Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

A Case Study on the Fire of Factory Buildings in Korea

Jee,Nam-Yong,Lee,Kyung-Ku,Suh,Chee-Ho 한국화재소방학회 1997 한국화재소방학회 학술대회 논문집 Vol.1997 No.-

According to the fire statistics of the Ministry of Home Affairs, the fire ratio in factories, work places and warehouses shows 21.5% among total fire of buildings except the fire on cars or other fires. Especially, the buildings like factories and warehouses, which have a lot of ignitable sources and thus always have a strong possibility of fire, are needed to have well planned strategy in terms of life safety and property protection. In this respect, the present paper analyses the existing fire cases in factories, finds out the fire properties of factory buildings, and evaluates the codes concerning fire resistance and fire severity.

정신분열병 환자에서 가족력, 산과적 합병증 및 신체미세기형의 관련성에 관한 연구

안용민,김용식,정희연,신지용,윤세창,배안,이중서,주은정,이창인 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구목적 : 저자들은 태생기 동안에 받는 유전외적 요인, 즉 환경적 요인이 산발성 정신분열병 환자들의 발병에 크게 관여할 것이라고 가정하였다. 이를 검증하기 위하여 형제 중 1인 이상이 발병하여 가족력을 분명히 알 수 있는 정신분열병 환자군(이하 형제 환자군)과 가족력이 없는 산발성 정신분열병 환자군(이하 산발성 환자군) 및 정상대조군을 대상으로 산과적 합병증, 신체미세기형 및 정신분열병의 임상 양상을 비교하였다. 방 법 : 연구 대상은 형제 환자군 43명(남 22명, 여 21명), 산발성 환자군 43명(남 23명, 여 20명), 정상대조군 43명(남 20명, 여 23명)이었다. 산과적 합병증은 Lewis 척도를 이용하여 평가하였고 신체미세기형은 Waldrop 척도를 이용하여 측정하였다. 임상 양상으로서 발병 연령, 병전 기능 수준, 정신병리, 약물에 대한 반응, 회복시의 전반적 기능 수준, 지연성 운동장애의 유무를 평가하였다. 결 과 : 정상대조군과 정신분열병 환자군 전체를 비교하였을 때 산과적 합병증과 신체미세기형의 총점과 각 소항목의 점수에 차이가 없었다. 산발성 환자군과 형제 환자군을 비교하였을 때 산과적 합병증의 전체 점수에서는 유의한 차이가 없었으나, 출생 당시에 태아가 받은 스트레스 항목의 점수가 산발성 환자군에서 유의하게 높았다. 신체미세기형에서는 전체 점수 및 입의 미세기형 점수가 산발성 환자군에서 유의하게 높았다. 신체미세기형의 전체 점수가 4점 이상인 환자수도 산발성 환자군에서 높은 경향성을 보였다. 산과적 합병증과 신체미세기형 사이의 상호 연관성은 찾을 수 없었다. 정신분열병의 임상 양상 중에서는 Krawiecka 척도의 총점 및 양성 증상 점수와 회복시의 전반적 기능 수준만이 형제 환자군에 비해 산발성 환자군에서 유의하게 높았다. 성별에 따라서는 형제 환자군에서 남자 환자의 산과적 합병증이 유의하게 높았다. 결 론 : 본 연구를 통해 산과적 합병증 및 신체미세기형 연구가 정신분열병의 원인을 규명하기 위한 유용한 방법임이 시사되었지만, 가족력, 산과적 합병증 및 신체미세기형의 관련성에 대해서는 분명한 결론을 내리지 못하였다. The authors hypothesized that sporadic schizophrenic patients had more chances of receiving environmental insults during the fetal neural development compared with familial schizophrenics. We tested our hypothesis by comparing obstetric complications(OCs), minor physical anomalies(MPAs) and other clinical features, and examining the correlation between OCs and MPAs in schizophrenic patients who had one or more sibling with schizophrenia(sibling group) and sporadic schizophrenics(sporadic group) and normal controls. OCs were evaluated by the scale of Lewis, and MPAs were measured by the Waldrop scale. There were no significant difference in OCs and MPAs between schizophrenic and control groups. Sporadic group had significantly higher fetal distress, total Waldrop score and Waldrop score for mouth than sibling group. And there was a tendency that the number of subjects having the Waldrop score over 4 points was greater in the sporadic group. No significant correlation was observed between CCs and MPAs. The scores of initial psychopathology and post-treatment functioning were much higher in the sporadic group, but the other clinical feature showed no difference. Although male patients had more OCs than female patients in sibling group, no sex difference were observed as a whole. Our results suggest that, if the methodological weakness were complemented, OCs and MPAs would be useful tools in the search for the cause of schizophrenia.

