膽石症에 對한 超音波撮影機의 診斷的 價値

張信珉,瀋鍾虎,金吉洙,金鎭漢,梁相基,李聖煥 대한적십자사 1983 적십자병원지 Vol.10 No.2

정상임신에 병존한 난소의 난포막황체화 낭포 1례 보고

장무정(MC Chang),신민균(MK Shin) 대한산부인과학회 1971 Obstetrics & Gynecology Science Vol.14 No.5

정상임신에 병존한 난소의 난포막황체화 낭포 1례 보고를 하는 바이다. Textbooks describe, lutein cystic cystic enlargement of the ovaries are frequently found in associaton with hydatidiform mole and choriocarcinoma or rarely in adenoma of the pituitary gland. Literatures of last 15 years report, theca lutein cysts of the ovaries are found occasionally in association with abnormal pregnancy and even with normal pregnancy. This report is of a patient who complained of a large rapid growing ovarian mass at 8 week`s gestation, which was lined by luteinized theca interna and granulosa cells.

자궁낭포 3례 보고

장무정(MC Chang),신민균(MK Shin) 대한산부인과학회 1971 Obstetrics & Gynecology Science Vol.14 No.5

자궁낭포 3례 보고하는 바이다. Cysts and cystic cavities of the uterus are frequently observed during gynecologic pathological examination. In contrast with cysic cavities, true cysts of the uterus are rare1,2). Because the entity is unusual, we wish to present 3 cases of cyst of the uterus in this paper.

惡性膣黑色腫의 1例

金宰旭,申玟均,張武丁,崔英實 대한산부인과학회 1972 Obstetrics & Gynecology Science Vol.15 No.7

밀폐공간 종류별 유해가스 발생 농도 평가

박현희,함승헌,신민아,장경조,윤충식,유계묵,정광재,이구용 한국산업보건학회 2009 한국산업보건학회지 Vol.19 No.4

Confined spaces are inherently dangerous workplace and many fatal and nonfatal accidents have been reported. In Korea, total 237 occupational accidents have been reported during 1999-2007. Out of 237 cases, 76 %(179 cases) was classified as fatal. Even though these accidents occur in various kinds of confined spaces, there has rarely been reported on the health hazard agent, i.e., the types of gases and their concentration ranges. Therefore in this study, we evaluated several toxic and asphyxiating gas concentrations in various confined spaces. We surveyed 57 manholes, 3 sewage treatment plants, 2 yellow radish manufacturing companies and 7 barges to measure the concentrations of oxygen(O2), hydrogen sulfide(H2S), carbon monoxide(CO), ammonia(NH3). Lower Explosion Limits(LEL) and Volatile Organic Compounds(VOCs). Those four types of confined spaces occupies 56% of accidents during last 9 years in Korea. In 57 manholes, the concentration varied according to the types of manholes; rainfall and sewage, and by location; residential and industrial areas. Sewage manhole in industrial area was evaluated as the most hazardous than other types of manhole like rainfall manholes, residential sewage manholes. The highest H2S concentration and the lowest O2 concentration at sewage manhole in industrial area were 300 ppm, 8.7% respectively. In 3 sewage treatment plants, H2S and NH3 concentrations were reached up to the 500 ppm and 200 ppm respectively. Two yellow radish manufacturing companies showed the concentrations of 316 ppm, 505.2 ppm, 90 ppm and 15.7% for H2S, CO, VOCs and O2, respectively. Seven barges showed 15.9%~20.9% oxygen concentration. Gas species and concentration ranges varied by the types and location of confined spaces; CO, H2S, O2 could be hazardous in manhole, especially manhole connected to sewage plants. CO, H2S, LEL, O2, NH3 should be controlled in sludge silo and sluge pumping confined spaces in sewage treatment plant. The activity of lifting out radish from the storage tank was evaluated more hazardous rather than the other activities in yellow radish manufacturing industry. The employers must conduct the survey to identify all possible confined spaces in their local workplace prior to performing the tasks. At the national level to reduce the accidents in the confined spaces, we suggest that systemic approach and active education program including possible hazards, standard operation procedures, ventilation plan, and personal protective equipment in confined spaces should be implemented.

Plasma Adiponectin Concentration and Its Association with Metabolic Syndrome in Patients with Heart Failure

원호연,강석민,신민정,오재원,홍남기,박성하,이상학,장양수,정남식 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.1

Purpose: Plasma adiponectin concentrations are inversely related with metabolic syndrome (MetS), and MetS is associated with increased risk for heart failure (HF). However, the relationship between adiponectin and MetS in HF remains undetermined. Therefore, we tested whether MetS was associated with the degree of plasma adiponectin concentrations in HF patients. Materials and Methods: One hundred twenty eight ambulatory HF patients with left ventricular ejection fraction of <50% (80 males, 61.8±11.9 years old) were enrolled for this cross-sectional study. Echocardiographic measurements were performed, and plasma concentrations of adiponectin, lipoproteins, apolipoproteins (apoB, apoA1) and high sensitive C-reactive protein (hsCRP) were measured. Results: Adiponectin concentrations in HF patients with MetS (n=43) were significantly lower than those without MetS (n=85) (9.7±7.0 vs. 15.8±10.9 μg/mL, p=0.001). Higher concentrations of apoB (p=0.017), apoB/A1 ratio (p<0.001), blood urea nitrogen (p=0.034), creatinine (p=0.003), and fasting insulin (p=0.004) were observed in HF patients with MetS compared with those without MetS. In HF patients with MetS, adiponectin concentrations were negatively correlated with hsCRP (r=-0.388, p=0.015) and positively correlated with the ratio of early mitral inflow velocity to early diastolic mitral annular velocity, E/E' (r=0.399, p=0.015). There was a significant trend towards decreased adiponectin concentrations with an increasing number of components of MetS (p for trend=0.012). Conclusion: Our study demonstrated that adiponectin concentrations decreased in HF patients with MetS, and that relationship between adiponectin, inflammation and abnormal diastolic function, possibly leading to the progression of HF.

