Effects of Tested Pack Containing Plant Extracts on Elasticity and Size of Women’s Breasts

Yea Hun Choi(최예훈),Min-Kyung Park(박민경),Yong Gyun Kim(김용균),Sang Mong Lee(이상몽),Hong Joo Son(손홍주),Hyean Cheal Park(박현철),Sun Tae Kim(김선태),In Soo Choi(최인수),Keun Ki Kim(김근기) 한국생명과학회 2012 생명과학회지 Vol.22 No.3

본 연구는 콩과식물과 허브식물 및 국내 자생식물체들로부터 estrogen 생성과 대사에 활성을 나타내는 물질을 발굴하기 위하여, 12종의 식물체로부터 식물 유래의 isoflavone류를 포함한 2차대사산물을 용매로 추출하여 지방세포의 지방합성과 축적에 활성을 조사하였다. 활성을 보이는 Q. acutissima, C. lanceolata, P. mirifica, P. bambusoides 및 S. repens 5종의 식물체 용매추출물을 전체중량의 3% 되게 첨가하여 천연 팩을 제조하였으며 임상실험을 통하여 가슴의 탄력과 크기변화에 미치는 영향을 조사하였다. C. lanceolata 추출물을 25 μg/ml 농도로 처리한 곳에서 3T3-L1의 세포성장을 control과 비교했을 때 130% 이상 증가시켰으며, 지방의 축적은 S. repens H2O 추출물을 처리한 곳에서 190% 정도 지방축적량이 많았으며, C. lanceolata와 P. bambusoides EtOH 추출물을 처리한 곳에서도 각각 145%와 154% 활성이 높게 나타났다. 지방합성을 촉진하는 식물체추출물들을 첨가하여 천연 팩을 제조하였으며, 제조한 팩으로 더마프로에 가슴크기 변화와 탄력에 미치는 영향 등의 임상실험을 의뢰하였다. 임상 실험 결과, 가슴둘레, 탄력, 볼륨이 모두 유의적으로 향상되는 것을 확인할 수 있었고. 효능에 관한 설문평가 결과, 사용효과 항목에서 80% 이상의 긍정적으로 답하였으며, 사용 후 2주간 효과에 대해 65%이상이 긍정적인 응답을 하였다. 사용성 설문평가 결과 또한 피험자의 90%이상이 긍정적으로 평가하였다. 피부 안전성 평가에서는 피험자 6명이 사용 중 가려움을 호소하였으나, 그 증상이 미약하여 사용에는 문제가 없었으며, 1명은 사용 3일 후 홍반이 관찰되었으나 5일 후 소멸되었고, 그 외의 다른 이상반응은 관찰되지 않아 인체에 대한 부작용의 문제는 없었다. 이상의 연구 결과, Q. acutissima, C. lanceolata, P. mirifica, P. bambusoides 및 S. repens의 추출물을 혼합하여 첨가한 겔타입의 팩 제조물은 여성의 가슴크기 향상과 탄력유지에 유효하다는 사실을 세포수준의 실험과 임상실험에서 그 효과를 확인 할 수 있었다. In this study, we purified the extracts from the seeds and the roots of various plant species, including Q. acutissima, C. lanceolata, P. mirifica, P. bambusoides, and S. repens, and then investigated the effects of these extracts on cell growth and fat accumulation in adipocytes. We found that the extracts purified from Q. acutissima, C. lanceolata, P. mirifica, P. bambusoides, and S. repens more effectively increased the cell growth, as well as promoting the fat accumulation in adipocytes to a greater extent, than other extracts in vitro. Therefore, we made breast packs containing these effective extracts, and then investigated whether they were effective in enhancing the elasticity and volume of women’s breasts. The measurements of breast elasticity and size revealed that the breast packs efficiently increased the elasticity and size of women’s breasts. Furthermore, evaluation of the questionnaires related to usage of the breast packs indicated great satisfaction in terms of the lift, firmness, and elasticity of breasts. In conclusion, extracts purified from Q. acutissima, C. lanceolata, P. mirifica, P. bambusoides, and S. repens leading to cell growth and fat accumulation in adipocytes can effectively contribute to improving the elasticity and size of women’s breasts.

