구개편도에 발생한 과오종 1예

나형균,배창훈,김용대,송시연 대한이비인후과학회 2011 대한이비인후과학회지 두경부외과학 Vol.54 No.10

Hamartoma is a tumor-like malformation in which the tissues are arranged haphazardly with an excess of one or more of its components, although the underlying reasons for the occurrence of hamartoma is not fully understood. Hamartoma commonly originates from the lung, kidney and intestine. However, hamartoma is very rare in the head and neck, especially in the palatine tonsil. Presenting symptoms of hamartoma are typically vague and nonspecific. Complete surgical removal of the hamartoma is the treatment of choice as incomplete treatment leaves the risk of recurrence. Recently, we have experienced a 22 year-old male patient who presented with a mass at the posterior pillar area of the right palatine tonsil of several years. The mass was resected completely and confirmed histologically as a hamartoma. Therefore, we report this case with a brief literature review.

이하공간에 발생한 점액선 선종양 과오종 1예

김상욱(Kim Sang Wook),이성민(Lee Sung Min),이강현(Lee Kang Hyun),박기준(Park Ki Joon),박혜상(Park Hae Sang) 대한두경부종양학회 2019 대한두경부 종양학회지 Vol.35 No.2

Hamartomas are non-neoplastic malformations or congenital errors of tissue development. Hamartoma is com-posed by an excessive growth of mature tissue present in wrong proportions and abnormal arrangements. The lesion usually presents as a submucosal mass with ill-defined margins. Hamartoma occurs in all areas of the body, especially in the liver, spleen, kidney and lung. However, hamartoma is very rare in the head and neck. Presenting symptoms of hamartoma are typically vague and nonspecific. Treatment of hamartomas consists of adequate surgical excision. We present a 59 year-old male patient who presented with submental swelling. Malignancy could not be ruled out with preoperative radiologic examination, so surgical excision was planned. The mass was excised with transcervical approach. Histopathologic examination has confirmed the mass as a mucinous gland adenomatoid hamartoma.

Intrahepatic Cholangiocarcinoma Arising from Biliary Hamartomas in Patients with Recurrent Acute Cholangitis: A Case Report and Literature Review

이상민,김기배,한정호,우창곡,채희복,박선미 대한소화기학회 2023 대한소화기학회지 Vol.82 No.3

Biliary hamartomas are tumor-like malformations of the liver. Biliary hamartomas are a type of fibrocystic disorder originating from ductal plate malformation and are typically considered benign, but with the risk of malignant transformation. In this case report, we present a rare occurrence of intrahepatic cholangiocarcinoma (ICC) that developed from biliary hamartomas, along with a literature review. A 76-year-old man with a diagnosis of biliary hamartomas had a history of recurrent cholangitis for 12 years, necessitating cholecystectomy, ERCP, and repeated antibiotic treatments. During his last episode, imaging studies revealed a hypervascular infiltrative mass in the right posterior liver segment. A liver biopsy confirmed adenocarcinoma and subsequent surgical pathology revealed ICC originating from biliary hamartomas. Chronic inflammation in the bile duct associated with biliary hamartomas may serve as a potential trigger for malignant transformation, as observed in this case. Therefore, close surveillance is essential for patients with biliary hamartomas presenting with infectious complications.

A case of adult onset rhabdomyomatous mesenchymal hamartoma

( Joongoon Kim ),( Moonhyung You ),( Yeonwoong Kim ),( Byeongsu Kim ),( Donghoon Shin ),( Jongsoo Choi ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Rhabdomyomatous mesenchymal hamartoma is an uncommon benign lesion, which is usually congenital, polypoid. This lesion is primarily located on the head and neck. This hamartoma typically presents as a nodule or skin tag, but has also been described as a solitary indurated plaque or depressed plaque. The critical histopathologic finding is the existence of individualized fascicles of striated muscle affecting the dermis and subcutaneous fat tissue. A 39-year-old male presented with a single walnut sized normal skin colored soft elevated plaque on the chin for about 2 years. We performed punch biopsy, and histopathologic exam showed skeletal muscles and adipose tissues in the dermis. Because of cosmetic morbidity due to large size of hamartoma, he didn’t want surgical treatment. We report a rare case of adult onset rhabdomyomatous mesenchymal hamartoma. Although our patient and other reported cases had no clinically observable abnormalities, we recommend systemic evaluation in the patient with rhabdomyomatous mesenchymal hamartoma because etiology of this disease can be associated with aberrancy in the embryonic migration.

