치매방지 작업기구 사용이 항산화효소 활성에 미치는 영향

조경혜,박정은,윤지윤,문세보,박효영,정인옥,이정원 서울여자대학교 자연과학연구소 2001 자연과학연구논문집 Vol.13 No.-

We developed an occupational therapy tool to maintain and improve the cognitive function for the elderly who have senile dementia. 86 elderly people took a mininal mental state examination (MMSE) for the therapy to perform the occupational therapy, and divided into three groups based on avarage ages and MMSE values. The occupational therapy was treated three times per week for 10 weeks. The results showed that there were significant differences in the performing scores before and after the treatment ; the scores for the occupational therapy were increased significantly (p<0.001) and the performing time was shortened from 6-week throughout 10-week regimen. This study was to examine the effect on the activity of antioxidant enzymes by occupational therapy. The activities of antioxidant enzymes such as catalase, Glutathion-6-phosphate dehydrogenase (G6PDH), and superoxide dismutase (SOD) were increased to the normal standard by the occupational therapy for the elderly having dementia. The recovery of activities of antioxidant enzymes was obvious in severe demented elderly compared to those in normal or mild demented elderly. These results suggest that the occupational therapy had an beneficial effect on the protection against the oxidative stress especially for severe demented elderly, and the occupational tool need to be modified so as to improve the protection against the oxidative stress for normal and/or mild demented elderly.

許任의 鍼灸經驗方에 대한 考察

朴世貞,安昌範 동의대학교 한의학연구소 1997 동의한의연구 Vol.1 No.-

Hu-Im was an excellent acupuncturist who cared for two Kings of Sun-Jo and Kwanghae-Gun in Yi dynasty, He left a his creative work, Chim-Gu-Kyegng-Hum-Bang, while the former Doctors have followed Chinese Acupuncture, in spite of his underprevileged position. I have examined the Hu-Im, studied Chim-Gu-Kyeong-Hum-Bang The results were as follows 1. He corrected the wrong acupunctural points of Shaoshang(LU_(11)), Hegu(LI₄), Shenmen(HT_(7)), Jianjing(GB_(21)), Xuanzhong(GB_(39)), Zusanli(ST_(36)) 2. He didn't use lots of acupunctural points of 14 main meridians. 3. He used lots of the Moxibustion Techniques, followed the theory of the Reinforcing and Reducing techniques of the Moxibustion as Young-Chu Bae-Su. 4. He followed the theory of the Reinforcing and Reducing techniques of the acupuncture as So-San-whua-Bup and Tu-Chun-Rang-Pub.

WHO 침구임상 지침서 개정을 위한 국제회의 보고

박히준,서정철,김세현,김상우,안경애,임사비나,김용석,최도영,강성길 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

The Working Group on the revision of Clinical Research Methodology for Acupuncture met in Seoul, Republic of Korea from 24 to 26 August 2005. The main objectives of the meeting were to review the regional publication guidelines for Clinical Research on Acupuncture, to make necessary revisions in the guidelines, to make recommendations on further collaboration and activities in the field of research on acupuncture, and to discuss scientific evidence-based approaches in the clinical research on acupuncture. Fourteen members from the eight Member States, one secretariat staff from the WHO Regional Office for the Western Pacific and ten observers from the Republic of Korea attended the meeting. The members presented their papers to review the current status of clinical research on acupuncture. The drafts of proposed revision to the previous guidelines for clinical research methodology on acupuncture were discussed extensively. The issues covered during the discussion included: the definition of the new terms; reorganization of clinical research design; revision and update of contents (e.g., control group); introduction of Institutional Review Board (IRB) on the section of ethical approval; additional outcomes including health-related quality of life (HRQOL), qualitative measures, etc. In the course of these discussions, the working group developed the revised guidelines for clinical research on acupuncture and made recommendations for promoting the dissemination of the revised guidelines.

