Slide Session : OS-IFD-07 ; Infectious Disease : In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus

( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.

부르따뉴의 부활

이산호 프랑스문화예술학회 1999 프랑스문화예술연구 Vol.1 No.-

La Bretagne est le pays de la mer, des forets mystherieux dt des legendes. Jusqu'au milieu du XVIIIe siecle, ce pays dont les habitants qui formaient un etat different du reste de la France par le genie, les moeurs et la langue, a reste pEr connu dans l'histoire et la litterature. Les oeuvres de Chateaubriand sont pleines de l'ame bretonne. Dans les Martyrs dont queques descriptions concernent le paysage breton et les environs du chateau paternel, Chateaubriand a fait renaitre la vie meme de ses aieux, leurs caracteres, leurs moeurs et leur culte druidique. La Bretagne a recu pour longtemps d'un de ses plus illustres fils, Chateaubriand son image. Avec sa couleur historique et locale, le tableau de la Bretagne dans les Martyrs marque une etape interessante de la formation des idees de l'ecole romantique. Poete-historien, Chateaubriand a cree L'histoire romantique avec la description vivante des tableaux historiques, et il a fait entrer pour la premiere fois son pays natal, la Bretagne, dans la litterature francaise. Apres lui, elle a tenu une place importante dans l'histoire francaise, grace a Renan, Lamennais, Michelet et Augustin Tierry.

샤또브리앙과 낭만주의적 역사

이산호 중앙대학교 인문과학연구소 2001 人文學硏究 Vol.32 No.-

대형할인점 리모델링 프로젝트의 CM at Risk 적용 타당성에 관한 연구

최규산,이호경,박영호,백준홍 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

Remodeling projects are on a increasing trend because of the old buildings built in 1960-70's, the preference for energy saving and the changes of social demands and government policies, etc. And also discount-store projects, which are rapidly increasing, are characterized by the fact that they are repetitive and have analogous scale and structure. Therefore, it is necessary to develop the concept discount-store model and apply the appropriate project delivery system for a successful execution of the projects. The purpose of this study is to analyze the characteristics of the discount-store remodeling projects and propose CM at Risk for the optimum delivery system of those projects.

경추 손상후 사망례에 대한 분석

정호성,김상은,이준형,박철완,이 근 大韓應急醫學會 1996 대한응급의학회지 Vol.7 No.1

Mortality after cervical spine injury(CSI) is reported as high as 10∼30%, and it is intimately related to the initial management and cardiopulmonary function. We analyzed the cause of death for 29 patients who expired at Chung Ang Gil Hospital after CSI between 1990 and 1994. Of 198 patients with CSI, 43 patients(21m7%) died. Except 14 cases with concomitant fatal head injury and/or multiple systemic injuries, the mortality rate of CSI was 14.6%. Male to female ratio was over 6:1. Fourth to sixth decades constituted 69.0%. Common causes of CSI were traffic accidents(58.6%) and fall/slip(34.5%). The level of CSI was above C5(upper cervical group: UCG) in 65.5%, and below C4(lower cervical group: LCG) in 34.5%. Most of them(86.2%) died within four weeks after CSI. Early death(within 7 days) was more common in the UCG(57.9%) than the LCG(20.0%). Associated injuries were found in 72.4%, and the head injury was the most common one. The higher the Injury Severity Score(ISS), the earlier the patients expired(Fisher`s test, P<0.05). On arrival, hypotension(systolic blood pressure below 90mmHg), bradycardia(less than 60/min), and respiratory arrest was found in 31.0%, 34.5% and 17.2%, respectively. The episode of bradycardia was found in 58.6%. It was more common in cases of early death(69.2%) than those of the late death(50.0%). Hypoxia, hypercarbia, and acidosis was observed in 20.7%, 17.2%, and 51.7%, respectively. Respiratory failure was responsible for the majority(89.7%) of death. In UCG and the cases of the early death, primary respiratory dysfunction was the main cause of death, while in LCG and the cases of the late death, pulmonary complication was the major reason(Fisher`s test P<0.01, P<0.01, respectively).

회전자 구조에 따른 SRM의 토오크 특성해석

정도영,이상호,서진우,오홍석,최경호 三陟大學校 1997 論文集 Vol.30 No.1

The switched reluctance motor(SRM) has a simple rotor construction with no windings. It also has simple concentrated windings on the stator. Thus, it is expected to be a lower cost machine to manufacture than the squirrel cage induction motor. This paper presents an advanced rotor structure type, well-round rotor type in SRM. To design the improved SRM we have used FEM and studied and compared with each other. The static torque, instantaneous torque and average torque are more improved than that of typical rotor type which has been a lot of used for SRM.

