요부수핵탈출증에서 Thermography의 진단적 가치

신현택,신승우,송재철,정석희,이종수,김성수,신현대 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

Objectives : Lumbar radiculopathy is a common disease in oriental rehabilitation medicine. It can be diagnosed by physical examination, plain X-ray, Myelography, CT, MRI, EMG etc. But those methods are not useful in observing the clinical procedure. Objectvie evaluating the clinical procedure is very important in treatment of lumbar radiculopathy. Mehthods : We studied the clinical efficacy of thermography in lumbar radiculopathy during conservative managements. We studied 36 patients with lumbar radiculopathy convinced by MRI. The had low back pain and radiating pain on one side. Thermography had taken before an after 4 weeks treatments, and compared with clinical procedure Results and conclusions : Thermography is not pertinent as a primary diagnostic method in lumbar radiculopathy, but useful in observing the clinical procedure. And it can be recommended as a objective evaluation for lumbar radiculopathy.

비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

Hg^2+에 의한 토마토 뿌리조직 마이크로솜 H^+-ATPase의 가역적 저해

신대섭,조광현,김영기 충북대학교 첨단원예기술개발연구센터 1999 연구보고서 Vol.4 No.-

토마토 뿌리조직의 마이크로솜 ATPase 활성에 대한 중금속의 효과를 조사하기 위하여 뿌리조직으로부터 마이크로솜을 분리하였고, enzyme-coupled assay를 이용하여 마이크로솜 이온펌프(ATPase)의 활성을 측정하였다. 여러 가지 중금속 이온들 중 Hg2+은 마이크로솜 ATPase 활성을 농도 의존적으로 저해하였으며, Gd3+ 과 Fe3+, La3+, Zn2+ 그리고 Pb2+ 등은 마이크로솜 ATPase의 활성을 현저히 저해하면서 동시에 assay에 사용된 효소를 저해하였다. 그러나, CS+과 BA2+은 마이크로솜 ATPase 활성에 영향을 미치지 않았다. Hg2+은 원형질막과 액포막에 위치하는 H+-ATPase들의 활성을 10 μM 이상의 농도에서 급격히 저해하였고, 1 mM 이상의 농도에서 완전히 저해하였으며, 두 효소들에 대한 활성저해의 Ki 값은 각각 80 , μM, 58 μM로 나타났다. Hg2+에 의해 저해된 ATPase의 활성은 DTT의 농도를 증가시킴에 따라 회복되어, HG2+에 의한 ATPase 활성저해는 가역적임을 확인하였다. 이러한 결과들은 Hg2+이 원형질막과 액포막에 위치한 H+-ATPase들을 비선택적이고 가역적으로 저해함을 보여준다. In order to characterize the effects of heavy metal ions on the microsomal ATPase activities, microsomes were prepared from the roots of tomato plant and the activity of microsomal ATPase was measured by an enzyme-coupled assay. Hg2+ inhibited the activity of microsomal ATPase in a dose-dependent manner, while Gd3+, Fe3+, La3+, Zn2+, and Pb2+ inhibited not only the ATPase activity but also the activities of enzymes used in the assay. However, Cs+ and Ba2+ showed no significant effect. Hg2+ inhibited the activities of both plasma membrane and vacuolar membrane H+-ATPases. In the dose-response to Hg2+, the activities of both microsomal H+-ATPases were severely inhibited at the concentration of Hg2+ above 10μM and were completely inhibited at 1 mM Hg2+. Apparent Ki values of Hg2+ on the inhibitions of plasma membrane and vacuolar membrane H+-ATPases were 80 μM and 58 μM, respectively. The Hg2+-induced inhibitions were reversible since the addition of dithiothreitol completely reversed the inhibitory effects of Hg2+.These results suggest that the inhibitory effects of Hg2+ on both plasma membrane and vacuolar membrane H+-ATPases are nonselective and reversible.

유지 투석중인 만성 신부전환자에서 허혈성 심질환의진단 지표로서의 심장트로닌-I의 유용성

신병철,강대웅,정지용,류봉관,서영욱,김정인,김범윤,김현리,정종훈 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