Factors Associated with Gastrointestinal Symptoms among Rotating Shift Nurses

Sun-Kyung Hwang,Yun Ji Lee,Bokyoung Kim,Min-Eun Cho,Yea-In Yoon 한국성인간호학회 2021 성인간호학회 학술대회 Vol.2021 No.8

Aim(s): This study aimed to investigate common gastrointestinal (GI) symptoms and their associated factors among rotating shift nurses in tertiary hospitals. Method(s): In this cross-sectional study, nurses with rotating shifts were enrolled from two tertiary hospitals in South Korea. A self-administrated questionnaire consisting of general and occupational characteristics, lifestyle, sleep related characteristics, Evaluation of a Gastrointestinal Symptoms Questionnaire, Depression, Anxiety Stress Scale (DASS)-21, and Pittsburgh Sleep Quality Index (PSQI) was used for survey. The data were analyzed using the descriptive analysis, Independent t-test, One-way ANOVA, Pearson’s correlation, and Hierarchical multiple regression analysis. Result(s): Of 128 nurses with rotating shifts, the GI symptoms frequently experienced were in the order of empty feeling (82.0%), abdominal rumbling (75.8%), bloating (75.0%), heartburn (66.4%), and belching (6.02%). 42.4% of the participants had at least one more moderate GI symptoms and 7.0% with one or more severe GI symptoms. The average sleep quality (PSQI) score was 8.04 (SD=3.35), including 83.6% with poor sleep quality (PSQI ≥5). The mean of depression, anxiety, and stress were 7.57 (SD=7.84), 6.58 (SD=6.87), and 10.89 (SD=6.45), and the prevalence of them were 32.0%, 13.3%, and 28.2%, respectively. It showed that factors significantly associated with the severity of GI symptoms were sleep quality (β=.47), job stress (β=.23), sleep duration (β=.22), and general stress (β=.17) in the final model, and its explanatory power was 40.5% by total variance (F=4.55, p=.035). Conclusion(s): It shows that physical symptoms, especially GI symptoms, among rotating shift nurses were associated with poor quality, short sleep duration, and high stress level. The physical symptoms, sleep disorders, and psychological problems of nurses were interrelated with each other. Therefore, we should be more concerned about their health status, working conditions and quality of life among nurses.

Effects of intervention for postural balance and mobility in age-related macular degeneration: A systematic review

Yunji Lee,Sun-Kyung Hwang,Min-Eun Cho,Bokyoung Kim,Yea-In Yoon 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10

Aim(s): Age-related macular degeneration (AMD) leads to difficulty in mobility and risk of falls due to decreased balance and distance sensitivity through impaired central vision. This review aimed to examine the effectiveness of interventions to improve the direct acuity and adaptability of postural balance and mobility in AMD. Method(s): We searched the literature published until May 20, 2021, in Medline, PubMed, EMBASE, CINAHL, and Cochrane databases for systematic reviews conducted using the Cochrane Handbook’s guidelines (PROSPERO registration: CRD42021200271). Eligible articles included studies in adults with vision loss due to AMD and were designed for randomization or non-control trials to improve postural balance and mobility. Studies including children or evaluating the effects of pharmacological and surgical treatments were excluded. Two authors assessed the risk of bias and quality using the Risk Of Bias In Non-randomized Studies-of Intervention (ROBINS-I) tool and the revised Cochrane Risk –of -Bias (RoB2) tool for randomized trials. Result(s): The extracted seven studies, published in 2007 or later, included 761 participants. The interventions applied in seven studies were as follows: multidisciplinary rehabilitation program (3), device application (2), training using the platform (1), and dancing program (1). Most studies (6/7) measured the outcomes as a subcategory of vision-related quality of life, and two studies directly used the balance data from the platform and Dynamic Gait Index. Although insufficient reporting of intervention content was observed, all studies showed significant improvements in outcomes. Conclusion(s): Rehabilitation programs, including mobility training, improved postural balance and vision-related quality of life in AMD. Nurses should monitor the changes in balance and mobility due to vision loss and consider the methods for improving them to increase the quality of life and safety in older adults.

