경구면역을 통한 항원 특이적 IgA 항체 합성에 있어 Cholera Toxin과 Alginate-Microsphere의 효과

송민형,유진수,권명상,성승룡,김용희,권익찬,정서영,양재명,김평현 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.3

Secretory (S-IgA) isotype antibody (Ab) is known to play an essential role in the primary defense against various infectious agents in mucosal tissue. However, it has been mostly unsuccessful in the induction of antigen (Ag)-specific IgA Ab response in this site by peroral vaccination. In the present study, we investigated the effect of cholera toxin (CI) as a mucosal adjuvant and alginates-microspheres as a carrier on BSA-specific IgA Ab response in gut-associated lymphoid tissue`(GALT). Peroral immunization of BSA plus CT conferred a great BSA-specific IgA response but IgG response on intestinal fluid (IF). In contrast, intraperitoneal immunization of BSA with Freund's adjuvant readily induced BSA-specific IgG response but IgA response in IF. Further, number of CT specific IgA-secreting cells was substantially increased in mesenteric lymph node when CT-encapsulated-VI alginates-microspheres was administered perorally. Taken together, these results indicate that peroral immunization of soluble antigen in combination of CT or microspheres significantly enhances antigen-specific IgA response in GALT.

河川 水質解析 模型의 水理學的 改善方案

宋在偶,朴永軫 弘益大學校 科學技術硏究所 1995 科學技術硏究論文集 Vol.6 No.-

River pollution problems become more serious, and it is required that development of consistent plan for water quality or river system through the efficient use of water quality modeling. The characteristics of water quality in the downstream of the Han River were analyzed by deterministic technique. QUAL2E model was updated to simulate the water qualities, and improvable methods were applied on hydraulic analysis and estimation of optimal reaction coefficients. The varied flow analysis was performed in the reach of Paldang dam to Indogyo considering the effect of Jamsil submerged weir. A Sensitivity analysis was made to determine the significant reaction coefficients and an optimization technique by BFGS was used to estimate them. The calibration and verification were performed by using observed water quality data for the Han River. The Computed BOD, DO, T-N and T-P concentrations showed good agreements with the observed. The prediction of water quality in the river was made for the various discharge conditions and wastewater treatment alternatives.

N個 프로세스에 의하여 竝行遂行하는 R/W에 관한 硏究

송영재,최범재 慶熙大學校 1986 論文集 Vol.15 No.-

In this paper, the algorithm for N-asynchronous processes reading and writing shared data while data are being modified by another process is proposed. The classical concurrent reading and writing problem is solved by using mutual exclusion. Though mutual exclusion solved concurrent R/W problem, it involved waiting. For the purpose of reducing waiting time by mutual access of shared data, copying of shared data is permitted. This algorithm takes advantage of ability is make copies of the shared data. Consequently, copying of shared data can be reduced and even eliminated However, one of the most notable deficiencies of this algorithm is that the writer, during a single pass, may nave to make n copies for the reader. In the future, it should be studied about reducting copying buffer numbers of shared data and using original nature of shared data.

곡률비 분포에 의한 유로이동해석과 유로 만곡부의 이동한계

宋在偶,朴永軫 弘益大學校 科學技術硏究所 1993 科學技術硏究論文集 Vol.3 No.-

A study on the channel migration of rivers is very important problems in a point of view river disaster protection and river preservation. The purpose of this study is to examine the lateral migration rate by the curvature ratio (R/W) and maximum limitation of meander belt. The results of data anlysis, channel migration rate (M) represented that the zone of bend development and the zones of curvature ratio 2∼4 were lager 12% than other zones for Seom River. The range of R/W value are concentrated 2∼4 for study rivers, the value can be regarded to the possibility of bank erosion. The results of the study indicate that analysis of the channel changes in river geometry can provide the basic data for long-term development of river basin.