Background : Coronary disease is highly prevalent in patient with end stage renal disease (ESRD) and account for much of their observed morbidity and mortality. Troponin-I consistently maintains a high sensitivity and specificity and is most sensitive marker for ischemic heart disease (IHD). Method : We examed 49 hernodialyzed patients (22 male, 27 female) without evidence of acute coronary syndrome (ACS) for 6 months. Biochemical markers were measured in serial predialysis blood samples. For analysis, we used two cardio-specific assays for troponin-T (cTnT) as well as for troponin-I (cTnI) and compared the results with CK-MB (reference value ≤ 4.0 ng/mL) concentration. Results : Myocardial ischemia was observed in 47% (23/49) of patients. cTnT level above 0.1 ng/mL. and cTnI level above 0.5 ng/mL, were observed in 22% (11/49) and 20% (10/49) of patients respectively. cTnI revealed significantly higher positive rate in patients with myocardial ischemia than the patients without myocardial ischemia (43 % vs 30%) (p<0.05). cTnT and CK-MB revealed no difference in positive rate between the patients with and without myocardial ischemia (cTnT : 30% vs 15% and CK-MB : 30% vs 19%). The sensitivity and specificity of cTnI to myocardial ischemia were higher than those of cTnT and CK-MB (sensitivity 43% vs 30% and 30%. specificity 100% vs 85% and 81%). Conclusion: Both cTnT and cTnI are useful in ruling out myocardial injury in chronic renal failure patients. But. cTnI is a more sensitivity and excellent specificity of ischemic heart disease than cTnT and CK-MB in hemodialyzed patients. In patients with ischemic heart disease, the presences of DM and advanced age were higher than those in patients without ischemic heart disease (p<0.05). Among the baseline characteristics old age, elevated LDH and diabeties were significant more frequent in the patients with elevation of cardiac troponin-I (p>0.5 ng/mL) than those with cardiac troponin-I (p<0.5 ng/mL), p=0.038, p=0.049, and p=0.045, respectively. Our results suggest that these cTnI is the potential diagnostic marker for the prediction of IHD in ESRD patients.

장골에 발생한 전이성 골종양의 수술적 치료

신현대,김영모 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

The sixteen patients who had had metastatic bone tumors in long bone were treated with operation from January 1994 to August 1996. We analyzed the cases in the aspects of age and sex distribution, primary origin site and metastatic site in long bone, Mirels scoring system and the duration of survival. The results were as follows ; 1. Six patients were male and 10 patients were female. The mean age of both group was 58.2 years old. female was 55 years and male was 63.5 years. Female was more younger than male. The peak incidence was in the 6th decade. 2. The main primary cancers were lung(31.25%) and breast(25%). 3. All sixteen patients had had eighteen pathologic fractures in long bone. Eight cases at the femur subtrochanter, five at the humerus shaft, two at the femur intertrochanter, two at the femur shaft and one at the tibia shaft. 4. To the Mirels scoring system, All cases scored above eight and no significant difference between fracture group and nonfracture group in X2-test. 5. Among the sixteen patients, twelve had been dead. One of them had been dead before operation with self-discharge, six patients survived less than six months, two patients survived from six to a year, two patients survived from a year to two years and one patient survived more than two years.

筋骨格系 領域에서 Thermography의 臨床的 活用에 對한 考察

신현택,정석희,이종수,김성수,신현대 동국대학교 한의학연구소 2000 東國韓醫學硏究所論文集 Vol.8 No.2

근골격계 질환은 임상에서 가장 흔하게 접할 수 있는 대상의 하나로 그 진단과 평가가 매우 중요하며 여러 가지 진단기기와 평가방법이 이용되고 있다. Thermography는 기존의 진단기기와 달리 질병의 기능적인 측면을 평가할 수 있다는 점과 통증과 같은 주관적인 표현을 어느정도 객관화할 수 있다는 점에서 임상적 가치가 고려되고 있다. 본 연구는 최근 국내외의 임상 논문을 대상으로 근골격계 영역에서 Thermography의 활용 동향을 고찰하여 진단적 가치를 확인하고자 하였다. Thermography는 척추신경병증, 근막동통증후군, 말초신경병증, 반사성 교감신경 이영양증, 레이노 증후군, 악관절 장애 및 일부 기타 질환에서 적용되었으며, 대부분의 질환에서 보조적인 진단기기로 활용가치가 있었다. 특히, 질병의 경과 관찰과 약물 및 기타 처치에 대한 효과 판정에 유용하였으며, 레이노 증후군 및 반사성 교감신경 이영양증과 같은 질병에서는 일차적인 진단기기로도 활용이 가능하였다. 향후 근골격계 영역에서 Thermography의 보다 폭넓은 적용을 위해서는 질환에 따른 적절한 촬영방법의 개발 및 결과 판독에 대한 객관성 확보가 있어야 할 것이다. The purpose of this study is to assess the usefulness of thermography in patients with musculoskeletal disease. Thermography is noninvasive, easy to reading, objective and physiologic instrument by measuring and imaging infrared energy emitted from skin surface. Thermography can show the skin temperature changes in various conditions of the body with musculoskeletal disease. This literature review was done for the usefulness of thermography in diagnosing musculoskeletal disease. In conclusion, thermography was adapted in radiculopathy, NIPS, peripheral neuropathy, RSD, Raynaud's phenomen, TMJ dysfunction, etc. It was useful as a secondary diagnostic method in those diseases, also possible as a primary diagnostic method in RSD, Raynaud's phenomen. And, it might be reliable tool for estimating dlsease procedure and consequence after treatment. But, the objectivity of the reading and the development of the operating method are required for further adaptation in musculoskeletal disease.