Treadmill exercise restores high fat diet-induced disturbance of hippocampal neurogenesis through β2-adrenergic receptor-dependent induction of thioredoxin-1 and brain-derived neurotrophic factor

Han, Tae-Kyung,Leem, Yea-Hyun,Kim, Hee-Sun Elsevier 2019 Brain Research Vol.1707 No.-

<P><B>Abstract</B></P> <P>A high-fat diet (HFD) is known to induce metabolic disturbances that may lead to cognitive impairment. In the present study, we investigated whether a regular treadmill exercise program would improve HFD-induced hippocampal-dependent memory deficits in C57BL/6 mice. Weight gain and hepatic triglyceride levels were profoundly elevated following administration of a 60% HFD for 23 weeks, and this change was attenuated by 23-weeks of treadmill running. The exercise regimen attenuated impairments in memory function of HFD-fed mice in a water maze test and recovered HFD-induced anti-neurogenic effects as shown by immunohistochemistry data with Ki-67 and doublecortin (DCX) antibodies. Moreover, the treadmill exercise resulted in anti-inflammatory, antioxidant, and neuroprotective effects in the HFD-fed brain. The exercise inhibited HFD-induced microglial activation, expression of proinflammatory cytokines (tumor necrosis factor-α and interleukin-1β), and NF-κB activity in the dentate gyrus (DG) of the hippocampus. In addition, the exercise reduced malondialdehyde levels elevated by HFD and recovered antioxidant superoxide dismutase and glutathione levels in hippocampal DG of HFD-mice. The exercise also reduced the number of apoptotic cells induced by HFD, as shown by TUNEL staining in the DG region. Finally, we demonstrated that the thioredoxin-1 (TRX-1) and brain-derived neurotrophic factor (BDNF) levels were recovered by exercise, which was demonstrated to act via β2-adrenergic receptor enriched in synaptosomes of the DG. Therefore, our data collectively suggests that regular exercise may be a promising approach to preventing HFD-induced memory impairments via anti-inflammatory, antioxidant and neuroprotective mechanisms in the hippocampal DG region.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Regular exercise improves HFD-induced memory impairments. </LI> <LI> Regular exercise recovers HFD-induced decrease in hippocampal neurogenesis. </LI> <LI> Regular exercise ameliorates HFD-induced neuroinflammation and oxidative stress. </LI> <LI> Regular exercise increases TRX-1 and BDNF expression in the hippocampal DG area. </LI> <LI> Exercise-induced TRX-1 and BDNF expression depend on β2-adrenergic receptor. </LI> </UL> </P>

Determination of Atmospheric Perfluorocarbon Background Concentrations of fL/L Range at the Western Coastal Area of Korea

HyeKyeong Kim,Sun Kyung Yea,Chul-Un Ro,Chong Bum Lee,Meongdo Jang,Gangwoong Lee,Eunjin Yoo,Jin-Seok Han 강원대학교 환경연구소 2002 環境硏究 Vol.19 No.-

Treatment Outcomes of Cavitary Nodular Bronchiectatic-type Mycobacterium Avium Complex Pulmonary Disease

( Ganghee Chae ),( Yea Eun Park ),( Yong Pil Chong ),( Hyun Joo Lee ),( Tae Sun Shim ),( Kyung-wook Jo ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