NaNO₂의 N 핵사중극 공명 연구

박영민,송승기,강재필,서용문 명지대학교 자연과학연구소 1995 자연과학논문집 Vol.12 No.-

펄스형 핵사중극 공명장치(Pulsed system)를 이용하여 상온에서 NaNO? 분말시료의 위와 아래 공명진동수, 핵사중극 결합상수, 비대칭인자와 스핀-스핀완화시간을 구하였다. FID공명선으로부터 구한 값은 υ+=4.6354 NHz/ υ-=3.5983 MHz, e?qQ/h=5.4891 MHz와n=0.3779이었다. 90?,ι, 180? 펄스연속(spin-echo 신호)과 r를 변화시켜 얻은 진폭을 이용하여 스핀 -스핀 완화시간 T2를 측정하였다. 이결과 υ(T?)=2.50ms, υ-(T?)=2.17ms임을 보였다. Measurements of the upper and lower resonance freqency, quadrupole coupling constant, asymmetry parameter and spin-spin relaxation time are reported for NaNO? powder sample by using the pulsed NQR system at room temperature.From FID line-shapes, we obtained υ=4.6354 MHz, υ=3.5983 MHz, e?qQ/h=5.4891 MHz and η=0.3779. The spin-spin relaxation time T? was maesured using a 90?,ι, 180? pulsed sequanco (spin-echo signals) and varying τwhile measuring the amplitude of the echo. The result showed υ+(T?) =2.50 ms and υ+(T?) =2.17ms.

신장의 원시성 신경외배엽 종양

송상용,조은윤,이정원,고재향,김미경,김대식,고영혜 대한병리학회 1998 Journal of Pathology and Translational Medicine Vol.32 No.3

山사 抽出液이 白鼠의 肥滿模型에 미치는 影響

高光宰,宋勇善 한국전통의학연구소 1998 한국전통의학지 Vol.8 No.1

山사抽出液이 gold thioglucose와 高脂肪食餌로 誇發한 肥滿 마우스에 미치는 效果와 前脂肪細肥의 增殖과 分化에 미치는 影響을 觀察한 結果 다음과 같은 結果를 보였다. 1. 山사抽出液은 肥滿白鼠의 體重增加를 抑制하는 效果를 나타냈다. 2. 山사 抽出液은 血淸 transaminase의 개선을 確認할 수 있었다. 3. 山사 抽出液은 肝의 脂質및 體脂訪의 增加를 抑制하는 效果를 보였다. 4. 山시 抽出物은 子宮周圍 脂訪組織 및 肝의 重量에서도 有意性있는 減少 效果가 認定되었다. 5. 山사 抽出液이 前脂訪細胞인 未分化狀態의 3T3-L1細胞의 增殖을 抑制하는 效果를 보였다. 6. 山사 抽出物은 自然分化時 3T3-L1細胞의 分化能에 有意性있는 결과를 보였다. 7. 山樓 抽出液은 誇發分化時 3T3-L1의 分化能에 有意性있는 脂訪細胞分化의 抑制效果틀 나타냈다. 以上의 效果로 미루어 보아 山사 抽出液은 脂訪細胞의 過多한 分化와 增殖,蓄積에 따른 肥滿症과 脂訪肝 및 代謝疾患의 臨床治療에 應用될 수 있을 것으로 思料된다. Fructus crataegi water extract may be effect on the obesity of white mouse induced by gold thiogluoose. It is researched to elucidate the effects of Fructus crataegi water extract on the obesity of white mouse induced by gold thiogluoose and the differetiation and growth of preadipocyte, 3T3-L 1. The results are as follows; 1. Fructus crataegi water extract improved the blood level of transaminase on the obesity of white mouse induced by gold thiogluoose. 2. Fructus crataegi water extract inhibited the increase of liver fat and body fat on the obesity of white mouse induced by gold thioglucose. 3. Fructus crataegi water extract inhibited the increase of body weight on the obesity of white mouse induced by gold thiogluoose. 4. Fructus crataegi water extract inhibited the growth of undifferentiate preadipocyte 3T3-L 1. 5. Fructus crataegi water extract influenced on the adipocyte differentiation of 3T3-L 1 cell line in the uninduced differentiation of mouse by Fe 10, 100㎍/㎖. 6. Fructus crataegi water extract decreased weight of liver and preuterine lipid tissue of obese mouse induced by the administration of gold thiogluoose. 7. Fructus crataegi water extract showed the effects of inhibition on the adipocyte differentiation of 3T3-L1 Cell line in the induced differentiation. The above results suggested that the Fructus crataegi water extract may be used on the obesity induced by the overgrowth and differentiation of adipocyte. and the accumulation of fat on liver and body.

