventful,and there was no sign of recurrence on endoscopic examination.