여성의 건강관련 체력에 관한 연령별 비교

지용석,임선태,유재현 대한스포츠의학회 2004 대한스포츠의학회지 Vol.22 No.1

The aim of this study was to investigate the differences of health related fitness variables in korean women. A total of 419 women were recruited and divided into five age groups; 20s(n=163), 30s(n=99), 40s(n=79), 50s(n=61) and over 60s(n=17). In the results, the cardiopulmonary(F=10.150, p=0.001) and muscular endurance(F=3.360, p= 0.010) variables of 20s and 60s were significantly higher and lower than those of other four groups respectively. However, no differences were found among five groups in back strength, grip strength, and flexibility. The body mass indices(BMI) of 50s and 60s were significantly(F=21.033, p=0.001) higher than those of other four groups respectively. As a conclusion, from the results we think that the korean women may be favorable to be prescribed for the exercise programs, which can develop the cardiopulmonary and muscular endurance but decrease the fat mass.

골프연습장의 환경특성이 행동의도에 미치는 영향 : 지각된 가치와 고객만족의 매개역할 Mediating Roles of Perceived Value and Customer Satisfaction in Golf Training Facilities Context

지진호,이용기 문화관광연구학회 2002 문화관광연구 Vol.4 No.4

This study was to examine the effect of store environment on behavior intentions such as world-of-mouth and switching intentions through the mediating roles of perceived value and customer satisfaction. For these purposes the authors developed a structural model which consists of several variables after factor analysis was performed. Data were collected from 146 respondents who visited golf training facilities. The data were analyzed with LISREL 8W.

장기간 운동이 노인들의 심혈관계 기능 변화에 미치는 효과

지용석,김동진,유신환 대한스포츠의학회 2004 대한스포츠의학회지 Vol.22 No.1

The purpose of this study was to investigate the change of related factors in cardiovascular function variables after long duration regular exercise programs. The subjects of this study were 40 older man and women residing Seoul-Seniors-Tower. All of subjects divided to four groups, exercise group 20(man = 10, women = 10) was participating in an exercise program for 3 years, and the other group or non-exercise group 20(man = 10, women = 10) was not in that program. In the results, Changes of cardiovascular function were significantly improved in peak oxygen uptake, ventilation, rest blood pressure of cardiovascular function variables in male or female exercise groups after 3 years' exercise program. Also, we have been known to the facts that although the cardiopulmonary variables of men are superior to those of women, if being exercised for a long time, the women's cardiopulmonary variables(e.g. Endurance time, HRrest, SBPrest, SBPmax, DBPrest, RPPrest, and RPPmax) would not different from those of the men especially in old ages. As a conclusion, we could know that not only the regular exercise might increase or change almost the cardiovascular function variables except for V ˙O2max, Ventilation, and HRmax of elderly people, but also the sex's differences were vanished in endurance time, HRrest, SBPrest, SBPmax, DBPrest, RPPrest and RPPmax between males and females. Therefore, we might tell that exercise programs could provide an excellent parameters for enforcing or keeping the cardiovascular functions of elderly people.

