Ki - 1 임파종 1 예

강민모(Min Mo Kang),김경재(Kyoung Jae Kim),이지현(Ji Hyun Lee),최석문(Seog Mun Choi),안기성(Ki Sung Ahn),황기석(Kee Suk Whang),김용진(Yong Jin Kim),박재복(Jae Bok Park) 대한내과학회 1993 대한내과학회지 Vol.45 No.4

A 60-year-old man was admitted to our hospital complaining of fever with chillness and anarexia for 12 weeks. Physical examination revealed supraclavicular lymphadenopathy and left inguinal lymphadenopathy. Abdominal CT scan showed the evidence of maked lymphadenopathy on retraperitoneal, external iliac, obturator, left inguinal, and celiac lymph nodes. A pathologic diagnosis of Ki-1(+) lymphoma was made by the biopsed supraclavicular lymph node because the node consisted of large cells with pleomorphic nuclei, scanty cytoplasm, large basophilic nucleoli, atypical vacuoli and large cells were positive for leukocyte common antigen, Ber-H2, marker, and B-cell marker.

日本地域의 韓國學 및 數學의 硏究動向

柳基龍,李基東,李仁錫,李尙憲 慶北大學校 東洋文化硏究所 1982 東洋文化硏究 Vol.9 No.-

지연성으로 발생한 외상성 횡격막 파열의 임상적 고찰

이정희,서홍주,이석기 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Background: Diaphragmatic rupture may occur from blunt or penetrating thoracoabdominal trauma, which may be undiagnosed initially in the acute trauma, work-up and may remain unrecognized. Delayed traumatic diaphragmatic rupture is reported with increasing frequency and is associated with high morbidity and mortality. The purpose of this study was to present our experience and found out early diagnostic method, clinical presentation and management. Matehals and Methods: From March 1998 to February 2004, the 6 patients of delayed diaphragmatic rupture in our hospital were operated. We reviewed the diagnostic interval, symptom, diagnostic method, operative method and complication. Resutt: They were 3 men and 3 women. Mean age was 56.8:t15.8 years(range 29-69). Most common symptom was dyspnea. Delayed diaphragmatic rupture was right-sided in 4 patients, left-sided in 2. The average operative interval of delayed diaphragmatic rupture was 18.8 months(range 5-48). The diagnosis was chest x-ray and thoracic CT. Operative approach were only thorax in 4 patients and both thorax and abdomen in 2. Postoperative complication were observed in 4 patients, and the overall mortality was none. Conclusion: The delayed case of traumatic diaphragmatic rupture tends to be overlooked without suspicion, In all patients with thoracoabdominal blunt injury a rupture of the diaphragm must be suspected. With a high suspicion, a thorough physical examination and diagnostic method is recommended in order to avoid early or late complications.

분리막 시스템을 이용한 정수공정의 연구

이기완,고태석 동신대학교 환경연구소 1998 환경연구 Vol.3 No.1

황룡강을 수원으로 하는 상수원수와 침전상징수의 정수를 위하여 MF(정밀여과)공정을 적용하였다. 현장에서의 실험결과는 낮은 운전압력일수록 높은 탁도 제거율을 보였으며, 상징수의 탁도는 2~4 NTU로서 MF처리시 1kg/㎠에서는 0.3~0.4 NTU로 2kg/㎠에서는 0.4~0.5 NTU로 감소되었다. 이들 유출탁도는 음용수 기준인 1.1 NTU를 민족 할 정도이었다. 원수는 15~20 NTU의 높은 탁도로서 원수를 직접 MF처리할 경우, 유출수는 1kg/㎠에서 1.9~4.8 NTU로 2kg/㎠ 에서 2.1~4.9 NTU로 나타났다. 이들 탁도는 처리수 기준을 초과하였으므로, 기준을 만족하기 위해서는 다단계의 MF 처리가 권장된다. 막 의 역세척 소요시간은 약 6분이 적합하였다. MF처리공정은 재래식 모래여과기와 비교할 때 작은 소요부지 면적, 막의 내구성과 수명, 약품비등에서 수처리에 효과적임을 보여주었다. MF(Micro Filtration) process was applied to the treatment of raw water and clarified water in water treatment plant sourced from the Hwangryong river. As results of experiments and field study the lower the operating pressure, the higher the turbidity removed. Turbidity of clarified water were reduced from 2~4 to 0.3~0.4 NTU at 1kg/㎠ and 0.4~0.5 NTU at 2kg/㎠ by MF process. These effluent turbidities were acceptable to the drinking water standard of 1.1 NTU. For the raw water of high turbidity with 15~20 NTU the effluents were 1.9~4.8 NTU at 1kg/㎠ and 2.1~4.9 NTU at 2kg/㎠. These turbidities exceeded the standard value of treated water. To meet the standard, multistage operations were executed with the raw water and its turbidity decreased to 0.1 NTU. The proper time for backwashing of the unit was about 6 minutes. Compared with a traditional sand filter, MF process showed the effectiveness of Water treatment due to small area, long life spans and less chericals required.

