Poster Session : PS 0831 ; Upper GI Tract : Clinical Factors to Predict Angiographically Detectable Non-Variceal Upper Gastrointestinal Bleeding in Patients Refractory to Endoscopic Treatment

( Tae Hwan Ha ),( Tae Hoon Oh ),( Sung In Yu ),( Min Kim ),( Jong Wook Kim ),( Won Ki Bae ),( Jae Hyung Kim ),( Seung Suk Baek ),( Mi Jin Ryu ),( Ye Na Choi ),( Ji Young Park ),( Eileen L Yoon ),( Tae 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Non-variceal upper GI bleeding (NVUGIB) is a common medical problem that has signifi cant association with morbidity and mortality. Angiographic detection and subsequent transarterial embolization (TAE) is a primary treatment option when medical and endoscopic treatments fail. We investigated clinical factors that could affect the success of the angiographic detection and prognosis after TAE in patients with NVUGIB refractory to endoscopic therapy. Methods: A retrospective analysis of the clinical data was done in patients with failed endoscopic treatment who underwent angiography for the treatment of acute NVUGIB between May 2002 and May 2013. Patients were divided into detection or non-detection groups according to the presence of bleeding stigmata in angiographic fi nding. Rebleeding defi ned as subsequent bleeding event within 7 days and mortality within 30days were analyzed as outcome parameters after TAE following detection in angiography. Results: A total 45 patients 37 (male, mean age, 65.9±14.9 years) were analyzed and classifi ed as a detection group (n=25, 55.5%) and non-detection group (n=20, 44.6%). Peptic ulcers were the most common cause of refractory NVUGIB. Larger transfusion amount (5.7±3.9 unit vs. 3.5±2.8 unit; P=0.03), prolonged aPTT level (34.2±17.3 sec vs. 21.8±13.8 sec; P=0.01) and short time interval between last endoscopy and angiography (17.5±25.9 hours vs. 34.3±59.5 hours; P=0.04) were found to be signifi cant factors for predicting angiographic detection. TAE was performed in all patients detected in angiography. Rebleeding (44%) was significantly associated with higher Rockall score (8.3±1.5 vs. 6.6±2.4; P=0.046) and mortality (12%) was signifi cantly associated with higher Rockall score (9.3±0.6 vs. 7.1±2.2; P=0.002) and higher level of BUN (55.3±47.4 vs. 27.6±17.4; P=0.01). Conclusions: Clinical characteristics associated with angiographic detection in patients with NVUGIB refractory to endoscopic therapy were severe bleeding, bleeding tendency and early angiographic intervention. The Rockall score is useful parameter for predicting rebleeding and mortality after TAE.

Regeneration of Bovine Mammary Gland in Immunodeficient Mice by Transplantation of Bovine Mammary Epithelial Cells mixed with Matrigel

Woo Tae Ha1,Hyun Jung Park,Won-Young Lee,Ha Yeon Jeong,Hyuk Song 한국동물생명공학회(구 한국동물번식학회) 2017 Reproductive & Developmental Biology(Supplement) Vol.41 No.2

With the global demand for dairy protein for consumption growing annually, there has been increasing activity in the research field of dairy protein synthesis and production. From a manipulation perspective, it is more difficult to use live cattle for laboratory studies on the production of milk as well as of dairy protein such as casein, as compared with using laboratory animals like rodents. Therefore, we aimed to develop a mouse model of bovine mammary alveolar ducts for laboratory-scale studies. We studied the formation of the bovine mammary gland ductal structure by transplanting the MAC-T bovine alveolar cell line into mice. MAC-T cells (1×107) were suspended in Matrigel and injected into the dorsal tissue of 8-week-old male BALB/C nude mice. Histological analysis of tissue dissected from the MAC-T cell-transplanted mice after 6 weeks showed the typical morphology of the tubuloalveolar female gland, as well as glands made up of branching ducts that were surrounded by smooth muscle with small alveoli budding off the ducts. In addition, the epithelial markers CK14 and CK18 were expressed within the duct-like structure. Prolactin was detected in the duct interior in these CK14+ and CK18+ cells but not in the non-transplanted MAC-T cells. These results showed that duct-like tissue had been successfully formed after 6 weeks of transplantation of the CK14+ and CK18+ MAC-T cells into mice dorsal tissue. This mouse model will be a useful tool for further research on the bovine mammary gland.

