추적관찰 중 종괴의 크기가 커진 경화성 혈관종 1례

안형수,장안수,이준혁,박성우,고은석,백상현,박재성,허균,신화균,박춘식 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

We report a case of a sclerosing hemangioma of the lung with increased size during follow up, a rare benign neoplasm of the lung. A 32-year-old woman had round increased opacity in right upper lobe on posteroanterior chest radiograph. That lesion has grown slowly over four years. Computed tomographic scan showed a well circumscribed lung mass in medial aspect of right upper lobe. Radiological differential diagnosis for the lesion included inflammatory pseudotumor, atypical carcinoid, lung cancer and localized fibrous tumor of pleura. Nonspecific findings were shown by the bronchoscopy and percutaneous transthoracic needle aspiration. Anterior and apical segmentectomy was carried out and the lesion was pathologically diagnosed as sclerosing hemangioma of lung.

탄화물 입자 강화 7075 Al 합금 기지 복합재료의 미끄럼마멸 특성 연구

강석하,박형철,강신철,김용석 국민대학교 생산기술연구소 2002 공학기술논문집 Vol.25 No.-

Effects of the type and volume fraction of carbide-particle-reinforcements on dry sliding wear behavior of 7075 Al alloy matrix composites were investigated. SiC, TiC and B₄C reinforced 7075 Al alloy matrix composites were manufactured by a pressureless infiltration technique and wear tested. Wear tests were carried out using a pin-on-disk wear tester with varying loads of 3N-160N at a constant sliding velocity of 0.2m/s. AISI 52100 bearing steel ball was a counterpart of the composites. Wear resistance of the composites was always higher than that of the monolithic alloy except the TiC reinforced 7075 Al matrix composite. The resistance increased with the increase of volume fraction of the reinforcing particles. Among the composites, the TiC reinforced composite had the lowest wear resistance and the B4C reinforced composite showed the highest wear resistance.

중학생의 외상응급처치 교육에 대한 효과

고경숙,박형숙,조균영 韓國學校保健學會 2009 韓國學校保健學會誌 Vol.22 No.2

Purpose This study was aimed to investigate the effect of knowledge and competence of first aid treatment among middle school students after the education on the injury treatment. Methods : The study design was randomized pretest and post-test control group nonsynchronized design. Study subjects were 32 Srd-grade students of Y middle school in P city and 34 Srd-grade students of M middle school in P city in this research. Among two Srd-grade classes. one classes were randomly assigned to experimental group (32 students) and two were control group (34 students). The intervention for experimental group was providing five-time 45-minute injury treatment education. Results : 1. The First hypothesis : After intervention on the injury treatment education, knowledge of injury treatment in the experimental group was significantly higher than that of the control group(t=-6.480, p<.001). 2. The Second hypothesis After intervention on the injury treatment education, competence of injury treatment in the experimental group was significantly higher than that of the control group(t= -15.121, p<.001). Conclusion These findings suggest that the injury treatment education can facilitate knowledge of injury treatment, competence of injury treatment in the middle school student. Therefore, it is considered that the injury treatment education can be utilized as a effective way to implement the 7th nation curriculum.

흰쥐 생체시료 중 5-플루오로우라실 및 테가푸르의 안정성

장지현,박종국,강진형,정석재,심창구,구효정 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.3

5-Fluorouracil (5-FU) is an antimetabolite anticancer agent active against many types of solid tumors. Tegafur (TF), a prodrug of 5-FU, is frequently used in combination with uracil as dihydropyrimidine dehydrogenase (DPD) inhibitory fluoropyrimidine. We studied the stability of 5-FU and TF in biological fluids of rats and determined their bioavailability (BA) and excretion into bile, and urine. The drug concentrations were analyzed by an HPLC method. At room temperature, there was a 14-30% decrease in the concentration of 5-FU and TF in bile, urine, and plasma specimen at 10 and 100 μg/ml over 240 min. No significant difference was noted among the sample types or between two different concentrations of 10 and 100 μg/ml. The decrease in drug concentration was significantly less in samples kept on ice (6-12%) for both drugs. These data indicate that biological fluid samples containing 5-FU or TF in plasma, urine, or bile should be placed on ice during the sample collection. Following these storage guidelines, samples were collected after administration 50 ㎎/㎏ of each drug via i.v. or oral route. BA was 1.5 folds greater for TF (60%) than that of 5-FU (42%). Approximately 0.52 and 3.3% of the i.v. doses of 5-FU and TF was excreted into bile, respectively. Renal clearance of 5-FU was about 16% of its total body clearance. These results suggest that instability of 5-FU and TF in biological fluids should be considered in pharmacokinetic or pharmacogenomic studies.