특수형 방사성 동위원소 운반캡슐의 안정성 평가

이주찬,서기석,구정회,방경식,한현수,박성원 대한방사선 방어학회 2001 방사선방어학회지 Vol.26 No.1

특수형 방사성물질 운반캡슐은 국내외의 수송관련 법규에 규정된 기술기준을 만족하도록 설계, 제작되어야 한다. 본 연구의 목적은 하나로에서 생산된 192Ir 특수형 동위원소 운반캡슐의 건전성을 평가하는데 있다. 법규에서 규정된 낙하시험, 타격시험, 굽힘시헝 및 가열시험조건에 대한 안전성 시험을 수행하였으며, 각각의 시험 전후에 누설시험을 수행하였다. 또한, 안전성시험과 더불어 컴퓨터코드를 이용한 전산해석을 수행하여 안전성시험 전에 시험결과에 대한 예측자료로 활용되었다. 낙하시험 및 가열시험 결과 캡슐 표면에서 약간의 흠집과 변형이 발생하였으나, 각각의 시험에서 평가기준이 되는 캡슐의 손상이나 용융 등은 발생하지 않았다. 또한 각 시험 후 수행한 누설시험 결과 누설이 발생하지 않았다. 따라서 특수형 방사성물질 운반캡슐은 법규에서 규정하는 기술기준을 만족하도록 설계, 제작되었음이 입증되었다. All of sealing capsules to transport a special form radioactive material should be designed and fabricated in accordance with the design criteria prescribed in IAEA standards and domestic regulations. The objective of this study is to demonstrate the safety of a shipping capsule for 192Ir special form radioisotope which produceed in the HANARO. The safety tests were carried out for the impact, percussion, bending and heat test conditions. And leakage tests were carried out before and after the each test. Also, the safety analyses were performed using computer codes in order to verify the test results. The capsule showed slight scratches and deformation, and maintained its structural and thermal integrities in all tests without any severe damage or melting. It also met the allowable limits of leakage rate after earth test. Therefore, it has been verified that the capsule was designed and fabricated to meet all requirements for the special form.