The Comparisional Analysis of Colostrum Protein between the First and Third Days after Calving using Proteomic Analysis

Woo Tae Ha1,Hyun Jung Park,Won-Young Lee,Ha Yeon Jeong,Hyuk Song 한국동물생명공학회(구 한국동물번식학회) 2017 Reproductive & Developmental Biology(Supplement) Vol.41 No.2

The colostrum proteins are an important energy source for newborns and improves their innate immune system. Recently, there are many interest about beneficial factors in colostrum to health and many products using colostrum are attentive into dietary supplements in global industry. The aim of this study was to compare the enriched proteins between the colostrum from the first and the third day after calving using proteomic analysis and to analyze which enriched protein will be useful to industry of dietary supplements. In this study, cows in the experimental group were fed a standard composition of feed for 12 months, after which we collected the colostrum on the first and the third day after calving. By comparison between the first and the third day colostrum, several factors, including beta-lactoglobulin, fibrinogen gamma-B chain, complement C3, zinc-alpha-2 glycoprotein, bP47 protein, beta casein, and alpha-S2 casein were enriched in the third day colostrum, whereas immunoglobulin gamma 1 and beta- casein A2 were enriched in the first day colostrum. The results suggest that the colostrum composition depends on time and the first day colostrum is important to establish the primary specific immune system, whereas the third day colostrum might regulate the non-specific immune system and increase nutrition using casein and the third day colostrum might be useful dietary products for supporting the immune system.

돈분뇨 액비 시용이 양파의 생육, 양분흡수량 및 토양 화학성에 미치는 영향

이종태(Jong Tae Lee),하인종(In Jong Ha),김희대(Hee Dae Kim),문진성(Jin Seong Moon),김우일(Woo Il Kim),송원두(Won Doo Song) 한국원예학회 2006 원예과학기술지 Vol.24 No.2

벼와 양파 2모작 논토양에서 효율적인 돈분뇨 액비 시용을 위하여 액비 시용에 따른 양파의 생육, 양분흡수량 변화와 토양의 이화학적 특성을 조사하였다. 사용된 액비의 질소, 인산 및 칼륨 함량은 각각 4.2, 0.34, 1.2g kg⁻¹ 등이었다. 추비용 액비는 시용 10일 전에 물로 2배 희석하여 월 2회씩 4회와 6회로 나누어 시용하였다. 기비는 질소표준시비량 기준으로 19,280kg ha⁻¹로 시용하였으며 추비에 사용된 액비량은 101,910kg ha⁻¹이었다. 양파의 초장은 정식 136일 후부터 186일까지 급격히 증가하였으며 화학비료구, 액비기비+화학비료 추비구 및 액비기비+액비 4회 추비구 간에는 차이가 없었으나 무비구와 액비전량 기비구는 양분부족으로 생육이 저조하였다. 구 비대초기의 구경은 무비구에서 가장 컸으나 그 이후 화학비료구와 액비시용구에서 크게 증가하였다. 엽 생체중의 변화는 초장과 유사한 경향을 보인 반면 구 생체중은 구경과 비슷한 경향을 나타내었다. 초장과 엽중은 화학비료구와 액비전량 기비구 및 액비기비+액비 6회 추비구간 다소 작았으나 구경, 구중 및 엽수는 처리간 차이가 뚜렷하지 않았다. 양파 구와 잎의 양분흡수량은 전 생육기간에 시그모이드 형을 나타내었으며 잎과 구의 양분흡수량은 각각 잎과 구의 생육이 진전됨에 따라 증가하는 경향이었다. 화학비료구와 액비기비+화학비료 추비구 및 액비 4회 추비구간에 양분흡수량의 차이는 없었고 액비전량 기비구에서 잎의 질소와 칼륨흡수량이, 구의 질소흡수량이 화학비료구보다 적었다. 무비구는 질소, 칼륨 및 마그네슘 흡수량이 다른 처리구보다 적었다. 액비기비+액비 4회 추비구에서 질소와 인산이용률이 각각 23.5%, 13.2%로 가장 높았으나 액비기비+액비 4회 추비구에서 칼륨이용률이 높았고 상품 수량도 55.0Mg ha⁻¹로 가장 많았다. 구의 질소, 인산 및 칼륨함량은 생육이 진전됨에 감소하는 경향이었고 잎의 질소함량은 생육초기에 가장 많은 반면 칼륨함량은 구비대 초기에 가장 많았다. 수확 후 토양 pH, 질산태 질소, 교환성 칼륨 및 EC 농도는 화학비료구보다 액비시용구에서 약간 증가하였다. 본 연구 결과를 종합해 볼 때 돈분뇨 액비를 기비로 시용하고 3배 희석한 액비를 2월과 3월에 4회 추비하면 균형적인 양분공급이 가능하고 적정 수량도 확보할 수있었다. This study was carried out to evaluate the effect of liquid pig manure (LPM) on the nutrient uptake, yield of onion and soil properties. The LPM applied to onion field contained 4.2 g kg⁻¹ N, 0.34 g kg⁻¹ P, 1.2 g kg⁻¹ K and it was diluted with water by 1:2 for top-dressing, which was applied separately 4 or 6 times from February to April. The LPM application rate for basal fertilization was 19,280 kg ha⁻¹ which included 80 kg N, 6.6 kg P, and 22 kg K. The application rate for top-dressing was 101,910 kg ha⁻¹ which included 160 kg N, 13 kg P, and 53 kg K. The plant height was not almost different among treatments until 136 days after planting. Thereafter, it enlarged abruptly until 186 days, on May 4. The significant difference among CF and LPM + top-dressing by CF or LPM I was not shown, but no fertilizer and LPM only (it was applied totally as basal fertilization) made plant height of onion lessen at the maximum growth stage because of insufficient nutrients. The plant diameter increased after 136 days, and there was a significant difference between CF or LPM and no fertilizer from 186 days after planting. The leaf weight was similar tendency to plant height while bulb weight was similar to plant diameter. The amount of nutrient uptake in leaf coincided with leaf growth and the nutrient uptake in bulb swelled simultaneously with bulb growth. The difference between CF and LPM + top-dressing by CF or LPM I was not significant in nutrient uptake of onion leaf and bulb. But LPM only decreased in nitrogen and potassium of leaf and in nitrogen of bulb. And no fertilizer made a remarkable difference to others in nitrogen, potassium and magnesium of leaf and bulb. The utilization of nitrogen and phosphorus in LPM + top-dressing by CF were 23.5%, 13.2% respectively, more than the others. The LPM + top-dressing by LPM I was most available with potassium, and it leaded the most abundant marketable yield by 55.0 t ha⁻¹ as well. The nitrogen, phosphorus, and potassium contents in bulb were inclined to decrease with progress of onion growth. The nitrogen contents in leaf maximized at the initial growth stage while potassium contents increased at the initial bulbing stage. The LPM application increased pH, nitrate nitrogen, potassium and EC in soil more than chemical fertilizer (CF) did.

