외상성 신동맥 색전증 1례

한병규,김욱현,문기혁,송윤섭,박영호 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Renal artery thrombosis may result from external trauma of a blunt nature. Such injury is induced by rapid deceleration resulting in the stretching of the renal vasculature, disruption of the arterial intima-the least elastic layer of the arterial wall and eventual thrombosis. The treatment of renal artery thrombosis is controversial, with physician's options divided between prompt surgical exploration with vascular repair and clinical observation. We experienced 1 case of traumatic renal artery thrombosis and report that with a brief review of the literature.

소형엔진의 배출가스측정방법에 따른 질소산화물 및 매연에 관한 연구

한영출,나완용,오용석,문병철,박봉규,박귀열 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.3

Recently, increasing usage of diesel vehicle, many countries try to reduce the pollutant materials by emission regulation standard. Particularly, in our country, the supplement ratio of diesel vehicle is high, and air pollution by vehicle exhaust gas is very serious. So, in study, we tested exhaust gas by various mode in light duty diesel engine. Therefore, we can know about NOx and smoke seriousness.

금강의 수질, 어패류, 이끼 및 토양중의 중금속의 함량 조사

한인전,홍춘표,최용규 공주대학교 사범대학 과학교육연구소 1993 과학교육연구 Vol.24 No.1

This survey is to study the corresponding degree of water pollution of the Kum river areas, covering the eight places of main stream of the river from the Daechung dam to Kangkyung county, and two trivutary streams of Kap stream, and Miho stream. Besides, the heavy metal content of the fishes, shellfish, moss, and soil in the main stream of Kum river is investigated, whose results are as follows: 1. The water quality The water quality of the area from the Daechung dam to the Sintanjin county is first grade for the standard of drinking water in terms of BOD, COD values, that of both Kap stream and Miho stream is third or fourth grade respectively, and the other areas are turned out to be second grade. The water of the Daechung dam to the Sintanjin has little NO₂-N and ??, which can be said to be possible for the drinking water. The quantity of ?? and ?? in the water of all the areas is below the standard for the available drinking water, but, that of Kap stream and Miho stream is about two or three times higher than other areas. 2. Heavy metal The content of Cd, Cu, Mn, and Zn are shown to be comparatively less than that of Co, Fe, Ni, and Pb. And the content of Cu, Mn, Zn are less than the possible standard value for the drinking water. The relationship of the heavy metal content of the fish and shellfish were in order of Co>Zn>Cu>Cd, for the moss, Zn>Pb>Co>Cu>Cd, and for the soil, Zn>Pb>Cu>Co>Cd. The most of collecting samples in the Kumnam area have lots of heavy metals, and Pb is well contained in shells than fishes. When summarize the above result, the water in the Daechung dam and Sintanjin area is comparatively favorable for the drinking water, and the water quality below the Kumnam areas appears to be wores because of influx of Kap stream and Miho stream. In short, the necessary counter measure is to be required for the good preservation of water of fine quality in Kum River.

토오크 양에 따른 세라믹 브라켓의 파절 저항성

한정흠,장민희,임용규,이동렬 대한치과교정학회 2007 대한치과교정학회지 Vol.37 No.4

프레탈정 (실로스타졸 100mg)에 대한 실로스탄정 (한국유나이티드 제약)의 생물학적 동등성

용철순,이경희,최진석,박병주,정세현,김용일,박상만,유봉규,이종달,최한곤 한국병원약사회 2003 병원약사회지 Vol.20 No.2

Bioequivalence of one cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and Cilostan^(R)(Korea united Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Sixteen normal male volunteers(age 20~30 years old)were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 100㎎ of cilostazol were orally administered, blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameter. The results showed that the differences in C_(max), T_(max) and AUC_(t) between one tablet were 16.08%, 18.88% and 17.57%, respectively. The powers (1-β) for C_(max), T_(max) and AUC_(t) were 85.03%, 83.92% and 80.12%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilostan^(R) tablet is bioequivalent to Pletaal^(R) tablet.

