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Thiocarbamyl Ciprofloxacin 유도체의 합성 및 항균작용
최규룡,임채욱,임철부 중앙대학교 약학연구소 1994 약학 논총 Vol.8 No.-
Ten new thiocarbamyl ciprofloxacin derivatives and six their pivaloyloxymethyl esters were synthesized and evaluated for their antibacterial activity in vitro. Compound[11],N-methylthiocarbamyl ciprofloxacin exhibited the growth inhibitory activity at a concentration of 0.5㎍/ml against S. aureus SG 511, 0.12㎍/ml against Ps. aeruginosa 1771M and 0.06㎍/ml against Ps. aeruginosa 1592E. In general, aliphatic substituted thiocarbamyl ciprofloxacin showed more potent antibacterial activity than aromatic substituted thiocarbamyl ciprofloxacins.
최규룡 梨花女子大學校 醫科大學 醫科學硏究所 1995 EMJ (Ewha medical journal) Vol.18 No.3
안과 영역에 있어서 만성질환 중 비가역적인 실명원인 가운데 중요한 광우각형 녹내장 가운데 그 발견빈도가 증가하고 있는 저안압성 녹내장에 대하여,여러 위험 인자중에 안과에서 그 발견이 간편하고 쉬운굴절이상에 대하여 그 연관성을 알아보고자 이화여자대학부속 목동병원 안과에 내원한 환자중 저안압성녹내장으로 진단받은 94안을 대상으로 굴절이상을측정한 결과 다음과 같은 결론을 얻었다. 1) 저안압성 녹내장 환자 94안중 남자는 52안(55.3%), 여자 42안(44.7%)로서 남자에서 10.6%가량 많았다. 2) 평균 연령은 남자 43.28±7.96세,여자 47.08±8.20세 이었고 평균 안압은 남자에서 15.59±3.26mmHg,여자에서 15,23±2.89mmHg로서 연령과 안압의 성별차이는 없었다. 3) 굴절이상별 분포로는 근시안이 72안(76.6%),정시안 11안(11.7%), 원시안이 11안(11.7%)로서동일 연령군에 있어서 근시안의 유병율 72.9%에 비하여 근시안의 비율이 다소 높았으며, 특히 -3.12 dio-pter 이상의 중등도 이상 근시의 비율은 동일 연령대조군의 8.7% 에 비 하여 저 안압성 녹내장에서는 30.8%로 월등히 많았다. 이상의 결과로 근래 증가하고 있는 굴절이상 중근시환자에 특히 -3.12 diopter이상의 중등도 이상근시에 대하여는 자각증상이 전혀 없는 저안압성 녹내장의 조기발견을 위하여 집단적인 검진이나 녹내장에 대한 정밀검진이 필요할 것으로 사료된다. There are many suggestive risk factors f3r the development of open angle glaucoma includingage, race, family history, myopia, diabetes, systemic hypertension and migrain. Myopia is acommon clinical entity and the importance of low tension glaucoma seems to be increasingreceatly. Nine four eyes of Low tension glaucoma(LTG) were examined for intraocular pressure, visual field test fundus examination, gonioscopic examination and refractive state. We analysedthe prevalence of myopia in patients with Low tension Glaucoma and compared with normalpopulation of similar age. The results were as fo11ows 1) There were ninety four eyes with LTG and more men(55.3%) than women(44.7%) hadbeen affected, the mean age at diagnosis was 43.28±7.96 years in melt, 47.08±8.20 years inwomen and the mean IOP at diagnosis was 15.59±3.26 mmHg in men, 15.23±2.89 mmHg.In women. 2) Seventy two eyes(76.6%) were refractive myopia, and the percentage of myopia in LTGwas greater than reported for a normal population of similar age(72.9%). 3) The percentage of myopia greater than -3.12 diopter was 30.8% in LTG and only 8.7%in normal controls.