Background We investigated the treatment outcomes of patients with cavitary nodular bronchiectatic (C-NB) Mycobacterium avium complex (MAC) pulmonary disease (PD) by comparing the outcomes between patients with the fibrocavitary (FC) type and those with the C-NB type who received guideline-based therapy (GBT) composed of daily three-drug oral antibiotics with an injectable aminoglycoside. Additionally, we analysed whether treatment with oral antibiotics only would result in acceptable outcomes in the C-NB type. Methods Between 2002 and 2019, patients with cavitary MAC-PD who received three-drug oral antibiotics with or without injectable aminoglycoside for ≥1 year were enrolled at a tertiary referral centre in South Korea. We compared the 1-year microbiological cure rate according to the radiological type and treatment regimen. Results The overall 1-year microbiological cure rate of 154 patients with cavitary MAC-PD who received GBT was 75.3%. Among these, the microbiological cure rate of the 114 patients with the C-NB type was higher than that of the 40 patients with the FC type (80.7% vs. 60.0%, respectively; p = 0.009). Then, of the 166 patients with the C-NB type treated with oral medications with or without injectable drug, 83.7% achieved 1-year microbiological cure. The cure rate was similar between those who received oral medications only and those treated with the inclusion of an injectable aminoglycoside (90.4% vs. 80.7%, respectively; p = 0.117). Conclusions The outcomes of the C-NB type MAC-PD treated with GBT were significantly more favourable than the FC type. The C-NB type could be successfully treated with oral medications only.

일개 대학병원 신경외과중환자실에서 Clostridium difficile 관련 설사 감소를 위한 CQI활동

박은숙,장경희,윤영옥,이정신,김태곤,여한승,김선호,신정원,이경원,김준명 한국의료QA학회 2001 한국의료질향상학회지 Vol.8 No.1

Background : The Clostridium difficile is the most important identifiable cause of nosocomial infectious diarrhea and colitis, which lengthens hospital stay. Recently incidence of C. difficile has been increasing in an university hospital, and an intervention for prevention and control of C. difficile associated diarrhea(CDAD) was in prompt need. Methods : Subjects were the patients in the neurosurgical intensive care unit(NCU) where C.difficile was most frequently isolated. To increase participation of various departments, we used the CQI method, because management of CDAD requires a wholistic approach including control of antibiotics, barrier precaution and environmental cleaning and disinfection. Duration of the CQI activities was 9 months from April to December 1999. Results : The identified problems were misuse and overuse of antibiotics, lack of consciousness of medical personnels and the possibility of transmission from the contaminated environment and tube feeding. Education for proper use of antibiotics and management of C.difficile infection, use of precaution stickers, supplement of handwashing equipments, emphasis on environmental disinfection, and the change of the process of tube feeding were done. The CDAD rate in NCU was significantly decreased after the CQI program(8.6 case per 1,000 patient days from January to April 1999 vs 4.8 from May to December 1999). The distribution of neurosurgical wards including NCU among the total number of isolated C.difficlie from the clinical specimens dropped from 49.4% in January to April to 33,7% in May to December. The average hospital stay of the neurosurgical department changed from 19.6 days to 15.2 days. Also, the effect of the CQI activities for C.difficile may have affected the incidence of vancomycin resistant enterococci(VRE). Duration and dosage of certain antibiotics used in the NS department were decreased. The distribution of neurosurgical department in the number of VRE isolated patients declined from 18.4% to 11.1%. Conclusion : Infection control of resistant organisms such as C.difficile is likely to be successful when management of environmental contamination an collaborative efforts of decreasing the patients’ risk factors such as antibiotics management and decreasing the length of hospital stay come simultaneously. For this work, related departments need to actively participate in the entire process under a common target through discussions for identifying problems and bringing up solutions. In this respect, making use of a CQI team is an efficient method of infection control for gathering participation and cooperation of related departments.