PSPICE Macromodeling에 의한 PLL의 주파수 특성연구

鄭天錫,朴明烈,金世烈,金洪九 울산대학교 1996 공학연구논문집 Vol.27 No.2

본 논문은 범용화되어있는 Microsim 사의 PSPICE를 이용해서 위상동기루프(PLL) Micromodeling으로 설계하여 시뮬레이션 하였다. PLL 회로는 위상검출기와 전압제어 발진기 그리고 루프 필터로 이루어져 있다. RC 저역통과 필터와 Butterworth 필터 그리고 Chebyshev 필터 등을 이용하여 입력주파수 변화에 따른 루프필터의 주파수 특성을 분석하였다. 그리고 전압제어 발진기의 자주발진주파수를 2.5kHz, 19kHz로 고정할 때의 주파수 스펙트럼을 분석하였다. 자주발진주파수 2.5kHz에서 Chebyshev 필터의 경우 upper lock range와 lower lock range는 똑같이 1,056Hz, 1,056Hz였고 upper capture range와 lower capture range는 536Hz, 540Hz였다. 또한 시뮬레이션 과정에서 삼각파를 구형파로 바꾸는 VCO의 슈미트 트리거단에서 수렴문제로 인하여 19KHz 이상에서는 상당히 긴 시뮬레이션 시간을 필요로 하는 단점이 있었다. 그렇지만 낮은 주파수대에서 주파수 특성 분석의 용이함과 정확성 및 복잡한 회로의 간략화에서 매크로모델링의 타당성을 보였다. With today's general simulator, PSPICE, a phase-locked loop(PLL), which consists of a phase detector(PD), a voltage-controlled oscillator(VCO), and a low-pass filter(LPF), is designed and simulated in macromodeling technique. By using a RC LPF, a Butterworth, and a Chebyshev LPF in turn, the frequency characteristics of the outputs according to the variations of the inputs are analyzed respectively. When 2.5KHz and 19KHz are selected as two specified free running frequencies in VCO block, the frequency spectrums of the outputs show that in case of the Chebyshev LPF at 2.5KHz, the upper and lower rock ranges have the same frequency ranges, 1056Hz, and the upper and lower capture ranges are 536Hz and 540Hz respectively. Furthermore, the simulation takes a long time especially above 19KHz, because of the convergence problem at schmitt trigger section, where the triangular wave is changed into the rectangular wave. However, this paper shows some validity that this macromodeling technique is one of the easy and accurate methods in analyzing the frequency characteristics, and useful in simplifying the complicated circuits at low frequency band below 19KHz.

근적외선을 이용한 두개강내 혈종의 진단

박정율,홍기선,김상대,김세훈,임동준,조태형 대한체열학회 2003 대한체열진단학회지 Vol.3 No.1

영상분석장치를 이용한 미세흔적의 형태비교 및 특성분석에 관한 연구(Ⅲ) : 총기 발사흔 중 강선흔의 형태 비교

박성우,이정필,김동환,임세혁,김영만 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

초기 성공적인 심폐소생술후 혈청 Interleukin-6 농도의 발현양상

박규남,박승현,황두영,김형국,이환,최경호,이원재,정욱성,김학주,김세경 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.4

Objective : To investgate patterns of serial serum interleukin-6(IL-6) concentrations after initial successful cardiopulmonary resuscitation, and to access differences in serum IL-6 concentrations in patients with Cerebral Performance Category(CPC, 1-2) and CPC(3-5) at the 5th day after cardiacpulmonary resuscitation(CPR). Methods : We studied prospectively 12 patients with spontaneous circulation after cardiopulmonary resuscitation. Venous blood samples were taken 2, 4, 12, 24, 48 and 72 hours after restoration of spontaneous circulation to measure serum IL-6 levels by the enzyme-linked immunosorbent assay. Results : Serum IL-6 concentrations in the severe neurolgically disabled group(CPC, 3-5) were significantly increased at 2, 24 and 48 hours after restoration of spontaneous circulation compared with the less neurolgically disabled group. Also, serum IL-6 concentrations in the severe neurolgic disabled group showed dual peak at 4 and 24 hours. Conclusion : Our study demonstrates significant increase of serum IL-6 in patients with CPC(3-5) after successful cardiopulmonary resuscitation and the significant correlation between early increase of serum IL-6 and poor neurologic outcome. It suggests that early increase of serum IL-6 can be used as a prognostic marker after successful cardiopulmonary resuscitation.

