콩 단백 성분 및 연령이 암컷 흰쥐의 혈장 지질 농도와 인지질 지방산 패턴에 미치는 영향

정은정(Eun-Jung Chung),김수연(Soo-Yeon Kim),김지영(Ji-Young Kim),안지영(Ji-Young Ahn),박정화(Jung-Wha Park),차명화(Myung-Hwa Cha),이양자(Yang-Cha Lee Kim) 한국식품영양과학회 2003 한국식품영양과학회지 Vol.32 No.2

혈중 지질농도는 식이단백질 종류보다는 연령의 영향을 많이 받아, young군보다 old군의 총 콜레스테롤, TG, HDL-콜레스테롤, LDL+VLDL-콜레스테롤 및 AI 모두 높았다. 한편 콩 단백질군에서 HDL-콜레스테롤 수준이 증가하고, LDL+VLDL-콜레스테롤와 AI는 감소하여, 심혈관질환에 대한 콩 단백질의 유익한 효과를 확인할 수 있었다. 식이단백질에 의해 유의한 영향을 받은 혈장 인지질의 지방산조성중 22:0, 18:1ω9, ∑MUFA 조성은 카제인군에서 콩 단백질군 보다 높았으며, 반대로 ∑SFA 조성은 카제인군에서 낮았다. 연령에 의해 혈장 인지질 지방산 조성에 있어 유의한 차이를 보인 지방산 중 22:0, 18:1ω9, 22:1, 18:3ω3 및 22:4ω6는 young군에서 높은 반면에, 22:6ω3, ∑ω3, 18:2ω6, 20:4ω6, ∑ω6 및 ∑PUFA의 조성비율은 old군에서 높게 나타났다. 이와 같이 식이 단백질의 종류보다 연령의 영향력이 더 많이 나타난 것은 혈중 콜레스테롤 수준이 식이 단백질보다는 연령의 영향을 더 크게 받았기 때문으로 생각된다. 혈장 인지질 지방산의 대사지표 중 Δ7-desaturation index(16:0⇒16:1ω7)와 Δ9-desaturation index(18:0⇒18:1ω9)가 식이 단백질의 영향을 받아 카제인군에 비해 콩 단백질군에서 유의하게 낮았다. Δ7- 및 Δ9-desaturation index만이 식이 단백질의 영향을 받은 것은 식이 단백질보다 desaturase 활성에 더 큰 영향력을 미치는 콜레스테롤이 식이에 첨가되었기 때문이라 생각된다. Δ-4 desaturation index (22:4ω6⇒22:5ω6)는 young군에 비해 old군에서 높았으며, elongation index(20:4 ω6⇒22:4ω6)는 old군에서 낮았다. 대부분의 elongation과 desaturation 단계는 연령에 따라 유의한 차이를 보이지 못하였으나, ω3계 지방산의 전체적인 elongation-desaturation 단계를 나타내는 ∑products-fatty acid(ω3)/α-LNA(ω3) 비율이 old군에서 young군보다 유의하게 높아, 연령에 따른 PUFA 대사의 변화가 관찰되었다. 이상에서와 같이, 콩 단백질의 섭취로 흰쥐 혈장 인지질의 ∑MUFA 조성은 낮고 ∑SFA 조성은 높아 다른 지질 강화성분의 섭취와 유사한 결과를 나타내었다. 혈중 콜레스테롤 수준이 높은 old군에서 체내 막조직의 유동성을 유지하기 위해 PUFA의 합성 특히 ω3계 지방산의 elongation-desaturation이 증가하여 총 PUFA 조성이 young군보다 높았다. 연구결과로 이소플라본을 포함한 콩 단백질의 혈중 지질저하 기전에 대해 체계적인 설명은할 수 없지만, 콩 단백질이 혈장 지방산의 조성을 변화시킴으로써 간접적으로 심혈관계 질환에 대해 유익한 효과를 미침을 알 수 있었다. 한편, 이러한 혈관의 건강과 관련된 콩의 유익한 효과는 이소플라본과 같은 콩의 특정 성분의 단독효과라기보다는 콩 단백질과의 복합효과에 의한 것이라는 주장은 매우 설득력 있다고 생각된다. Effects of soy protein concentrate (SPC) containing isoflavone and casein diets on plasma phospholipid (PLs)-fatty acid patterns were investigated in 7- & 40- wk old female rats. Diets containing 16% SPC (soy/young: SY, soy/old: SO) and casein (casein/young: CY, casein/ old: CO) supplemented with 0.5% cholesterol were fed for 4 wks. Fatty acid compositions of plasma PLs were determined by TLC and GLC. Compared to the dietary protein effects, age effects on serum lipids were more profound. The levels of total cholesterol (Chol.), triglyceride, HDL-Chol., (LDL+VLDL)-Chol. and atherogenic index (AI) were higher in older groups (OC & OS) than younger groups (YC & YS). Soy groups had higher HDL-Chol. level and lower (LDL+VLDL)-Chol. and AI, compared with casein groups. The compositions of C22:0, C18:1ω9 and sum of MUFA in plasma PLs were significantly higher in casein group (CY & CO) than soy group (SY & SO), but those of sum of SFA were higher in soy group. The compositions of C22:0, C18:1ω9, C22:1, C18:3ω3 and C22:4ω6 were higher and those of C22:6ω3, sum ofω3, C18:2ω6 C20:4ω6, sum ofω6 and sum of PUFA were lower in plasma PLs of younger rats. The average P/S and ω3/ω6 ratio in older group was higher. The Δ-7 desaturation index (16:0⇒16:1ω7) and Δ-9 desaturation index (18:0⇒18 : 1ω9) were lower in soy group than casein group, while Δ-6 and Δ-5 desaturation index were not affected by dietary protein. The Δ-4 desaturation index (22:4ω6⇒22:5ω6) were higher and, elongation index (20:4ω6⇒22:4ω6) were lower in older group. The ratio of the products of ω3 fatty acid series/precursor of ω3 fatty acid series (C18:3) was significantly higher in older group, which in- dicated that age affected the plasma PUFA metabolism. On the other hand, older rats had higher serum cholesterol level compared with younger rats. Taken together, these changes in fatty acid composition might cause minimal changes in the membrane fluidity induced by the increase serum cholesterol level.

