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이주영,류수진,박예진,황순호,이마세,김인종,김동현,김신규 慶熙大學校 1996 論文集 Vol.25 No.-
Sythesis of β-naphthol derivatives and their anti-tumor activity were investigated. Binaphthol 1 obtained from β-naphthol by oxidative C-C bond formation(phenoloxydation) was converted into its derivatives. Treatment of 1 with POCl_3 followed by aziridine introduction gave phosphoryl aziridine 3. Also, diaziridine 5 was obtained from 1 by chlorination and successive aziridine introdution. Typical chemical transformation of 1 to obtain ester-type afforded compound 7 and 8. Compound 5 was the most effective derivative of the tested compounds on their anti-tumor activity.
방창훈,이진호,예용택 한국산업안전학회 2002 한국안전학회지 Vol.17 No.3
The purpose of this study was to present the thermal characteristics of the working uniform exposed to the radiation heat. The effect of exposure time and exposure distance on the changes and the relationship between physical properties were investigated experimentally. Regardless of the kind of working uniform, the surface temperature of the working uniform with exposed time sharply increases as exposed distance is more close and the reaching tie of steady state is shorter. The surface temperature of working uniform exponentially decreases as exposed distance become more distant. For the safety of the working man, it is necessary that he work far away at a fixed standard distance from the radiant heat source.
Protective Effect of Carnosine Against Zn-Mediated Toxicityin Cortical Neuronal Cells
Jin-Joo Hue,Ah-Ram Lee,Yea Eun Lee,Min-Hang Cho,Ki-Nam Lee,남상윤,윤영원,Jae-Hwang Jeong,Sang-Hwa Lee,이범준 한국독성학회 2007 Toxicological Research Vol.23 No.1
Zinc is an endogenous transition metal that can be synaptically released during neuronal activity. However, zinc may contribute to the neuropathology associated with a variety of conditions. Carnosine expressed in glial cells can modulate the effects of zinc on neuronal excitability as a zinc chelator. We hypothesize that carnosine may protect against neurotoxicity of zinc in cortical neuronal cells. The cortical neuronal cells from newborn rats were prepared and exposed to zinc chloride and/or carnosine at various concentrations. Zinc at the doses of 0 to 500 μM decreased neuronal cell viability in a dosedependent manner. Additionally, at the concentrations of 100 and 200 μM, it significantly decreased cell viability in an exposed time-dependent manner (p < 0.05). Treatment with carnosine at the concentrations of 20 and 200 μM significantly increased neuronal cell proliferation by approximately 14% and 20%, respectively, compared to the control (p < 0.05). At the concentrations of 100 and 200 μM zinc, 20 μM carnosine significantly increased the viability of neuronal cells by 18.3% and 12.1%, and 200 μM carnosine also increased it by 33.5% and 28.6%, respectively, compared to the normal control group (p < 0.01). These results suggest that carnosine at a physiologically relevant level may protect against zinc-mediated toxicity in neuronal cells as an endogenous neuroprotective agent
Lee, Yea Eun,Hue, Jin-Joo,Lee, Ki-Nam,Nam, Sang Yoon,Ahn, Byeongwoo,Yun, Young Won,Jeong, Jae-Hwang,Lee, Beom Jun The Korean Society of Veterinary Science 2008 大韓獸醫學會誌 Vol.48 No.3
There are accumulating evidences that high levels of dietary iron may play a role in colon carcinogenesis. Elevated iron status has been associated with oxidative stress. Phytic acid (PA) functions as an antioxidant by chelating divalent cations and prevents formation of reactive oxygen species responsible for cell injury and carcinogenesis. The protective effect of PA was investigated on formation of aberrant crypt foci (ACF) induced by azoxymethane (AOM) in iron-overloaded male F344 rats. After acclimation with AIN-93G purified diet (35 ppm Fe, normal control diet) for one week, animals were fed iron-overloaded diet (350 ppm Fe) and PA (0.5% or 2% PA in water) for 8 weeks. Animals received two (1st and 2nd week) injections of AOM (15 mg/kg b.w.) to induce colonic ACF. The colonic mucosa was examined for the total numbers of aberrant crypt (AC) and ACF after staining with methylene blue. The blood and serum were analyzed with a blood cell differential counter and an automatic serum analyzer. Iron-overloaded diet increased the concentration of iron in liver of the rats. But iron-related parameters in blood were not changed among experimental groups. The numbers of ACF per colon and AC per colon were $178.8{\pm}33.2$ and $448.4{\pm}110.2$ in the iron-overloaded F344 rats. The total AC was significantly increased, compared with normal-diet AOM control group (p < 0.05). The treatments of PA at the dose of 0.5% slightly decreased the number of ACF and AC per colon to $153.6{\pm}29.5$ and $396.3{\pm}107.5$. However, there were no significant differences in the total numbers of ACF and AC between the AOM control group and PA (0.5% or 2%)-treated groups. These results suggest that PA may not affect the formation of ACF or AC induced by AOM in ironoverloaded F344 rats.
Phytochemical Constituents from the Stem Bark of Phellodendron amurense Rupr.
Lee, Jin-Hwan,Lee, Byong-Won,Moon, Yea-Hwang,Yang, Min-Suk,Jang, Ki-Chang,Park, Ki-Hun The Korean Society for Applied Biological Chemistr 2005 Journal of Applied Biological Chemistry (J. Appl. Vol.48 No.2
Three limonoids and two phenolics were isolated from stem bark of Pellodendron amurense Rupr. (Rutaceae) and were defined clearly as calodendrolide (1), obacunone (2), limonin (3), methyl 4-hydroxybenzoate (4), and syringin (5) based on NMR spectroscopy results obtained with the aid of X-ray crystallographic analysis. This is the first report on the isolation of calodendrolide (1) from this plant.
Yea Eun Lee,Jin-Joo Hue,Ki-Nam Lee,Sang Yoon Nam,Byeongwoo Ahn,Young Won Yun,Jae-Hwang Jeong,Beom Jun Lee 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.3
Iron is essential for life and has numerous biochemical roles. Phytic acid (PA) has been recognized as a natural antioxidant by its chelating properties and reducing the catalytic activities of many divalent transition metals. We investigated the effect of PA on the formation of aberrant crypt foci (ACF) induced by azoxymethane (AOM) in dietary iron-deficient F344 rats. After acclimation for one week, six-week old F344 male rats were fed with the AIN-93G purified diet (normal diet) or an iron-deficient diet (3 ppm Fe, only 10% vs control diet) for 8 weeks. PA (0.5% or 2% PA in water) was given for drink throughout the experimental period. Animals were treated subcutaneously with AOM (15 ㎎/㎏) twice (1<SUP>st</SUP> and 2<SUP>nd</SUP> week of the experiment) to induce colonic ACF. After sacrifice, the colonic mucosa were examined for the total numbers of aberrant crypt (AC) and ACF after staining with methylene blue. The blood and serum were analyzed with a blood cell differential counter and an automatic serum analyzer. Iron-deficient diet induced an anemic status of rats as indicated by significantly low values in RBC count, hemoglobin, hematocrit, mean corpuscular volume, and mean corpuscular hemoglobin, compared with the AOMtreated control (P<0.01). However, treatments of PA increased these values. Treatment with 2% PA significantly increased the numbers of both ACF/colon and AC/colon in iron deficient rats, compared with the respective control (P<0.05). The number of large ACF (≥4 AC/ACF), which had been suggested to possess a greater tumorogenic potential than small ACF (≤3 AC/ACF), was significantly enhanced by treatment with 2% PA (P<0.05). These results suggest that PA may promote colon carcinogenesis in irondeficient status in rats.