Measurement of Choroidal Thickness in Normal Eyes Using 3D OCT-1000 Spectral Domain Optical Coherence Tomography

( Joong Won Shin ),( Yong Un Shin ),( Hee Yoon Cho ),( Byung Ro Lee ) 대한안과학회 2012 Korean Journal of Ophthalmology Vol.26 No.4

Purpose: To study choroidal thickness and its topographic profile in normal eyes using 3D OCT-1000 spectral domain optical coherence tomography and the correlation with age and refractive error. Methods: Fifty-seven eyes (45 individuals) with no visual complaints or ocular disease underwent horizontal and vertical line scanning using 3D OCT-1000. The definition of choroidal thickness was the vertical distance between the posterior edge of the hyper-reflective retinal pigment epithelium and the choroid/sclera junction. Choroidal thickness was measured in the subfoveal area at 500 μm intervals from the fovea to 2,500 μm in the nasal, temporal, superior, and inferior regions. The spherical equivalent refractive error was measured by autorefractometry. Statistical analysis was used to confirm the correlations of choroidal thickness with age and refraction error. Results: The mean age of the 45 participants (57 eyes) was 45.28 years. Detailed visualization of the choroid for measuring its thickness was possible in 63.3% of eyes. The mean subfoveal choroidal thickness was found to be 270.8 μm (standard deviation [SD], ±51 μm), in horizontal scanning and 275.0 μm (SD, ±49 μm) in vertical scanning. The temporal choroidal thickness was greater than any 500 μm interval in corresponding locations, and there was no significant difference between the superior and inferior choroid as far as 2,000 μm from the fovea. Age and refractive error were associated with subfoveal choroidal thickness in terms of regression (p < 0.05). Conclusions: Choroidal thickness in normal Korean eyes can be measured using 3D OCT-1000 with high resolution line scanning. The topographical profile of choroidal thickness varies depending on its location. Age and refractive error are essential factors for interpretation of choroidal thickness.

스펙트럼영역 빛간섭단층촬영기를 이용하여 관찰한 정상소아에서 후극부 맥락막의 형태

김지현,김진선,이규원,이정호 대한안과학회 2013 대한안과학회지 Vol.54 No.11

Purpose: We assessed changes of the choroidal thickness in healthy Korean children using enhanced depth imaging (EDI) optical coherence tomography (OCT) and evaluated the association of choroidal thickness and axial length. Methods: Seventy-nine eyes (79 children) within ±1 diopter spherical equivalent underwent horizontal and vertical scan using EDI OCT. Two observers determined independently the choroidal thickness at 1 mm intervals from 3 mm nasal and 4 mm temporal to the fovea and 1 mm superior and inferior to the fovea using the manual caliper provided by the device software. Statistical analysis was performed to evaluate variations of choroidal thickness at each location and to correlate choroidal thickness and axial length. Intraclass correlation coefficient (ICC) was calculated. Results: The subjects’ mean age was 7.67 years. The mean axial length was 22.96 mm and mean subfoveal choroidal thickness was 296.13 μm. The thinnest choroidal thickness was 160.57 μm at 3 mm nasal to the fovea and the thickest was 319.49 μm at 4 mm temporal to the fovea. The choroidal thickness at 1 mm superior (294.70 μm) and inferior (287.11 μm) to the fovea showed no statistical significance compared with the subfoveal choroidal thickness. The mean choroidal thickness was thicker at 3 mm and 2 mm nasal to the fovea in eyes with shorter than the mean axial length (p < 0.05). For the assessment of intra-observer reproducibility, the ICC ranged from 0.995 to 0.998 (p < 0.001). Conclusions: The choroidal thickness increased from the nasal to the temporal direction at the posterior pole and eyes with shorter axial lengths tended to present thicker choroids at the nasal area in healthy Korean children. J Korean Ophthalmol Soc 2013;54(11):1708-1714