콘텍트 렌즈 착용이 누액층(Tear Film)에 미치는 영향
최규룡,박민수,안정숙 梨花女子大學校 醫科大學 醫科學硏究所 1994 EMJ (Ewha medical journal) Vol.17 No.4
Clinically, the diagnostic method of dry eye and adaptation of contact lens wearing have been the slit lamp examination, tear film break up time(BUT) measurement and Schirmer test. There have been many reports that Schirmer test and BUT measurement can be influenced by may factors, especially the mothods of measuring it. So the question of their repeatability and reproducibility has not yet been solved. We studied the influence of contact lens wearing on the tear film phenol red thread test between contact lens wearers and non-wearers. The results as follows : 1) The mean value measured by the PRT method was 13.92±7.68mm in right eye, 15.03±7.68mm in right eye, 21.48±6.30mm in left eye among the contact lens-non wearing group. 2) There was statistically significant decreased value of PRT in the contact lens wearing group. 3) There was not statistically significant difference between contact lens type, duration of contact lens wearing, duration of exchanging of contact lens, contact lens wearing time perone day.
협우각형 녹내장에서 아르곤 레이저와 Nd-Yag 레이저 병합 조사 홍채절개술의 효과
최규룡 梨花女子大學校 醫科大學 醫科學硏究所 1995 EMJ (Ewha medical journal) Vol.18 No.4
Laser iridectomy with combined application of the argon and the Nd-YAG laser was perfomed on 48 eyes with narrow angle glaucoma. Patients were followed for from minimum 3months to maximum 18 months and were evaluated the success rate of iridectomy patency, thepostoperative intraocular pressure(after 3 months), the number of application and the postoperative complications. In this study, the results obtained are as follows : 1) Patency rates of iridectomy site were 87.5%. 2) Postoperative intraocular pressure was well controlled except 3 cases after 3 months later(19mmHg>), and the number of prophylactic contralateral healthy eye was 17. 3) Postoperative complications were transient eccentric pupil, corneal bum, mild iritis andhyphema,lOP spiking and localized anterior capsular opacity. Additional laser iridectomy were needed in 4 cases and trabeculertomy were 2 cases.
Nerve Fiber Analyzer에 의한 망막 시신경 섬유층 두께의 생체 계측
최규룡 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.2
The nerve fiber birefringence imaged by the scanning laser polarimetry ophthalmoscope per-mits the nerve fiber laser to be distinguished from the rest of the retina. The Nerve fiber Analyzer(LDT,Inc) resolves the nerve fiber layer thickness to a reproducibility of 10um. To evaluate the direct measurements of the retinal nerve fiber layer in normal glaucoma eyes, I have used the NFA. Retardation is higher in 15 normal subject than 75 glaucoma suspect & glaucome eyes, thickness of NTG eyes are significantly(p<0.05) less than those of POAG. With these quantitative measurements, it may be possible to monitor glaucomatous progression by detecting the changes and damage of nerve fiber layer. However, it may requeire to eliminate spurious measurememnt in areas of peripapillary atrophy, and reduce operator input in image acquisition(focus, patient alignment and eveness of illumi-nation).
후발성 백내장에서 Q-Switched Nd : YAG Laser를 이용한 후낭 절개술의 시력개선 효과
최규룡 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.1
Background : To evaluate the effects of Nd : YAG Laser posterior capsulotomy, I performed posterior capsulotomy on after cataract(72 eyes) by using Q-switched Nd:YAG laser from March 1994 to August 1995. Results : The results were as follows; 1) 24 aphakic eyes(33.3%), 45 ECCE with PCL inserted pseudophakic eyes(62.5%), 3 KPE with PCL inserted pseudophakic eyes(4.2%) were followed. 2) On performing posterior capsulotomy, the power setting of Nd:YAG laser was ranged from 2.0 to 2.9mJ(62.5%), more than 40 pulses were used in 35 eyes(48.6%). 3) Postoperative visual acuity was improved in 68 eyes(94.4%) and 0.5 or better in 47 eyes(65.3%) 4) Ocular complications after posterior capsulotomy were transient increase of intraocular pressure(8.3%), sustained increased intraocular pressure(4.2%), anterior uvetis(2.8%), vitreous prolapse(2.8%), corneal damage(2.8%), intraocular lens damage(1.4%), cystoid macular edema(1.4%), retinal detachment(1.4%). Conclusion : As the results, posterior capsulotomy with the Nd : YAG laser offers several advantages over primary or secondary surgical capsulotomy and has fewer complications.