만성 B형 간염에서 라미부딘 치료중 발생한 Viral Breakthrough 예의 임상 결과

안수현,장윤정,오성남,최도원,백수정,정원석,최창원,김경오,임형준,조남영,박종재,김재선,박영태,이명석,연종은,변관수,이창홍 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.4

목적: 만성 B형 간염의 치료 중 발생하는 약제 내성 변이종은 임상적으로는 치료 중 음전되었던 혈청 HBV DNA가 다시 양전되는 viral breakthrough 로 진단할 수 있다. 현재 약제 내성 변이종이 발생했을 경우라도 라미부딘 치료를 계속 유지하는 것을 권장하고 있으나, viral breakthrough 발생 예들의 장기적 임상경과가 아직도 불명확하여 이것을 일반화하기는 어려운 상황이다. 이에 라미부딘 사용 중 viral breakthrough 가 발생한 예들을 대상으로 그 임상경과를 알아보고자 하였다. 대상과 방법: 9개월 이상 라미부딘을 투약한 만성 B형 간염 환자로 viral breakthrough가 발생한 74명을 대상으로 하였다(남/여 54/20, 평균연령 42세). Viral breakthrough 후 혈청 ALT치, 총 빌리루빈치, HBV DNA 역가, HBeAg, anti-HBe를 정기적으로 검사하면서 임상경과를 관찰하였다. Viral breakthrough 후 라미부딘의 투약기간은 평균 13개 월(1-41개월)이었다. 결과: Viral breakthrough 발생후 혈청 ALT치가 정상으로 유지되었던 환자는 8예(11%)에 불과했고 나머지 66예(89%)에서는 ALT치가 증가하였으며, 이중 30예(41%)에서 급성 악화(ALT 정상 상한치의 5배 이상 상승)를 보였다. 급성악화는 viral breakthrough 후 3개월 내에 19예 (63%)에서 발생하여 3개월 내에 발생한 예가 많았으나 12개월 이상 지나서 나타나는 예도 약 20%에서 있었다. 비대상성 악화는 6예에서 관찰되었다. Viral breakthrough 후 급성악화가 일어난 예와 없었던 예의 비교에서 급성악화를 예측할 수 있는 인자는 발견할 수 없었다. Viral breakthrough 후 발견할 수 없었다. Viral breakthrough 후 HBeAg이 음전된 예는 8예(11%)였으나 그 임상경과는 양호하지 않았다. 결론: 만성 B형 간염 환자 에서 라미부딘 투여 중 발생한 viral breakthrough 예 중 상당수에서 급성악화가 발생하였으며, HBeAg 이 소실되더라도 그 임상경과는 양호하지만은 않았다. Viral breakthrough 발생 후 주의 깊은 임상경과 의 관찰이 요구되며, 앞으로 viral breakthrough 후 급성악화 예에 대한 대규모 연구와 적절한 치료방향의 제시가 이루어져야 할 것으로 생각된다. Background/Aims: Long-term lamivudine therapy can induce the emergence of lamivudine resistant hepatitis B virus (HBV) mutants. Clinically emergence of the mutant is expressed by the reappearance of disappeared HBV DNA in serum. Continued lamivudine treatment has been usually recommended in cases of viral breakthrough. However, the clinical outcome in patients with viral breakthrough is not clear. The aim of this study was to investigate the clinical course of chronic hepatitis B patients after viral breakthrough during lamivudine therapy. Methods: A total of 74 patients with chronic hepatitis B who showed viral breakthrough after at least 6 months of lamivudine treatment were included in this study. They had positive HBeAg and HBV DNA before treatment. The median follow-up duration after breakthrough was 13 months. Results: After viral breakthrough, only 8 patients (11%) maintained normal ALT levels and 66 patients (89%) showed elevation of ALT. 30 patients (41%) showed acute exacerbation of hepatitis (ALT increase over five-times upper normal limit). These acute exacerbations occurred within three months after breakthrough in 19 patients (63%). In the cases of acute exacerbation, 6 patients showed decompensated progression such as elevation of serum total bilirubin. One of them died of hepatic failure. A predictive factor for acute exacerbation was not found. HBeAg seroconversion occurred in 8 patients after viral breakthrough but their clinical course was highly variable. Conclusions: Chronic hepatitis B patients who had viral breakthrough during lamivudine therapy should be followed carefully and regularly in mind of potential clinical deterioration. New strategies are needed to manage the cases of acute exacerbation after viral breakthrough.(Korean J Hepatol 2002;8:389-396)

