유약 흰쥐에서 장 허혈이 장 조직에 미치는 영향 및 Interleukin-10의 효과

박영실,김동철,전정식 대한소아과학회 2004 小兒科 Vol.47 No.3

백서 뇌의 Ciliary Neurotrophic Factor 발현에 관한 면역조직화학적 연구

천현미,이영호,김원식 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

It was reported recently that ciliary neurotrophic factor (CNTF) is mainly present in the Schwann cells and asrocytes and maintain the motor neurons in postnatal periods. But there is no detailed research about the localization of CNTF. Several articles showed that there were many regions which have CNTF positive neurons. To test the unsettled CNTF immunoreactivity, the immunohistochemistry with CNTF antibody (Research & Development of the BML, Japan) was performed in th erat brain. The adult female rats weighing aound 200g were fixed by perfusion and 40-㎛-thick frozen sections were taken, and perform CNTF immunohistochemistry. The CNTF immunoreactivity was observed in the astrocytes of the optic nerve, olfactory nerve, fimbriae of the hippocampus, internal capsule, and cingulum, and in the non-astrocytes of the pyramidal tracts, the ventral portion of the pontine nucleus, and the central portion of the medulla oblongata. These data show that CNTF immunoreactivities present mainly in the astrocytes between the nerve fiber bundles in the cerebrum and in the non-astrocytes of the brain stem.

단상 4중 멀티레벨 AC-DC 컨버터를 사용한 입력전류의 특성 개선

김천식,김은수,서기영,이현우 慶南大學校 附設 工業技術硏究所 2002 硏究論文集 Vol.20 No.-

본 논문은 입력전류 개선방법으로 buck 컨버터를 조합하여 컨버터의 입력전류를 계단파 형태로 제어하는 binary 조합을 이용한 단상 4중 Multi-level AC-DC 컨버터를 제안하고, 타당성을 시뮬레이션과 실험을 통하여 확인하였다. 동등한 용량의 AC-DC 컨버터를 중첩·다중화를 만들면 입력전원의 단위 역률 제어가 가능하고, 고속 스위칭에 따르는 문제를 저감시킬 수 있고, 필터가 불필요하게 되어 대용량화에 적용시킬 수 있는 등의 장점이 있다. This paper proposed the single phase quadruple multi-level AC-DC converter using binary combine which controls input current by combining buck converters to improve input current characteristic, and confirmed its validity throughout simulation and experiment. By multiplying and duplicating of AC-DC converter of equal capacity has the advantage of being able to control unit power factor of input current and reducing of the problem caused by high frequency switching, and appling to high power converter because filter is not necessary.

자궁경부종양에서 Cathepsin-D 표현의 의의

이춘희,김세진,전상식,이택후,조영래,채종민 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1

Various clinical and histopathologic characteristics are currently used to obtain prognostic information about cervical carcinoma, but they do not predict the outcome for any individual patients. Thus, there is a need to identify additional tumor characteristics that are able to predict more accurately the outcome for an individual patient with cervical cancer. In this study, we explored the relationship between cathepsin-D expression and progression of the cervical neoplasia, the correlation between response to neoadjuvant chemotherapy and cathepsin-D expression, and we investigated if tumor cell cathepsin-D expression could serve as a prognostic factor in cervical carcinoma. Tumor tissues were obtained from 14 patients with cervical intraepithelial neoplasia and 52 patients with squamous cell carcinoma of the cervix. Cathepsin-S expression was identified by immunohistochemical methods using monoclonal antibody cathepsin-D (BioGene). Positive cathepsin-D immunoreaction in greater than 30% of carcinoma cells was scored as high expression. High cathepsin-D expression was seen in 15 of 52 invasive cancer but was absent in cervical intraepithelial neoplasia. It was shown that cathepsin-D expression was independent of the rumor grade, tumor size, lymph node involvement, depth of invasion, parametrial invasion, and response to chemotherapy. In disease free survival analysis by log-rank test, cathepsin-D expression was not significantly associated with survival. These results show that cathepsin-D expression is not a clinically useful adjunct to assessment of prognosis in invasive squamous cell carcinoma of the cervix.

노인의 식이 콜레스테롤 및 식이섬유 섭취가 혈중지질과 체중에 미치는 영향

양춘호,문용식,김중언 群山大學校 1997 論文集 Vol.25 No.-

The purpose of this study was to investigate the effects of dietary cholesterol and dietary fiber on blood liquid component and body weight of 60's older. The subjects were 12 of older. The subjects were ranomly assigned to one two group( experimental and control). Each group ender up with 6 subject. The measurement items were total cholesterol, TG, HDL, LDL, body weight. The entire investigation period was 8wks The subject in the utitlized the 2×5 factorial repeated measure The results were as follows: First, There were statistically significant difference between cholesterol, TG, HDL, body weight of the control group and the experimental group. Second, There were statistically significant difference among Cholesterol, TG, HDL, LDL, and body weight means of treatment period. Third, There were not show statistically significant difference between group and treatment period.

