연령증가에 따른 혈압요소들의 좌심실비대 및 관동맥질환과의 관련성

박재석,박창규,박미영,박재형,김용현,나진오,신성희,서순용,홍순준,박성미,임홍의,김응주,서홍석,오동주,노영무 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

생분해성 PLA를 이용한 안경테의 적용 및 그의 물성 연구

홍기헌 ; 김용석 김천대학교 2011 김천대학교 논문집 Vol.32 No.-

Poly (lactic acid) (PLA) is well known as a biodegradable thermoplastic polyester with good physical properties. In recent year, environmental deterioration caused by synthetic plastic is serious. So, PLA is a one way to solve the problem. This study investigated the optimum conditions of injection moulding and the properties of the biodegradable eyeglass frame, such as tensile strength, elongation, mould shrink-age, dyeability and elastic deformation. Biodegradable eyeglass frame (temple) can be made with injection moulding machine in the optimum conditions. Materials were used PLA only and plasticizer modified PLA, respectively. Tensile strength and elongation of PLA was around 600kgf/cm' and 6 10% respectively. Those of plasticizer modified PLA was 560kgf/cm' and 25% respectively. PLA temple has brittle characteristics not flexibility. But the property was not significant with respect to the various injection moulding conditions. And tensile strength decreased and elongation increased with addition of the plasicizer. Dyeability was excellent for all sam-ples. After high deformation, the frame can not recover completely. Elastic recovery of plasticizer modified PLA was better than that of PLA only.

Cone beam형 전산화단층영상에서 골의 형태와 밀도의 평가

홍상우,김규태,최용석,황의환 대한구강악안면방사선학회 2008 Imaging Science in Dentistry Vol.38 No.1

Purpose : Diagnostic estimation of destruction and formation of bone has the typical limit according to capacity of x-ray generator and image detector. So the aim of this study was to find out how much it can reproduce the shape and the density of bone in the case of using recently developed dental type of cone beam computed tomography, and which image is applied by new detector and mathematic calculation. Materials and Methods : Cone beam computed tomography (PSR 9000N, Asahi Roentgen Ind. Co., Ltd., Japan) and soft x-ray radiography were executed on dry mandible that was already decalcified during 5 hours, 10 hours, 15 hours, 20 hours, and 25 hours. Estimating and comparing of those came to the following results. Results : The change of inferior border of mandible and anterior border of ramus in the region of cortical bone was observed between first 5 and 10 hours of decalcification. The reproduction of shape and density in the region of cortical bone and cancellous bone can be hardly observed at cone beam computed tomography compared with soft x-ray radiography. The difference of decrease of bone density according to hours of decalcification increase wasn’t reproduced at cone beam computed tomography compared with soft x-ray radiography. Conclusion : CBCT images revealed higher spatial resolution. However, contrast resolution in region of low contrast sensitivity is the inferiority of images’ property.

사람 위선암에서 cathepsin L의 발현증가

홍원선,홍석일,박인철,손영숙,정훈용,양석균,김해련,민영일 울산대학교 의과대학 1996 울산의대학술지 Vol.5 No.1

cathepsin L은 lysosomal cysteine 단백분해효소로서 기저막(basement membrane)과 세포외기질(extracellular matrix)을 파괴하여 암세포의 침윤과 전이에 중요한 역할을 하는 물질로 알려져 있다. 이러한 cathepsin L에 대한 mRNA 발현도를 5개의 사람 위선암(gastric adenocarcinoma) 세포주와 5명의 위선암 환자에서 채취한 조직에서 방사능으로 표지된 cathepsin L특이 cDNA를 사용한 Northern blot법으로 측정하였다. 위암의 전이병소에서 수립한 세포주인 SNU-5, SNU-16, MKN-45와 Kato Ⅲ에서는 cathepsin L mRNA가 발현되었으나 원발병소에서 수립한 AGS 세포주에서는 mRNA의 발현이 관찰되지 않았다. 5명의 위암 환자에서는 원발병소, 전이가 확인된 임파절 및 암 근처 정상 위점막에서 각각 조직을 채취하여 cathepsin L mRNA의 발현을 측정하였다. 원발병소와 전이병소에서는 모두 cathepsin L mRNA가 발현되었으나 정상 위점막조직에서는 전예에서 mRNA 발현이 관찰되지 않았다. 한편 mRNA의 발현도는 1예에서는 전이병소가 원발병소에 비해 높았으나, 2예에서는 전이병소에서 발현도가 낮았으며, 나머지 2예에서는 원발병소와 전이병소 사이에 차이가 없어, 원발병소와 전이병소 사이에 mRNA의 발현도의 일관성 있는 경향은 관찰되지 않았다. 이상의 결과는 cathepsin L은 위암의 발생과 진행에 있어 암세포의 침윤과 전이를 촉진하는 것 이외에 또 다른 역할을 할 가능성을 시사하고 있다고 사료된다. Cathepsin L, a lysosomal cysteine protease, is known to play an important role in cancer invasion and metastasis by degrading the components of basement membrane and extracellular matrix. The mRNA expression of cathepsin L was determined by Northern blot analysis using a radiolabeled cDNA specific for cathepsin L in five human gastric adenocarcinoma cell lines and five surgical specimens of primary gastric adenocarcinomas, their metastatic lymph nodes and matched adjacent normal mucosae. The mRNA of cathepsin L was expressed in all of the four cell lines established from the metastatic sites, SNU-5, SNU-16, MKN-45 and Kato Ⅲ, while not detected in one cell line established from the primary site, AGS. The mRNA was expressed in all of the five primary and five metastatic cancer specimens tested, while it was not detected in all matched normal mucosae. The intensities of the mRNA expressions, however, did not show the consistent pattern between primary sites and metastatic lymph nodes. These results suggest that cathepsin L may have the other function in addition to facilitation of the invasion and metastasis during the development and progression of stomach cancer.