폐구역절제술로 제거된 기관지 내 연골성 과오종 -수술치험 1예-

조성호,박성달 대한흉부외과학회 2005 Journal of Chest Surgery (J Chest Surg) Vol.38 No.9

In comparison to parenchymal hamartoma, endobronchial hamartoma is rare benign neoplasm of the lung. Most parenchymal hamartomas are asymptomatic and are found incidentally. However, endobronchial hamartomas are frequently discovered through respiratory symptoms as a result of bronchial irritation or obstruction. A 47-year-old male patient was admitted to our hospital due to dry cough 1 month prior to admission. On bronchoscopic examination, a polypoid mass was found completely obliterating the anterior segmental bronchus of the left upper lobe. We report a case of endobronchial chondroid hamartoma, which was resected by anterior segmentectomy of the left upper lobe. 폐실질내 과오종에 비해 기관지 내 과오종은 드문 질환으로 폐실질 내 과오종이 우연히 발견되는것에 비해 기관지 내 과오종은 기관지 폐색에 의한 증상이 유발되어 발견되는 경우가 많다. 47세 남자가 한 달간의 기침을 주소로 내원하였다. 기관지 내시경에서 좌상엽 전구역을 폐쇄하고 있는 과오종이 발견되었으며 좌상엽전구역 절제술로 제거되었다. 저자들은 좌상엽 전구역 절제술로 제거된 기관지내 과오종을 경험하여 보고하는 바이다

Refractive Errors, Retinal Findings, and Genotype of Tuberous Sclerosis Complex: A Retrospective Cohort Study

류소영,강훈철,이성철,변석호,김성수,이승규 연세대학교의과대학 2023 Yonsei medical journal Vol.64 No.2

Purpose: To examine the refractive errors, retinal manifestations, and genotype in tuberous sclerosis complex (TSC) patients in a Korean population. Materials and Methods: A total of 98 patients with TSC were enrolled in Severance Hospital for a retrospective cohort study. The number of retinal astrocytic hamartoma and retinal achromic patch within a patient, as well as the size, bilaterality, and morpho logical type were studied. In addition, the refractive status of patients and the comorbidity of intellectual disability and epilepsy were also examined. Results: Retinal astrocytic hamartoma was found in 37 patients, and bilateral invasion was observed in 20 patients (54%). TSC1 mutation was associated with myopia (p=0.01), while TSC2 mutation was associated with emmetropia (p=0.01). Retinal astrocytic hamartoma was categorized into three morphological types and examined as follows: type I (87%), type II (35%), and type III (14%). Single invasion of retinal astrocytic hamartoma was identified in 32% of the patients, and multiple invasions in 68%. The TSC1/TSC2 detection rate was 91% (41/45). Among them, TSC1 variant was detected in 23 patients (54%), whereas TSC2 variant was detected in 18 patients (40%). The results showed that TSC2 mutations are correlated with a higher rate of retinal astrocytic ham artoma involvement (all p<0.05), and multiple and bilateral involvement of retinal hamartomas (all p<0.05). However, the size of retinal astrocytic hamartomas, comorbidity of epilepsy, or intellectual disability did not show correlation with the genetic variant. Conclusion: TSC1 variant patients were more myopic, while TSC2 variant patients showed association with more extensive in volvement of retinal astrocytic hamartoma.

