치료 저항성 환청을 나타내는 만성 정신분열병 환자에서 측두두정부 반복 경두개자기자극의 효과

정경희,최충식,박진수,이규항,함웅,이승환,채정호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : It has been reported that repetitive transcranial magnetic stimulation (rTMS), which stimulate the focal region of brain may relieve auditory hallucination in patient with schizophrenia. This study was aimed to evaluate the effect of rTMS on left and right temporopahetal cortex in schizophrenic patients with treatment-resistant auditory hallucination. Methods : Twenty-six patients with chronic schizophrenia with treatment -resistant auditory hallucination were randomly a1-located to rTMS group on left and right temporoparietal head regions. The rTMS was applied to TP3/4 region by EEG 10-20 international system at 1 Hz for 20 minutes per day for 101reatment days. A Figure of eight TMS coil with a solid core was used for rTMS at 100% of individual motor threshold. Efficacy was evaluated with Auditory Hallucination Rating Scale (HRS), Positive and Negative Symptoms Scale (PANSS), Clinical Global Impression (CGI) Scale on 5 and 10 days of treatment. Results : Ten days administration of l-Hz rTMS to temporopahetal cortex significant improved frequency (p<0.001) and attentional salience (p=0.038) of auditory hallucination, Positive (p<0.001) and negative symptom (p=0.02), and CGI-impro-vement (p<0.001). There were no significant differences between right and left side stimulations. Conclusion : These results suggest that the low frequency rTMS on temporopahetal cortex may be useful in treating Schizo-phrenic patients with treatment-resistant auditory hallucination and it could be a useful novel treatment option.

유기용제노출이 직업적 청력손실에 미치는 영향

이지호,고영주,이헌,강정학,유철인,이충렬,김양호 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.4

목적 : 산업 장에서 노출되는 유기용제가 청력역치에 어떠한 영향을 미치는가를 5년 동안의 추적조사를 통하여 파악하고자 하였다. 방 법 : 유기용제와 소음에 동시에 노출된 근로자 43명과 소음노출수준, 연령, 근무경력을 짝짓기 한소음노출군을 대상으로 문진과 이경검사, 소음노출 수준, 유기용제노출수준을 조사하였다. 결과 : 1. 전체 근로자의 각 주파수별 청력역치 변화양상에서 500Hz∼2000Hz에서는 추적기간 동 소음동안 현저한 변화가 없었고, 4000Hz 및 8000Hz에서는 역치가 증가하는 경향을 나타내었다. 2.유기용제와 소음에 동시에 노출된군에서 소음 노출군에 비해 4000Hz 이상에서 청력역치가 높게 나타났으나, 통계적인 유의성은 없었다(p(0.05). 3.반복측정 분산분석 법으로 각 주파수별 평균청력 역치의 연차적 변화에 미치는 영향을 분석한 결과 유기용제 노출은 통계적으로 유의한 영향이 없었으나(p)0.05), 소음노출수준은 250Hz, 2000Hz 및 4000Hz에서, 연령은 250Hz와 500Hz에서 통계학적으로 유의한 영향을 미치는 것으로 나타났다(p(0.05). 4.소음노출군파 동시노출군 각각에서의 청력역치 변화량을 paired t-test로 비교한 결과 250Hz∼4000Hz에서는 통계학적 유의성이 없었으며(p(0.1), 8000Hz에서만 경계치 (p=0.0884)의 유의성을 나타내었다. 5.요인들의 영향을 보정한 상태에서 관찰하기 위해 관찰기간동안의 청력역치변화량을 종속변수로 두고 일반선형모형을 이용하여 주파수별로 관찰한 결과 8000Hz에서만 모델에 통계학적 유의성이 있었으며 (p(0.05), 여기서 소음노출수준이 통계학적으로 유의한 영향을 미치는 것으로 나타났고(p(0.05), 유기용제노출은 경 계수준이 었다(p=0.087). 결론 : 청력에 대한 유기용제의 영향이 소음과 연령에 비해 상대적으로 미미하여 명확한 결론에 이르지는 못하였으나, 다소 영향이 있는 것으로 생각되어 유기용제의 영향에 대한 추가연구가 필요할 것으로 판단된다. 또한 보다 효과적인 근로자들의 청력관리를 위해서는 소음 외 산업 장에서 동시에 노출되는 여러 유해물질들을 고려하여야 할 것이다. Objectives : This study was to evaluate the impacts of simultaneous exposure to noise and mixed solvents on workers'hearing threshold level (HTL) over five-year period. Methods : The study was conducted by interview and annual audiometric test on workers in ship building industry from 1994 to 1998. The cases(workers who exposed to noise and mixed solvent simultaneously) were 43 male workers and controls (workers who exposed to nolle) were selected by matching method with regard to age, sex, carrier, and noise exposure level. To assess the impacts of solvent exposure on hearing threshold level, with considering other factors, general liner model was used. Results : 1. The audiogram of all subjects showed typical sensorineural hearing loss pattern. The mean HTLe were increased at high frequency (4000HB and 8000Hz) for study period. 2. The HTLs of cases were more increased than those of controls at high frequencies (4000Hz and 8000Hz), but there was not statlstical significance. 3. The impact of age on the HTL was statistically significant at 250Hz and 500Hz (p(0.05), and the impact of noise on the HTL was statistically significant at 250Hz, 2000Hz and 4000Hz (p(0.05), but the impact solvent exposure on the HTL was not significant. 4. The changes in HTLs of cases were higher than those of controls at high frequency, there were not statistical significance at 4000Hz, but only at 8000Hz (p=0.087). 5. Statistical analysis of the general linear model implicated that the changes in HTL was impacted by noise exposure bevel significantly (p=0.031) and Impacted by solvent exposure weakly (p=0.087) at 8000Hz. Conclusions : The results of this study suggest that workers who simultaneously exposed to noise and mixed solvent were at risk for more affected HTL than those exposed to noise exposure only, but we could not find definitive evidence. Further detailed studies must be made in large number of workers.