외상성 주관절 구축의 수술적 치료

신현대,이원석 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

The eleven consecutive patients who had contracture of the elbow joint were treated by anterior capsulectomy and distraction arthroplasty without fascial interposition or anterior capsulectomy only. The ten elbows were post-traumatic contracture, and the one elbow was the ankylosis due to prolonged immoobilization after rain injury. Five patients were treated with distraction arthroplasty by modified Mayo Clinic Device and six patients underwent anterior capsulectomy under general or regional anesthesia. The mean preoperative arc of the total motion was 52 degrees(from 44 to 92 degrees of flexion). At follow-up examination, twelve to forty months postoperatively, of eleven patients, the mean arc of the total motion was 108 degrees (from 14 to 122 degrees of flexion). There were seven complications in seven of the eleven patients. Of these, the two were heterotopic ossification recurred in the posterior capsule of the elbow joint, so subsequently the ulnohumeral arthroplasty was performed at postoperative 8 months and 30 months later. The transient ulnar nerve injuries were occurred in two patients. The injured nerve dysfunction was resolved spontaneously. Two patients occured superficial wound infection. The pin site infection was occurred in one patient. The infection was subsided by dressing and antibiotics. Nine of the eleven patients who were followed for average 19 months satisfied with the results of the procedure because of the improved activity in carrying out daily life. No patients showed aggravation of pain. The three severely unstable elbow was improved from 3 points to 1 point on stability points. It was concluded that results of distraction arthroplasty and anterior capsulectomy could be gratifying and the range of motion of elbow was improved Significantly. But the technique is demanding and the rate of complications such as ulnar paresthesia or pin site infection is high especially distraction arthroplasty.

玄胡索의 이온參透療法을 通한 生體透過性에 關한 硏究

申鉉澤,申鉉大 慶熙大學校韓醫科大學韓醫學硏究所 1999 慶熙韓醫大論文集 Vol.22 No.1

Iontophoresis is the process whereby electrically charged drugs are transfered through skin via electrical potential which is nontraumatic and painless. It is possible to medicate electrically any surface tissue with drugs having a positive or negative charge. I am interested in applying herbal medicine to a new method of treatment in musculoskeletal inflammatory conditions instead of western medicine. It is necessary to study on the passage through skin of herbal medicine before application of iontophoresis clinically. Corydaline Standard and Corydalis Tubar Extract Solution were selected and studied. The results were following. 1. It was proved Corydaline Standard and Corydalis Tubar Extract Solution are absorbed through skin by intophoresis. 2. In the case of Corydaline Standard, the absorption increased more in impregnating on negative electrode, and there was statistical significance as compared with impregnating on positive electrode. 3. In the case of Corydalis Tubar Extract Solution, the absorption increased more in impregnating on positive electrode, and there was statistical significance as compared with impregnating on negative electrode. 4. In all group, there were no significant changes in the absorption during the experimental period.