망막정맥폐쇄 환자에서 시력과 맥락막두께와의 상관관계

노광명,김창주,이승욱,이상준 한국망막학회 2019 Journal of Retina Vol.4 No.2

Purpose: To clarify the correlation between visual acuity and changes of choroidal thickness in retinal vein occlusion patients (RVO). Methods: A total of 100 patients were reviewed and 35 patients (35 eyes) were included. They were diagnosed with RVO through fundus photography and fluorescein angiography. And they were at least 6 months of follow-up. We compared the choroidal thickness, macular ischemia range, macular thickness and range, initial visual acuity, final visual acuity, and treatment methods. The choroidal thickness, degree of macular ischemia, and edema were assessed by fluorescein angiography and optical coherence tomography (OCT) within 2 weeks of the initial visit. We analyzed changes of subfoveal choroidal thickness with enhanced depth imaging of Spectralis HRA+OCT. Results: The mean initial choroidal thickness of 35 eyes was 293.26 ± 61.63 μm, which was significantly thicker than that of the opposite eye (240.77 ± 69.79 μm). Choroidal thickness decreased after 6 months of treatment. The changes in the initial and late choroidal thickness were 50.0 ± 29.5 μm and 26.6 ± 21.6 μm, respectively, in the visual acuity group and the non-visual acuity group, respectively. The changes in central macular thickness were 226.1 ± 165.7 μm and 73.5 ± 81.5 μm, respectively (p = 0.004, p = 0.018). Visual acuity showed no statistically significant correlation. Conclusions: There was no significant correlation between visual acuity and choroidal thickness in RVO patients. Rather, it correlated with changes in choroidal thickness and central macular thickness. This suggests that there is a pathophysiologic relation between macular edema and choroidal thickness. 목적: 망막정맥폐쇄 환자에서 시력과 맥락막두께의 상관관계를 알아보고자 한다. 대상과 방법: 2011년 1월부터 2013년 12월까지 안저사진과 형광안저혈관조영술을 통해 망막정맥폐쇄로 진단받고 최소 6개월 이상 경과 관찰이 가능하였던 총 100명을 대상으로 환자 기록지를 후향적으로 조사하였다. 맥락막두께, 황반허혈의 범위, 황반부종의 정도와 범위, 초진시력, 6개월 이후 시력, 치료 방법을 비교하였다. 맥락막두께와 황반허혈 및 부종의 정도는 초진 후 2주 이내에 촬영한 형광안저혈관조영술과 빛간섭단층촬영을 통하여 평가하였다. 중심와아래 맥락막두께의 변화를 분석하였고 맥락막두께는 빛간섭단층촬영의 enhanced depth imaging을 이용하여 측정하였다. 결과: 35안의 초기 맥락막두께는 평균 293.26 ± 61.63 μm로 반대안 240.77 ± 69.79 μm에 비해 유의하게 두꺼웠으며, 치료 시행 6개월 이상 경과 후 맥락막두께는 감소하였다. 초기, 후기 맥락막두께의 변화량은 시력 호전군과 시력 비호전군에서 각각 50.0 ± 29.5 μm, 26.6 ± 21.6 μm였고, 황반두께의 변화량은 각각 226.1 ± 165.7 μm, 73.5 ± 81.5 μm였다(p = 0.004, p = 0.018). 초진 및 6개월 이후 시력과 맥락막두께 사이에는 통계적으로 유의한 상관관계를 보이지 않았다. 결론: 망막정맥폐쇄 환자에서 시력과 맥락막두께 사이에 유의한 상관관계는 없었다. 오히려 맥락막두께와 황반두께의 변화와 관련을 보였다. 이는 황반부종과 맥락막두께 간의 병태 생리학적 상관관계가 있음을 시사한다.

결절맥락막혈관병증에서 중심맥락막두께에 따른 애플리버셉트 유리체강내주입술의 효과 분석

이동훈(Dong hun Lee),정성용(Seong yong Jeong),문종원(Jong won Moon),이준엽(Jun yeop Lee),사공민(Min Sa gong) 대한안과학회 2016 대한안과학회지 Vol.57 No.10