The Association Between Long Working Hours and Infertility

Ahn Joonho,Lee Sang Ha,Park Min Young,Oh Soo Hyun,Lee Wanhyung 한국산업안전보건공단 산업안전보건연구원 2021 Safety and health at work Vol.12 No.4

Background: This study aimed to investigate whether working long hours was related to infertility among female Korean workers, while taking age into consideration. Methods: We used data from the 2018 National Survey on Fertility and Family Health and Welfare in Korea that is a cross-sectional, nationally representative, and population-based survey. Infertility was defined as women who were not pregnant after regular unprotected intercourse for a year. Working long hours was classified as ≥52 hours, and subgroups as per age were classified on the basis of being younger or older than 40 years of age. Differences in infertility risk between the long working hour group and none were estimated in crude and fully adjusted logistic regression models with age-group stratification. Results: Of 5,909 Korean female workers, the crude and adjusted odds ratios (95% confidence intervals) of infertility for working long hours were 1.295 (0.948-1.737) and 1.303 (0.921-1.809), respectively. In the subgroup of patients below 40 years of age, the crude and adjusted odds ratios (95% confidence interval) were 1.957 (1.216-3.039) and 1.921 (1.144-3.120), whereas those aged 40 years or older had 0.994 (0.647-1.471) and 0.939 (0.560-1.501), respectively. The weighted prevalence of infertility increased as weekly working hours increased only for the younger than 40-year subgroup. Conclusions: Infertility is associated with working long hours, especially in young-aged workers. Thus, the working schedule must be structured to better suit young female workers.

스포츠行動이 스포츠參加者의 Lifestyle에 미치는 影響

안영필,김유수,조만태 東亞大學校 附設 스포츠科學硏究所 1993 스포츠科學硏究論文集 Vol.11 No.-

The purpose of this study was to make on offer the basic data of sport marketing in the field of sport behavior research. The AIO(Activities, Interests and Opinions) approach is used to operationalize the lifestyle concept. Questionaires cotaining 38 AIO statements are administered to a total 600 members of a privately owned sport club in Busan, Korea. 452 usable questionnaires were returned, resulting in a response rate of 75.3%. The sampling was chosen by the stratified random sampling method. factor analysis is used to identify the overall structure of club member's life style. factor scores are compared for differences in gender and generation status. The result of the study include : (1) There exist eight factors representing dimensions of sport participant's lifestyle. There are named as sensitive of fashion, performance of Brand, Achievement, stability directed, Self-Confidence, Nihilism, Health-Conscious, Self-affirmative. (2) When gender is considered, mean factor scores differ significantly for 5 of the 8 factor dimensions. (3) When generation is considered, meanfactor scores differ significantly for 3 of the 8 factor dimensions. There findings confirm that lifestyle is and observable construst and differs according to gender and generation.