고주파용 칩인덕터 유리소재 개발

김영호,송민석,윤영진,박찬욱,이재열 嶺南大學校 工業技術硏究所 2003 工業技術硏究所論文集 Vol.31 No.1

The glass systems of SiO_2-Al_2O_3-B_2O_3-K_2O were fabricated with the composition of SiO_2 65∼76wt%, B_2O_3 20∼30wt%, Al_2O_3 0.3∼4.5wt%, and K_2O 0.5∼2.5wt% for mother glass of high frequency chip inductor. The glasses were prepared by quenching the melt from 1500℃ and analyzed by X-ray diffraction. The specimens were prepared with composites of ball milled glasses powder mixed with 0∼50wt% of alumina powder. After heat treating at 850℃∼950℃, sintering behaviors were observed by measuring the density of specimens as a function of temperature and the amount of alumina. Dielectric constants and dissipation factors were evaluated with HP-4192A as well as other crucial properties such as strength, softening point and thermal expansion. The density, dielectric constant and dissipation factor of specimen were 2.61g/㎟, 5.9∼6.2 and 0.0013∼0.0016 at 1㎒, respectively.

人工甘味料의 合成過程에 對한 再考

박숙자,안송자,유영자,윤정자,윤종은,이명재,정규영,황민자 梨花女子大學校 藥學硏究所 1963 梨花藥學硏究 Vol.- No.4

우리나라 지역 직업성질환 감시체계의 현황과 전망

임종한,장성실,김성아,문재동,채창호,홍윤철,김수영,김진석,김영욱,한상환,이혜숙,원종욱,송동빈,하은희,강성규 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

기존의 특수건강진단과 작업환경측정을 통한 직업병 관리가 진폐증, 소음성난청 등의 소수 특정질환에 국한되고 실제 직업병 발생 규모 파악이나 신종 직업병의 발견에 한계를 보인다는 사실은 산업의학전문가들 사이에서도 공감을 이루고 있다. 미국과 영국 등에서의 직업성질환 감시체계에 대한 경험은 우리 나라의 직업성질환 감시체계 구축에도 새로운 자극제가 되면서, 1998년이후 인천, 대전, 여천, 구미, 부울경 지역에서 지역 직업성질환감시체계를 산업보건관리의 중요한 시스템으로 구축하려는 노력이 확산되고 있다. 새로이 구축되어지는 이들 지역 직업성질환 감시체계는 감시하고자 하는 대상질환, 활용 가능한 인적자원 및 자료원, 지역 의료체계의 특수성 등에 따라서 목적과 방법을 달리하면서 독특한 형태로 발전을 하고 있다. 각 지역단위 감시체계들이 그 상황에 맞게 독특한 목적과 전략들을 발전 시키면서도, 향후 발전할 국가적인 차원의 직업성질환 감시체계 구축을 위하여 직업성질환 감시의 기본 전략 등을 공유하는 등의 노력이 필요하다. 환례 정의 및 기본적인 등록 서식의 공유, 직업성질환 감시 자료원의 발굴, 공동의 정보 네트워크 및 직업성질환 감시 데이터베이스 구축 등 직업성질환 감시활동을 지원하기 위한 여러 기초 인프라 구축에 힘을 모아야 할 것이다. 우리 나라에서 직업성질환 감시체계를 성공적으로 구축하기 위해서는 수집된 자료의 질 관리를 위한 직업성질환 감시의 원칙 제정과 감시 전략의 공유 등이 필요하며, 전국적인 직업성질환 감시체계의 하부구조라고 할 수 있는 지역감시체계의 기초 토대 마련과 강화작업이 절실하게 필요하다.