출아효모에서 TAR 클론닝법을 이용한 고등동물의 게놈으로부터 특정 염색체 부위의 분리

박정은,윤영호,이윤주,김광섭,윤세련,안태진,임선희,선우양일 동아대학교 기초과학연구소 2003 基礎科學硏究論文集 Vol.20 No.1

복잡한 게놈 분석에 용이하도록 효모의 인공 염색체(YAC) 클론닝 시스템은 발달되어왔다. YAC은 박테리아의 인공 염색체(BAC)보다 더 큰 단편을 클론닝할 수 있고, 또한 클론된 단편을 쉽게 변형시킬 수 있다. 형질전환과 연계된 재조합법(Transformation-Associated Recombination; TAR)은 게놈 라이브러리를 만들지 않고 직접 게놈 DNA로부터 분리하고자 하는 유전자나 특정 염색체 부분을 클론닝 할 수 있는 방법이다. 이 방법은 spheroplast transformation을 수행하는 동안, 목적으로 하는 유전자의 5' 그리고 3' 염기 배열(hooks)을 지닌 TAR 벡터와 게놈 DNA 사이에서 일어나는 상동성 재조합에 의해 이루어진다. 효모 내의 in vivo 재조합을 이용한 TAR 클론닝법은 복잡한 게놈으로부터 목적의 염색체 부분을 원형 YAC의 형태로서 선택적으로 분리할 수 있다. 그러므로 TAR 클론닝 법은 특정 염색체로부터 YACs을 만드는데 매우 유용하여, 전체 게놈으로부터 특이적 유전자나 유전자의 family를 분리하는데 효과적인 방법으로 사료된다. Yeast artificial chromosome (YAC) cloning systems have advanced the analysis of complex genomes considerably. They permit the cloning of larger fragments than do bacterial artificial chromosome systems, and the cloned material is more easily modified. Transformation-associated recombination (TAR) is a cloning technique that allows specific chromosomal regions or genes to be isolated directly from genomic DNA without prior construction of a genomic library. This technique involves homologous recombination during spheroplast transformation between genomic DNA and a TAR vector that has 5' and 3' gene targeting sequences (hooks). Using in vivo recombination in yeast, TAR cloning selectively isolates, as circular YACs, desired chromosome segments or entire genes from complex genomes. We propose that TAR cloning can provide an efficient means for generating YACs from specific chromosomes and that TAR cloning may be useful for isolating families of genes and specific genes from total genome DNA.

경골 골수정 고정술후 교합나사의 파단

박형빈,강번중,송해룡,구경회,정순택,조세현 대한골절학회 2002 대한골절학회지 Vol.15 No.4

목 적 : 경골 골절에서 골수정 고정술후 발생하는 교합나사 파단의 빈도와 발생 원인을 밝히고자한다. 대상 및 방법 : 1995년 3월부터 2000년 10월까지 골수정으로 치료하였던 경골 간부골절 82예중 내고정물 파단이 발생하거나 골유합이 이루질 때까지 추시 가능하였던 75예를 대상으로 하였다. 내고정물 파단 빈도와 위치, 골절의 양상, 술후 골절부 신연 및 골유합 이상 여부를 조사하였다. 결 과 : 교합나사 파단은 7예였고 (9.3%), 근위부 두 번째 나사의 파단이 가장 흔하였다. 교합나사으 ㅣ파단은 AO분류 B형과 C형 골절, 술후 골절부가 신연된 경우, 개발성골절, 자연유합 및 불유합의 경우 발생하였다. 결 론 : 교합나사 파단의 주된 요인은 골절부의 골과 골 접촉이 불안정하기 때문이며, 개방성 골절, 지연유합 및 불유합도 교합나사 파단의 위험인자라고 생각한다. 교합나사 파단을 예방하기 위해서는 수술시 골절부 신연을 피해야하며 골절부 골접촉이 불안정한 경우 완전 체중부하를 골유합시까지 제한하여야할 것으로 생각한다. Purpose : The aims of this study were to investigate the prevalence and the causes of crew breakage in tibia nailing. Materials and Methods : Between 1995 and 2000, eighty-two tibial diaphyseal fracture were treated with interlocking nails. The loss of follow-up was 7 cases. We retrospectively reviewed seventy-five cases. We investigated the rate and location of metal failure and evaluated the fracture pattern, the presence of distraction after nailing and union abnormality. Results : Screw breakage was identified in seven cases (9.3%) and most frequently occurred on the second proximal locking screw. Screw breakage occurred in AO type B or C type fractures, fracture site distraction after nailing, open fracture, delayed union and nonunion. Conclusion : The main cause of screw breakage is unstable bone to bone contact on the fracture site caused by comminution of distraction. The open fracture, delayed union, and nonunion also contributing factors for screw breakage. For preventing screw breakage, it is necessary to avoid fracture site distraction and delay full weight bearing in cases having unstable fracture site contact.