奉化 智林寺 磨崖如來三尊像 小攷

申大鉉 한국문화사학회 2003 文化史學 Vol.0 No.19

경북 봉화 지림사 마애여래삼존좌상은 국보 제201호 봉화 북지리 마애여래좌상과 거의 비슷한 위치에 자리한다. 그 동안 한 번도 학술적 주목을 받은 바가 없었지만 7세기 중반에서 7세기 후반에 걸친 시기에 조성된 신라의 마애불로 학술적 가치가 높은 마애불이다. 현채 보존상태가 나빠 급속도로 풍화되고 있어서 이에 대한 연구가 시급하며, 앞으로 보존과 관리를 위해서는 국가 및 지방문화재로의 지정이 필요하다. 현재의 지림사 일대는 '한절'로 불리던 대규모 사찰이 자리한 곳으로, 북지리 석조 반가여래좌상도 같은 경내에서 출토되었다. 지림사 마애여래삼존좌상은 북지리 마애여래좌상과 영주 가흥동 마애여래좌상과 아울러 신라의 수도 慶州가 아닌 외곽 지역에 봉안된 대표적 신라 불상이라는 점에서 매우 주목되는 작품들이다. 그런데 북지리 마애 여래삼존좌상 역시 여러 가지 면에서 이들 불상과의 親緣性이 눈에 띠어 이 불상 조성시기의 下限이 7세기 후반을 넘지 않을 것으로 추정된다. 오히려 일부 양식에서는 통일신라 이전 삼국시대 말에 해당하는 7세기 중반의 요소가 있어 시기가 좀 더 올라갈 가능성도 있는 것이다. 지림사 마애여래삼존좌상은 갸름한 얼굴에 눈 둘레가 움푹 패인 모습이 뚜렷한데, 이것은 멀리 중국 남북조시대의 불상의 영향을 받은 것이고, 특히 좌우 협시상의 얼굴 가운데 도톰하게 표현된 두 뺨의 모습은 북지리 마애불과 가흥동 마애불의 풍만한 뺨과 흡사하지만, 도통하면서도 긴장감이 느껴지고 있어 兩 마애불보다 시기가 좀 더 앞서는 형식이 아닐까 추정해 볼 수 있다. 본존상의 경우에 특히 두드러지지만, 佛身 주위의 巖面을 깊숙이 파내어 마치 佛龕 안에 봉안된 것과 같은 효과를 주려고 한 점은 북지리 마애불과 비슷한 意匠이다. 삼존상 가운데 본존상과 우협시상 사이 아래에는 규모가 아주 작은 僧像이 조각되어 있는데, 배치된 자리가 자연스럽지 못하고 규모가 지나치게 작다는 점으로 볼 때 후대에 조각한 것으로 보인다. 좌협시상 옆에는 三層木塔像이 조각되어 있다. 마애목탑상은 경주 남산의 탑곡 마애불상군 등에서 類例를 살펴볼 수 있기는 하지만 매우 드문 일에 속한다. 그런데 석탑이 아니라 목탑을 표현한 것으로 볼 때 이 마애불상의 조성시기를 7세기 중반 이전으로 추정하는 일이 가능하다. 이와 같이 지림사 마애여래삼존좌상은 여러 가지 면에서 7세기 중후반의 자료로서, 이 시기의 국내 실물자료가 절대적으로 부족한 현실에서 당시의 마애불 및 불상 연구에 소중한 자료가 되는 것이다. Jilim-sa temple is build in 7th century in Silla-Dynasty located on Bukjili, Bongwha-gun, Gyoungsang-bukdo. There is Bukjiri Buddhist image carved on rock cliff dating to 7~8th century in this temple. That is found by reachers in 1964, and is regarded a major buddhist image of Silla-Dynasty by those of scholars. At that time another buddhist image carved on rock cliff is found, too. That is positioned near by Bukjiri Buddhist image carved on rock cliff, dating to 7th century. But this buddhist images carved on rock cliff are not concemrd to study by scholars. I studied for this seated buddhist images carved on rock cliff on way look-in jilim-sa temple three months ago, so I naming it "The three Buddhist images carved on rock cliff in Jilim-sa temple". And it carved on the rocks in the back of Wontongjon(圓通殿) which is the main hall of this temple. In the rocks, there are several carving of three buddha imagrs, a monk image, and wooden-stupa image. I will demonstrate each types of it. First, the middle buddha image is resembled from 5-6th century images of China. For examples, there are several special features in the shape of face. Especially, the eyes are dugged sunken, and the face is small and longish. The left buddha image has the circle light near the head(頭光). And carved more high-relief globally than other. The right budha image is smaller than left, the feather of this image is the expression of the buddha dress's wrinkles, the wrinkles are crossed each other in front of breast. the monk image is located between the middle seated buddha image and the right. Maybe, in my opinion, this image is carved in later ages because of the unmatural position of it and of its unskillful carving. The wooden-stupa image is located on the right of rocks, then the shape of it showed the style of early 7th century. So I reach a conclusion that the three seated Buddhist images carved on rock cliff in jilimsa temple are enshrined in the period from middle to late 7th century.

축산폐수처리를 위한 탈수기와 침전조 개발에 관한 연구

신대윤,최현규 조선대학교 환경연구소 1998 環境硏究 Vol.14 No.1

Centrifugal filter and filtration type sedimentation tank are built to investigate their capacity and the optimal condition to treat swine wastewater physical-mechamically. 1. As the result of the separation and the experiment of sludge which is over 0.2㎜ of the diameter of the particles, in 180rpm of the rotation speed and 50ℓ/min of filtration velocity of centrifugal filter, 1.3∼4.7㎏ of sludge, 60∼70% of hydration rot per 1㎥ of filtrates, was removed. 2. Removal rate of SS of filtrates through filtration type sedimentation tank was more than 90%, and BOD and COD more than 50% when filtrate had been kept for 6 months in air-tight container, it generated a little gas and little precipitation.