Fabrication of Slica-Polythiophene Core-Shell Nanoparticles and Their Application to Electrorheological Fluids

권은별,장정식 한국공업화학회 2005 한국공업화학회 연구논문 초록집 Vol.2005 No.1

Multiple Endocrine Neoplasia Type 1 Presenting as Hypoglycemia due to Insulinoma

권은별,정활림,심영석,이해상,황진순 대한의학회 2016 Journal of Korean medical science Vol.31 No.6

Multiple endocrine neoplasia (MEN) mutation is an autosomal dominant disorder characterized by the occurrence of parathyroid, pancreatic islet, and anterior pituitary tumors. The incidence of insulinoma in MEN is relatively uncommon, and there have been a few cases of MEN manifested with insulinoma as the first symptom in children. We experienced a 9-year-old girl having a familial MEN1 mutation. She complained of dizziness, occasional palpitation, weakness, hunger, sweating, and generalized tonicclonic seizure that lasted for 5 minutes early in the morning. At first, she was only diagnosed with insulinoma by abdominal magnetic resonance images of a 1.3 × 1.5 cm mass in the pancreas and high insulin levels in blood of the hepatic vein, but after her father was diagnosed with MEN1. We found she had familial MEN1 mutation, and she recovered hyperinsulinemic hypoglycemia after enucleation of the mass. Therefore, the early genetic identification of MEN1 mutation is considerable for children with at least one manifestation.

Fabrication of Silica-Polythiophene Core-Shell Nanospheres as Dispersed Materirals for Electrorheological Fluids

권은별,장정식 한국고분자학회 2006 한국고분자학회 학술대회 연구논문 초록집 Vol.2006 No.4

Changes in the Predicted Adult Height after Gonadotropin-Releasing Hormone Agonist Treatment in Girls with Idiopathic True Precocious Puberty

권은별,이승준,차민아,김세영 대한소아내분비학회 2012 Annals of Pediatirc Endocrinology & Metabolism Vol.17 No.3