그레이브스 병 치료 후 재발 위험 인자에 관한 연구

이영창,유명희,윤석기,변동원,서교일,김극배 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

연구 배경 : 그레이브스 병에 대한 항갑상선제 치료후 적절한 치료 여부 평가 및 재발 위험성을 예측하기 위하여 여러 가지 예후 판정 인자들이 연구되어 왔으며, 이러한 인자들 중 TRH(thyrotropin-releasing hormone) 자극 시험이 가장 믿을 만한 검사중에 하나로 알려져 있다. 그러나 TRH 자극 검사가 정상으로 나와도 재발하는 경우가 많으며, 현재로는 이러한 경우에 재발을 예측하는 예후 인자에 대한 연구는 전무한 실정이다. 금번 연구에서는 TRH 자극 시험 후 TSH(thyroid stimulating hormone)가 정상적인 반응을 보인 환자를 대상으로 재발 및 관해여부를 예측할 수 있는 인자들을 찾고자 하였다. 대상 및 방법 : 항갑상선제제 치료 종료후 TRH 자극 시험을 시행하였던 그레이브스 병 환자 총 84명 중, 정상적인 TSH 반응을 보이면서 1년 이상 추적 관찰이 가능하였던 32명의 환자를 대상으로 하였다. 처음 진단 시와 치료 종료 시에 T3(triiodothyronine), T4(thyroxine), T3/T4 비, TSH, TRAb, Anti-TPO Ab(anti-thyroperoxidase antibody)를 측정하였으며, 치료 종료 2개월후에는 TRH 자극 검사를 하여 TSH 증가폭(△TSH) 및 유리 T_(3) 증가폭(△FT_(3))을 구하였다. 모든 측정치는 평균±표준편차로 표시하였으며, SPSS software를 이용하여 Student's paired t-test, chi-square test, Wilcoxon signed ranks test를 시행하였고, 유의 수준 0.05 이하를 통계적으로 유의하다고 판단하였다. 결과 1) 총 32명의 환자 중 재발한 환자(Group Ⅰ)는 22명(69%) 이었으며, 재발한 환자(Group Ⅱ)는 10명(31%) 이었다. 2) 진단 초기 총T3 치는 Ⅰ 군에서 342.0±126.2ng/dl, Ⅱ 군에서 493.0 ±142.2 ng/dl로 Ⅱ군에 비해 유의하게 증가되었다(p<0.05). 3) Anti-TPO Ab는 Ⅰ군에서 2.9±4.4, Ⅱ군에서 22.3±22.3 U/mL로 나타나 Ⅱ군에서 유의하게 증가되었다.(p<0.05) 4) 양군에서 치료 종료후 재발시 대부분의 환자가 1년 이내에 재발하였다. 5) TRH 자극· 검사후 유리 T3 증가폭 및 TSH 증가폭은 양군간에 차이가 업ㅅ었다(1.5±0.9 vs 1.2±1.0 pmol/L, 12.54±7.56 vs 11.23±4.21 mU/L, p>0.05) 결론 : TRH 자극 검사후 정상적인 TSH 반응을 보인 환자에서 재발 및 관해여부를 치료 초기 T3 및 치료 종료시 Anti-TPO Ab로 예측할 수 있었으며, 이들 측정치가 증가해 있을수록 재발의 가능성이 많음을 알 수 있었다. 또한 투약 중단후 초기 12개원의 추적기간 동안 관해가 유지되면 그 이후엔 재발의 가능성이 현저히 줄어 들었으며, 이 후 좀더 많은 환자들을 대상으로 하는 장기적인 추적연구가 진행 되어야 할 것으로 사료된다. Background : Many studies were undertaken to find parameters that could predict the clinical course of patients with Graves' disease after withdrawal of antithyroid drugs. In many parameters, TRH (thyrotropin-releasing hormone) stimulation test and T3 suppression test were considered to be one of the most reliable for predicting remission. But recently, some studies showed that the measurement of free T3 and FT3 are to be a more accurate than other thyroid function test. In this study, we measured T_(3), T_(4), T_(3)/T_(4), TSH (thyroid stimulating hormone), TRAb (TSH receptor antibody), FT3 and other known useful parameters to compare the factors influencing the relapse of Graves disease after antithyroid medication. Patients and methods : Among the 84 Graves' disease patients who had done the TRH stimulation test after withdrawal of antithyroid medication, we examined 32 patients who showed normal TSH response and followed up more than one year. T_(3), T_(4), T_(3)/T_(4), TSH and TRAb levels were measured at the time of diagnosis and at the end of therapy. Serum TSH and FT_(3) levels were measured after TRH stimulation, after two months of withdrawal of medication. Statistical evaluation was Performed by SPSS software in combination with Student's Paired t-test, chi-square test, Wlicoxon signed-ranks test. p-value less than 0.05 was considered to be significant. Results 1. In the 32 patients with Graves disease, 10 patients(31%) relapsed(Group Ⅰ) and 22 Patients(69%) remained in remission(Group Ⅱ). 2. Initial serum T3 level was significantly higher in group Ⅰ than group Ⅱ(342.0 ±126.2 vs. 493.0±142.2 ng/dl, p<0.05). 3. Anti-TPO Ab level was significantly higher in group Ⅰ than group Ⅱ(22.3±22.3 vs 2.9±4.4 U/mL, p<0.05). 4. In group Ⅰ and Ⅱ most patients showed relapse within 1 year after antithyroid medication. 5. After TRH stimulation test, serum FT_(3), and TSH level were not significantly different between group I and Ⅱ(p>0.05). 6. Serum T_(4), T_(3)/T_(4), TSH, TRAb levels were not significantly different from group Ⅰ and Ⅱ. Conclusion : In this study, we found increased relapse rate in the patients with Graves' disease whose initial serum T3 and anti-TPO Ab levels were high, so these parameters could be used to predict the relapse of Graves' disease. In the case of more than 12 months remission period after withdrawal of antithyroid medication, no relapse wsa observed in this study, but study should be done in the large population of patients with Graves' disease.

