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Ceftriaxone is widely used in patients for the treatment of serious gram-negative infections. Ceftriaxone can induce some potential side effects, including neurotoxicity,however, nonconvulsive status epilepticus has rarely been reported. We report a case of acute reversible neurotoxicity associated with ceftriaxone. A 65-yr-old woman with chronic kidney disease developed altered consciousness during ceftriaxone treatment for urinary tract infection. The electroencephalogram demonstrated continuous bursts of generalized, high-voltage, 1 to 2 Hz sharp wave activity. Neurologic symptoms disappeared following withdrawal of ceftriaxone. The possibility of ceftriaxone-induced neurotoxicity should be considered in patients developing neurological impairment during ceftriaxone use, and the discontinuation of the drug could lead to complete neurological improvement.
Metal matrix composites of two magnesium alloys (AM100 and ZC63) with saffil alumina fibre reinforcements were produced using a squeeze infiltration technique. Mechanical properties were assessed, followed by analysis of the fractured specimens. From the strength, toughness and the fractographic analysis, attempts were made to elucidate the influence of the matrix, fibre volume fraction and the fibre/matrix interface on the properties. Metal matrix composites of two magnesium alloys (AM100 and ZC63) with saffil alumina fibre reinforcements were produced using a squeeze infiltration technique. Mechanical properties were assessed, followed by analysis of the fractured specimens. From the strength, toughness and the fractographic analysis, attempts were made to elucidate the influence of the matrix, fibre volume fraction and the fibre/matrix interface on the properties.
The production of premium quality castings for structurally safe components for aerospace and automotive applications requires that porosity and inclusions be minimized or eliminated to negate their harmful influence on the mechanical properties. Also in order to achieve a competitive advantage in the automotive industry it has become necessary to use Al alloy scrap to keep the cost-down of the material. A riser and runner part of a cylinder head from the gasoline engine of an automobile was used as the Al alloy scrap. For in-house recycling of Al alloy scrap the variations of the content of alloying elements, microstructures, mechanical properties, and volume of inclusions were examined with respect to the frequency of scrap use and the variations of various inclusions were measured according to different melt treatments. The contents of Mg, Si, Ca, and Sr decreased, but Fe increased with the frequency of scrap use. The tensile strength and yield strength of Al alloy scrap were slightly decreased but not significantly changed, but the fracture toughness and elongation to failure almost halved due to the increase of total volume of inclusions according to the frequency of scrap use. The majority of oxide film and inclusions in Al alloy scrap was removed by a fluxing treatment, but the fluxing treatment followed by a treatment in a Gas Bubbling Filtration (GBF) resulted in a significant increase in the volume of oxide film. The fluxing treatment was the most effective in removing the oxides and inclusions from the Al scrap melt.
A 48-year-old woman visited the emergency room for abdominal pain and fever. She had undergone large common bile duct (CBD) stone extraction with endoscopic retrograde cholangiopancreatography (ERCP) ten times in the previous 14 months. We initially thought that the rapid, recurrent bile duct stone production was due to the dilatation of the CBD diameter, so we had planned a hepaticojejunostomy. However, the serum white blood cell count at 11th visit was 113,500/μ, and computed tomography showed multiple CBD stones. To resolve the cholangitis, ERCP with lithotripsy was performed. A peripheral blood smear and bone marrow biopsy revealed acute myeloid leukemia, and induction chemotherapy was started. Risk factors for recurrent CBD stones include biliary stasis due to anatomical problems, systemic disease such as hemolytic anemia, and altered immune mechanism and bacterial overgrowth. We report a patient in whom bile duct stones recurred over several months before the onset of acute leukemia.