응집공정제어를 위한 Pilot Filter의 적용성 검토

변석호,한무영,강창호 대한토목학회 1996 대한토목학회 학술발표회 논문집 Vol.1996 No.2

연령연관황반변성에서 망막혈관종성증식과 동반된 망막색소상피 박리의 임상양상과 일차적인 광역학치료의 결과

변석호,홍진표,이효,오상준,김성수,고형준,이성철,권오웅 대한안과학회 2006 대한안과학회지 Vol.47 No.9

Purpose: To evaluate the incidence of retinal angiomatous proliferation (RAP) and retinal pigmented epithelial detachment (PED) in Korean age-related macular degeneration (ARMD) patients and results of photodynamic therapy (PDT) with verteporfin. Methods: Between May 2001 and December 2004, two hundred fifty-eight patients diagnosed of ARMD were evaluated and nine eyes of seven patients were as having RAP with PED. All patients underwent two or more sessions of PDT. Best-corrected visual acuity (BCVA), fundus photography, fluorescein angiography and ICG angiography were performed before and after treatment. Results: The incidence of RAP with PED was 2.8%. The mean age of onset was 71.7 and five of seven patients were female. After 17 months and mean 2.3 PDT treatments, mean BCVA decreased from 0.2 to 0.04. In two eyes, additional Transpupillary thermotherapy was undertaken. Occlusion of RAP and flattening of PED was observed in one eye, and four evolved toward stage 3 RAP. Three eyes with PDT developed tear of retinal pigmented epithelium. Conclusions: Korean ARMD patients showed a low incidence of RAP and poor visual outcomes even with treatment.

정수기에서의 HFC-134a 배출특성에 대한 연구

변석호,김승도,이영표 한국대기환경학회 2013 한국대기환경학회 학술대회논문집 Vol.2013 No.8

선천성 수정체 결손증 환자에 적용된 인공수정체 광학부 포획 1예

변석호,김완수 대한안과학회 2006 대한안과학회지 Vol.47 No.11

Purpose: To report the effect of the optic capture in the treatment of congenital lens coloboma. Methods: A 5-year old boy was transferred to Maryknoll Hospital with congenital lens coloboma in his right eye. Lens coloboma at superotemporal area and capsular cataract around the coloboma was observed in the slit lamp examination. Posterior continuous curvillinear capsulorrhexis was performed after irrigation and aspiration of the lens. Optic was captured behind the posterior capsule while its haptics were placed in the sulcus. Results: Best corrected visual acuity improved from preoperative 20/63 to 20/20 postoperatively. Intraocular lens decentration and rotation and other sight threatening complications were not found during the follow up period. Conclusions: Optic capture is thought to be a safe and effective means to prevent IOL decentration and posterior capsular opacity in the treatment of congenital lens colobomas.

3가지 친수성 아크릴 인공수정체의 안정성 비교

변석호,김완수,Suk Ho Byeun,M,D,Wan Soo Kim,M,D,Ph,D 대한안과학회 2006 대한안과학회지 Vol.47 No.10

Purpose: To evaluate the stability of three different hydrophilic acrylic intraocular lenses (IOLs), which have different shapes. IOLs included in this study are three-piece acrylic IOL with PMMA (Polymethylmethacrylate) haptics (Hydroview? H60M, Bausch &Lomb, U.S.A), one-piece acrylic IOL with broad optic-haptic junction (Centerflex?570H, RAYNER, UK), and one-piece acrylic IOL with narrow optic-haptic junction (Aquasens, Ophthalmic Innovations International, U.S.A). Methods: We evaluated 69 patients (100 eyes) who had undergone cataract surgeries and who had hydrophilic acrylic IOLs implanted from September, 2003 to March, 2004. Forty eyes implanted with three-piece acrylic IOL with PMMA haptics, 40 eyes implanted with one-piece acrylic IOL with broad optic-haptic junction, and 20 eyes implanted with one-piece acrylic IOL with narrow optic-haptic junction were included. Slit lamp examination, best corrected visual acuity (BCVA), anterior chamber depth (ACD), refraction, and IOL decentration were evaluated at one week and at one, three, and six months postoperatively. Results: There was no statistically significant difference in BCVA, ACD, mean SE or decentration between patients implanted with three different types of hydrophilic acrylic IOL during the 6 month follow-up period (P>0.05). However, Postoperative myopic shift was discovered in 4 eyes (4/20) with Aquasens. Conclusions: There were no statistically significant difference in the Stabilities of the 3-different hydrophilic acrylic IOLs. However, patients who were implanted Aquasens shold be observed carefully because Aquasense has the posibilitiy to have myopic shift more than 1 Dioptor.