브레이징 온도 변화에 따른 ZrO2와 Ti-6Al-4V의 접합 특성

기세호,박상윤,허영구,정재필,김원중 大韓齒科補綴學會 2012 대한치과보철학회지 Vol.50 No.3

Purpose: In this study, brazing characteristics of ZrO2 and Ti-6Al-4V brazed joints with increasing temperature were investigated. Materials and methods: The sample size of the ZrO2 was 3 mm × 3 mm × 3 mm (thickness), and Ti-6Al-4V was 10 mm (diameter) × 5 mm (thickness). The filler metal consisted of Ag-Cu-Sn-Ti was prepared in powder form. The brazing sample was heated in a vacuum furnace under 5 × 10-6 torr atmosphere, while the brazing temperature was changed from 700 to 800℃ for 30 min. Results: The experimental results shows that brazed joint of ZrO2 and Ti-6Al-4V occurred at 700 - 800℃. Brazed joint consisted of Ag-rich matrix and Cu-rich phase. A Cu-Ti intermetallic compounds and a Ti-Sn-Cu-Ag alloy were produced along the Ti-6Al-4V bonded interface. Thickness of the reacted layer along the Ti-6Al-4V bonded interface was increased with brazing temperature. Defect ratios of ZrO2 and Ti-6Al-4V bonded interfaces decreased with brazing temperature. Conclusion: Thickness and defect ratio of brazed joints were decreased with increasing temperature. Zirconia was not wetting with filler metal, because the reaction between ZrO2 and Ti did not occur enough. 연구 목적: 온도 변화에 따른 ZrO2와 Ti-6Al-4V의 접합 특성에 대해 알아보기 위하여 새로운 브레이징 합금을 제조하고, 브레이징 온도가 접합 특성에 미치는 영향에 대하여 조사하고자 하였다. 연구 재료 및 방법: 본 연구에서 사용된 시편으로는 실험용 ZrO2 모재(ZirBlank-PS, Acucera, Inc., Gyeonggi-do, Korea)는 소결 전의 블록형태(65 mm × 36 mm × 12 mm (t))이며, 이를 잘라 사포(#2400)로 표면연마 후 소결하였다. 소결된 ZrO2 시편의 크기는 3 mm × 3 mm × 3 mm (t) 이다. Ti-6Al-4V 모재(Ti 6Al 4V ELI CG Bar, TMS, Washington, USA)는 직경 10 mm × 5 mm (t)를 사용하였다. 소결된 ZrO2와 Ti-6Al-4V의 접합을 위하여 브레이징 합금을 제조하였다. 시편을 3군으로 나누어A군은 700℃에서, B군은 750℃에서, C군은 800℃에서 각각 브레이징 하였다. 브레이징 부의 두께와 결함율의 측정은 각 군당 하나의 시편으로 각 시편 당 5회씩 반복 측정하여 평균값을 취하였다. 결과: 브레이징 합금을 사용하여 진공 브레이징을 수행한 결과 ZrO2 와 Ti-6Al-4V 는 700℃ - 800℃에서 양호한 접합을 보였다. 브레이징 후 브레이징 온도 변화에 따른 브레이징 부의 두께 및 결함율의 변화는SEM을 사용하여 측정하였다. 브레이징 온도가 700℃에서 800℃로 증가함에 따라 CuTi 금속간 화합물 층 및 Ti-Sn-Cu-Ag계 화합물 층의 두께는 각각 4.5 ㎛에서 10.3 ㎛로, 3.1 ㎛에서 5.0 ㎛로 증가되었다. 또한 브레이징 온도가 700℃에서 800℃로 증가함에 따라 브레이징 접합계면의 결함율은 ZrO2 및 Ti-6Al-4V 계면에서 각각25%에서 16.3%, 5%에서 1.5%로 감소되었다. 결론: 브레이징 온도가 700℃에서 800℃로 증가됨에 따라, 브레이징 접합계면의 결함율은 ZrO2 및 Ti-6Al-4V 계면에서 모두 감소되었다. 이는 결함부에서 ZrO2와 활성원소인 Ti과의 반응이 충분히 일어나지 않아서 브레이징 합금이 ZrO2에 웨팅되지 않은 것이 원인이라고 사료된다.