Purpose: We evaluated the effects of the timing of treatment initiation with gonadotropin-releasing hormone agonist (GnRHa) on the change in predicted adult height (PAH) in girls with idiopathic true precocious puberty (TPP). Methods: Data for this retrospective study were collected on 104 girls with TPP who were treated with GnRHa for 36 months, between January 2002 and March 2012. Results: The PAH SDS differed before and after treatment in all patients (-1.91 ± 1.47 vs. -1.37 ± 1.17 after 1 year of treatment, -1.96 ± 1.58 vs. -0.48 ± 1.11 after 3 years of treatment)as well as in Group 1 (-2.15 ± 1.54 vs. -1.51 ± 1.20 after 1 year of treatment, -2.09± 1.59 vs. -0.55 ± 1.19 after 3 years of treatment) and Group 2 (-1.57 ± 1.34 vs. -1.17 ± 1.12after 1 year of treatment, -1.50 ± 1.55 vs. -0.21 ± 0.74 after 3 years of treatment). This result could be due to improvement in bone age advancement during the treatment. The difference between mid-parental height SDS and PAH SDS was decreased after GnRHa treatment. However, the means of PAH SDS did not surpass the mid-parental height SDS. Conclusion: GnRHa treatment can preserve growth potential by slowing bone age progression, resulting in short adult height, but it cannot alter the genetic growth potential. 목적: 특발성 진성 성조숙증 환자에서 최종 성인키의 감소는 문제가 되어왔다. 이에 본 연구에서는 성선자극호르몬 방출호르몬 효능약제 치료 시작 시기가 예측 성인키의 변화에 미치는 영향에 대해 연구하고자 하였다. 대상 및 방법: 환자들이 8세 전에 유방의 발달을 보이거나, 성장속도의 급격한 증가와 골연령 진행을 보이는 경우, 성선자극호르몬 방출호르몬 자극검사를 실시하여 황체형성 호르몬이 기저치의 2~3배 이상 증가되고 최고농도는 5 IU/L 이상인 경우를 기준으로 104명의 환자를 성조숙증으로 진단하였다. 이 환자들을 8세 이전에 GnRHa로 치료를 시작한 60명의 환자 군(Group 1)과 8세에서 9세 사이에 치료를 시작한 44명의 환자 군(Group 2)으로 분류하였다. 이들을36개월간 추적 관찰하여 나이, 골연령, 키를 기준으로한 Bayley-Pinneau 방법 예측 성인키를 계산하였으며, 두 군간의 차이를 후향적으로 연구하였다. 결과: 치료 1년 후 PAH는 전체 환자에서는 152.10±8.30 cm에서 154.02±5.71 cm으로 증가하였으며, Group 1에서는 151.30±8.97 cm에서 153.23±5.79 cm으로, Group 2에서는 153.25±7.18 cm에서 155.16±5.45 cm으로증가하였다. 이와 같은 변화는 치료 기간이 연장될수록 뚜렷해져 치료를 3년동안 지속한 환자들에서는 151.57±9.13 cm에서157.94±5.81 cm으로 증가하였으며, Group 1에서는 151.0.±9.78 cm에서 157.94±5.81 cm으로, Group 2에서는153.33±6.84 cm에서 159.90±3.64 cm으로 증가하였다. 치료 기간 동안 골연령과 역연령의 차이는 치료 1년 후 전체 환자에서 1.99±1.16세에서 1.5±0.75세로 감소하였으며, Group 1에서는 2.37±1.04세에서 1.70±0.71세로, Group 2에서는 1.46±1.11세에서 1.28±0.84세로 감소하였다. 치료 3년 후에는 전체 환자에서는 2.03±1.19세에서 0.62±0.67세로, Group 1과 Group 2에서는 각각, 2.31±1.07세에서 0.76±0.67세로, 1.10±1.14세에서 0.178±0.45세로 변화를 보였다. PAH의 표준편차점수와 MPH의 표준편차 점수의 차이(PAH SDS-MPH SDS)는 치료 1년 후 전체 환자에서는 -1.49±1.44에서 -0.96±1.10으로 변화하였으며, Group 1에서는 -1.72±1.45에서 -1.08±1.09로 Group 2에서는-1.18±1.37에서 -0.78±1.10으로 변화하였다(P=0.20, Fig 5). 치료 2년 후에는 전체 환자에서는 -1.51±1.40에서 -0.44±0.98으로 변화하였고, Group 1에서는 -1.66±1.51에서 -0.57±1.03으로, Group 2에서는 -1.27±1.22에서 -0.26±0.87로 변화하였다. 하지만 PAH SDS의 평균은 MPH SDS의 평균을 넘지 못했다. 결론: 성선자극호르몬 방출호르몬 효능약제 치료는 골 성숙을 지연시킴으로써 성조숙증 환자들의 성장 가능성을 보존하지만, 환자들이 가진 유전적인 성장 가능성은 변화시키지 못한다. 또한 PAH의 획득은 환자들의 치료 시작시기보다는 진단 당시의 키와 MPH와 관련성을 가지는 것으로 보인다.

소아 천식 환자에서 비염과 천식과의 관계: 알레르기비염과 비알레르기비염 비교

권은별 ( Eun Byul Kwon ),백지현 ( Ji Hyeon Baek ),김형윤 ( Hyeong Yun Kim ),윤정원 ( Jung Won Yoon ),신윤호 ( Youn Ho Shin ),지혜미 ( Hye Mi Jee ),최선희 ( Sun Hee Choi ),한만용 ( Man Yong Han ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.3

Purpose: We aimed to determine the prevalence of allergic rhinitis and nonallergic rhinitis, difference in symptoms between allergic rhinitis and nonallergic rhinitis, and the association between lung function and the degree of asthma control in children with asthma. Methods: One hundred seventy patients who were followed-up for asthma treatment at the department of pediatrics of CHA Bundang Medical Center were enrolled in this study. We conducted the questionnaire regarding coexistence of rhinitis, childhood asthma control test (C-ACT), and the basic lung function test. The patients were classified as allergic rhinitis group and nonallergic rhinitis group according to the response to 11 common inhalation and food allergens, and assessed the degree of asthma control and the severity of rhinitis. Results: One hundred thirty patients (73%) were found to have rhinitis. Of these, 79 patients (53%) had allergic rhinitis and 34 patients (20%) had nonallergic rhinitis. The allergic rhinitis group was older than the nonallergic rhinitis group or the nonrhinitis group (7.73±2.85 vs. 5.97±2.48 vs. 6.12±2.70, P<0.001). Nasal itching sense was more prevalent in the allergic-rhinitis group than in the nonallergic rhinitis group (3.23±1.90 vs. 2.44±1.56, P=0.036). There was an inverse correlation between the rhinitis and C-ACT (r= -0.329, P<0.05). Of note, nasal obstruction symptom was highly correlated with C-ACT (r=-0.334, P<0.001). Conclusion: Allergic rhinitis and nonallergic rhinitis were highly prevalent in the pediatric patients with asthma and both of them had a significantly adverse impact on asthma control by rhinitis-itself. Therefore, regardless of atopic status, clinicians should focus on relieving rhinitis symptoms. (Allergy Asthma Respir Dis 2013;1:241-247)