목적: 결절맥락막혈관병증 환자에서 중심맥락막두께에 따른 애플리버셉트 유리체강내주입술의 효과 차이를 분석하고자 하였다. 대상과 방법: 본원에서 결절맥락막혈관병증으로 진단 받고 애플리버셉트 유리체강내주입술을 받은 환자 중 6개월 이상 경과 관찰이 가능했던 60명 60안의 의무기록을 후향적으로 분석하였다. 주사 전 측정한 중심맥락막두께에 따라 얇은 군, 중간 군, 두꺼운 군으로 나누고 주사 후 6개월 동안의 최대교정시력, 중심맥락막두께, 중심황반두께 및 최대 망막색소상피박리 높이의 변화와 3개월째 결절 폐쇄율, 6개월째 황반부종 소실률을 비교 분석하였다. 결과: 총 60안 중 얇은 군은 14안(23.3%), 중간 군은 33안(55.0%), 두꺼운 군은 13안(21.7%)이었으며, 주사 전 평균 중심맥락막두께는 각각 178.50 ± 28.42 μm, 287.03 ± 43.58 μm, 379.77 ± 17.09 μm였다. 세 군 간 초진 시 연령, 성비, 최대교정시력, 중심황반두께 및 최대 망막색소상피박리 높이는 유의한 차이가 없었다. 치료 6개월 후 최대교정시력은 얇은 군에서만 유의한 호전을 보였고 (p=0.005) 중간 군과 두꺼운 군에서는 호전은 되었지만 통계적 유의성은 없었다(p=0.063, p=0.692). 중심맥락막두께, 중심황반두께 및 최대 망막색소상피박리 높이는 세 군 모두에서 유의한 감소를 보였다. 중심맥락막두께가 얇을수록 첫 주사 후 3개월째 완전 결절 폐쇄율과 6개월째 황반부종 소실률이 높았다(p=0.013, p=0.004). 결론: 애플리버셉트 유리체강내주입술은 결절맥락막혈관병증의 치료에 있어서 효과적이었고, 중심맥락막두께가 얇을수록 더 좋은 치료 결과를 보였다. <대한안과학회지 2016;57(10):1577-1585> Purpose: To evaluate the effect of intravitreal aflibercept according to subfoveal choroidal thickness in patients with polypoidal choroidal vasculopathy (PCV). Methods: We retrospectively analyzed the medical records of 60 eyes from 60 patients with PCV treated with intravitreal aflibercept. The patients were followed for at least 6 months after the first injection. Using software, subfoveal choroidal thickness was manually measured as the distance from the hyper-reflective line of Bruch’s membrane to the chorioscleral interface on optical coherence tomography. The patients were divided into three groups based on subfoveal choroidal thickness. Visual acuity, subfoveal choroidal thickness, central macular thickness and largest pigment epithelial detachment (PED) height, polyp regression rate, and dry macula rate were evaluated to analyze the anatomical and functional outcomes. Results: Baseline mean subfoveal choroidal thickness were 178.50 ± 28.42 μm in the thin group (14 eyes, 23.3%), 287.03 ± 43.58 μm in the medium group (33 eyes, 55.0%), and 379.77 ± 17.09 μm in the thick group (13 eyes, 21.7%). Baseline age, sex, visual acuity, central macular thickness, and the largest PED height did not differ significantly among the three subgroups. Only the thin group showed significant improvement of visual acuity at 6 months (p = 0.005). Subfoveal choroidal thickness, central macular thickness, and largest PED height were significantly decreased after treatment in all subgroups and did not differ among the subgroups. Compared with the other groups, the thin subfoveal choroidal thickness group showed higher polyp regression rate at 3 months and higher dry macula rate at 6 months (p = 0.013 and p = 0.004, respectively). Conclusions: Intravitreal aflibercept injection was effective for the treatment of PCV, and thin subfoveal choroidal thickness was associated with better anatomical and functional outcomes. J Korean Ophthalmol Soc 2016;57(10):1577-1585

중심장액맥락망막병증에서 다른 눈의 중심와아래 맥락막 두께

이승현,정혜원,김형찬,Seung Hyen Lee,Hyewon Chung,Hyung Chan Kim 대한안과학회 2012 대한안과학회지 Vol.53 No.7

Purpose: To determine the relationship between subfoveal choroidal thickness of fellow eyes and choroidal vascular hyperpermeability in unilateral central serous chorioretinopathy (CSC). Methods: Thirty patients with unilateral CSC and 28 normal subjects underwent enhanced depth imaging spectral-domain optical coherence tomography to evaluate bilateral subfoveal choroidal thickness. The subfoveal choroidal thickness was measured from the outer RPE border to the inner sclera border. Choroidal vascular hyperpermeability was visualized with indocyanine green angiography (ICGA) and analyzed. Results: The mean subfoveal choroidal thickness in the affected eyes (439.6 ± 136.5 μm) was significantly thicker than that in fellow eyes (340.0 ± 103.3 μm, p = 0.002), and both showed statistically significant difference compared with normal subjects (266.5 ± 111.5 μm, p < 0.001, p = 0.019). The subfoveal choroidal thickness of fellow eyes with choroidal vascular hyperpermeability was 370.0 ± 176.5 μm, which differed significantly (p = 0.037) from the choroid without choroidal vascular hyperpermeability. The choroidal thickness of acute CSC was 441.6 ± 118.6 μm, and that of chronic CSC was 454 ± 166.5 μm, a difference that was not statistically significant (p = 0.676). Conclusions: The subfoveal choroid with hyperpermeability was thicker than that without hyperpermeability on ICGA in the fellow eyes of patients with unilateral CSC. Enhanced depth imaging spectral-domain optical coherence tomography can indirectly evaluate the effects of choroidal hyperpermeability by noninvasively measuring the choroidal thickness. J Korean Ophthalmol Soc 2012;53(7):982-987