Monocrotaline으로 유발시킨 흰쥐 폐고혈압에 대한 Flunarizine의 약리작용

안형수,이영미 同德女子大學校 1997 同大論叢 Vol.27 No.1

Monocrotaline treatment (60mg/kg, i.p.) in normotensive rats resulted the indications and related toxicities of pulmonary hypertension, including the increase of hematocrit value, right ventricle hypertropy, pulmonary edema and lethality, after 4 weeks later. However, daily administrtion of flunarizine (5mg/kg, p.o.) for 4 weeks seemed to decrease the above responxes, and also there was no significant change on the systemic mean arterial blood pressure and heart rate. In the anesthetized rats, hypotensive effect induced by isoproterenol bolus injection was signficantly inhibited in flunarizine-treated pulmonary hypertensive rats, comparing to the untreated rats, even if those by acetylcholine, adenosine and ATP were not. In the isolated pulmonary artery experiments, vasorelaxation induced by isoproterenol, but not acetylcholine, adenosine or ATP, were also selectively inhibited in flunarizine treated rats, comparing to the control rats. Also vasoconstriction induced by norepinephrine were increased in flunarizine treated rats comparing to the control rats, but those by KCI were not. However, pretreatment of flunarizine did not significantly affected on the vasodilation induced by acetylcholine, isoproterenol, adenosine or ATP and on the vasoconstriction induced by norepinephrine in isolated pulmonary artery of the normal rats. These results suggest that flunarizine will decrease the pathogenesis of pulmonary hypertension through the change of α- and β-adrenergic receptor activity in pulmonary artery due to the up-regulation of voltage dependent Ca++ channels.

셸리(Percy Byshe Shelley)의 『인생승리』 (The Triumph of Life) 연구

안영수 경희대학교 인문학연구소 2002 인문학연구 Vol.6 No.-

The evaluation of Shelley's fame as a poet was ambivalent. Until 1840 he was generally ignored in literary circles, though he had a few keen admirers, among them Thomas Hardy and Bernard Shaw included. Then, between 1850 and 1890, Shelley became respectable as a poet. The important themes Shelley has pursued throughout his short but active poetic career can be summed up as following: devotion to nature, a keen interest in science, and a radical egalitarian tendency toward social and political issues, and an agnostic attitude about all kinds of religions. All these interests are resulted in his strong faith in man's liberty, freedom, and happiness despite he is doomed to suffer due to tyrannies of kings and churches, hence building an earthly paradise envisioned in Prometheus Unbound. The Triumph of Life is an unfinished poem due to his untimely death in 1822. Many critics agree in that Shelley left this unfinished in the form of a Dantean dream-vision, in which the poet faces up to the discovery that human history has been a continuous process of human suffering and defeat. Unfortunately, however, we cannot be sure what the theme was of this unfinished poem since the title is doubly ambiguous. As King-Hele is aptly defined, 'Triumph' may mean simply 'procession,' for the existing fragment describes a process of phantoms. More probably, 'triumph' means 'victory.' If so, is it the victory of Man over nature and the restraints now stifling him? Of is it the victory of Life over men? The grim picture of the existing fragment, and references to Life the 'conqueror' might imply the gloomier alternative, but we have to be careful about the conjecture whether it would be an happy ending or otherwise. As to the question posed at the end of the fragment "then, what is Life?", I intend to find a possible answer based on the light imagery which recur throughout the poem. As he maintained in his essay "On Life", that "What is life? Thoughts and feelings arise, with or without our will, and we employ words to express them," Life, even if it's endless sufferings and pains continually defeating man's creative power, can be redeemed thanks to man's imagination.