소아 천식 환자에서 비염과 천식과의 관계: 알레르기비염과 비알레르기비염 비교

권은별 ( Eun Byul Kwon ),백지현 ( Ji Hyeon Baek ),김형윤 ( Hyeong Yun Kim ),윤정원 ( Jung Won Yoon ),신윤호 ( Youn Ho Shin ),지혜미 ( Hye Mi Jee ),최선희 ( Sun Hee Choi ),한만용 ( Man Yong Han ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1991 소아알레르기 및 호흡기학회지 Vol.1 No.3

Purpose: We aimed to determine the prevalence of allergic rhinitis and nonallergic rhinitis, difference in symptoms between allergic rhinitis and nonallergic rhinitis, and the association between lung function and the degree of asthma control in children with asthma. Methods: One hundred seventy patients who were followed-up for asthma treatment at the department of pediatrics of CHA Bundang Medical Center were enrolled in this study. We conducted the questionnaire regarding coexistence of rhinitis, childhood asthma control test (C-ACT), and the basic lung function test. The patients were classified as allergic rhinitis group and nonallergic rhinitis group according to the response to 11 common inhalation and food allergens, and assessed the degree of asthma control and the severity of rhinitis. Results: One hundred thirty patients (73%) were found to have rhinitis. Of these, 79 patients (53%) had allergic rhinitis and 34 patients (20%) had nonallergic rhinitis. The allergic rhinitis group was older than the nonallergic rhinitis group or the nonrhinitis group (7.73±2.85 vs. 5.97±2.48 vs. 6.12±2.70, P<0.001). Nasal itching sense was more prevalent in the allergic-rhinitis group than in the nonallergic rhinitis group (3.23±1.90 vs. 2.44±1.56, P=0.036). There was an inverse correlation between the rhinitis and C-ACT (r= .0.329, P<0.05). Of note, nasal obstruction symptom was highly correlated with C-ACT (r=.0.334, P<0.001). Conclusion: Allergic rhinitis and nonallergic rhinitis were highly prevalent in the pediatric patients with asthma and both of them had a significantly adverse impact on asthma control by rhinitis-itself. Therefore, regardless of atopic status, clinicians should focus on relieving rhinitis symptoms. (Allergy Asthma Respir Dis 2013;1:241-247)

시장활동에 참여했던 북한 여성들의 비공식 사회관계망 고찰

조현정,권은별 건국대학교 인문학연구원 2022 통일인문학 Vol.91 No.-

본 연구는 시장활동에 참여했던 북한 여성들의 비공식 사회관계망 형태와 특징을 현상학적으로 탐색하는 것을 목적으로 하였다. 연구결과 비공식 사회관계망 형태는 다음과 같다. 첫째, 북한의 여성들은 친분 관계망을 통해 적극적인 ‘연대와 재결속’을 다지고 있다. 둘째, 경제수단 관계망을 통해 소매와 도매 장사를 위한 ‘목적’ 관계를 형성하고 있다. 셋째, 지역사회 관계망을 통해 경제적 능력과 입지를 견고히 하기 위한 ‘이해’ 관계를 형성하고 있다. 다음으로 북한 여성들의 비공식 사회관계망의 특징은 다음과 같다. 첫째, ‘과시적 소비’를 통한 구별짓기가 확산되고 있다. 둘째, ‘사회적 자원’을 확장하기 위한 줄다리기에 사력을 다하고 있다. 본 연구는 북한 여성들의 비공식 사회관계망을 통한 인간관계 상호작용의 형태와 특징을 실증적으로 밝혀냈다는 점에서 의의가 있다. 북한 여성들의 비공식 사회관계망은 변화되는 의식과 실천을 통해 가족 구조와 지역사회 전반에 소극적 저항을 기반하는 균열을 만들어내고 있으며 점차 사회변동의 주요한 자원이 될 것으로 예측된다. 북한 정부의 통제에도 불구하고 여성들의 시장활동은 불가피하게 활성화될 수밖에 없다. 북한의 여성들은 자신의 비공식 사회관계망을 굳건히 다지면서 경제적 능력과 삶의 질을 높이기 위한 ‘타협’과 ‘협력’을 적극 활용할 것이다. 그러므로 경제적 능력을 갖춘 북한 여성들의 행위 주체성에 대한 논의가 과대·과소 평가되는 것과 같은 오류를 범해서는 안 되며, 북한 사회의 제한적 상황에서 이들의 가능성을 열어둘 필요가 있다.