RTVue 빛간섭단층촬영기로 측정한 맥락막 두께와 연관인자에 관한 연구

진상욱,최우석,서홍융,노승수,노세현 대한안과학회 2015 대한안과학회지 Vol.56 No.7

목적: 정상안압녹내장(normal tension glaucoma, NTG) 및 원발성개방각녹내장(primary open angle glaucoma, POAG)에서 RTVue(Optovue, Fremont, CA, USA)를 이용하여 측정한 황반하와 유두 주위 맥락막 두께를 비교하고 이에 영향을 미치는 인자들에 대해알아보고자 하였다. 대상과 방법: 퓨리에 영역 빛간섭단층촬영(Fourier-domain optical coherence tomography, FD-OCT)으로 측정한 황반하와 유두 주위 맥락막, retinal nerve fiber layer (RNFL), 그리고 ganglion cell complex (GCC) 두께를 비교, 분석하였다. 또한 황반하와 유두주위 맥락막 두께에 영향을 미칠 수 있는 인자들과의 상관관계를 비교, 분석하였다. 결과: 정상 대조군 32명, POAG 32명, NTG 52명이 포함되었다. 각 군 간 맥락막 두께를 비교한 결과, 황반하와 유두 주위 맥락막두께는 NTG에서 가장 얇았다. NTG에서는 황반하와 유두 주위 맥락막 두께에 영향을 미치는 인자는 나이, 안축장, 이완기 혈압의 야간혈압하강, 이완기 혈압의 변동성, GCC 두께였고, POAG에서는 나이, 안축장만이 영향을 미치는 인자였다. 결론: 정상인에 비해 POAG와 NTG에서 RTVue로 측정한 황반하와 유두 주위의 맥락막 두께가 더 얇았고 POAG보다 NTG에서 더 얇았다. NTG에서는 나이, 안축장, 큰 폭의 이완기 야간혈압하강과 혈압의 변동성이, POAG에서는 나이, 안축장이 맥락막 두께에 영향을 미치는 인자였다. Purpose: To compare the macular choroidal thickness, ganglion cell complex thickness, peripapillary choroidal thickness and retinal nerve fiber layer thickness among normal, primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients using RTVue (Fourier-domain optical coherence tomography; Optovue, Fremont, CA, USA). Methods: A retrospective analysis of 32 normal controls, 32 POAG and 52 NTG patients was performed. Choroidal thickness,ganglion cell complex thickness and retinal nerve fiber layer thickness were compared among normal controls, POAG and NTG subjects. Additionally, the factors influencing choroidal thickness (age, axial length, spherical equivalent, central corneal thickness,mean deviation, nocturnal dip, blood pressure variability) were analyzed. Results: A total of 32 normal controls, 32 POAG and 52 NTG patients were enrolled in this study. Macular and peripapillary choroidal thicknesses were significantly thinner in the NTG patients. In NTG subjects, the significant influencing factors associatedwith macular and peripapillary choroidal thicknesses were age, axial length, nocturnal dip (diastolic blood pressure), diastolic blood pressure variability and ganglion cell complex thickness. In POAG patients, significant influencing factors associated with macular and peripapillary choroidal thicknesses were age and axial length. Conclusions: Choroidal thickness was significantly thinner in NTG patients compared with normal controls and POAG patients. Factors influencing choroidal thickness in NTG patients were age, axial length, nocturnal dip (diastolic blood pressure), diastolic blood pressure variability and ganglion cell complex thickness. In POAG patients, significant factors influencing choroidal thickness were age and axial length.

