18–30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구

장윤경,송태진,김용재,허지회,이경열,김영은,장민욱,조수진,강석윤 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3

Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18–30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry. Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke. Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42–15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3). Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.

하악골에 발생한 심부성 치성섬유종의 치험 2예

김일규,김영렬,김종철,유선열 대한악안면성형외과학회 1986 대한악안면성형외과학회지 Vol.8 No.1

溫室保溫커튼의 材料特性에 따른 保溫效果分析

金榮福,金容換,李昇揆,金成泰,羅又禎,閔永鳳,朴重春,崔東烈 慶尙大學校 1991 論文集 Vol.30 No.2

The effects of the material properties of thermal curtains upon reduction of the greenhouse heat loss were studied. A theoretical analysis procedure with equations and computer programs was developed to estimate them by using energy balance principles. Curtain effectiveness for every three kinds pf value level of the material properties were studied and compared. The results of this study would be useful for the developent and management of greenhouse thermal curtains.

아동기에 주의력결핍 과잉행동증상을 경험한 성인의 정신병리와 기질 성격 요인

송열매(Yul-Mai Song),이건석(Kounseok Lee),한덕현(Doug Hyun Han),이영식(Young Sik Lee),민경준(Kyung Joon Min),박진영(Jin Young Park),김준원(Jun Won Kim) 대한소아청소년정신의학회 2013 소아청소년정신의학 Vol.24 No.4

Objectives:The objective of this study is to find out the differences in psychopathology, temperament, and character factors between young adults with and without childhood attention-deficit hyperactivity disorder (ADHD) symptoms. Methods:The subjects consisted of 314 university students (male=72, female=242) in Gongju. They were divided into childhood ADHD group (N=54) and normal group (N=260) to the Wender-Utah Rating Scale. Participants were assessed using Korean Adult ADHD Scale, Beck Depression Inventory-II, Beck Anxiety Inventory, Kimberly Young’s Internet Addiction Test, Barratt Impulsiveness Scale, Paranoia Scale, Korean-Schizotypal Ambivalence Scale, Lubben Social Network Scale, and Temperament and Character Inventory-Revised. Descriptive statistics, t-test, chi-square, spearman correlation, and stepwise multiple regression were applied to analyze the data. Results:Participants with childhood ADHD symptoms had high level of adult ADHD symptoms (p<.001), impulsiveness(p=.001), depression (p<.001), anxiety (p<.001), internet addiction (p<.001), paranoia tendency (p<.001) and low level of selfesteem (p<.001) compared to normal group. Self-directedness (p<.001) was lower, Harm avoidance (p=.001) and Self-transcendence (p=.029) were higher in the childhood ADHD group. In correlation and stepwise multiple regression, childhood ADHD symptoms were significantly associated with cooperativeness (r=-0.515 and β=-0.547, p<.001 respectively). Conclusion:This result showed that young adults with childhood ADHD symptoms had various forms of psychopathology and childhood ADHD symptoms were influenced by character such as cooperativeness. Therefore, more thorough evaluation regarding childhood ADHD symptoms is needed.

열형광 CaSO₄ : Dy 소자의 최적 제조조건에 관한 연구

양정선,장시영,김장렬,김두영,남영미,박재우 濟州大學校 産業技術硏究所 2000 산업기술연구소논문집 Vol.11 No.1

An experimental investigation has been performed to determine optimal conditions for preparing the thermoluminescent CaSO_(4):Dy pellets which have been widely used as personal radiation dosimeter material. Our investigation has shown that an optimal weight concentration of the dopant Dy in the bulk CaS0_(4):Dy is 0.1 mol%. and an optimal temperature of adding Dy in the preparing process is 320℃. An optimal time and temperature for sintering the CaSO_(4):Dy crystal produced from the chemical process are found to be 2 hours and 800℃. respectively. The maximum thermoluminescent sensitivity was observed when the CaSO_(4):Dy crystal was pulverized to grain sizes of 63 - 200 m in diameter before being fabricated into pellets. The commercial Teflon was selected as an adhesive for the fabrication of the CaSO_(4):Dy pellets with an optimal mixing ratio of the Teflon and CaSO_(4):Dy being 70 to 30 in weight.

열형광 CaSO₄:Dy 소자의 최적 제조조건에 관한 연구

김장렬,남영미,장시영,김두영,양정선,박재우 제주대학교 산업기술연구소 2000 尖端技術硏究所論文集 Vol.11 No.1

An experimental investigation has been performed to determine optimal conditions for preparing the thermoluminescent CaSO4:Dy pellets which have been widely used as personal radiation dosimeter material. Our investigation has shown that an optimal weight concentration of the dopant Dy in the bulk CaSO4:Dy is 0.1 mol%, and an optimal temperature of adding Dy in the preparing process is 320 ℃. An optimal time and temperature for sintering the CaSO4:Dy crystal produced from the chemical process are found to be 2 hours and 800 ℃, respectively. The maximum thermoluminescent sensitivity was observed when the CaSO4:Dy crystal was pulverized to grain sizes of 63 - 200 ㎛ in diameter before being fabricated into pellets. The commercial Teflon was selected as an adhesive for the fabrication of the CaSO4:Dy pellets with an optimal mixing ratio of the Teflon and CaSO4:Dy being 70 to 30 in weight.

야자 활성탄에 의한 폐수성분 제거 효율에 관하여

김용권,옥치율 부산교육대학교 과학교육연구소 1993 科學敎育硏究 Vol.18 No.-

By studying the relations between natures of activated carbon based on coconut shell and its changes with COD, SS and pH, it is shown that the results of sand filter and activated carbon adsorption of waste-water from automaker company turn out good. But this study shows that the only activated carbon adsorption treatment is not good enough when the concentration of untreatment water is too high.