결절성경화증에서 망막 성상세포과오종의 안저자가형광, 형광안저혈관조영 및 스펙트럼영역 빛간섭단층촬영 소견

권영기(Young Ki Kwon),강동진(Dong Jin Kang),임종찬(Jong Chan Lim),김종호(Jong Ho Kim),박동호(Dong Ho Park),신재필(Jae Pil Shin) 대한안과학회 2016 대한안과학회지 Vol.57 No.1

Purpose: To analyze the structural and morphological characteristics of retinal astrocytic hamartomas in tuberous sclerosis patients using fundus autofluorescence, fluorescein angiography and spectral-domain optical coherence tomography. Case summary: Fundus examination, fundus autofluorescence, fluorescein angiography and spectral-domain optical coherence tomography were performed in three patients with tuberous sclerosis and the morphological and structural characteristics of retinal astrocytic hamartomas were analyzed. In the fundus autofluorescence, type 1 retinal astrocytic hamartoma showed hypofluorescence and type 3 showed central hyperfluorescence and surrounding hypofluorescence. Spectral domain optical coherence tomography showed dome-shaped hyper-reflectivity within the nerve fiber layer and focal adhesion of the vitreous cortex in the type 1 retinal astrocytic hamartoma. No abnormalities were observed in the outer retinal layer and retinal pigment epithelium. In the type 3 retinal astrocytic hamartoma, optical coherence tomography showed disorganization of retinal tissue and posterior shadowing. Intratumoral cavitation and moth-eaten appearance caused by intratumoral calcification were observed and the vitreous cortex adhered to the top of the tumor and showed traction. Retinal arterial sheathing was observed in all cases and hyper-reflectivity of the arterial wall was noted on optical coherence tomography. Conclusions: Fundus autofluorescence, fluorescein angiography and spectral-domain optical coherence tomography are helpful for the classification and diagnosis of retinal astrocytic hamartomas found in tuberous sclerosis patients as well as for differentiation from other lesions.

Pancreatic hamartoma diagnosed after surgical resection

Ho-Hyun Kim,Chol-Kyoon Cho,Young-Hoe Hur,Yang-Seok Koh,Jung-Chul Kim,Hyun-Jong Kim,Jin-Woong Kim,Young Kim,Jae-Hyuk Lee 대한외과학회 2012 Annals of Surgical Treatment and Research(ASRT) Vol.83 No.5

A pancreatic hamartoma is a rare benign lesion that may be mistaken for malignancy. A pancreatic hamartoma can present with vague, non-specific symptoms, which can be difficult to diagnose despite modern diagnostic tools. We report here a pancreatic hamartoma diagnosed after surgical resection. A 52-year-old female presented with postprandial abdominal discomfort. Abdominal computed tomography and pancreatic magnetic resonance imaging revealed a 2.2 × 2.5-cm cystic mass in the pancreatic head. The patient underwent a pylorus-preserving pancreaticoduodenectomy. The histopathological and immunohistochemical studies helped make the diagnosis of pancreatic hamartoma. Here, we report a case of pancreatic hamartoma and review the relevant medical literature.

폐과오종의 세침흡인 세포학적 소견

이태진,이진숙,공경엽,강신광,노재윤,Lee, Tae-Jin,Lee, Jin-Sook,Gong, Gyung-Yub,Khang, Shin-Kwang,Ro, Jae-Y. 대한세포병리학회 2000 대한세포병리학회지 Vol.11 No.1

Pulmonary hamartomas are uncommon benign tumors, usually discovered radiologically as a solitary coin lesion in asymptomatic individual. The approach to the patient with a peripheral lung nodule has changed with the increasing acceptance of fine needle aspiration cytology(FNAC) as a rapid, safe, inexpensive, and highly accurate diagnostic tool. However, a few reports describing the FNAC findings of pulmonary hamarioma have appeared in the cytologic literature and the experience of FNAC is limited. We reviewed all 9 cases of pulmonary hamartoma with histologic confirmation after FNAC seen at Asan Medical Center since 1995 to evaluate cytologic findings and to determine the value of FNAC in identifying that lesion. Originally, seven of nine patients were diagnosed as pulmonary hamartoma, while two patients were diagnosed as inflammatory lesion and adenocarcinoma of each. On review, eight of nine patients were considered as diagnostic of pulmonary hamartoma. The diagnostic findings in FNAC of pulmonary hamartoma were the presence of fibrillary myxoid tissue with spindle cells as well as hyaline cartilage.

심외막에서 발생한 지방성 과오증

강현욱,김정란,서정욱,지제근 대한병리학회 1989 Journal of Pathology and Translational Medicine Vol.23 No.1