스펙트럼영역 빛간섭단층촬영으로 측정한 녹내장 환자의 맥락막 두께 분석

김지원,류진영,최규룡,Ji Won Kim,MD,Jin Young Rhew,MD,Kyu Ryong Choi,MD,PhD 대한안과학회 2014 대한안과학회지 Vol.55 No.6

Purpose: To evaluate the choroidal thickness in patients with primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG) using spectral-domain optical coherence tomography (SD-OCT), and to explore the relationship between the choroidal thickness and glaucoma. Methods: A retrospective analysis was performed on patients who had been diagnosed with POAG or NTG at Ewha Womans University, Mokdong Hospital. SD-OCT scans were obtained to estimate retinal nerve fiber layer (RNFL) thickness, macular thickness, and subfoveal and peripapillary choroidal thickness in groups of POAG patients, NTG patients, and normal controls. Results: A total of 21 patients with POAG, 53 patients with NTG, and 42 normal subjects were enrolled in this study. RNFL thickness and macular thickness were significantly thinner in the POAG and NTG groups compared to the normal subjects. In contrast, there were no significant differences in subfoveal and peripapillary choroidal thickness among the 3 groups. There was no significant correlations between the peripapillary choroidal thickness and retinal nerve fiber layer thickness. Conclusions: Choroidal thickness does not seem to differ between glaucoma patients and normal subjects, and there were no significant correlations between the choroidal thickness and glaucomatous optic neuropathy. J Korean Ophthalmol Soc 2014;55(6):868-876

근시환자에서 스펙트럼영역 빛간섭단층촬영기를 이용한 굴절력 및 안축장에 따른 맥락막두께의 변화

김은주,김지현,구성현,이규원,이정호 대한안과학회 2012 대한안과학회지 Vol.53 No.12

Purpose: To investigate the choroidal thickness changes with the Enhanced Depth Imaging (EDI) technique according to refractive errors and axial length in Korean myopia patients. Methods: A total of 90 eyes from 90 patients with myopia (between the ages of 19 and 39 years) underwent spectral-domain optical coherence tomography (SD-OCT)-EDI evaluations. Spherical equivalent was measured by cycloplegic refraction and axial length was obtained by IOL master?. The subfoveal choroidal thickness was analyzed according to age, sex, axial length and spherical equivalent by linear correlations. Results: The average age of all subjects was 25.44 years, mean spherical equivalent was -5.06 diopter (D), mean axial length was 25.70 mm, and mean choroidal thickness was 281.47 μm. In a multiple regression model, the patients’ age had no statistical effect on subfoveal choroidal thickness. Subfoveal choroidal thickness decreased by 13.58 μm per -1D increase in refractive errors and by 33.99 μm per 1 mm increase in axial length when adjusted for sex and age. In addition, subfoveal choroidal thickness was 59.82 μm thicker in men than in women when adjusted for axial length and spherical equivalent (p < 0.001). Conclusions: Among young Korean myopia patients, subfoveal choroidal thickness was significantly related with refractive errors and axial length. Moreover, choroidal thickness was thicker in men than women when adjusted for refractive errors and axial length.