항 Vancomycin 내성균성 항생물질을 생산하는 Streptomyces sp.AMLK-335의 배양조건

이기형,임대석,최경희,이경호,김창한,김정환 건국대학교 동물자원연구센터 2000 動物資源硏究誌 Vol.21 No.-

본 연구는 새로운 항 vancomycin 내성균성 항생물질을 개발하기 위하여 실시되었으며, 전국 각지의 토양 시료로부터 분리한 방선균 중 vancomycin 내성균주인 K-98 Enterococcus faecium 642, K-98 Enterococcus faecium 637 균주에 대하여 항생물질을 생산하는 분리균주 AMLK-335를 선정하여 이 균주의 항생물질 생산에 대한 최적 발효 조건을 검토한 결과, 탄소원 첨가로는 glycerol(0.5%), 질소원 첨가로는 yeast extract(0.5%)가 가장 효과적으로 항생물질 생산에 이용되었고, 비타민을 첨가에 따른 항생물질 생산성의 차이는 크게 나타나지 않았으나, calcium pantothenate 첨가시 항균활성이 비교적 높아졌으며, 금속이온의 첨가는 K+, Pb+, Ba²+, NA²+ , Ca²+를 첨가하였을 때는 항생물질의 생산성이 비교적 높아졌으며, 그중 Ca²+ 첨가구가 가장 생산성이 높았으며, Fe²+ , Hg+의 금속이온을 첨가하였을 때는 항생물질 생산성이 감소하였으며, CaCO₃첨가는 비첨가구보다 높은 항생물질 생산성을 보였으나, 첨가량에 따른 영향은 대체적으로 없었다. pH의 변화에 따른 생산성은 전반적으로 pH가 항생 물질 생산에 영향을 미치지 못하였으나, pH 4.5∼6.0 부근에서는 비교적 높은 항생물질 생산성을보였으며, 통기량에 따른 항생물질 생산성은 통기량이 많을수록 항생물질 생산이 좋았다. 한편 배양기간에 따라 항생물질 생산성을 조사한 결과, 5일째에 가장 높은 항생물질 생산성을 나타내었으며, pH의 변화는 배양 초기에 하강하였다가 점차 상승하는 경향을 보였다. This study was carried out for examining antibiotic productivity of the strain Streptomyces sp. AMLK-335 producing anti-VRE antibiotic. According to different condition, the strain was cultured for 4 days at 27℃ and determined cell growth, pH value and antibiotic productivity using disk diffusion method. In the experiment, the strain Streptomyces sp. AMLK-335 was examined various culture conditions which was added 8 carbon sources, 12 nitrogen sources, 8 vitamins and 11 metal ions in each time and controlled concentration of CaCO₃, initial pH and aeration. From the studies of conditions for antibiotic production, antibiotic productivity was the best to use 0.5% glycerol as carbon source and 0.5% yeast extract as nitrogen source. When several vitamins were added to medium, there was little difference in antibiotic productivity. But the addition of calcium pantothenate slightly increased antimicrobial activity. The addition of metal ion, such as K+, Pb+, Ba²+, NA²+ and Ca²+ slightly increased antibiotic productivity except Fe²+ and Hg+. The addition of CaCo₃showed higher than non-addition experiment in antibiotic production, but there wasn't generally influenced at addition concentration. According to pH change, antibiotic productivity was increased at pH 4.5∼6.0, and when there was a lot of aeration, antibiotic productivity was increased.

