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부유대역 용융응고법으로 제조된 YBa_2Cu_3O_x 산화물초전도체의 미세구조와 전기적 특성
노태형,송정환,장규철,한이섭,김소정,구본급,김호기 대전산업대학교 반도체기술연구소 2000 半導體技術硏究所報 Vol.2 No.-
The YBa_2Cu_3O_x-20 wt% Y_2BaCuO_5 composition designed in YBCO system was synthesized by solid state reaction method. The optimum condition of hot zone temperature and growth rate in floating-zone melt were 1080 ℃ and 2.5 mm/hour, respectively. In samples growth as these condition, the low angel boundaries in grain direction and small amount of amorphous phase known as decreasing characteristics of superconducting materials between grain boundaries in microstructure are investigated by polarized light microscopy on the whole. The critical current density(Jc) at 77k of sample using powder fabricated with no CeO_2 and doped 5 wt%CeO_2 were 8,000 A/㎠(Jc : 561A) and 12,000 A/㎠(Jc: 826A) at 0 T by direct current transport method, respectively.
Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet
Han, So-Ra,Oh, Ki-Sook,Yoon, Yoo-Sik,Park, Jeong-Su,Park, Yun-Sun,Han, Jeong-Hye,Jeong, Ae-Lee,Lee, Sun-Yi,Park, Mi-Young,Choi, Yeon-A,Lim, Jong-Seok,Yang, Young The Korean Nutrition Society 2011 Nutrition Research and Practice Vol. No.
Target herbal ingredient (THI) is an extract made from two herbs, Scutellariae Radix and Platycodi Radix. It has been developed as a treatment for metabolic diseases such as hyperlipidemia, atherosclerosis, and hypertension. One component of these two herbs has been reported to have anti-inflammatory, anti-hyperlipidemic, and anti-obesity activities. However, there have been no reports about the effects of the mixed extract of these two herbs on metabolic diseases. In this study, we investigated the metabolic effects of THI using a diet-induced obesity (DIO) mouse model. High-fat diet (HFD) mice were orally administered daily with 250 mg/kg of THI. After 10 weeks of treatment, the THI-administered HFD mice showed reduction of body weights and epididymal white adipose tissue weights as well as improved glucose tolerance. In addition, the level of total cholesterol in the serum was markedly reduced. To elucidate the molecular mechanism of the metabolic effects of THI in vitro, 3T3-L1 cells were treated with THI, after which the mRNA levels of adipogenic transcription factors, including C/$EBP{\alpha}$ and $PPAR{\gamma}$, were measured. The results show that the expression of these two transcription factors was down regulated by THI in a dose-dependent manner. We also examined the combinatorial effects of THI and swimming exercise on metabolic status. THI administration simultaneously accompanied by swimming exercise had a synergistic effect on serum cholesterol levels. These findings suggest that THI could be developed as a supplement for improving metabolic status.