한국인의 혈관내피성장인자 3’ 비번역 부위의 유전자 다형성과 당뇨망막증과의 상관성

변석호,오현섭,안보영,홍선표,김진국,권오웅 대한안과학회 2005 대한안과학회지 Vol.46 No.11

Purpose: Recent studies suggest that increased expression of the vascular endothelial growth factor (VEGF) may play a role in the pathogenesis of diabetic complications. The aim of this study was to assess the potential association of VEGF gene polymorphisms with disease expression of retinopathy in patients with diabetes mellitus. Methods: We studied 96 diabetic patients to determine whether there is an association between diabetic retinopathy in VEGF and VEGFR gene; all patients were unrelated Korean individuals (PDR, n=32; NPDR, n=25; no DMR, n=39). We analyzed VEGF and VEGFR SNP by restriction fragment mass polymorphism (RFMP). PCR was performed with primers designed to introduce a type IIS restriction endonuclease recognition sequence (FokI, BstF5I) ahead of the polymorphism site. The enzymatic cleavage of the products resulted to excision of two oligonucleotide fragments containing the variation site, and then masses of the resulting oligonucleotide fragments were examined by matrix assisted laser desorption time of flight mass spectrometry (MALDI-TOF MS). Difference are seen as the presence, absence, or mass change in peaks corresponding to the fragments affected by existence of polymorphism that have base substitution at the site of variation. Results: We found that the genotype frequencies of two polymorphisms shown to be completely linked to each other (rs3025039; vf1, rs3025040; vf2) and one polymorphism (rs3812867; vfr1) within 3`-untranslated regions (3`-UTR) of the VEGF and VEGFR1 significantly differed between patients with and without retinopathy. The frequencies of the vf1, vf2 and vfr1 did not differ significantly between the NPDR and PDR group Conclusions: These data implicate the polymorphisms in the 3`-UTR of the VEGF and VEGFR1 genes as risk factors for diabetic retinopathy.

정상 직경 내경동맥에 의한 시신경 압박으로 발생한 시야장애 1예

변석호 ( Suk Ho Byeon ) , 홍욱표 ( Wook Pyo Hong ) , 안진형 ( Jin Hyung Ahn ) , 박병우 ( Byung Woo Park ) 대한안과학회 2004 대한안과학회지 Vol.45 No.11

정상 직경 내경동맥에 의한 시신경 압박으로 발생한 시야장애 1예

변석호 ( Suk Ho Byeon ),홍욱표 ( Wook Pyo Hong ),안진형 ( Jin Hyung Ahn ),박병우 ( Byung Woo Park ) 대한안과학회 2004 대한안과학회지 Vol.45 No.11

수명곡선을 활용한 폐일반냉장고 발생량 추정방법 개발 적용에 대한 연구

김현경,변석호,김승도 한국폐기물자원순환학회 2015 한국폐기물자원순환학회지 Vol.32 No.8

This paper applied a new methodology to estimate the generation rate of waste refrigerator using Population Balance Model as well as assigning Weibull Distribution Function as probability distribution function (PDF) of lifespan. In order to determine the generation rate of waste refrigerator, it is necessary to estimate yearly sales quantity of new refrigerator and lifespan PDF of refrigerator. The average lifespan of refrigerator is determined to be 16.8 years as a result of averaging the lifespans of 4,682 waste refrigerators. We also developed a methodology to calibrate the PDF of lifespan of waste refrigerator. The generation rate of waste refrigerator in 2014 is estimated to be 1,822,633 decreasing sharply with time. The new methodology developed here can be applied to estimate the generation rates of other e-wastes.

Leigh 증후군 환아에서의 안과적 이상 소견

김교륭,변석호,강훈철,이준수,김흥동,이영목 대한소아청소년과학회 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.2

Purpose:Leigh syndrome is a typical type of mitochondrial disease. This study was conducted to analyze the types of ophthalmologic symptoms and results of funduscopy conducted in the ophthalmologic examination of patients with Leigh syndrome. Methods:Funduscopy was conducted on 24 subjects, who were chosen among those diagnosed as having mitochondrial respiratory chain complex defect and who were clinically suitable for the criteria of Leigh syndrome. Their clinical features, ophthalmologic symptoms, and ophthalmologic examination results were retrospectively analyzed. Results:Of the 24 patients with Leigh syndrome, 11 developed ophthalmologic symptoms and no abnormal finding was observed in 13. The most frequent abnormal finding was visual disturbance in 5 patients. Funduscopy revealed abnormal findings in 17 patients; retinal pigmentation was the most frequent abnormality and was seen in 9 patients. Conclusion:Funduscopy can be an important screening test to find ophthalmologic abnormalities among patients with mitochondrial disease (MD), including those patients whose ophthalmologic symptoms are inconspicuous. It is predicted that an improved screening test can be made in the future that will identify risk factors related to ophthalmologic symptoms. 목적:사립체 질환의 종류 중 대표적으로 알려진 Leigh 증후군 환아에서 안과적 증상의 종류와 실제 안과 진료에서 시행한 안저 검사 결과를 분석하였다. 방법:사립체 호흡 연쇄 복합체 결함을 진단받고 임상적으로 Leigh 증후군의 기준에 합당한 환아 중에서 안저 검사를 시행하였던 24명을 대상으로 하였다. 대상 환아 들의 임상 양상과 안과적 증상, 안저 검사 결과를 후향적으로 분석하였다. 결과:24명의 Leigh 증후군 환아 중 안과적 증상이 있는 경우가 11명(48%)이었고, 특이 증상이 발견되지 않았던 경우가 13명(54.2%)이었다. 이상 증상으로는 시력 이상이 5명(20.8%)로 가장 많았다. 안저 검사 결과에서 이상 소견이 17명(70.8%)에서 관찰되었으며, 다양한 이상 소견 중에서 망막의 색소침착이 9명(37.5%)로 가장 많았다. 결론:사립체 질환에서 안과적 증상이 뚜렷하지 않은 환자에서도 안저 검사가 안과적 이상을 찾아낼 수 있는 중요한 선별검사일 수 있으며, 앞으로 안과적 증상과 관련된 위험 요인을 발견한다면 좀더 상황에 맞는 선별적인 검사가 진행될 수 있을 것으로 판단된다.