加減理中湯의 BALB/c 마우스의 抗癌 및 免疫調節作用에 미치는 影響

河智容,李俊 대한동의병리학회 1998 동의생리병리학회지 Vol.12 No.2

과거에는 감염성 질환에 의한 사망이 대부분을 차지하였으나 최근에는 인류의 고령화추세와 식생활의 변화, 스트레스, 그리고 여러 가지 공해 등으로 인한 성인병으로 사망률이 점차 증가하고 있는 추세이다. 성인병에서도 특히 종양으로 인한 사망률이 급격히 증가하여 우리나라는 물론 세계적으로도 중요한 사망원인의 하나로 대두되고 있다. 이러한 현실에서 세계각국에서 종양 치료에 관하여 많은 연구가 수행되어 왔으나 아직까지 수술이나 화학약물, 방사선, 골수이식법등의 기존의 치료법은 치료률을 제고시키지 못하며 많은 부작용을 수반하여 면역요법, 호르몬요법, 명상요법, 천연물요법 등으로 새로운 연구가 모색되고 있는 실정이다. 한의학에서도 예로부터 종양과 유사한 질환을 치료해온 처방을 중심으로 각종 동물실험 등을 통해서 이에 대한 검증이 시도되고 있다. 본 연구는 가감이중탕의 시험관내 세포독성능을 알아보기 위하여 MTT법으로 각 농도별로 처리된 검액을 CT-26 세포에 적정농도로 처리하여 생존율 및 ??을 측정하였고, BALB/c계 생쥐를 이용한 동물실험으로 종양 세포를 복강에 이식시킨후 검액을 투여하여 생존율을 관찰하여 검액의 항암능을 측정하였으며, methotrexate를 이용하여 면역기능을 저하시킨 생쥐에 있어서의 NK-activity, IL-2의 생산능을 측정하여 면역증강효과를 관찰하였다. Median survival time을 측정한 결과 가감이중탕 투여군은 대조군에 비해 8.89%의 연장효과가 있었으나 유의성은 없었고, CT-26 세포를 이용한 시험관내 세포독성 실험에서는 5㎍/well, 2.5㎍/well, 1.25㎍/well, 0.625㎍/well에서 유의성이 있었으며 생존율에 의한 ??은 2.17㎍/well로 나타났다. NK-activity에서는 가감이중탕 투여군이 작동세포와 표적세포의 비율이 100:1, 50:1, 10:1의 경우에 있어 각각 28.97%, 26.41%, 12.36%의 유의성있는 증가를 보였다. IL-2의 생산능을 측정한 결과 가감이중탕 투여군이 대조군에 비해 5.96%의 유의성있는 증가를 보였다. In order to investigate the antitumor effect of Gagamijungtang after CT-26 cells were transplanted in BALB/c mice, and immune responses in mice induced by methotrexate, the extract of Gagamijungtang was orally administered to the mice for 21 days. Experimental studies were performed for measurance of median survival time, cell-cytotoxicity in vitro, natural killer cell activity, productivity of interleukin-2. The results were summarized as follows: 1. Median survival time in Gagamijungtang-treated group was slightly prolonged, as compared with control group(8.89%). But that had no significance. 2. On the MTT assay, cell viability was significantly inhibited by 5㎍/well, 2.5㎍/well, 1.25㎍/well, and 0.625㎍/well of Gagamijungtang concentration inhibited cell viability significantly(P< 0.05). IC50 for cell viability was 2.17㎍/well. 3. Natural killer cell activity in Gagamijungtang-treated group was significantly increased on 100:1, 50:1, 10:1 E/T(effector cell/target cell) ratio as compared with control(P< 0.05). 4. Production of interleukin-2 in Gagamijungtang-treated group was significantly increased as compared with control(P<0.05).

요양보호사의 노화사실 인지정도가 수급자의 태도에 미치는 영향

윤지용,임춘식,이용주 한남대학교 사회과학연구소 2011 사회과학연구 Vol.20 No.1

본 연구는 303명의 요양보호사를 대상으로 설문조사하여 노화사실인지 정도와 노인에 대한 태도를 파악하였으며, 이를 통해 요양보호사의 노화사실인지정도가 노인에 대한 태도에 미치는 영향을 분석한 연구결과 첫째, 요양보호사의 노화사실 인지정도가 노인에 대한 태도에 영향을 미치므로, 노화사실 인지정도를 높일 수 있도록 교과과정 및 교육 내용을 개선해야 한다. 둘째, 학력 및 종사기관에 따라 노화사실 인지정도에 유의한 차이가 있으며, 소득수준이 높을수록 노화사실 인지정도가 높은 것으로 나타남에 따라, 요양보호사의 처우를 개선하고 요양보호서비스의 질을 개선하며 요양보호사가 전문직으로서 종사할 수 있는 제도적인 장치를 마련해야 한다. 셋째, 과거에 함께 거주했던 노인에 대한 생각은 노인에 대한 태도에 유의한 영향을 미치는 것으로 나타났기 때문에 노인과 자녀간의 관계를 회복시키기 위한 사회적 프로그램 개발이 필요하다. 넷째, 노화사실인지정도와 노인에 대한 태도에 영향을 미치는 요인을 파악하기 위한 보다 광범위한 연구가 지속되어야 한다. The purpose of this study was to examine the awareness of care helpers on the aging of elderly care receivers and their attitude to them in a bid to determine the impact of care helpers' awareness of elderly people's aging on their attitude to them. The subjects in this study were 303 care helpers. The findings of the study were as follows: Frist, the awareness of the caregivers on the aging of elderly people affected their attitude toward them. Therefore a better curriculum should be prepared to teach care helpers to take an accurate notice of the degree of elderly people's aging, and what to teach in the curriculum should carefully be selected. Second, there were significant differences in their awareness of the degree of elderly people's aging according to their academic credential and type of workplace. Those who earned a larger income were better cognizant of the degree of aging. So it's required to take institutional measures to provide care helpers with better treatment, to boost the quality of their service and to turn them into dedicated professionals. Third, the way they looked at the elderly people with whom they dwelled in the past had a significant impact on their attitude to the elderly, and the development of programs that aim at restoring the relationship between elderly people and their adult children is required. Fourth, more extensive and prolonged research efforts should be made to find out what factors influence the awareness of care helpers on the degree of elderly people's aging and their attitude toward them.

