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Chung Ee-Yung,Lee C-Hang-Hoon,Park Ki-Ho 한국발생생물학회 2001 한국발생생물학회 학술발표대회 Vol.2001 No.-
R. Philippinarum is dioecious and oviparous. In the early vitellogenic oocyte, the Golgi apparatus and mitochondria present in the perinuclear region are involved in the formation of lipid droplets and in lipid granule formation. In the late vitellogenic oocyte, the endoplasmic reticulum, mitochondria in the cytoplasm are involved in the formation of proteid yolk granules. At this time, exogenous lipid granular substance and glycogen particles in the germinal epithelium are passed into the ooplasm of oocyte through the microvilli of the vitelline envelope. Ripe oocytes are about 55-60 m in diameter. The spawning period was once a year between early June and early October, and the main spawning occurred between July and August when seawater temperature was approximately 20 C. The reproductive cycle of this species can be categorized into five successive stages: early active stage (February to March), late active stage (April to May), ripe stage (April to August), partially spawned stage (June to October), and spent/inactive stage (August to March). Gonad developmental phases by histological qualitative analysis showed similar results with those of quantitative image analysis.
Park, Hee Jin,Baek, Dongwon,Cha, Joon-Yung,Liao, Xueji,Kang, Sang-Ho,McClung, C. Robertson,Lee, Sang Yeol,Yun, Dae-Jin,Kim, Woe-Yeon American Society of Plant Biologists 2019 The Plant cell Vol.31 No.1
<P>The High Expression Of Osmotically Responsive Gene 15–Evening Complex–histone deacetylase 9 histone-modifying complex regulates photoperiodic flowering via transcriptional repression of <I>GIGANTEA</I>.</P><P>In plants, seasonal inputs such as photoperiod and temperature modulate the plant’s internal genetic program to regulate the timing of the developmental transition from vegetative to reproductive growth. This regulation of the floral transition involves chromatin remodeling, including covalent modification of histones. Here, we report that HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 15 (HOS15), a WD40 repeat protein, associates with a histone deacetylase complex to repress transcription of the <I>GIGANTEA</I> (<I>GI</I>)-mediated photoperiodic flowering pathway in Arabidopsis (<I>Arabidopsis thaliana</I>). Loss of function of HOS15 confers early flowering under long-day conditions because elevated <I>GI</I> expression. LUX ARRHYTHMO (LUX), a DNA binding transcription factor and component of the Evening Complex (EC), is important for the binding of HOS15 to the <I>GI</I> promoter. In wild type, HOS15 associates with the EC components LUX, EARLY FLOWERING 3 (ELF3), and ELF4 and the histone deacetylase HDA9 at the <I>GI</I> promoter, resulting in histone deacetylation and reduced <I>GI</I> expression. In the <I>hos15-2</I> mutant, the levels of histone acetylation are elevated at the <I>GI</I> promoter, resulting in increased <I>GI</I> expression. Our data suggest that the HOS15–EC–HDA9 histone-modifying complex regulates photoperiodic flowering via the transcriptional repression of <I>GI</I>.</P>
Esculetin의 caspase-3 활성을 통한 U937 인체 혈구암세포의 세포사멸 유도
박철(Cheol Park),현숙경(Sook Kyung Hyun),신우진(Woo-Jin Shin),정경태(Kyung Tae Chung),최병태(Byung Tae Choi),권현주(Hyun Ju Kwon),항혜진(Hye Jin Hwang),김병우(Byung-Woo Kim),박동일(Dong Il Park),이원호(Won Ho Lee),최영현(Yung Hyun C 한국생명과학회 2009 생명과학회지 Vol.19 No.2
Esculetin, a coumarin compound, has been known to inhibit proliferation and induce apoptosis in several types of human cancer cells. However, the molecular mechanisms involved in esculetin-induced apoptosis are still uncharacterized in human leukemia cells. In this study, we have investigated whether esculetin exerts anti-proliferative and apoptotic effects on human leukemia U937 cells. It was found that esculetin could inhibit cell viability in a time-dependent manner, which was associated with the induction of apoptotic cell death such as increased populations of apoptotic-sub G1 phase. Apoptosis of U937 cells by esculetin was associated with an inhibition of Bcl-2/Bax binding activity, formation of tBid, down-regulation of X-linked inhibitor of apoptotic protein (XIAP) expression, and up-regulation of death receptor 4 (DR4) and FasL expression. Esculetin treatment also induced the degradation of β-catenin and DNA fragmentation factor 45/inhibitor of caspase-activated DNase (DFF45/ICAD). Furthermore, a caspase-3 specific inhibitor, z-DEVD-fmk, significantly inhibited sub-G1 phase DNA content, morphological changes and degradation of β-catenin and DEE45/ICAD. These results indicated that a key regulator in esculetin-induced apoptosis was caspase-3 in human leukemia U937 cells.