Determination of Atmospheric Perfluorocarbon Background Concentrations of fL/L Range at the Western Coastal Area of Korea

Kim, Hye-Kyeong,Yea, Sun-Kyung,Ro, Chul-Un,Lee, Chong-Bum,Jang, Meong-Do,Lee, Gang-Woong,Yoo, Eun-Jin,Han, Jin-Seok Korean Chemical Society 2002 Bulletin of the Korean Chemical Society Vol.23 No.2

As part of perfluorocarbon (PFC) tracer release experiment conducted at the western coastal area of Korea in February 2001, the background concentration level of perfluorocarbons (PFCs) in the atmosphere was determined by gas chromatography with electron capture detector. Prior to the PFC tracer release experiment in the field, air samples were collected using active samplers and the background concentrations of PFCs were determined. The concentrations of perfluoromethylcyclohexane ($C_7F_{14}$, PMCH) in the western coastal area of Korea were in the range of 5.8-8.7 fL/L. The mean concentration of the PMCH in the region exhibited no significant spatial and temporal variations. This concentration level is somewhat higher and has larger standard deviation than those of studies previously conducted in USA and Europe on the background concentration levels of PFCs. Because the background concentration of PMCH in Korea is still very low and consistent temporally and spatially, the PMCH tracer can be used suitably for the studies of long-range atmospheric transport.

Neutrophil-Lymphocyte Ratio and Monocyte-Lymphocyte Ratio According to the Radiologic Severity of Mycobacterium avium Complex Pulmonary Disease

Kim Mi-Ae,Park Yea Eun,Chong Yong Pil,Shim Tae Sun,Jo Kyung-Wook 대한의학회 2022 Journal of Korean medical science Vol.37 No.40

Background: To date, no study has investigated whether the neutrophil-lymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR) have a clinical value in Mycobacterium avium complex (MAC)-pulmonary disease (PD). Methods: We aimed to assess whether the baseline NLR and MLR were different according to the severity of MAC-PD based on the radiologic classification by retrospectively analyzing 549 patients treated in a tertiary referral center in South Korea. Results: Both NLR and MLR were significantly higher as 3.33 and 0.43 respectively in the fibrocavitary type, followed by 2.34 and 0.27 in the cavitary nodular bronchiectatic type and significantly lower as 1.88 and 0.23 in the non-cavitary nodular bronchiectatic type. Conclusion: The baseline NLR and MLR showed a distinct difference in accordance with the radiologic severity of MAC-PD.

Efficacy of Fluoroquinolone as a Substitute for Ethambutol or Rifampin in the Treatment of Mycobacterium Avium Complex Pulmonary Disease According to the Radiologic Type

( Jang Ho Lee ),( Yea Eun Park ),( Yong Pil Chong ),( Tae Sun Shim ),( Kyung-wook Jo ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

Objective During the treatment of Mycobacterium avium complex pulmonary disease (MAC-PD), ethambutol or rifampin is often discontinued due to adverse events. In this study we investigated the treatment outcomes when fluoroquinolone is substituted for ethambutol or rifampin in MAC-PD treatment according to radiologic type. Methods Between 2006 and 2019, 225 patients who initiated guideline-based therapy (GBT) and whose treatment duration was ≥1 year were enrolled at a tertiary referral centre in South Korea, including 178 patients with cavitary disease (fibrocavitary and cavitary nodular bronchiectatic types) and 47 patients with noncavitary nodular bronchiectatic (NC-NB) type. We compared microbiologic cure at 1 year between the patients maintaining GBT and those who replaced ethambutol or rifampin with fluoroquinolone (moxifloxacin or levofloxacin). Results The overall microbiologic cure rate of the 178 patients with cavitary disease was 71.3%. Among these, the microbiologic cure rate of the 16 patients who substituted fluoroquinolone for ethambutol was lower than that of the 156 patients who maintained GBT (37.5% vs. 74.4%, respectively; P = 0.007), which was also statistically significant in the multivariate analysis. The outcomes of the six patients in which fluoroquinolone was selected as an alternative to rifampin were similar to that of those receiving GBT. The microbiologic cure rate of the 47 patients with NC-NB was 83.0%; the treatment outcomes were similar whether the patients maintained GBT or replaced ethambutol or rifampin with fluoroquinolone. Conclusions In cavitary MAC-PD, substituting fluoroquinolone for ethambutol resulted in inferior patient outcomes. In other cases, treatment outcomes seemed to be similar.