Afloqualone(Arobest^(�))이 뇌척수 병변시 동반된 강직의 치료효과에 대한 임상적 연구

윤승호,박상균,이제운,김봉옥 최신의학사 1992 最新醫學 Vol.35 No.3

우수방사성의약품 생산시설 개발

신병철,정원명,박상현,이규일,박경배,박진호 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

Manufacturing facilities of the pharmaceuticals must meet certain level of the cleanness required so that foreign substances such as dust, moisture, heat, microorganism, or virus do not contaminate the product. In case of radiopharmaceuticals for medical treatment and diagnosis, not only should the operators and environment be protected from radiation but also need to be isolated from the foreign contaminant. Therefore, manufacturing facilities for radiopharmaceuticals must satisfy the design standards of both hot cell and clean room which are specified by GNP. However, standards of maintaining negative pressure for preventing spread of radioactive contaminant in isolated facilities conflict with the standards of maintaining positive pressure for keeping cleanness. To solve this problem, are pressure of hot cell was designed lower than in the adjacent area to meet standards of the radiation safety. To keep higher cleanness in certain part of the hot cell for filling, minimal relative positive pressure allows. In order to effectively maintain the cleanness that is required for production of Tc-99m generator, which takes 70% of whole demand of radiopharmaceuticals, the rooms placed in each side of production room are used as a buffer area and three lead hot cells are installed in production room. In this research, we established the appropriate engineered design concept for Tc-99m generator manufacturing facility, which satisfies both GMP cleanness standard for preventing particles, bacteria, other contaminants and the regulations of radiation safety for supervising and controlling the amount of radiation exposure and exhausted radioactivity. And the concept of multi-buffer zones is introduced to apply negative air pressure for hot cell with first priority and to continue relative positive air pressure for clean room.

Visual Attentional Pattern of the Eyewitness in a Mock Crime with Weapon Presence

San Ho Lee(San Ho Lee),Chankyu Lee(Chankyu Lee),Gi-Eun Lee(Gi-Eun Lee),Jang-Han Lee(Jang-Han Lee) 한국자료분석학회 2022 Journal of the Korean Data Analysis Society Vol.24 No.5

The weapon focus effect is defined as eyewitnesses focus more on weapons than other details(e.g., perpetrator) of the crime scene which cause memory bias. The present study investigated how the presence of a weapon affects the visual attention and memory of the eyewitness. Participants were randomized within two groups: the weapon focus effect condition(WC) and the novelty condition(NC). The participants' visual attention pattern(dwell time) was measured while participants were observing the interaction between the two individuals(clerk and customer) at the mock crime slide show. At the end of the experiment, the participants were asked about what they saw on the slide show. As a result, it was confirmed that the weapon condition showed a different attention pattern from those in the non-weapon condition. Overall, both groups were found to spend more time on target objects(knife/cashier's check), but WC participants spent longer time on clerks when weapons were presented than NC participants. On the other hand, in both groups, there was no difference in memory. This study provided evidence for the visual attention patterns of eyewitnesses at simulated crime scenes with weapons.

An exploratory study on the effect of mental rehearsal on the virtual body swapping illusion

San Ho Lee(San Ho Lee),Gi-Eun Lee(Gi-Eun Lee),Jang-Han Lee(Jang-Han Lee) 한국자료분석학회 2022 Journal of the Korean Data Analysis Society Vol.24 No.3

The body swapping illusion is a perceptual phenomenon in which one perceives a virtual (or another) body as being one’s own. The aim of this study was to investigate the effects of mental rehearsal on the generation of the body swapping illusion. Participants were 58 male undergraduate students. Participants were randomly assigned to either the physical rehearsal (n=20), mental rehearsal (n=18), or control condition (n=20). There were no significant differences in state and trait anxiety, simulator sickness, or immersive tendencies between groups, but there were significant differences in the body swapping illusion and a sense of presence between conditions. Subsequent post-hoc analyses revealed that the body swapping illusion was significantly greater in the physical and mental rehearsal conditions than the control condition, and the sense of presence was significantly greater in the physical rehearsal than in the control condition. In conclusion, we found that mental rehearsal exerted similar effects as physical rehearsal ingenerating the illusion of body swapping. This suggests that generating the illusion of body swapping through mental rehearsal may be applicable in clinical settings.