최근 6년간 연세의료원에서 경험한 한국인 안면골 골절에 대한 임상적 연구

권준호,이충국,이의웅,민우석,윤중호,박형식 大韓顎顔面成形外科學會 1989 Maxillofacial Plastic Reconstructive Surgery Vol.11 No.1

This is a series of continuing research on facial bone fractures of Koreans worked by Dept. of Oral and Maxillofacial surgery, Dental College of Yonsei University, Seoul, Korea, since 1972. The study was based on a series of 630 patients with facial bone fractures treated as in patient at Yonsei Medical Center, Yonsei University, during the period of Jan. 1982 through Dec, 1987. The results obtained are as follows: 1. The ratio of Men to Women was 4.3 : 1, and admissions for facial bone fractures have been increased year after 1984. 2. The age frequency was highest in the third decade(38.3%). and fourth, second, fifth decade in orders. 3. The traffic accident was the most frequent cause of facial bone fractures(51.3%). 4. The most common location of facial bone fractures was the Mandible(35.3%), and Zygoma complex(29.8%), Nasal bone(15.0%), Maxilla(11.0%) were next in order of frequency. 5. In 291 patients of Mandible fractures, 226(77.7%) had fractures only in Mandible and 65(22.3%) had another facial bone fractures. The most frequent fracture site of mandible was the Symphysis(43.0%) and Angle(22.4%), and Simple fracture was the most frequent in type of fracture(66.9%). Intermaxillarty fixatin & Open reduction was major method of treatment(36.9%). 6. In 394 patients of Midface fractures 323(82.0%) had fractures only in Midface and 71(18.0%) had another facial bone fractures. The most frequent site of Midface fractures was zygoma complex & zygomatic arch(42.7%), and Simple fracture was the most common type of fractures. Observation(Maxilla :44.2%, Zygoma :51.0%) and Open Reduction(Maxilla :20.0%. Zygoma :23.5%) were the major method of treatment. 7. The frequency of Nasal bone fracture was about 1/5 of Midface fractures, and Closed Reduction(42.2%) was the major method of treatment. 8. The complication was reported in only 16 patients, and Malunion was the major complication. 9. Head(44.4%), Lower extrimities(14.5%) and Eye(12.3%) were injured commonly with facial bone fractures. 10. The elapsed time from injury to hospital was within 24 hours in 73.8% of patients, however 15.5% of patients arrived the hospital 72 hours after injury.