흰쥐에서 Cumambrin A의 대동맥 이완작용

홍용근,양민석,박윤배 Plant molecular biology and biotechnology research 2005 Plant molecular biology and biotechnology research Vol.2005 No.

We previously reported that the exogenous administration of cumambrin A, a sesquiterpene lactone from the dried flowers of Chrysanthemum boreale Makino has a pharmacological effect on normalization of blood pressure in the spontaneously hypertensive rats (SHR). In the present study, we further investigated the effect of cumambrin A on the relaxation of phenylephrine-induced precontracted rat aortic artery rings. The potency of cumambrin A was then compared to verapamil, a well known Ca^(2+)-channel blocker. The results demonstrate that the isolated rat aortic arteries are relaxed to basal tension at a concentration of 5X10^(-5)M cumambrin A treatment. The results also show that the phenylephrine-induced contraction is inhibited by a pretreatment of cumambrin A. Co-treatment of cumambrin A and verapamil showed a strong synergetic effect on the relaxation of rat aortic artery rings. Thus, these data demonstrate that cumambrin A is a potent relaxant of rat aortic smooth muscle and suggest that cumambrin A modulates intracellular or extracellular Ca^(2+) mobilization.

구형 Helicobacter pylori의 중성구 매개 산화활성

홍원선,김혜원,이학성,명승재,정훈용,양석균,김진호,민영일,정명희 대한암예방학회 2000 Journal of cancer prevention Vol.5 No.3

사구체 수의 증감을 비교할 수 있는 기준 개발

김용진,이지은,이국주,최영호,홍정석 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.1

Background: The number of glomerulus has been considered one of the etiologic factors especially for focal segmental glomerulosclerosis. However, glomeruli are too many to calculate them correctly. Although the fractionator method has became convinced, in which they used selected sections, not whole kidney sections, with same intervals, it is also very hard to get good results. Because it is still very time-consuming and laborous work which leads to make big observers' biases. Methods and Materials: We designed the index for glomerular number to estimate the tendency of increase or decrease of the number of it in different kidneys and which was evaluated by other conventional methods including fractionator method. Index was based upon the theory by Nyengaard; "the number of glomerulus correlates with the weight of kidney, which is positively correlated with body weight". Calculating formula is the number of glomeruli/surface areas of cortices, which contain calculacted glomeruli multiplies by kidney weight/body weight. Results: We applied this index to kidneys of FGSKist mouse and those of RFM/Nga mouse. The former is spontaneous glomerulosclerosis model with heavy protein uria and renal faille and the latter is the mother side of FGS/Kist mouse but has no glomerular disease or protein aria. The number of glomerulus of FGS/Kist mouse was decreased by 30% to those of RFM/Nga mouse. Conclusion: This index was useful and reliable for estimating the relative glomerular number between two groups.

精神障碍者 家族의 精神障碍에 對한 態度調査

金鐘碩,金容植,河圭燮,梁益弘,李符永 서울대학교 의과대학 정신과학교실 1989 서울醫大 精神醫學 Vol.14 No.1

Adiabatic 하며 Noncyclic 한 경우의 기하 위상고찰

李用山,金洪錫 대진대학교 1994 大眞論叢 Vol.2 No.-

For a cyclic evolution, the value of the geometrical phase is unique. we discuss that, for a noncyclic evolution, it may have two different values in cases with and without measurements in the projective Hilbert space, respectively. that which value of them will be calculated depends on the use of geodesic rule. In order to illustrate this, we propose the calculation method of Berry s phase by the use of geodesic rule in the systems of adiabatic and noncyclic evolution curves.

R-12 냉매용 냉동장치의 성능에 미치는 R-12와 R-134a 냉매의 효과

이홍기,장동호,정용진,강형석 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.B

High pressure, pressure ratio, refrigerating effect, heat transfer from the condenser and the power of the compressor etc. of a self-made refrigeration equipment for R-12 are investigated when R-12 and R-134a are used as the coolants. The comparison between the performance for R-12 and that for R-134a is made. As a result, R-134a is better than R-12 in the view of high pressure, refrigerating effect and the coefficient of performance and vice versa in the view of pressure ratio, exit gas temperature from the compressor and heat transfer from the condenser.