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위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동
이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.
이진호,최선웅,강길선,노승무,민병무,김용백,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
"Biomaterials" are nonviable materials used in medical devices, intended to interact with biological systems. They should have "biocompativility", which is defined as the ability of materials to perform with an appropriate host response in a specific application. It includes many materials that are often classified as biomaterials. Metals, ceramics, polymers, glasses, carbons, and composite materials are some examples. Among them, biodegradable polymers are discussed in this revies article. Since a biodegradable polymeric implant does not have to be removed surgically once it is no longer needed, biodegradable polymers are of value in short-term applications that require only the temporary presence of a polymeric implant. Main short-term medical applications of biodegradable polymers include the temporary tissue scaffold, the temporary adhesion barrier, the drug delivery device, and the multifunctional implant. In this article, the properties, processing methods, and medical applications of the biodegradable polymers are reviewed.
Choi, Sun-Woong,Lee, Jin-Ho,Lee, Kyu-Hee,Bang, Sung-Jin,Ahn, Jong-Sung,Lee, Keun-Hyung,Chung, Kyeong-Soo,Oh, Jung-Yeon,Kim, Jin-Hyang,Yang, Joon-Mook,Noh, Seung-Moo,Min, Byung-Moo,Kim, Young-Beak,Kim, 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
A method for processing and the drug releasing behavior of 5-Fluorouracil(5FU)/ Polyglycolic Acid(PGA) composite, applicable to medical devices, was investigated. A preliminary results indicated that the method utilizing melt processing could be a simple means by which the composite can be processed without referring to more involved and difficult-to-achieve solvent processing method. It is shown that the effectiveness of 5-FU was maintained during tests, even after the processing temperature of 230℃. The release patterns from the various sized samples have indicated that the observed release may have occurred in one or two stages, depending on the sample thickness and that a longer experimental times may be required to elucidate the complete release pattern. Although a further and more detailed analysis need to be performed to better understand the controlled release behavior of 5FU/PGA composite, the current results have provided the possibility of utilizing melt processing as a tool to produce medical devices for successful drug delivery applications,
Comparison of Landfill Gas Generation and Recovery from An Existing Facility at Ulsan, S. Korea
( Muhammad Sohail ),( Aafaq Ur Rehman ),( Beak Jin Woong ),( Yousuf Jamal ),( Hung-suck Park ) 한국폐기물자원순환학회(구 한국폐기물학회) 2015 한국폐기물자원순환학회 3RINCs초록집 Vol.2015 No.-
Comparison study of landfill gas generation and recovery was carried out for the enhancement of landfill gas (LFG) from Seongam landfill facility situated at Ulsan, South Korea. Field sampling and measurements at the site were performed in order to investigate the possibility of enhanced gas recovery. US Environmental Protection Agency (EPA) LandGEM mathematical model (version 3.02) and stoichiometric measurements were considered for the estimation of landfill gas generation. It was noted that the existing facility has limited gas recovery potential in comparison to prediction by EPA landGEM model. Reasons for this limited recovery are found to be the improper landfill covering, blockage of gas extraction pipe screen openings and improper gas management of leachate collection well. A proper landfill final cover, installation of cover for leachate collection well and dewatering system for removing blockage are suggested to reduce the gaseous emissions to the environment.