시험 스트레스시 적대감이 혈청 코르티솔 농도와 혈압 및 맥박에 미치는 영향

이충원,박정호 啓明大學校 醫科大學 1995 계명의대학술지 Vol.14 No.4

This study was designed to test the hypothesis that the students with high hostility scores were associated with higher serum cortisol vlevels, and higher responsivity of blood pressure and pulse rate, under the written examination stress in comparison to the students with lower hostility scores. Fifty two medical students gave informed consents to participate in the study. Hostility levels were measured by the Cook-Medley hostility scale, and the response variables were serum cortisol, systolic and diastolic blood pressures, and pulse rates. Coo-Medley hostility scale were administered about one month prior to examination, Serum cortisol levels, systolic and diastolic blood pressures, and pulse rats were measured three times durung the experimental period, about one month before examination, during examination and about one month after examination, respectively. Serum cortisol levels were measured in duplicates by the Coat-A-count radioimmunoassay procedure(??I) and blood presures and pulse rates were measured by two standardized automatic sphygomomanometers. The response variables compatible with the hypothesis were serum cortisol and pulse rate in Cook-Medley hostility tatal scores where serum cortisol concentration of the student with low total scores was 9.43±μ21.82 g/dl and that of the students with high total scores was 9.56 ±2.97 ㎍/dl before examintion. The former showed little changes(9.36±2.34 ㎍/dl) but the latter did a marked increase(11.14±2.14 ㎍/dl) during examination and the serum cortisol levels of both returned to the baseline levels after examination(Period and periodXsubjects effects, p<0.05). And serum cortisol in cynicism subsets and pulse rate in paraniod aliennation subset of Costa et al's two subsets and serum cortisol, systolic blood pressure in social avoidance subset of Barefoot et al's six subsets were compatible with the hypothesis. Serum cortisol levels showed a borderline significance with cynicism subset of Barefoot et al's (0.05<p<0.1). These results suggest that total scores and some subsets of Cook-Medley's hostility scale may be involved in the biomechanism between hostility and coronary heart disease.

통신상품간 시장잠식현상과 경쟁도입의 효과분석

이상호,정충영,이현우 한국경영과학회 1996 한국경영과학회지 Vol.21 No.1

We consider a consumer self-selection model in which a regulated firm faces two market segmants wig differing valuation of quality of telecommunication services and examine some economic implications from the behaviors of the firm. In the context of a regulated monopolist, even though the results depend on the degree of privatization, the firm could lower the quality of the low-end model and reduce the price of the high-end in order to alleviate cannibalization. This justifies the provision of universal service policy in the telecommunications market. Based on this self-selection model, we also analyze an extended model of product introduction and show that the monopolist will introduce new product with the same introduction time of social planner. However, when we consider competition among firms, the market equilibrium may not guarantee the efficient time of product introduction.

심실중격을 박리하며 파열된 선천성 발살바동 동맥류로 뇌경색증이 동반된 2예

최락경,김인원,정승묵,한춘호,고충원,임달수,박헌식,홍석근,황흥곤 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.5

만성 간장 질환자에서 뇌 MRI 상의 pallidal index와 생물학적 망간지표들 간의 관련성

최영희,박능화,신정우,김효경,김성률,정태흠,박지강,이헌,유철인,이충렬,이지호,김양호 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.2

목적 : 만성 간장 질환자를 대상으로 T1강조 자기공명영상(MRI)에서 나타나는 담창구 부위의 고신호강도 소견(pallidal index, PI)과 생물학적 망간 지표들 간의 관련성을 알아본다. 방법 : B형간염 바이러스에 의한 간경변증으로 진단 받은 40세 이상의 환자 31명과 정상 대조군 10명을 대상으로 설문조사와 혈액 및 소변검사, 뇌 MRI를 시행하였다. 전체 41명 가운데 검사 전 수혈을 받았던 환자군 9명을 제외하고 전체 32명의 자료를 분석하였다. 망간 축적에 관련된 객관적 지표로서 T1 강조 MRI에서 나타나는 담창구 부위의 고신호강도를 전두부 백색질 신호강도로 나눈 수에 100을 곱하여 구한 PI를 택하였다. 환자군과 대조군 사이의 PI와 망간농도들의 평균을 비교하였다. 여러 변수들과 PI와의 상관성을 보기 위해서는 상관분석을 시행하였다. 결과 : 간장 질환자 22명 가운데 18명(81.8%)에서 뇌 MRI 상 고신호강도가 나타났다. 대조군 10명에서는 아무도 MRI 소견상 고신호강도가 나타나지 않았다. 간장 질환자에서의 평균 PI는 122.62로 대조군의 106.23보다 유의하게 높게 나타났다(p<0.01). 간장 질환자의 전혈에서 망간농도는 2.34㎍/㎗으로 대조군의 1.44㎍/㎗와 비교하여 유의하게 높게 나타났다(p<0.05). 혈장과 소변 내 망간농도는 대조군에서 다소 높게 나타났으나, 통계적으로 유의하지는 않았다. 또한 혈색소, 빌리루빈, AST가 대조군과 환자군 사이에서 유의한 차이가 있었다(p<0.05). 전혈(p=0.489, P<0.01, n=29)과 적혈구(p=0.573, P<0.01, n=22) 내 망간농도와 PI 사이에는 각각 유의한 상관관계가 있었다. 그러나 혈장과 소변 내 망간 농도와 PI와의 상관관계는 통계적으로 유의하지 않았다. 총빌리루빈 또한 PI와 유의한 상관관계를 나타내었다(p=0.509, P<0.01, n=32). 결론 : 전혈 또는 적혈구 내의 망간 농도가 뇌 내 망간 침착으로 인한 T1 강조 MRI상 담창구 부위의 고신호 강도를 잘 반영하는 유용한 지표이다. Objectives: The objectives of this study were to clarify which biological manganese exposure indices reflect the pallidal signal intensities in magnetic resonance imaging (MRI) in liver cirrhotics. Methods: We examined whole blood, plasma, RBC and urinary manganese concentrations, as well as, brain MRI in 22 cirrhotic patients and 10 healthy controls. From MRI scans we calculated the signal intensity of the globus pallidus using the pallidal index (PI), the ratio of the globus pallidus to subcortical frontal white-matter signal intensity in axial T1 -weighted MRl planes multiplied by 100. In addition, we studied the relationships between PI and other measurements. Results: The high signal intensity in the globus pallidus on T1-weighted MRI was observed in 18 (81.8%) patients. There was a significant correlation between whole blood and RBC manganese concentration, and PI on MRI. According to multiple linear regression, whole blood and RBC manganese concentration reflected PI on MRI better the other indices did. Conclusions: Whole blood and RBC manganese concentrations could be useful as biological manganese exposure indices that reflect PI on MRI.