Cathepsin L derived from skeletal muscle cells transfected with bFGF promotes endothelial cell migration

정지형,Eun Kyoung Im,진태원,이승민,Soo Hyuk Kim,Eun Young Choi,신민정,이경혜,장양수 생화학분자생물학회 2011 Experimental and molecular medicine Vol.43 No.4

Gene transfer of basic fibroblast growth factor (bFGF)has been shown to induce significant endothelial migration and angiogenesis in ischemic disease models. Here, we investigate what factors are secreted from skeletal muscle cells (SkMCs) transfected with bFGF gene and whether they participate in endothelial cell migration. We constructed replication-defective adenovirus vectors containing the human bFGF gene (Ad/bFGF) or a control LacZ gene (Ad/LacZ) and obtained conditioned media, bFGF-CM and LacZ-CM,from SkMCs infected by Ad/bFGF or Ad/LacZ,respectively. Cell migration significantly increased in HUVECs incubated with bFGF-CM compared to cells incubated with LacZ-CM. Interestingly, HUVEC migration in response to bFGF-CM was only partially blocked by the addition of bFGF-neutralizing antibody, suggesting that bFGF-CM contains other factors that stimulate endothelial cell migration. Several proteins, matrix metalloproteinase-1 (MMP-1), plasminogen activator inhibitor-1 (PAI-1), and cathepsin L, increased in bFGF-CM compared to LacZ-CM; based on 1-dimensional gel electrophoresis and mass spectrometry. Their increased mRNA and protein levels were confirmed by RT-PCR and immunoblot analysis. The recombinant human bFGF protein induced MMP-1,PAI-1, and cathepsin L expression in SkMCs. Endothelial cell migration was reduced in groups treated with bFGF-CM containing neutralizing antibodies against MMP-1 or PAI-1. In particular, HUVECs treated with bFGF-CM containing cell-impermeable cathepsin L inhibitor showed the most significant decrease in cell migration. Cathepsin L protein directly promotes endothelial cell migration through the JNK pathway. These results indicate that cathepsin L released from SkMCs transfected with the bFGF gene can promote endothelial cell migration.

담석증에 대한 초음파촬영기의 진단적 가치

이성환 ( Sung Hwan Lee ),양상기 ( Sang Ki Yang ),반종호 ( Jong Ho Ban ),장신민 ( Shin Min Chang ),김길수 ( Gill Su Kim ),김진한 ( Jin Han Kim ) 대한내과학회 1982 대한내과학회지 Vol.25 No.8

성인 속립성결핵의 임상적 관찰

송창섭 ( Chang Sup Song ),이근배 ( Keun Bae Lee ),반종호 ( Jong Ho Ban ),장신민 ( Shin Min Chang ),김길수 ( Gill Su Kim ),김진한 ( Jin Han Kim ),서명수 ( Myeoung Su Seo ) 대한내과학회 1982 대한내과학회지 Vol.25 No.7

건물 저층과 고층에서 환기와 공기정화 식물을 통한 라돈 농도의 비교

공유진(Yu-jin Gong),남소영(So-Yeong Nam),신민서(Min-Seo Shin),장혜림(Hey-Rim Jang),전민철(Min-Cheol Jeon),유세종(Se-Jong Yoo),김성호(Seong-Ho Kim) 한국방사선학회 2020 한국방사선학회 논문지 Vol.14 No.7

본 연구는 건물의 저층과 고층에서 환기와 공기정화 식물을 통한 라돈의 농도 변화를 정량적으로 측정하고자 하였다. 건물의 저층과 고층에서 라돈 농도 측정을 위해 시간을 설정하고 라돈 측정기를 이용하여 실내를 폐쇄 했을 때와 환기, 공기정화식물을 배치했을 때의 라돈 농도를 각각 측정하여 비교하였다. 폐쇄, 환기, 공기정화식물 배치에 따라 라돈 농도 변화에 유의한 차이를 보이는지 검증하고자 일원배치 분산분석(One-way ANOVA)를 시행하였다. 실험 결과 건물의 저층과 고층에서 환기와 공기정화식물 배치를 통한 라돈 농도의 감소는 통계적으로 유의한 차이를 보였으며, 환기와 공기정화식물을 배치 했을 때에는 통계적으로 유의한 차이점을 나타내지 않았다. 따라서 건물내 환기 뿐만 아니라 공기정화식물을 적절히 활용하면 라돈 농도를 효과적으로 감소시킬 수 있을 것으로 사료된다. The objective of this study was to quantitatively measure the changes in radon concentration due to ventilation and air purification plants in the lower and upper floors of a building. This study measured and compared radon concentration in the lower and upper floors of the building by using a radon meter when the room was closed, it was ventilated, and air purification plants were installed at a specific time. One-way ANOVA was conducted to evaluate the effect of treatment (i.e., closure, ventilation, and air purification plants) on radon concentration. The results of this study showed that ventilation and air purification plants significantly decreased radon concentration in the lower and upper floors of the building, but the effect of ventilation and that of air purification plants were not significantly different. Therefore, it will be possible to reduce radon concentration effectively when ventilation and air purification plants are used appropriately.