고착협 내탈립 기계수확 적응 장류⋅두부용 콩 품종 ‘새금’

김현태(Hyun Tae Kim),한원영(Won Young Han),이병원(Byung Won Lee),고종민(Jong Min Ko),이영훈(Yeong Hoon Lee),백인열(In Youl Baek),윤홍태(Hong Tai Yun),하태정(Tae Joung Ha),최만수(Man Soo Choi),강범규(Beom Kyu Kang),김현영(Hyun Yeong K 한국육종학회 2019 한국육종학회지 Vol.51 No.4

The soybean cultivar, ‘Saegeum’, has been developed for preparing soy-paste and tofu. The soybean cultivars ‘Daepung’ and ‘SS98207-3SSD-168’ were crossed in 2003 to obtain ‘Saegeum’. Single seed descent method was used to advance the generation from F3 to F5, and the plant lines with promising traits were selected from F6 to F7 by pedigree method. The preliminary yield (PYT) and advanced yield trials (AYT) were conducted from 2009 to 2010, and the regional yield trial (RYT) was conducted in 12 regions between 2011 and 2013. The morphological characteristics of ‘Saegeum’ were as follows: determinate plant type, white flower, tawny pubescence color, and brown pod color. Flowering and maturity dates were August 2, XXXX and October 17, XXXX, respectively. Plant height, first pod height, number of nodes, number of branches, and number of pods were 79 cm, 18 cm, 16, 2.3, and 44, respectively. The seed characteristics of ‘Saegeum’ were as follows: yellow spherical shape, yellow hilum, and the 100-seed weight was 25.4 g. ‘Saegeum’ was resistant to bacterial pustule and SMV in the field test, and its lodging resistance was mildly strong, whereas its shattering resistance was excellent. The ability of this cultivar to be processed into tofu, soybean malt, and other fermented products was comparable with that of ‘Daewonkong’. The yield of ‘Saegeum’ in the adaptable regions was 3.02 ton ha-1. Thus, ‘Saegeum’ is adaptable to mechanized harvesting because of its high first pod height, as well as lodging and shattering resistance. (Registration number: 5929)

락탐화합물의 고리 확장 연구 : 입체 선택성과 Mechanism에 관한 연구 Study of Stereoselectivity and Mechanism

하진렬,최경민,김지아,원태진,신동수,이민주,안철진 昌原大學校 基礎科學硏究所 2002 基礎科學硏究所論文集 Vol.14 No.-

The ring expansion chemistry is one of the most important methods to prepare five-and six-membered heterocylic compounds. We have studied about γ-lactam ring expansion with stereoselectivity from β-lactam derivative. To do this chemistry, proton of N-benzyl group in β-lactam derivatives is eliminated by LDA and make carbanion.This anion make unstable 4-membered lactam intermediate, and then the ring is opened by homo clevage or hetero cleavage for releasing ring strain, followed by recyclization to one carbon to make γ-lactam ring with stereoselectivity in β-, γ- positions.