동해안 연안어항 해수중의 COD 및 중금속 함량에 관한 연구

김영철,주충열,신응배 漢陽大學校 環境工學硏究所 1999 環境科學論文集 Vol.20 No.-

동해 연안 일부어항의 해수에 대한 수질환경 자료로 DO, ?? 총질소, 총인 그리고 납, 카드뮴, 크롬, 비소 및 수은 등의 중금속을 측정·조사하였다. 측정결과, DO 5.1∼6.2㎎/l, ?? 0.9∼2.7㎎/l, 납 trace∼0.054㎎/l, 카드뮴 trace∼0.004㎎/l, 비소 trace∼0.002㎎/l, 그리고 수은 trace로 나타났다. 이러한 결과로부터 오염의 정도를 판단하기는 어려우나 환경부가 정한 해역의 수질환경기준과 비교하여 볼 때 중금속으로 인한 오염문제는 크게 우려할 수준이 아니나 일부어항의 ?? 용존산소, 총질소, 총인의 농도로 판단할 때 Ⅱ등급 또는 Ⅲ등급 수질로 나타났다. 이들 지역이 선박이 정착하거나 출입하는 어항임을 감안할 때 비교적 양호한 결과인 것으로 분석된다. The seawater was sampled from the East Coast and the contents of DO, ?? total nitrogen, total phosphates, and heavy metals(Pb, Cd, As, Hg) in the water were measured and analyzed. DO 5.1∼6.2㎎/l, ??0.9∼2.7㎎/l, total nitrogen<0.131㎎/l, total phosphate <0.019㎎/l, Pb <0.0542㎎/l, Cd<0.0038㎎/l, As<0.0016㎎/l, and Hg(trace) were detected by the analytical techniquies such as UV-visible spectrometry and atomic absorption spectrometry. The results shows that heavy metal contamination of the East Coast is equivalent to the detection limits of the first grade seawater. But, the amount of DO, ?? total nitrogen, total phosphates shown above indicates that the seawater in the East Coast is of second or third quality. In conclusion, the samples cannot be justified as the first quality. Considering that the sampling sites were seaports, the seawater in the East Coast is not seriously contaminated.

인체 흑색종 세포군에서의 Vascular Endothelial Growth Factor(VEGF) 분비

김현조,황규왕,조문균,박영립,이종성,이성열 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Backgroung : Vascular endothelial growth factor(VEGF) is an angiogenic cytokine expressed by many human and animal tumors. Ultraviolet radiation(UVR) has been causally linked to melanoma initiation and progression. UVR is a known melanocyte mutagen and induces specific mutations in cellular oncogenes such as p53 and ras. Activated H-ras activates tumor angiogenesis in other cell types, and angiogenic switching is accompanied by up-regulation of VEGF. Objective : The purpose of this study was to determine whether VEGF release from human melanoma cell lines was altered by activating ras mutations or by inactivation of p53 induction and whether VEGF release of these transfected melanoma cell lines was changed after UVR radiation. Results : 1. Release of VEGF from menolayer culture of melanoma cells was significantly higher in cells with activating ras mutations and lower in cells with expression of dominant negative p53. 2. In spheroid culture, dominant negative p53 decreases VEGF release in WM35 cells, but activating ras did not affect VEGF release significantly. 3. The control cell line(WM35Neo) had higher VEGF release in the spheroid culture than in the monolayer culture, and dominant negative p53 or activating ras did not affect VEGF release significantly between these two culture systems. 4. Higher cell density increases VEGF release in all tested melanoma cell lines was shown in both spheroid and monolayer culture. This cell density effect was strongest in cells with activated ras in monolayer culture. 5. UVR inhibits VEGF release in all tested melanoma cell lines, and this effect was stronger in monolayer culture than in spheroid culture. The effect of UVR on VEGF release was significantly lower in the DNp53 transfectants. 6. UVR decreased the cell viability in a dose dependent manner regardless of the cell density or cell culture system. Conclusion : VEGF release in human melanoma was inhibited by ultraviolet radiation at cytotoxic doses, and this effect is stronger in monolayer culture than in spheroid culture. VEGF release from melanoma cell lines was also influenced by p53, ras and cell growth conditions in a complex manner.

粉末洗濟에 대한 生分解度와 重金屬에 대한 硏究

김영철,김종섭,유찬주,주충열 漢陽大學校 環境工學硏究所 1997 環境科學論文集 Vol.18 No.-

현재 국내에서 시판중인 의류용 세탁 분말세제 6종을 대상으로 미생물에 의해 분해될 수 있는 정도를 파악하기 위한 생분해도(Biodegradability)를 측정하고 동시에 인체에도 직접적인 영향을 미치는 중금속(Pb,Cd,As 및 Hg)를 분석하였다. 분석결과 전제품이 KS 기준에 모두 적합하였으나 석유계 계면활성제인 AOS 또는 LAS가 다량 포함 되어있는 제품에서는 상대적으로 생분해도가 낮다는 것을 알 수 있으며 중금속 함유량은 제품 6종 모두 화장품 원료기준에 훨씬 못미치는 우수한 제품인 것을 알 수 있었다. As the subject of study of six kinds of laundry powder detergents for clothing that come into the domestic market at present, the biodegradabilities to understand the extent of microorganisms decomposition were measured and the heavy metals(Pb, Cd, As and Hg) to have a direct effect on human body were analyzed. Analysis results show that though they all suit KS(Korean Industrial Standards) well, powder detergents containing plenty of petroleum surface active agents have the lower biodegradability than the others and Heavy metal contents are that all of them are very good at the cosmetic material standards.