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수변 서식 톡토기 Yuukianura szeptyckii (Neanuridae)에 대한 카드뮴과 구리 독성 연구
김하경,신지민,정도현,정주영,김용은,위준,조기종,이윤식 한국환경생물학회 2024 환경생물 : 환경생물학회지 Vol.42 No.1
생태계는 생물에게 매우 다양한 환경조건의 서식처를 제공하며 이 서식처 내에 적응한 생물만이 생존, 성장, 번식하며 해당 서식처에 살아가게 된다. 또한 서식처의 환경조건들은 서식처로 유입한 화학물질의 생물유효도(bioavailability)에 크게 영향을 미쳐 생물들이 받는 부정적 영향이 서로 다를 수 있다. 본 연구에서는 생태독성평가에 적합한 ISO guideline 11276의 독성평가 표준종 중 토양 생태계에 다양한 서식처 조건 중 수변 생태계에서 적응하여 살아가는 Yuukianura szeptyckii의 중금속에 대한 평가 민감성을 확인하고 수변 서식처 중금속 생태독성평가종으로서의 가능성을 확인하는 데 있다. 결과는 카드뮴과 구리 모두 농도에 따른 유의한 독성영향을 보였다. 카드뮴의 경우 LC50은 280 mg kg-1, EC50은 66 mg kg-1, NOEC와 LOEC는 각각 25, 50 mg kg-1으로 나타났으며 구리의 경우에는 LC50은 911 mg kg-1, EC50은 151 mg kg-1, LOEC는 50 mg kg-1으로 나타났다. 기존의 국제표준종인 Folsomia candida와 국내표준종인 Allonychiurus kimi의 이전 결과 와 비교하면 더욱 민감한 독성값을 보였으며, 이러한 생존과 번식에 미치는 부정적 영향은 체내의 중금속의 유입 농도와 밀접한 관련을 보였다. Y. szeptyckii는 수분 함량이 높은 토양에서 중금속 생태독성평가에 민감한 종으로 나타났으며, 상대적으로 높은 습도를 보일 가능성이 높은 수변 생태계에 적합한 생태독성평가종으로 사용이 가능할 것으로 생각된다. The ecosystem provides a diverse array of environmental conditions for organisms, and only those that are capable of successfully adapting to these conditions within their habitats can endure, thrive, and proliferate. Further, the environmental conditions within these habitats can significantly affect the bioavailability of chemicals that are introduced therein, thus resulting in varied adverse impacts on the organisms. The present study aims to evaluate the sensitivity of Yuukianura szeptyckii - a species adapted to riparian - to heavy metals following ISO guideline 11276, with the objective of assessing its potential as an indicator species for ecotoxicological evaluations in riparian habitats. The findings revealed that cadmium and copper both had significant toxic effects depending on their concentrations. For cadmium, the LC50 was 280 mg kg-1, EC50 was 66 mg kg-1, and NOEC and LOEC were 25 and 50 mg kg-1, respectively. For copper, the LC50 was 911 mg kg-1, EC50 was 151 mg kg-1, and LOEC was 50 mg kg-1. Comparative analysis with previous results for the international standard species Folsomia candida and the domestic standard species Allonychiurus kimi indicated that Y. szeptyckii exhibited even greater sensitivity to toxicity values. The adverse effects on survival and reproduction were closely associated with the influx concentration of heavy metals in their bodies. Altogether, the results suggest that Y. szeptyckii is a sensitive species for ecotoxicological assessments in riparian habitats, thus making it suitable as an indicator species, particularly in riparian ecosystems that are characterized by relatively high humidity conditions.