미세절편체에 의한 절화류의 기내증식

이지영,이승우,김용구,정인식,설일환 慶熙大學校 1997 論文集 Vol.26 No.-

Experiments were conducted to find out the optimum cultural conditions for micro-cross sectioned leaf segments of Gypsuphila paniculata L. Gerbera hybrida and Dianthus caryophyllus. Survival percentages of micro-cross sectioned segments were the highest in gypsophila, followed by carnation. Gerbera showed on survived segments. In gypsophila, segments thicker than 400㎛ were required to obtain over 75% survival. The percentage of adventitious bud formation was much higher with 600㎛ segment as compared with 400㎛. The regeneration of micro-cross sectioned segments of gypsophila was not sensitively affected by the auxins at varying concentrations. The elongation of adventitious shoot was promoted by kinetin compared with BA. In segments of 600㎛ thickness, adventitious shoot formation was promoted by BA compared with kinetin Adventitious shoot formation or shoot growth was not affected by KNO_3 concentrations with the segments of 400㎛ thickness. But adventitious shoot elongation was promoted significantly with segments in 600㎛ thickness. KH_2PO_4 (170 mg/1, standard concentration of MS medium) was effective for adventitious shoot formation. MgSO_4 also promoted adventitious shoot formation myo-Inositol tended to be suppressed regeneration of gypsophila.

淸上補下丸이 黑色腫의 肺轉移 抑制 및 免疫調節作用에 미치는 影響

河智容,劉炳吉 대한한방종양학회 1998 대한한방종양학회지 Vol.4 No.1

1. 연구 배경 최근 놀라운 과학기술의 발전에 힘입어 난치병이라고 생각되어 오던 질환들이 하나씩 정복되어 가고 있으나 평균수명의 연장, 생활수준 향상으로 인한 고지방식, 스트레스 및 과학기술발전의 부작용 등을 이유로 새로운 질환들이 나타나고 있는 실정이다. 종양도 이런 대표적인 질환중 하나로 최근 경제적, 시간적으로 많은 투자를 해왔으나 아직까지 그 발생원인이나 성장기전 등이 자세히 밝혀지지 않았다. 이에 본 연구는 哮吼를 치료하는 淸上補下丸을 이용하여 흑생정의 폐전이 억제능과 이에 의한 면역증강에 관하여 연구하고자 하였다. 2. 연구결과 B-16세포를 이용한 C57BL/6계 마우스에 있어서의 폐전이 억제능을 측정한 결과 淸上補下丸 투여군이 대조군에 비해 검액처리 7일후에는 52.70%, 14일후에는 19.43%의 유의성있는 억제율을 보였으며, 淸上補下丸의 B-16 세포에 대한 직접적인 항암작용을 알아 보기 위한 시험관내 세포독성 실험에서는 淸上補下丸의 용량이 5ug/well, 2.5ug/well, 1.25ug/well, 0.625ug/well인 경우 유의성있는 효과를 얻을수 있었으며 생존율에 의한 IC_50은 2.17ug/well이었다. NK-activity를 측정한 결과 淸上補下丸 투여군이 작동세포와 표적세포의 비율이 100:1, 50:1의 경우에 있어서 72.63±5.17%, 26.94±2.43%를 보여 대조군에 비하여 각각 31.12%, 43.68% 유의성있는 증가를 보였다. IL.2의 생산능을 측정한 결과 淸上補下丸 투여군은 l392.00±22.3lpg/ml을 보여 대조군에 비해 4.04%의 유의성있는 증가를 보였다. In order to investigate the antitumor effect by Chungsangbohahwan after B-16 cells were transplanted in C57BL/6 mice, and the immune responses in mice induced by methotrexate, the extract of Chungsangbohahwan sas orally administered to the mice for 21 days. Experimental studies were performed for measurce of metatasis, cell cytotoxicity in vitro, natura killer cell activity, productivity of interleukin-2. The results were summarized as follows: 1. Inhibition of metastasis in Chungsangbohahwan-treated group was higher than control group woith significance on 7th day and 14th day. 2. On the MTT assay, cell viability was signigicantly inhibited by 5ug/well, 2.5ug/well, 1.25ug/well, and 0.625ug/well of Chunganbohahwan concentration inbited cell viiability sifnificantly(P<0.05). IC_50 for cell viability was 2.17ug/well. 3. Matural killer cell activity in Chungsangbohahwan-treated group was significantly incresed on 100:1, 30:1 E/T(effect ce;;/target ce;;) rato(P<0.05). 4. Produciton of interleukin-2 in Chungsangbohahwan-treated group was significantly increased(P<0.05).