맹장을 제거한 성계숫닭에 의한 國內産 肉鷄 내장분말의 有效 아미노산 利用率

李乙衍,金炯浩,車章玉,朴弘錫 全北大學校 1994 論文集 Vol.38 No.-

This study was designed to compare true digestible amino acid values for broiler offal meal with available amino acid values. Broiler offal meal was each force-fed to 6 intact and 6 caecectomised adult cockerels For each test, Cockerels were starved of food for 24 h, fed, and then excreta collected for 48 h. Crude protein, ether extract and ash of broiler offal meal were 50.5%, 16.7%, and 11.7%, respectively. True digestibilities of all seventeen measured amino acids were lower for caecectomised than intact cockerels, with the average difference being approximately 0. 10. True available amino acid of broiler offa meal was higher values for cystine and aspartic acid in intact than in caecetomised cockerels. Generally leucine, isoleucine and glutamic-acid were among the most available amino acids, while cystine, aspartic acid and threonine were among the least available amino acids in broiler offal meal for caecectomised cockerels.

수완진동 증후군에서 신경장해의 조기진단을 위한 객관화된 방법

윤재국,이헌,최나리,김석환,박형욱,이지호,유철인 大韓産業醫學會 2009 대한직업환경의학회지 Vol.21 No.2

목적: 통각과 진동감각 역치검사 및 수부와 수지의 악력, 그리고 수지의 운동기능검사(태평) 등과 근로자들이 호소했던 증상에 대한 HAVS의 스톡홀름 워크샵 분류와의 관련성을 통해 좀 더 객관화된 신경학적 조기검사 방법을 찾고 타당성을 검증하고자 하였다. 방법: 2000년 1월부터 2007년 12월까지 수부진동에 폭로되고 수부의 불편함을 호소하여 진동 장해에 대한 검사를 시행한 497명의 근로자를 대상으로 하였다. 일차적으로 문진을 통해 직업력에 대해 알아보고 과거력을 조사했다. 대상자들의 스톡홀름 워크샵 분류에 따른 소견을 확인하고 수부의 말초 순환기능 검사(손톱압박, 수지피부 온도), 신경기능 검사(통각과 진동각 역치), 운동기능 검사(악력, 태평) 등을 시행하였다. 다른 질환의 감별을 위한 몇 가지 이학적 검사를 실시하고 스톡홀름 워크샵 분류에 따른 검사 결과들을 분석하였다. 결과: 사용 도구는 그라인더 단독 사용이 265명 (67.3%)으로 가장 많았으며 평균 노출 연수는 14.8년이었다. 통각과 진동감각에서 스톡홀름 워크샵 분류 단계에 따른 역치가 증가하는 경향을 보였으나 통각은 양측 모두 통계적인 유의성이 없었고, 진동감각은 125와 250 Hz에서 양측 모두 유의했다(p=0.006-0.038). 수부와 수지의 악력은 단계가 올라갈수록 감소하는 경향을 보였지만 수부와 수지 모두 우측에서만 통계적으로 유의했다 (p=0.041, p<0.01, p=0.034). 태평 첫수는 단계가 올라 가면서 전반적으로 태핑 첫수가 감소하였으며 좌측에서만 통계적으로 유의했다(p=0.002-0.019). 결론: 본 연구는 수부 진동 노출자들의 수부 불편함에 대한 신경계통을 초기에 정량적으로 객관화하여 진단할 수 있는 단일 방법은 아직 없으며 일상생활의 불편함과 스톡홀름 워크샵 분류 등을 통한 주관적인 증상에 더하여 수지 통각과 진동감각 역치검사, 수부와 수지 악력검사, 운동기능검사(태핑) 등을 통합하면 초기에 객관적으로 진단하는 것이 가능할 것으로 판단된다. Objectives: In order to determine find out the best methods for a more objective detection of neurologic abnormality in early hand ann vibration syndrome(HAVS), early with analyzing the validity of each of the detection methods was analyzed. We evaluated the relationships between the sensorineural stage of Stockholm-revised vibration syndrome classification and the results of several tests. Methods: 497 workers were investigated for symptom, exposure duration, the types of tools used, and medical history from January 2000 to December 2007. Pain sense threshold, vibrotactile threshold, hand grasp force, finger grasp force, and a finger tapping frequency test were performed by the workers. Results: The grinder(67.3%) was the most commonly used tool and the mean exposure duration was 14.8 years. Although the pain sense and vibrotactile threshold level tended to increase according to sensorineural stage of the Stockholm classification, there was statistically significant difference in the vibrotactile threshold of 125, 250 Hz (P=0.006~0.038) but not in the pain sense threshold. Hand and finger grasp force tended to decrease according to the sensorineural stage of Stockholm classification and there was statistically significant difference(P=0.041, <0.001, 0.034) only on the right hand side. The tapping frequency also generally decreased according to the sensorineural stage of the Stockholm classification and there was statistically significant difference (P=0.002~0.019) only on the left hand side. Conclusions: Although there is no single standardized method that can objectively diagnose the Sensorineural component of early HAVS early, the combination of subjective symptoms, the sensorineural stage of Stockholm classification, the pain and vibrotactile threshold test, the hand and finger grasp force, and the finger agility (tapping) test can objectively detect sensorineural component of HAVS early.