Fabrication of Ag circuit embedded in PDMS substrate and its mechanical and electrical property with variations of photonic energy

Jung, Kwang-Ho,Kim, Jungsoo,Park, Bum-Geun,Lee, Choong-Jae,Sung, Hwan-Jin,Jung, Seung-Boo Elsevier 2018 JOURNAL OF ALLOYS AND COMPOUNDS Vol.748 No.-

<P><B>Abstract</B></P> <P>Ag circuit embedded in polydimethylsiloxane (PDMS) substrate were fabricated through photonic sintering and transfer of Ag nanoparticles (NPs) for reducing processing time, cost, damage to the substrate, and delamination caused by the low surface energy of PDMS. The photonic energy led to the microstructural evolution of a printed Ag circuit by rapid cluster formation and by removing the organics within several microseconds. Variations of surface roughness showed increasing trends at higher photonic energy conditions and drastic decrease after the embedding process. Hardness and electrical resistivity were measured before and after PDMS embedding, and after the second photonic sintering at various photonic energy conditions. The Ag circuit embedded in the PDMS substrate showed improved hardness by 207% due to the denser microstructure of the flipped surface and increased electrical resistivity increasing by 54% on average. Moreover, the effects of second sintering on the microstructure, electrical, and mechanical properties and the electrochemical reliability of the embedded Ag circuit are also studied.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Embedding of metal nanoparticles in PDMS substrate was devised. </LI> <LI> Ag nanoparticles were sintered at various photonic energy conditions and they show the microstructural evolution. </LI> <LI> Increased electrical conductivity and ECM lifetime of Ag circuit with increasing photonic energy were identified. </LI> </UL> </P>

An Optimal Method to Improve the Visual Quality of Medical Images

Choong-ho Shin, Chai-yeoung Jung 조선대학교 기초과학연구원 2015 조선자연과학논문집 Vol.8 No.2

As the visual quality of X-ray images is a critical reference for the accuracy of the clinical diagnosis, the methods to improve the quality of X-ray images have been investigated. Among many existing methods, using frequency domain filter is a very powerful method to improve the visual quality of images. In this paper, the inherent noises of the input images are suppressed by adding the Laplacian image to the subjected image. The medical X-ray images using the optimal high pass filter has shown improved edges. Further, the optimal high frequency emphasis filter has shown the improved contrast of flat areas by using the result image from the optimal high pass filter. Also the resulting images of the global contrast have improved by the histogram equalization. As a result, the proposed methods have shown enhanced contrast and edges of the images with noise canceling effect.

Poster Session 1 : oral Presentation ; Structural Basis of Protein Function and Regulation : Chemical inducer from amyloid fibril to protofibril of alpha-synuclein

( Choong Hwan Lee ),( Hyun Jin Kim ),( Jung Ho Lee ),( Hyun Ju Cho ),( Seun Ho Jung ),( Kwang Chul Chung ),( Seung R. Paik ) 한국생화학분자생물학회 (구 한국생화학회) 2005 62회 KSBMB Annual Meeting in 2005 Vol.- No.-