수공구조물이 하천환경에 미치는 영향에 관한 연구(I) : 수리학적특성 Hydraulic Characteristics

안승섭,최윤영,이수식 한국환경과학회 2002 한국환경과학회지 Vol.11 No.3

In this study, water protection reservoir is selected as the target which is located at the estuary of Teahwa river to analyze and examine the effects of hydraulic structure on river environment. This study aims at the definition of factors which cause the change of ecological environment of river due to the effects of the sediment protection reservoir, and the proposal of the direction of environmental friendly river space development through the analysis and examination of stream variation conditions and riverbed variation characteristics among many effects of hydraulic structure on river environment before and after removal of the sediment protection reservoir when design flow is yielded. Firstly, in case of removal the existing sediment protection reservoir, the hydraulic variation characteristics like depth drop due to removal of the sediment protection reservoir are thought of little because it is examined that depths drop with about 0.01m and 0.01~0.56m when low flow is yielded and design flood yielded, respectively. Nextly, as the examination result of the variation characteristics of flow velocity in case of removal the existing sediment protection reservoir, it is thought that the concern about riverbed erosion is not serious according to the analyzed result as the mean velocity of the channel section where the velocity varies in case of removal the sediment protection reservoir is about 0.07~1.36m/s when low flow is yielded, and is about 1.02~2.41m/s when design flood is yielded despite riverbed erosion is concerned as it is examined that flow velocity is getting increase as about 0.01m/s when low flow is yielded and about 0.01~0.44m/s when design flood is yielded. Lastly, from the prediction result of riverbed variation for each flow amount condition before and after removal the sediment protection reservoir, it is known that the variation range of riverbed is nearly constant when flow amount of the channel exceeds a specific limit as it is analyzed that the more flow amount, the more erosion and sediment in the channel section of down stream part of the sediment protection reservoir and the sediment protection reservoir-Samho-gyo, and the variation ranges according to flow amount between flood condition and design flood condition have little difference in the channel section of the upstream of Samho-gyo.

게르만어 모음교체와 고대영어 강변화 동사

안수영 東新大學校 1999 論文集 Vol.11 No.-

Ablaut, a traditional feature of Indo-European tense formation, is a morphologically conditioned alternation which can occur in lexical, derivational, or inflectional morphemes. The most frequent alternations are /e, e-, o, o-/ and φ. The place where the Germanic reflex of ablaut is most obvious is in the strong verb paradigm. Old English is seen to have evolved the Germanic principle with such consistency that virtually all its primary verbs came to be arranged in rigid ablaut series. OE strong verbs have been classified into seven classes according to the vocalism of their four principal parts, i. e., the present, the preterit singular, the preterit plural and the past participle. Its criteria, however, are not purely synchronic but are essentially affected by historical consideration. In other words, the 'traditional classification' takes into consideration several sound changes such as breaking, pre-nasal raising, etc. which blurred original about patterns. Even though it is obvious that the criteria for classification which is relevant in pre-Germanic or Indo-European are no longer functional, the 'historicism' of historical linguistics should not be depreciated too much.

Mg 其他 複合材料의 强化材 量 및 分布에 따른 機械的性質特性

안선규,하홍수,김영직,임병수 成均館大學校 科學技術硏究所 1997 論文集 Vol.48 No.1

The effect of different SiC particle size and weight fraction in Mg/SiC particle MMC on the mechanical properties has been investigated. In this study, different particle sizes of 7㎛, 20㎛ and 50㎛ were prepared with various weight fraction of 10wt.%, 20wt.% and 30wt.% for sample preparation. By tension tests, the properties of ultimate tensile stress, yield stress and % elongation were observed and by tension-tension fatigue tests, whose procedures are standardized in ASTM standard 647E-93, the ΔK vs, da/dN curves were also obtained. Finally, the crack propagation paths were observed by optical microscope.

세기변조방사선치료의 선량분포 검증에 관한 연구

권수일,신동호,송재영,안진호 京機大學校 2006 論文集 Vol.50 No.-

Film dosimetry as a part of patient specific intensity modulated radiation therapy quality assurance (IMRT QA) has been accomplished to develop the new optimization method of film isocenter offset and to suggest the new quantitative criteria for film doimetry after optimization. Five patients with head and neck cancers were measured in IMRT dosimetry by film method. Optimization method with the local minimum was developed to adjust the film isocenter offset error, which is the biggest part of systemic errors. The mean ratios were 5.33% and 7.09% for 5mm and 1 mm resolution dose data optimization respectively.