Computed tomographic beam-hardening artefacts: mathematical characterization and analysis

Park, Hyoung Suk,Chung, Yong Eun,Seo, Jin Keun Royal Society 2015 Philosophical transactions. Series A, Mathematical Vol.373 No.2043

<P>This paper presents a mathematical characterization and analysis of beam-hardening artefacts in X-ray computed tomography (CT). In the field of dental and medical radiography, metal artefact reduction in CT is becoming increasingly important as artificial prostheses and metallic implants become more widespread in ageing populations. Metal artefacts are mainly caused by the beam-hardening of polychromatic X-ray photon beams, which causes mismatch between the actual sinogram data and the data model being the Radon transform of the unknown attenuation distribution in the CT reconstruction algorithm. We investigate the beam-hardening factor through a mathematical analysis of the discrepancy between the data and the Radon transform of the attenuation distribution at a fixed energy level. Separation of cupping artefacts from beam-hardening artefacts allows causes and effects of streaking artefacts to be analysed. Various computer simulations and experiments are performed to support our mathematical analysis.</P>

Long-term Prognosis of Crohnʼs Disease and Its Temporal Change Between 1981 and 2012 : A Hospital-based Cohort Study from Korea

Park, Sang Hyoung,Yang, Suk-Kyun,Park, Soo-Kyung,Kim, Jong Wook,Yang, Dong-Hoon,Jung, Kee Wook,Kim, Kyung-Jo,Ye, Byong Duk,Byeon, Jeong-Sik,Myung, Seung-Jae,Yoon, Yong Sik,Yu, Chang Sik,Kim, Jin-Ho Oxford University Press 2014 Inflammatory bowel diseases Vol.20 No.3

Deletion of the Serotonin Receptor Type 3A in Mice Leads to Sudden Cardiac Death During Pregnancy.

Park, Hyewon,Oh, Chang-Myung,Park, Junbeom,Park, Hyelim,Cui, Shanyu,Kim, Hyung Suk,Namkung, Jun,Park, Sang-Kyu,Pak, Hui-Nam,Lee, Moon-Hyoung,Kim, Hail,Joung, Boyoung Japanese Circulation Society 2015 CIRCULATION JOURNAL Vol.79 No.8

<P>The serotonin receptor type 3 (Htr3) blocker is associated with QT prolongation and torsades de pointes. However, little is known about effects of Htr3 on the heart arrhythmia.Methods?and?Results:An electrophysiological study Involving knock-out (KO) female mice lacking functional Htr3a (Htr3a(-/-)) and their wild-type littermates during non-pregancy (NP) and late pregnancy (LP) was performed. Htr3a mRNA was present in the wild-type, but not in theHtr3a(-/-)mouse hearts. Serotonin and tryptophan hydroxylase 1 (Tph1), a rate-limiting enzyme of serotonin synthesis in hearts, is increased during pregnancy. The heart weight and size were increased in the pregnant mice regardless of a mutation. The QTc intervals were prolonged after pregnancy in both the wild (NP: 171.216.8 vs. LP: 247.714.3 ms; P<0.001) andHtr3a(-/-)mice (NP: 187.918.7 vs. LP: 275.611.0 ms, P<0.001). Compared with wild-type LP mice,Htr3a(-/-)LP mice had increased spontaneous ventricle tarchycardia (VT; 56% vs. 0%, P=0.002), VT inducibility (66% vs. 25%, P=0.002) and mortality (56% vs. 0%, P=0.002). Pharmacologic administration of serotonin and Htr3 agonists (m-CPBG) decreased the QT interval in wild mice, but not inHtr3a(-/-)mice.</P>

Inpainting based metal reduction in dental X-ray computed tomography

Hyoung Suk Park,Jae Kyu Choi,Kyung-Ran Park,Kyung Sang Kim,Yoon Mo Jung,Sang-Hwy Lee,Jong Chul Ye,Jin Keun Seo 한국산업응용수학회 2012 한국산업응용수학회 학술대회 논문집 Vol.7 No.1