터보 차져와 인터쿨러를 장착한 디젤기관의 시뮬레이션 연구

한영출,백두성,류규현,오용석,박만재 韓國工作機械學會 2000 한국생산제조학회지 Vol.9 No.4

Studies on the turbocharger itself or various aspects generated from turbocharged engine have been made. However, only a few researches have been made on the performance for the natural aspirated engine equipped with the turbocharger and the intercooler. In this study, the performance prediction program based on turbocharger theory is developed for simu-lation which may reduce the cost and the trial-and-error time. The program is verified with the experimental results for 11,000cc diesel engine with the turbocharger and the intercooler. Also, various factors which are invisible in experiment are predicted using this program.

鮮魚의 流通構造 分析과 그 改善方向

韓圭泳 군산대학교 1984 群山水産專門大學 硏究報告 Vol.18 No.2

The whole distribution structure of marine products has been to have many unreasonable points. To find out them, it has an analysis of operation realities, sending out goods types and distribution channel in our country fisheries market place. As a result, the point at issue has been pointed the complexities of distribution phase, multiplicity distribution and difficulties of freshness maintenance. Through these studies, we have concluded as follows as possible means to improve the functions of distribution structure of fresh fish. 1. To safeguard a manufacture, the authorities concerned marine should be promote the price up-holding projects to the extent of guarantee a manufactures year-gross-average production cost, 2. In the system of sale, a commission agency, illegal intermediate dealer, should be foster and develop an agent of fisheries co-operatives unit with qualified condition and capabilities. 3. It ought to be practice the network send out goods for price protection of both producer and consummer after mordernization of consignment shop facilities, and blocking private purchase and sale of fresh fish. 4. Through distribution phase of shortage, there are to improve payment system of duplication fee to unification, also to narrow the distribution margin. 5. The low-temperature distribution facilities should be enlargement for maintenance of fresh-temperature. 6. Also there should be cut down the expenses of package, landing, baded and unloaded, transporta-tion, storage with rationality of marine physical distribution system.

3종류 잔골재를 조합 사용한 시멘트 모르터의 특성

한천구,윤기원,박용규 청주대학교 산업과학연구소 2005 産業科學硏究 Vol.23 No.1

This paper investigated the engineering properties of cement mortar mixed with more than two kinds of fine aggregate. For fresh mortar properties, unit volume weight is constant regardless of mixing content and type of fine aggregate. An increase in contents of natural fine aggregate and crushed fine aggregate resulted in an increase in flow, whereas an increase in recycled fine aggregate contents reduced flow. Gap between maximum flow in N_(3)C_(0)R_(0) and minimum flow in N_(0)C_(0)R_(3) exhibited about 12%. Compressive strength at 28 days ranged from 32 to 36 MPa in order for crushed fine aggregate, natural fine aggregate and crushed fine aggregate showed compressive strength comparable to that of crushed fine aggregate. An increase of fraction of recycled fine aggregate in mixed fine aggregate resulted in a decrease in compressive strength. For drying shrinkage, N_(0)C_(0)R_(3) had the largest drying shrinkage among various mixture type. The combination of large contents of recycled fine aggregate and small contents of natural and crushed fine aggregate had a large amount of drying shrinkage.

아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.

근린약국에서 산제로 조제된 아테놀올정의 안정성

용철순,최한곤,이종달,유봉규 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.4

Prescription filling in powder form is performed in community pharmacy practice to adjust dose for children and patients who cannot swallow whole tablet. However, there are few reports regarding the stability of the active ingredient and possible microbial growth after the medication is dispensed to powder form. This study examined the stability of atenolol, an antihypertensive agent, and microbial growth in the unit dose pouches dispensed at twenty-one community pharmacies located in Taegu area. Randomly chosen first unit dose pouch contained 77.4% of the prescribed dose of the drug and there were only four community pharmacies that dispensed the drug within 10% deviation from the dose prescribed by physician. Surprisingly, there were three community pharmacies that dispensed the drug with greater than 40% deviation, which may pose a major concern regarding the efficacy and safety of the drug prescribed for the treatment of hypertension. Atenolol content during a month did not indicate significant change, showing 5.4%, 4.3%, and 3.3% of decrease in 50%, 80%, and 90% relative humidity conditions, respectively. Microbiological examination during a month showed less than 0.5 microorganism in high power field (hpf) in all the relative humidity conditions tested. Based on this study, pharmacy practice in community pharmacy needs to be rigorously regulated to ensure that the dose of the prescribed drug is properly incorporated into the unit dose pouch dispensed as powder form.