스펙트럼영역 빛간섭단층촬영으로 측정한 갑상선 안병증 환자와 녹내장환자의 맥락막 두께 분석

이보영,나태윤,최진아 대한안과학회 2017 대한안과학회지 Vol.58 No.8

Purpose: To compare the macular choroidal thickness in patients with thyroid-associated ophthalmopathy (TAO) with those with normal tension glaucoma (NTG). Methods: A total of 70 normal eyes, 74 eyes with TAO and 60 eyes with NTG were enrolled in this study. All patients underwent spectral-domain optical coherence tomography (SD-OCT) (Cirrus HD-OCT, Carl Zeiss Meditec Inc., Dublin, CA, USA). Macular choroidal thickness was assessed using enhanced depth imaging. The average macular choroidal thickness was defined as the average value of three measurements: at the fovea and at the points located 1.5 mm in the nasal and temporal directions from the fovea. Generalized estimating equations were used to uncover factors affecting the average macular choroidal thickness. Results: The average, superior and inferior quadrant retinal nerve fiber layer thicknesses were significantly thinner in the NTG group compared with the TAO and control groups (p < 0.001). The average macular choroidal thickness of the TAO group, NTG group and controls was 281.01 ± 60.06 μm, 241.66 ± 55.00 μm and 252.07 ± 55.05 μm, respectively, which were significantly different (p = 0.013). The subfoveal, nasal and temporal side choroidal thicknesses were significantly thinner in the NTG group compared with the TAO group (p = 0.014, 0.012 and 0.034, respectively). Subjects with TAO were associated with a thicker average macular choroidal thickness compared with the NTG group after adjusting for age, sex, spherical equivalent and intraocular pressure (β = 32.61, p = 0.017). Conclusions: Macular choroidal thickness was significantly thicker in patients with TAO compared with those with NTG. Further evaluation is required to determine if a thick choroid in subjects with TAO has any role in glaucomatous optic neuropathy. 목적: 갑상샘눈병증과 정상안, 정상안압녹내장 환자의 황반하 맥락막 두께를 비교해 보고자 한다. 대상과 방법: 정상군 70안, 갑상샘눈병증군 74안, 정상안압녹내장군 60안을 대상으로 하였다. 모든 환자는 스펙트럼영역 빛간섭단층촬영의 Enhanced Depth Imaging 방법으로 중심와 맥락막두께를 측정하였다. 평균 중심와 맥락막 두께는 중심와아래, 중심와 아래에서 각각 1.5 mm 비측 및 이측의 세 지점의 평균으로 정의하였다. 일반화 추정 방정식을 통하여 맥락막 두께에 미치는 변수를 알아보았다. 결과: 평균 중심와 맥락막 두께는 정상 252.07 ± 55.05 μm, 갑상샘눈병증 281.01 ± 60.06 μm, 정상안압녹내장 241.66 ± 55.00 μm로 유의한 차이를 보였다(p=0.013). 중심와아래, 비측, 이측 중심와 맥락막 모두 정상안압녹내장에서 갑상샘눈병증에 비해 얇았다(p=0.014, 0.012, and 0.034). 갑상샘눈병증에서 나이, 성별, 굴절률, 안압을 보정한 후에도 정상안압녹내장군에 비해 맥락막 두께가 유의하게 두꺼웠다(β=32.61, p=0.017). 결론: 갑상샘눈병증군에서 정상안압녹내장군과 정상군보다 유의하게 두꺼운 맥락막을 보였고 평균 망막신경섬유층 두께는 정상안압녹내장군이 갑상샘눈병증군보다 유의하게 얇았다. 갑상샘눈병증 환자에서의 두꺼운 맥락막이 녹내장 진행에 있어 어떠한 효과를 가지는지 향후 추가적인 연구가 필요할 것으로 보인다.

중심장액맥락망막병증 환자의 이환된 눈과 무증상 반대편 눈, 정상 대조군과의 맥락막두께 비교

조준희,배소현,한재룡,남우호,김하경,Joon Hee Cho,So Hyun Bae,Jae Ryong Han,Woo Ho Nam,Ha Kyoung Kim 대한안과학회 2012 대한안과학회지 Vol.53 No.1

Purpose: To compare the choroidal thickness in central serous chorioretiopathy (CSC) patients and normal controls using spectral domain optical coherence tomography (SD-OCT). Methods: The authors compared the choroidal thickness in eyes with CSC, fellow eyes and in normal eyes. In addition, the authors attempted to determine any correlation between choroidal thickness and other factors such as age, height of serous retinal detachment, and spherical equivalent. Choroidal thickness was measured using a perpendicular line from the outer margin of the subfoveal retinal pigment epithelium to the inner surface of the sclera. Results: Twenty-five eyes of 25 CSC patients, 17 fellow eyes and 29 age-matched normal eyes were examined and categorized as group 1, group 2 and group 3, respectively. Subfoveal choroidal thickness was 370.64 ± 58.06 μm in group 1, 301.85 ± 47.83 μm in group 2, and 261.84 ± 48.22 μm in group 3. The choroidal thickness in group 1 was significantly greater than those in group 2 and group 3, and the choroidal thickness in group 2 was significantly greater than that in group 3 (p = 0.001, p < 0.001, p = 0.004, respectively), where the choroidal thickness showed a negative correlation with age (p = 0.015). Conclusions: The choroidal thickness was greater in eyes with CSC and in their fellow eyes compared to that in normal eyes. The results suggest that CSC may be caused by choroidal vascular hyperpermeability and increased hydrostatic pressure in the choroid. J Korean Ophthalmol Soc 2012;53(1):87-93