配當支給政策變更이 株價에 미치는 影響

金暎圭,禹春埴 成均館大學校 韓國産業硏究所 1988 韓國經濟 Vol.16 No.-

수술실 오염도감소를 위한 수술실공조시스템에 대한 연구

김천숙,박은정,강규식,김지은,안기량,권진형,유시현,주영철,권순정 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background: The OR(operating room) should provide an optimum environment that is safe for the patient and the working personnel. The air ventilation system of OR has been studied to decrease the contamination of air. We investigated the flow and contamination of the air in OR at our hospital. Method: Cultures in OR were made and the number of bacteria and fungi were calculated. A two-dimensional model for the cross-section of an operation room is developed for the CFD (computational fluid dynamics) analysis. The characteristics of air flow in the empty operation room and in the occupied operation room are calculated by using a CFD program. Results: The current air ventilation system of our hospital does not deliver the clean air to the operating site efficiently in occupied OR. Conclusions: We suggested a new location of air ventilation system which improves air venting with little increase of the cost of equipment.

무기이온을 광증감제로 사용한 유해물질의 광분해

이춘식,김영희,박현건 진주산업대학교 1999 산업과학기술연구소보 Vol.- No.6

Photodegradation of benzene, carbaryl and aldrin were conducted with persulfate, nitrate and nitrite ion as sensitizers in aqueous solution. Persulfate and nitrate ions were proved to be effective to enhance the photodegradation of hazardous compounds. The sensitizing effect increased with increasing persulfate concentration, while nitrate ion showed the greatest sensitizing effect at 5㎎/l. In the case of the nitrite ion, no significant enhancement effect was observed, on the contrary, inhibited the photodegradation of hazardous compounds. With increasing nitrite concentration, photodegradation of hazardous compounds ran through a maximum value and decreased there after with increasing nitrite concentration.

갑상선암에서 MAGE 1-6 mRNA를 검출하는MAGE common primer의 의의

남철우,최영식,박요한,이강대 고신대학교의과대학 2006 고신대학교 의과대학 학술지 Vol.21 No.2

Background: MAGE (melanoma antigen gene) was named as cancer/testis specific antigens since their expression is only detected in the testis or cancer cells. Because of their relatively specific expression in the cancer cells, they have been considered as the early diagnosis of several cancers, or the appropriate targets for the specific immunotherapy mediated by cytotoxic T lymphocytes. Therefore, there were many reports about the expression of MAGE genes in various types of malignant tumors, but only a few reports in human thyroid neoplasms. The purpose of this study was to determine whether the MAGE common primers expressed in different histological types of thyroid tumors and to see the clinical usefulness of MAGE common primers on the thyroid tumors. Methods: Fifty-nine patients who underwent thyroidectomy at Kosin Medical Center from January, 2001 to April, 2002 were included in the study. Of the 59 patients 40 were papillary carcinoma, 4 follicular carcinoma, 3 medullary carcinoma, 1 anaplastic carcinoma, 4 nodular hyperplasia, 3 adenomatous goiter, and 4 follicular adenoma. Total cellular mRNA was extracted from those 48 cancer tissues, 11 benign tissues and additional eleven normal control thyroid tissues. Nested reverse transcriptase-polymerase chain reactions (nested RT-PCR) with the MAGE common primers designed to detect MAGE 1-6 genes were employed in this study. With probes confirmed by DNA sequencing. Results: Of those 48 cases of thyroid carcinomas 10 cases (20.8%) were expressed MAGE common primers. In the 40 papillary carcinoma, MAGE common primers were expressed in 17.5%. In the four follicular carcinoma, they were expressed in two cases, and in one case of one anaplatic carcinoma. However, in the three cases of medullary carcinoma, MAGE gene was not expressed. None of 11 benign tumors and 11 normal tissues expressed any of these MAGE common primers. The sensitivity of MAGE common primers in thyroid tumors was 20.8% and the specificity was 100%. Conclusion: These results suggested that MAGE common primers were expressed low in the malignant thyroid tumors but it was not expressed in benign tumors and normal tissues. It is suggested that MAGE common primers can be used for preoperative differential diagnosis of follicular carcinoma from benign follicular adenoma which cannot be made by fine needle aspiration cytology of thyroid tissue. However, further study is needed for clinical application of MAGE common primers expression as tumor markers in the thyroid tumors.

요하지통 환자에서 두 개의 캐눌라를 이용한 박동성 고주파 신경근 응고술의 임상 연구

김천숙,배재영,배덕구,강규식,안기량,권진형,김지은,유시현 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Dorsal root ganglion(DRG) block by the local anesthetics and steroids which has done classically in low back pain(LBP) patients with radiculopathy has high incidence of recurrence rate and side effects of steroids. Recently a new technique of pulsed radiofrequency thermocoagulation(P-RFTC) was introduced and substituted for it because of the benefits such as relatively low recurrence rate, low risk of nerve injury and comfort during the procedure. We experienced 15 patients who had LBP with radiculopathy and no or little response to epidural steroid injection. When we performed DR ganglionotomy by P- RFTC under the C-arm guide in these patients, we tried to approach the exact DR ganglion using tow cannulas - the one for obtaining patient's subjective symptoms and injection of contrast dye, the other for making a RF lesioning after identifying the impedance of sensory and motor stimulation. In conclusion, DR ganglionotomy by P- RFTC using two cannulas in LBP patients is an easy and safe procedure with satisfactory results.