김하경 서울대학교 라틴아메리카연구소 2012 이베로아메리카硏究 Vol.23 No.3
At the turn of the nineteenth century, Mexico experienced a series of historic events: the Caste War, the rise of the henequen industry, and the Porfirian project of modernization. These events, combined with the immigration policies at the time, begot an increase of East Asian immigration, which complicated the race-class dynamics especially in the state of Yucatán. Despite the arrival of East Asian immigrants initially as laborers, the changes in their class identity in the process of permanent settlement resulted in the creation of new social categories and the difficulty in positioning them in the existent social dynamics. Amid such difficulty was the contradiction in the Mexican reception of foreign immigrants. Even though Mexico welcomed East Asians in the first place, they were later excluded from the discourse of mestizaje. The account of the first wave of Korean immigration to Mexico is most notable as a case that demonstrates the contradictory attitudes and the complexity of the race-class dynamics in Mexico at the time. Forgotten by Korea due to a political turmoil in East Asia and disregarded by Mexico due to their diminishing economic value and small size, the Korean immigrants were indeed without a place in terms of national and cultural identity in the host country. That is, while Koreans as physical individuals inevitably mixed into Mexican society both biologically and culturally, Korean as an ethnicity was unable to become a part of what constituted Mexicanidad. By looking into the (lack of) Mexican references to Korean immigrants in official government correspondences and Yucatecan print media from 1904 to 1909, this thesis reinterprets the significance of Korean immigration from a Mexican perspective. Unlike most analyses that tend to read Korean immigration only as an extension of Korean history, it contextualizes the event within Mexican history. It also identifies the economic and political interests of the Mexican government and Yucatecan plantation owners in relation to its Korean population.
김하경,한영진,고기영,정민재,최경학,조용필,권태원 대한혈관외과학회 2018 Vascular Specialist International Vol.34 No.4
Purpose: Surgery is the most common risk factor for pulmonary embolism (PE) in patients with a recent venous thromboembolism (VTE). This study reviewed clinical outcomes of preoperative inferior vena cava filter (IVCF) use in patients with acute VTE during abdominal-pelvic cancer or lower extremity orthopedic surgeries. Materials and Methods: We retrospectively analyzed 122 patients with a recent VTE who underwent IVCF replacement prior to abdominal-pelvic cancer or lower extremity orthopedic surgery conducted between January 2010 and December 2016. Demographics, clinical characteristics, postoperative IVCF status, risk factors for a captured thrombus, and clinical outcomes were collected for these subjects. Results: Among the 122 study patients who were diagnosed with acute VTE in the prior 3 months and underwent preoperative IVCF replacement, 70 patients (57.4%) received abdominal-pelvic cancer surgery and 52 (42.6%) underwent lower extremity orthopedic surgery. There were no perioperative complications associated with IVCF in the study population and no cases of symptomatic PE postoperatively. A captured thrombus in the filter was identified postoperatively in 16 patients (13.1%). Logistic regression analysis indicated that postoperative anticoagulation within 48 hours significantly reduced the risk of a captured thrombus (odds ratio [OR], 0.28; 95% confidence interval [CI], 0.08-0.94; P=0.032). Conclusion: A captured thrombus in preoperative IVCF was identified postoperatively in 16 patients (13.1%). Postoperative anticoagulation within 48 hours reduces the risk of captured thrombus in these cases.
김하경,유홍석,표홍렬,노재명,주상규,이우진,박병석,김진만,강노을,신선혜,박혜윤 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Background: IBM Watson for Oncology (WFO) is a cognitive computing system which helps physicians quickly identify key information in a patient’s medical record, surface relevant evidence and explore treatment options. We evaluated the level of agreement between WFO and multidisciplinary tumor board (MDT) for lung cancer. Methods: From January to April 2018, newly diagnosed lung cancer cases in Chonnam National University Hwasun Hospital were retrospectively examined using WFO version 18.4 according to four treatment categories [surgery, radiotherapy, concurrent chemoradiotherapy (CCRT), and palliative setting]. Concordance between MDT and WFO was analyzed by Cohen's kappa value. Results: Total 132 cases were enrolled in this study. The concordance rate occurred in 92.4% (k=0.881, p<0.001) for the all cases. The strength of agreement was very good in stage 1 (92.4%, k=0.855), stage 4 NSCLC (100%, k=1.000) and extensive disease SCLC (100%, k=1.000). In stage 3 NSCLC, the strength of agreement was good (80.8%, k=0.622). And the concordance was moderate in stage 2 NSCLC (83.3%, k=0.556) and limited disease SCLC (84.6%, k=0.435). There were discordant cases in surgery (4/29, 13.8%) and CCRT (5/33, 15.2%), but discordance was not occurred in radiotherapy and palliative care. Conclusion: Treatment recommendations made by WFO and MDT were highly concordant for lung cancer cases especially in stage 1 NSCLC and metastatic stage. However, WFO was just an assisting tool in stage 2-3 NSCLC and limited disease SCLC, so shared decision making may be more important in this stage.