Prevalence and comorbidity of allergic diseases in preschool children

김형은,권은별,백지현,신윤호,엄혜영,지혜미,윤정원,한만용 대한소아청소년과학회 2013 Clinical and Experimental Pediatrics (CEP) Vol.56 No.8

Purpose: Allergic disease and its comorbidities significantly influence the quality of life. Although the comorbidities of allergic diseases are well described in adult populations, little is known about them in preschool children. In the present study, we aimed to assess the prevalence and comorbidity of allergic diseases in Korean preschool children. Methods: We conducted a cross-sectional study comprising 615 Korean children (age, 3 to 6 years). Symptoms of allergic diseases were assessed using the Korean version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire that was modified for preschool children. Comorbidities of allergic diseases were assessed by ‘In the last 12 months, has your child had symptoms?’. Results: The prevalence of symptoms of asthma, allergic rhinitis, and atopic dermatitis as recorded using the ISAAC questionnaire, within the last 12 months was 13.8%, 40.7%, and 20.8%, respectively. The symptom rates of allergic conjunctivitis, food allergy, and drug allergy were 14.8%, 10.4%,and 0.8%, respectively. The prevalence of allergic rhinitis in children with asthma was 64.3% and that of asthma in children with allergic rhinitis was 21.6%. The prevalence of rhinitis in children with conjunctivitis was 64.8% and that of conjunctivitis in children with rhinitis was 23.6%. Conclusion: The prevalence of current rhinitis in our preschool children is shown to be higher than that previously reported. Allergic conjunctivitis is closely associated with asthma and allergic rhinitis. However, further studies are warranted to determine the prevalence and effects of these comorbidities on health outcomes in preschool children.

The relationship between serum adiponectin and inflammatory cytokines in obese Korean juveniles

변성환,권은별,김세영 대한소아청소년과학회 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.12

Purpose: Obesity is related to systemic inflammatory processes causing cardiovascular complications. Intercellular adhesion molecule-1 (ICAM-1), CD40 ligand (CD40L), P-selectin are newly describedmediators of inflammation and have a significant effect in atherosclerosis. Adiponectin has shownanti-inflammatory effects in adults. The aim of this study was to evaluate the relationship betweenadiponectin and inflammatory mediators in children and adolescents. Methods: Fifty children or adolescents, twenty two with a body mass index (BMI) over 95th percentile,and twenty eight with a BMI below 75th percentile were included in the study. Serum soluble ICAM-1(sICAM-1), P-selectin, CD40L, lipid profiles, aspartate aminotransferase, alanine aminotransferase,glucose and insulin were measured to evaluate associations with adiponectin. Comparison of thesevariables was performed between the obese and the nonobese group. Results: We found a adiponectin to be significant lower and sICAM-1 significant higher in the obesegroup compared to the nonobese group, but there were no significant differences in P-selectin andsoluble CD40L. Adiponectin was negatively associated with ICAM-1 and P-selectin in the obese group. Conclusion: Negative associations of adiponectin with ICAM-1 and P-selectin in obese children andadolescents suggest that serum adiponectin level may represent the inflammatory status.

조영제용 나노입자 합성을 위한 강건설계 사례

박주영,김응규,권은별,전봉식,명완재,변재현 대한산업공학회 2019 대한산업공학회지 Vol.45 No.5

A robust design methodology is applied to help establish nanoparticles synthesis method using FeOOH, which ismore economical and patent free than using FeClx. Before this experimental study the between-batch dispersionof the diameter of the synthesized nanoparticles was large due to noise factors. In order to increase the level ofquality reproducibility, we identified the noise factors influencing the variation of the nanoparticle size, selectedcontrol factors and their levels, and conducted a robust design to secure the uniformity quality. The quality ofreproducibility of the thermal decomposition method was found to be improved from less than 50% to 93% byconfirmation experiment. Follow-up experiment was run to transfer the optimal condition of the laboratory to thepilot plant scale.