초미세 마이크로 소성성형 가공시스템 기술 개발

이낙규,최태훈,이혜진,최석우,박훈재,나원기 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

In this paper Research development about a micro metal forming manufacturing system has been developed. A micro forming system has been achieved in Japan and it's developed micro press is limited to single forming process. To coincide with the purpose to be more practical, research and development is necessary about the press which the multi forming process is possible. We set the development of the equipment including micro deep drawing, micro punching and micro restriking process to the goal. To achieve this goal, Research about micro forming process to be related to multi process forming must be preceded first. Material selection and analysis about micro forming process are accomplished in this paper. And the basis research to make actual system is accomplished.

Takayasu씨 동맥염의 수술적 치험 : 2례 보고 Report of 2 cases

이석기,임진수 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.2

We experienced two cases of surgical repair in Takayasu's arteritis. One case was a 37-year-old male patient admitted with the complaints of no pulsation of the radial artery and tingling sensation of left upper extremity. Aortogram and MRA (Magnetic Resorance angiography) revealed nearly complete obstruction of the proximal site of left subclavian artery and luminal narrowing of the left brachial artery on the peripheral angiogram. The other case was a 19-year-old male patient had undergone the none of left ulnar arterial pulsation. Aortogram showed the complete obstruction of the left subclavian artery. In each case, successful surgical treatment was accomplished with a bypass from the ascending aorta to the left subclavian artery using a ring tube graft and with a bypass between the left common carotid artery and left subclavian artery.

북한의 1990년대 경제위기와 기업지배구조의 변화

이석기 한국비교경제학회 2004 비교경제연구 Vol.11 No.1

The purpose of this paper is to analyze the changes of corporate governance of North Korean enterprises in conflicting situations during the 1990's when the official enterprise management system was maintained, albeit the material base of the centralized planning system was in reality destroyed due to extreme economic depression. The followings are main conclusions of this paper. First, throughout the planning process such as plan establishment, production, materials procurement, product disposal, and evaluation, 'Centralization (Ilwonhwa) and Details Description (sebuhwa) in planning' system has been weakened, and the substantial control of enterprises were enforced. Additionally, there was a lack of effective supervision by outsiders. In other words, insider control tendency arose in North Korea. While insiders of the USSR or China utilized the corporate control actively to pursue their profits, North Korean insiders use it passively al a mean of survival, so to speak the continuance of production. That is, insider control in North Korea can be considered as a 'Survival Pursuit Type' insider control, which is different from the USSR or China's 'Profit Pursuit Type' insider control. Since the official enterprise management system cannot guarantee reproduction, North Korean insiders tend to pursue survival through voluntary marketization. The marketization in the 1990's that did not accompany official changes of institution and currency economy led to the regressive marketization where the primary form of exchange was material for material. Second, as survival became a vital enterprise goal, corporate insiders showed extensive prearrangement to continue the production. During this process, managers' authority was relatively strengthened. In particular, the party secretary gave up innate supervision function for survival and allowed autonomy of the managers passively or conferred with managers actively. Not only managers but also directors who are responsible for production came to have bigger and stronger authority, which led to the partial decentralization of authority. As the distribution system has been destroyed, control of Government and Party on laborers has been weakened considerably and the relationship between enterprises and laborers encountered change. As enterprises are responsible for the living of laborers, laborers were likely to establish relationships directly with enterprises, not through government. Adversely, enterprises are partially dependent on laborers for cash income. There is a primitive contractual relationship that laborers pay currency income to companies while those companies provide the status of employee in return.