박의돈,이동욱,박혜영,김대원,정윤철,손현,조영기,Park, Euy-Don,Lee, Dong-Uk,Park, Hae-Young,Kim, Dae-Won,Chung, Yun-C,Son, Hyun,Cho, Yung-Ki 한국통신학회 2001 韓國通信學會論文誌 Vol.26 No.10
DWDM 전송 시스템에서 전송 용량 증대를 위하여 bit rate를 고속화하고 채널 간격을 줄이기 위해서는 전송로로 사용되는 광케이블의 분산특성이 상반되는 값을 갖도록 요구된다. 즉, 분산으로 인한 신호 왜곡을 줄이기 위해서는 광케이블의 분산이 작아야 하고, 비선형 현상을 억제하기 위해서는 분산이 커야 한다. 이러한 두 가지 상반된 분산 penalty를 동시에 해결하기 위한 방안으로 양과 음의 분산 값이 이산적으로 분포된 광섬유 케이블을 최초로 설계 및 제작하였다. 이러한 분산 분포 케이블을 위해 일반 단일 모드 광섬유(SMF)와 대응되는 음분산 값을 갖는 새로운 광섬유(NDF)를 설계 및 제조한 후, SMF의 +17 ps/km/nm 및 NDF의 -15 ps/km/nm의 분산영역이 6km의 케이블 내에 분포되도록 케이블을 제작하였다. 새롭게 개발된 케이블의 분산 값을 국지적으로는 높은 값을 가지면서도 전체적으로는 1.0 ps/km/nm의 평균 분산 값으로 NZSDF 대비 30% 이하를 가질 수 있음을 확인하였다. 또한, 제안된 케이블은 SMF 케이블과 동일한 케이블 시공 운용 환경에서도 정합함을 확인하였다.
암퇘지에 있어서 체성장에 따른 혈청 성 Hormone 의 농도변화에 관한 연구
박창식,이규승,정영호,정영채 ( Chang S . Park,Kyu S . Lee,Yung H . Chung,Yung C . Chung ) 한국축산학회 1982 한국축산학회지 Vol.24 No.4
The present study was carried out to study the serum concentrations of peptide and steroid hormones from birth to 110㎏ in growing pigs. Six crossbred female pigs at diestrus were used for collection of blood samples at different weight. FSH, LH, prolactin, estradiol, progesterone and cortisol were assayed by radioimmunoassay methods. Serum FSH concentrations did not change from birth to 110㎏ body weight and were not detected below 1.3 mIU/㎖. LH concentrations ranged from 1.6 to 2.3mIU/㎖. They increased at 50㎏ body weight and remained quite constant thereafter. Prolactin concentrations ranged from 2.4 to 3.0 ng/㎖. Estradiol concentrations were significantly high (250.2 pg/㎖) at birth and then rapidly dropped at 15㎏ body weight and remained fairly constant (from 27.2 to 29.7 pg/㎖) thereafter. Progesterone concentrations ranged from 0.8 to 2.7 ng/㎖. They were 1.5ng/㎖ at birth and 0.8ng/㎖ at 15㎏ body Weight, and then increased to 2.4 ng/㎖ st 30㎏ body weight and remained fairly constant thereafter. Cortisol concentrations ranged from 26.8 to 65.2 ng/㎖. They rose from a low of 26.8 ng/㎖ at birth to high of 51.2 ng/㎖ at 50㎏ of body weight and then gradually increased to 65.2 ng/㎖ at 110㎏ body weight.
강영배,김상희,장환,김창섭,김종염,권영방,이영옥,박정문,정운익,김공식,신종백,Kang Yung-Bai,Kim S.H.,Jang H.,Kim C.S.,Kim J.Y.,Kwon Y.B.,Rhee Y.O.,Park J.M.,Chung U.I.,Kim K.S.,Shin J.B. 대한수의사회 1987 대한수의사회지 Vol.23 No.5
Outbreaks of foulbrood in honey bees rearing on Cheju Island(an apiary with 172 colonies) and in Pusan City(an apiary with 100 colonies) were reported in April, 1987. The disease striked on Cheju Island was identified as American foulbrood caused by Bacil
LPA Receptors: Subtypes and Biological Actions
Choi, Ji Woong,Herr, Deron R.,Noguchi, Kyoko,Yung, Yun C.,Lee, Chang-Wook,Mutoh, Tetsuji,Lin, Mu-En,Teo, Siew T.,Park, Kristine E.,Mosley, Alycia N.,Chun, Jerold Annual Reviews 2010 Annual review of pharmacology and toxicology Vol.50 No.-
Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular signaling molecule by binding to and activating at least five known G protein??coupled receptors (GPCRs): LPA<SUB>1</SUB>??LPA<SUB>5</SUB>. They are encoded by distinct genes named LPAR1??LPAR5 in humans and Lpar1??Lpar5 in mice. The biological roles of LPA are diverse and include developmental, physiological, and pathophysiological effects. This diversity is mediated by broad and overlapping expression patterns and multiple downstream signaling pathways activated by cognate LPA receptors. Studies using cloned receptors and genetic knockout mice have been instrumental in uncovering the significance of this signaling system, notably involving basic cellular processes as well as multiple organ systems such as the nervous system. This has further provided valuable proof-of-concept data to support LPA receptors and LPA metabolic enzymes as targets for the treatment of medically important diseases that include neuropsychiatric disorders, neuropathic pain, infertility, cardiovascular disease, inflammation, fibrosis, and cancer.