비기능성 부신피질암 1례

하달봉,이경섭,손형규,이준희,원유홍,김동훈,장태정 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

비기능성 부신피질암은 발생 빈도가 극히 드문 악성 종양이며, 내분비학적 임상증상이 없어 주로 복부 종물에 의해 우연히 발견된다. 그래서 대부분 종양의 크기가 거대하고 전이로 진행된 경우가 흔하며, 절제술만으로는 치유 불가능한 경우가 많아 예후가 불량한다. 최근 저자들은 약 10년간 간헐적인 좌측 측복통과 흉부 압박감으로 내원하여, 이학적 검사 및 방사선학적 검사상 복부 종물이 확인되고 생화학적 검사에서 비기능성으로 판명된 52세 남자 환자에서 근치적 신절제술을 시행하여 병리조직검사상 비기능성 부신피질암으로 진단되었기에 문헌 고찰과 함께 보고하는 바이다. Nonfunctioning adrenocortical carcinoma is extremely rare, which is diagnosed most often in older man because of mass effect. Most tumors are discovered too late for curative resection, and advanced tumors are associated with a poor prognosis. Herein we report on a 52-year-old man with nonfunctioning adrenocortical carcinoma, treated by radical nephrectomy.

실내사무환경의 환경성담배연기(ETS)의 지표물질에 관한 연구

하권철,백남원,박동욱,윤충식,김원,최상준,박지영,최인자,김신범,강태선 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.2

The purpose of this research is to evaluate indoor office environment using the concentrations of nicotine, 3-enthenyl-pyridine(3-EP), and respirable suspended particulate(RSP), which are indicators for environmental tobacco smoke(ETS) and the correlations between indicators and environmental conditions(smoking density, smoking index). The mean air charge per hour (ACH) in smoking rooms was 10.4 and most of the smoking rooms showed non-compliance withe ASHRAE standard value except only one smoking rooms. The concentrations of RSP, 3-EP, nicotine showed log=normal distributions, and became different statistically depending on smoking condition(p〈0.01). The geometric mean concentration of RSP in smoking room was 441.7 ug/㎡ that is far exceeded environmental standard(150 ug/㎡). This implies that fine particulate in smoking room should be carefully controlled considering smoking density and ventilation fate. The mean concentrations of nicotine and 3-EP were 93.4 ug/㎥, respectively. The correlation coefficients between RSP and SI, 3-EP and SI, and Nicotine and SI were 0.67, 0.84 and 0.74, respectively. The correlation coefficient between nicotine and 3-EP, nicotine and RSP, and RSP and 3-EP were 0.76,0.78 and 0.57 respectively.

이종연료 층상분사를 이용한 디젤엔진을 NOx와 soot동시 저감에 관한 연구(제2보)

하종률,강병무,안현찬,이태원,윤수한 東亞大學校 2001 東亞論叢 Vol.38 No.-

To investigate the method of the simultaneous reduction of Soot and NOx, we developed a new conception for dual fuel stratified injection system in a Diesel Engine. Some parts of the injection system, ie. nozzle holder, delivery vale, were remodeled to inject diesel and methanol in order from one injector. The quantity of diesel and methanol was controled precisely by micrometers that were mounted at control lack of injection pump. The real injection quantity ratio of dual fuel was certificated by volumetric ratio at injection Quantity experiment. We could confirm the capability that soot and NOx simultaneously were reduced by diesel-methanol stratified injection from the results of combustion and exhaust characteristic.

디지털 생산성 향상을 위한 웹 보안 미들웨어시스템 구현에 관한 연구

하태용,이강원,신용백 한국생산성학회 2003 生産性論集 Vol.17 No.1

The puropose of this paper is the materialization of web security middle wear system for the improvement of digital productivity in e-business. Tnternet changed e-business information epochally and contributed in digital productivity enlargement through easy access of resources. But, Internet have a weakness security, because it is offered through many unspecific access. For this reason, the web security problem solution play important role in the digital productivity elevation in e-business environment. The role of security system is prevent resources of system from user who is not permitted. In a recent, there is a case that use strong interception system such as a security firewall for the security, but there is a fair difficulty at introduction expense and operation. Specially, A wrong policy decision have influence on all network and it could be a major cause for reduction network. This study proposes security solution though the research about middle wear embodiment such as user certification and access control from the view point of individuation web system defense.