<i>Artemisia asiatica</i> ethanol extract exhibits anti-photoaging activity
Jeong, Deok,Lee, Jongsung,Jeong, Seong-Gu,Hong, Yo Han,Yoo, Sulgi,Han, Sang Yun,Kim, Ji Hye,Kim, Sunggyu,Kim, Jin Sic,Chung, Young Soo,Kim, Jong-Hoon,Yi, Young-Su,Cho, Jae Youl Elsevier 2018 Journal of Ethnopharmacology Vol.220 No.-
<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P> <I>Artemisia asiatica</I> Nakai is a traditional herbal plant that has long been used in anti-inflammatory, anti-infective and skin protective remedies.</P> <P><B>Aim of the study</B></P> <P>In this study, traditionally known skin-protective activity of <I>Artemisia asiatica</I> Nakai was examined with its ethanol extract (Aa-EE) under various photoaging conditions using skin-originated cells, and the underlying mechanism was also examined using various types of cells.</P> <P><B>Materials and methods</B></P> <P>Effects of Aa-EE on cell viability, photocytotoxicity, and expression of matrix metalloproteinases (MMPs), cyclooxygenase (COX)-2, and moisturizing factors were measured in B16F10, HEK293, NIH3T3, and HaCaT cells under untreated and ultraviolet B (UVB)-irradiation conditions. Anti-melanogenic effect of Aa-EE was also examined by measuring both melanin content in B16F10 cells and tyrosinase activity. Anti-photoaging mechanism of Aa-EE was explored by determining the activation levels of signaling molecules by immunoblotting analysis.</P> <P><B>Results</B></P> <P>Aa-EE protected HaCaT cells from UVB irradiation-induced death. Aa-EE increased the expression of a type 1 pro-collagen gene and decreased the expression of matrix metalloproteinases, and COX-2 in NIH3T3 cells induced by UVB. Aa-EE increased the expression of transglutamase-1, hyaluronic acid synthase (HAS)-2, and HAS-3 in HaCaT cells and decreased the production of melanin in α-melanocyte-stimulating hormone-stimulated B16F10 cells by suppressing tyrosinase activity and the expression of tyrosinase, microphthalmia-associated transcription factor, tyrosinase-related protein (TRP)-1 and TRP-2.</P> <P><B>Conclusion</B></P> <P>The results suggest that Aa-EE could be skin-protective remedy with anti-photoaging, anti-apoptotic, skin remodeling, moisturizing, and anti-melanogenesis properties.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
A Design of New Surface Gradient Coil and Its Application to MR Computerized Tomography
Yi, Jeong-Han,Cho, Zang-Hee The Korean Society of Medical and Biological Engin 1992 의공학회지 Vol.13 No.3
A new three-channel surface gradient coil obtained by using numerical optimization and its application to MR computerized nomography are presented. The new surface gradient coil pro aided linear field gradient region more than twice wider compared with the t'irst surface gradi encl coil, removed torque and field offset, and reduced coupling between the surface gradient coil and combined surface rf coil. We realized the new surface gradient coil set with $30{\times}60{cm^2}$2 size, which generated more tharl 4G/cm with 100 amperes over a $4{\times}4{\times}4{cm^3}$ region with good linearity. The optimal geometries of the three-channel surface gradient coil and volun teer's high-resolution in wiuo spinal cord Images obtained by using the optimized surface gradi ent coil set are presented.
Lee, Jeong-Oog,Choi, Eunju,Shin, Kon Kuk,Hong, Yo Han,Kim, Han Gyung,Jeong, Deok,Hossain, Mohammad Amjad,Kim, Hyun Soo,Yi, Young-Su,Kim, Donghyun,Kim, Eunji,Cho, Jae Youl The Korean Society of Ginseng 2019 Journal of Ginseng Research Vol.43 No.1
Background: Compound K (CK) is an active metabolite of ginseng saponin, ginsenoside Rb1, that has been shown to have ameliorative properties in various diseases. However, its role in inflammation and the underlying mechanisms are poorly understood. In this report, the antiinflammatory role of CK was investigated in macrophage-like cells. Methods: The CK-mediated antiinflammatory mechanism was explored in RAW264.7 and HEK293 cells that were activated by lipopolysaccharide (LPS) or exhibited overexpression of known activation proteins. The mRNA levels of inflammatory genes and the activation levels of target proteins were identified by quantitative and semiquantitative reverse transcription polymerase chain reaction and Western blot analysis. Results: CK significantly inhibited the mRNA expression of inducible nitric oxide synthase and tumor necrosis factor-${\alpha}$ and morphological changes in LPS-activated RAW264.7 cells under noncytotoxic concentrations. CK downregulated the phosphorylation of AKT1, but not AKT2, in LPS-activated RAW264.7 cells. Similarly, CK reduced the AKT1 overexpression-induced expression of aldehyde oxidase 1, interleukin-$1{\beta}$, interferon-${\beta}$, and tumor necrosis factor-${\alpha}$ in a dose-dependent manner. Conclusion: Our results suggest that CK plays an antiinflammatory role during macrophage-mediated inflammatory actions by specifically targeting the AKT1-mediated signaling pathway.